CN108017583B - 一种可博美的制备方法 - Google Patents
一种可博美的制备方法 Download PDFInfo
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- CN108017583B CN108017583B CN201610941220.3A CN201610941220A CN108017583B CN 108017583 B CN108017583 B CN 108017583B CN 201610941220 A CN201610941220 A CN 201610941220A CN 108017583 B CN108017583 B CN 108017583B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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CN201610941220.3A CN108017583B (zh) | 2016-11-01 | 2016-11-01 | 一种可博美的制备方法 |
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CN201610941220.3A CN108017583B (zh) | 2016-11-01 | 2016-11-01 | 一种可博美的制备方法 |
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CN108017583A CN108017583A (zh) | 2018-05-11 |
CN108017583B true CN108017583B (zh) | 2021-04-06 |
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109400528B (zh) * | 2018-12-18 | 2022-03-15 | 深圳科兴药业有限公司 | 一种可博美的合成方法 |
CN109369525A (zh) * | 2018-12-29 | 2019-02-22 | 安礼特(上海)医药科技有限公司 | 罗沙司它的新晶型及其制备方法 |
CN112441975B (zh) * | 2019-09-03 | 2023-10-31 | 西藏嘉信景天药业有限公司 | 一种罗沙司他重要中间体的制备方法 |
CN112441976A (zh) * | 2019-09-03 | 2021-03-05 | 南京海润医药有限公司 | 罗沙司他重要中间体的制备方法 |
CN112679431B (zh) * | 2019-10-18 | 2023-05-05 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
CN113121438B (zh) * | 2020-01-10 | 2023-05-23 | 江苏希迪制药有限公司 | 一种异喹啉酮类化合物的制备方法 |
CN113444042A (zh) * | 2020-03-27 | 2021-09-28 | 南京海润医药有限公司 | 一种罗沙司他的制备方法 |
CN111533691A (zh) * | 2020-06-08 | 2020-08-14 | 重庆三圣实业股份有限公司 | 一种罗沙司他的制备方法 |
CN114933563B (zh) | 2020-06-19 | 2023-04-07 | 济川(上海)医学科技有限公司 | 一种罗沙司他及其中间体的合成方法和其中间体 |
CN112500344B (zh) * | 2020-11-18 | 2022-07-01 | 江苏豪森药业集团有限公司 | 罗沙司他晶型及其制备方法 |
CN112194624A (zh) * | 2020-11-18 | 2021-01-08 | 江苏豪森药业集团有限公司 | 一种异喹啉类化合物的晶型及其制备方法 |
Citations (7)
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---|---|---|---|---|
EP2357175A1 (en) * | 2003-06-06 | 2011-08-17 | Fibrogen, Inc. | isoquinoline derivatives AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN |
CN102264740A (zh) * | 2008-08-20 | 2011-11-30 | 菲布罗根有限公司 | 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途 |
EP2476669A1 (en) * | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisoquinoline compounds and methods of use thereof |
CN102936246A (zh) * | 2012-11-08 | 2013-02-20 | 江苏暨明医药科技有限公司 | 丁苯那嗪的合成方法 |
CN103539735A (zh) * | 2012-07-16 | 2014-01-29 | 菲布罗根有限公司 | 脯氨酰羟化酶抑制剂的晶体形态 |
CN104024227A (zh) * | 2011-07-22 | 2014-09-03 | 北京贝美拓新药研发有限公司 | 抑制脯氨酸羟化酶活性的化合物的晶型及其应用 |
CN104892509A (zh) * | 2015-06-04 | 2015-09-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
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2016
- 2016-11-01 CN CN201610941220.3A patent/CN108017583B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2357175A1 (en) * | 2003-06-06 | 2011-08-17 | Fibrogen, Inc. | isoquinoline derivatives AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN |
CN103145616A (zh) * | 2003-06-06 | 2013-06-12 | 菲布罗根有限公司 | 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途 |
EP2476669A1 (en) * | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisoquinoline compounds and methods of use thereof |
CN102264740A (zh) * | 2008-08-20 | 2011-11-30 | 菲布罗根有限公司 | 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途 |
CN104024227A (zh) * | 2011-07-22 | 2014-09-03 | 北京贝美拓新药研发有限公司 | 抑制脯氨酸羟化酶活性的化合物的晶型及其应用 |
CN103539735A (zh) * | 2012-07-16 | 2014-01-29 | 菲布罗根有限公司 | 脯氨酰羟化酶抑制剂的晶体形态 |
CN102936246A (zh) * | 2012-11-08 | 2013-02-20 | 江苏暨明医药科技有限公司 | 丁苯那嗪的合成方法 |
CN104892509A (zh) * | 2015-06-04 | 2015-09-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
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Address after: 221004 No.7, pantaoshan South Road, Xuzhou Economic Development Zone, Xuzhou City, Jiangsu Province Applicant after: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Applicant after: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Applicant after: JIANGSU WANBANG BIOPHARMACEUTICAL GROUP CO.,LTD. Address before: 221004 No.7, pantaoshan South Road, Xuzhou Economic Development Zone, Xuzhou City, Jiangsu Province Applicant before: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Applicant before: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Applicant before: Jiangsu Wan Bang Biochemical Medicine Co.,Ltd. Address after: 221004 No.7, pantaoshan South Road, Xuzhou Economic Development Zone, Xuzhou City, Jiangsu Province Applicant after: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Applicant after: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Applicant after: Jiangsu Wan Bang Biochemical Medicine Co.,Ltd. Address before: 221004 No.7, pantaoshan South Road, Xuzhou Economic Development Zone, Xuzhou City, Jiangsu Province Applicant before: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Applicant before: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Applicant before: JIANGSU WANBANG BIOPHARMACEUTICALS Co.,Ltd. |
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