IL93764A - Polynucleotides capable of hybridizing to a genomic sequence of hepatitis c virus, polypeptides encoded thereby and methods and kits using said polynucleotides or polypeptides - Google Patents

Polynucleotides capable of hybridizing to a genomic sequence of hepatitis c virus, polypeptides encoded thereby and methods and kits using said polynucleotides or polypeptides

Info

Publication number
IL93764A
IL93764A IL9376490A IL9376490A IL93764A IL 93764 A IL93764 A IL 93764A IL 9376490 A IL9376490 A IL 9376490A IL 9376490 A IL9376490 A IL 9376490A IL 93764 A IL93764 A IL 93764A
Authority
IL
Israel
Prior art keywords
hcv
genome
polynucleotides
polypeptides
hepatitis
Prior art date
Application number
IL9376490A
Other languages
English (en)
Other versions
IL93764A0 (en
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27406397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL93764(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to IL14367590A priority Critical patent/IL143675A/en
Priority to IL13246990A priority patent/IL132469A/xx
Publication of IL93764A0 publication Critical patent/IL93764A0/xx
Priority to IL14367501A priority patent/IL143675A0/xx
Publication of IL93764A publication Critical patent/IL93764A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL9376490A 1989-03-17 1990-03-16 Polynucleotides capable of hybridizing to a genomic sequence of hepatitis c virus, polypeptides encoded thereby and methods and kits using said polynucleotides or polypeptides IL93764A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL14367590A IL143675A (en) 1989-03-17 1990-03-16 Polynucleotide capable of hybridizing to a complement of a genomic sequence of hepatitis c virus, polynucleotide probe comprising said polynucleotide and methods using said probe
IL13246990A IL132469A (en) 1989-03-17 1990-03-16 Antibody composition comprising anti - hcv - antibodies and immunoassay using such antibodies
IL14367501A IL143675A0 (en) 1989-03-17 2001-06-11 Hepatitis c virus infection diagnostics and vaccines

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32533889A 1989-03-17 1989-03-17
US34133489A 1989-04-20 1989-04-20
US35500289A 1989-05-18 1989-05-18

Publications (2)

Publication Number Publication Date
IL93764A0 IL93764A0 (en) 1990-12-23
IL93764A true IL93764A (en) 2003-12-10

Family

ID=27406397

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9376490A IL93764A (en) 1989-03-17 1990-03-16 Polynucleotides capable of hybridizing to a genomic sequence of hepatitis c virus, polypeptides encoded thereby and methods and kits using said polynucleotides or polypeptides

Country Status (19)

Country Link
EP (3) EP1034785A3 (es)
JP (13) JP2656995B2 (es)
KR (2) KR0185373B1 (es)
AT (1) ATE286979T1 (es)
AU (3) AU666767B2 (es)
CA (1) CA2012482C (es)
DE (3) DE03016585T1 (es)
DK (1) DK0388232T3 (es)
ES (2) ES2020152T4 (es)
FI (3) FI106211B (es)
GR (1) GR910300016T1 (es)
HU (3) HUT54896A (es)
IE (2) IE20060608A1 (es)
IL (1) IL93764A (es)
MY (1) MY110260A (es)
NO (1) NO303941B1 (es)
PT (1) PT93480B (es)
UA (1) UA50829C2 (es)
WO (1) WO1990011089A1 (es)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
HUT54896A (en) * 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
GEP20002164B (en) * 1989-05-18 2000-07-10 Novartis Vaccines & Diagnostic Oligomers, method for detecting of hcv sequence, kit for its detecting, method for production of the blood free from hcv
EP0416725A3 (en) * 1989-07-14 1991-03-20 Chugai Seiyaku Kabushiki Kaisha Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production
CA2065287C (en) * 1989-09-15 1999-12-21 Tatsuo Miyamura New hcv isolates
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
IT1242183B (it) * 1989-12-18 1994-02-16 Wellcome Found Polipeptidi del virus dell'epatite non-a e non-b, post-trasfusionali, procedimento di produzione e corredo per il saggio dei relativi acidi nucleici virali.
US5308750A (en) * 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
AU638304B2 (en) * 1989-12-22 1993-06-24 Abbott Laboratories Hepatitis c assay
EP0435229A1 (en) * 1989-12-27 1991-07-03 Sanwa Kagaku Kenkyusho Co., Ltd. DNA of non-A, non-B hepatitis virus gene, its clone and use thereof
KR940000755B1 (ko) * 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드
US5747239A (en) * 1990-02-16 1998-05-05 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines
US5582968A (en) * 1990-02-16 1996-12-10 United Biomedical, Inc. Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
DE69133402T2 (de) * 1990-04-04 2004-11-11 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Protease von hepatitis-c-virus
AU7679491A (en) * 1990-04-04 1991-10-30 Protos, Inc. Hepatitis c virus protease inhibitors
JP2733138B2 (ja) † 1990-04-04 1998-03-30 カイロン コーポレイション 抗ｈｃｖ抗体の免疫アッセイに使用するｃ型肝炎ウイルス（ｈｃｖ）抗原の組合せ
US5443965A (en) * 1990-04-06 1995-08-22 Genelabs Incorporated Hepatitis C virus epitopes
CA2044296A1 (en) * 1990-06-12 1991-12-13 Hiroaki Okamoto Oligonucleotide primers, and their application for high-fidelity detection of non-a, non-b hepatitis virus
JP3050395B2 (ja) * 1990-06-12 2000-06-12 国立感染症研究所長 Ｃ型肝炎ウイルス抗原ポリペプチド、その産生方法および抗体の検出方法
CA2045326A1 (en) * 1990-06-25 1991-12-26 Hiroto Okayama Non-a, non-b, hepatitis virus particles
EP0464287A1 (en) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptide
US5747339A (en) * 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
WO1992000328A1 (en) * 1990-06-30 1992-01-09 Akzo N.V. Non-a non-b sequences
EP0468657A3 (en) * 1990-07-09 1992-02-05 Tonen Corporation Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis
ES2100185T3 (es) * 1990-07-11 1997-06-16 Shionogi & Co Secuencia de adnc y deteccion del virus de la hepatitis c.
CA2047792C (en) * 1990-07-26 2002-07-02 Chang Y. Wang Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines
WO1992002642A1 (en) * 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
JP3114731B2 (ja) * 1990-08-14 2000-12-04 国立感染症研究所長 Ｃ型肝炎ウイルス抗体検出用ペプチド抗原及びその使用方法
US6172189B1 (en) * 1990-08-24 2001-01-09 Abbott Laboratories Hepatitis C assay utilizing recombinant antigens
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
EP0544838A4 (en) * 1990-08-25 1997-09-10 New York Blood Center Inc Non-a, non-b hepatitis virus antigen, diagnostic methods and vaccines
US7863008B2 (en) 1990-08-25 2011-01-04 Bioprocess Pty Ltd. Method for detecting NANBV associated seroconversion
IE65107B1 (en) * 1990-10-05 1995-10-04 Akzo Nv Peptides immunochemically reactive with antibodies directed against hepatitis Non-A Non-B virus
DK0770679T4 (da) * 1990-11-03 2010-05-10 Siemens Healthcare Diagnostics HCV-specifikke peptider, sammensætninger dertil og anvendelse deraf
EP0556320B1 (en) * 1990-11-07 1999-03-24 Abbott Laboratories Monoclonal antibodies to hepatitis c virus and method for using the same
US5753430A (en) * 1990-11-07 1998-05-19 Abbott Laboratories Monoclonal antibodies to hepatitis C virus and method for using same
DE69133382T3 (de) * 1990-11-08 2009-10-08 Novartis Vaccines and Diagnostics, Inc.(n.d.Ges.d.Staates Delaware), Emeryville Asialoglycoproteine des Hepatitis C-Virus
JP2945759B2 (ja) 1990-11-08 1999-09-06 カイロン コーポレイション Ｃ型肝炎ウイルスアシアロ糖タンパク質
EP0485209A1 (en) * 1990-11-08 1992-05-13 Immuno Japan Inc. Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
JPH06504431A (ja) * 1990-11-08 1994-05-26 カイロン　コーポレイション Ｃ型肝炎ウイルスアシアロ糖タンパク質
WO1992009634A1 (en) * 1990-11-29 1992-06-11 Toray Industries, Incorporated Non-a non-b hepatitis virus antigen protein
EP0488812B1 (en) * 1990-11-30 1999-06-09 Immuno Japan Inc. Non-A, non-B hepatitis related nucleic acids, antigens, antibodies and their detection reagents
ES2138784T3 (es) * 1990-12-14 2000-01-16 Innogenetics Nv Antigenos sinteticos para la deteccion de anticuerpos contra el virus de la hepatitis c.
US6007982A (en) * 1990-12-14 1999-12-28 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
US5910404A (en) 1990-12-14 1999-06-08 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
DE4041304A1 (de) * 1990-12-21 1992-06-25 Mikrogen Molekularbiol Entw Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren
JP3483555B2 (ja) * 1991-01-31 2004-01-06 アボット・ラボラトリーズ 推定ｈｃｖエンベロープ領域に対するモノクローナル抗体およびその使用方法
DE69200512T2 (de) * 1991-03-01 1995-03-09 Akzo Nv Mit Antikörper gegen Hepatitis non-A, non-B-Virus immunochemische reaktive Peptide.
DE69216333T2 (de) * 1991-03-26 1997-07-10 Dade Int Inc Nicht-a, nicht-b hepatitis test
US5574132A (en) * 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
EP0510952A1 (en) * 1991-04-26 1992-10-28 Immuno Japan Inc. Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus
SK284205B6 (sk) * 1991-05-08 2004-10-05 Chiron Corporation Prirodzene sa nevyskytujúca nukleová kyselina, spôsob tvorby hybridizačného produktu a spôsob detekcie genotypov HCV
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
WO1992022655A1 (en) 1991-06-10 1992-12-23 Lucky Limited Hepatitis c diagnostics and vaccines
CA2070952A1 (en) * 1991-06-11 1992-12-12 Makoto Seki Gene of hepatitis c virus or fragment thereof, polypeptide encoded by the same
WO1992022571A1 (en) * 1991-06-13 1992-12-23 Baxter Diagnostics Inc. Immunoassay for non-a non-b hepatitis
DE69232871T2 (de) * 1991-06-24 2003-05-08 Chiron Corp Polypeptide des hepatitis c-virus (hiv)
IT1249685B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Medoto per la rivelazione di anticorpi contro il virus dell'epatite c e corredi per la sua realizzazione
IT1249684B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
AU2513592A (en) * 1991-08-21 1993-03-16 Abbott Laboratories Hepatitis c assay utilizing recombinant antigens to ns1
WO1993004089A1 (en) * 1991-08-21 1993-03-04 Abbott Laboratories Hepatitis c assay utilizing recombinant antigens from ns5 region
DE69227776T2 (de) * 1991-08-21 1999-07-01 Abbott Lab Monoklonale antikörper gegen mutmassliche hepatitis c-virus ns5-proteine und ihre anwendungsmethoden
WO1993004087A1 (en) * 1991-08-21 1993-03-04 Abbott Laboratories Hepatitis c assay utilizing recombinant antigens to c-100 region
EP0787807B1 (en) * 1991-08-27 2003-05-28 F. Hoffmann-La Roche Ag Primers and probes for hepatitis C detection
US5427909A (en) * 1991-09-09 1995-06-27 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
DE69232859T2 (de) * 1991-09-13 2003-04-10 Chiron Corp Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden
CA2119013A1 (en) † 1991-09-16 1993-04-01 Richard R. Lesniewski Hepatitis c assay
AU2683792A (en) * 1991-09-16 1993-04-27 Genelabs Technologies, Inc. Peptide based hepatitis c virus immunoassays
ZA927243B (en) * 1991-10-07 1994-01-26 Akzo Nv Non-A, Non-B peptides
JP3158177B2 (ja) * 1991-10-08 2001-04-23 国立感染症研究所長 Ｃ型肝炎診断薬
ZA927837B (en) * 1991-10-15 1994-03-11 Akzo Nv Monoclonal antibodiesto hepatitis C virus
WO1993009253A1 (en) * 1991-11-07 1993-05-13 Baxter Diagnostics Inc. Epitope mapping ot the c33c region of hcv
CA2123875C (en) 1991-11-21 2005-05-24 Peter Simmons Hepatitis-c virus testing
WO1993011158A2 (en) * 1991-12-06 1993-06-10 Akzo Nobel N.V. Non-a, non-b peptides
US5811246A (en) * 1991-12-17 1998-09-22 The Research Foundation Of State University Of New York Process for immobilization onto the surfaces of ELISA plates of a compound carrier complex and for immunization
WO1993015193A1 (en) * 1992-01-31 1993-08-05 Abbott Laboratories Mammalian expression systems for hcv proteins
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
BR9305435A (pt) * 1992-03-06 1994-12-27 Innogenetics Nv Processo para determinação de peptídeos correspondendo a epítopos imunologicamente importantes e seu uso em um processo para determinação de anticorpos ou peptídeos biotinilados correspondendo a epítopos imunologicamente importantes, processo para preparação dos mesmos e composições contendo os mesmos
US5866139A (en) * 1992-06-04 1999-02-02 Institut Pasteur Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications
JPH05344899A (ja) * 1992-06-11 1993-12-27 Kokuritsu Yobou Eisei Kenkyusho Ｃ型肝炎ウイルス外被タンパク質の産生法
UA39944C2 (uk) 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
DE69334328D1 (de) 1992-07-16 2010-06-10 Advanced Life Science Inst Inc Antigene Peptide zur Gruppierung des Hepatitis-C-Virus, Kit damit und Verfahren zur Gruppierung unter Verwendung dieses Kits
DE4240980A1 (de) * 1992-08-07 1994-02-10 Boehringer Mannheim Gmbh HCV Peptidantigene und Verfahren zur Bestimmung von HCV
JPH06311885A (ja) * 1992-08-25 1994-11-08 Mitsubishi Kasei Corp Ｃ型肝炎ウイルス遺伝子に相補的なアンチセンス化合物
DE69330372T2 (de) * 1992-09-10 2002-03-14 Isis Pharmaceuticals Inc ZUSAMMENSETZUNGEN UND VERFAHREN FüR DIE BEHANDLUNG VON MIT HEPATITIS C VIREN ASSOZIIERTEN KRANKHEITEN
US6423489B1 (en) * 1992-09-10 2002-07-23 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
AU5141993A (en) * 1992-09-28 1994-04-26 Chiron Corporation Methods and compositions for controlling translation of hcv proteins
US6057093A (en) * 1992-09-28 2000-05-02 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
JPH07501712A (ja) * 1992-09-29 1995-02-23 シーダーズ−サイナイ・メディカル・センター 微量ｒｎａまはたｒｎａおよびｄｎａ検出用の一段ｒｎａおよび結合一段ｒｎａおよびｄｎａポリメラーゼ・チェイン・リアクション
JPH06153959A (ja) * 1992-10-16 1994-06-03 Evernew Biotec Inc Ｃ型肝炎ウィルスの非構造タンパク質及びそれを用いての診断方法及びキット
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
JP2778886B2 (ja) * 1992-10-16 1998-07-23 エバーニュー バイオテック インコーポレイティド Ｃ型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット
AU6769594A (en) * 1993-04-22 1994-11-08 Genelabs Technologies, Inc. Hepatitis c virus immunodiagnostic antigens and antibodies
DE69434117T3 (de) * 1993-05-10 2009-10-08 Novartis Vaccines and Diagnostics, Inc.(n.d.Ges.d.Staates Delaware), Emeryville Verfahren zur typisierung von hepatitis c viren und dafür zu verwendende reagenzien
DE69433160T2 (de) 1993-05-12 2004-07-08 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region
US5610009A (en) * 1994-01-28 1997-03-11 Abbott Laboratories Mammalian expression systems for hepatitis C virus envelope genes
US5709995A (en) * 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
AU6946394A (en) * 1994-05-09 1995-11-29 Abbott Laboratories Method and reagents useful for improving immunoassay specificity
US6511812B1 (en) 1994-05-09 2003-01-28 Abbott Laboratories Method and test kit for use in improving immunoassay specificity
JPH10503364A (ja) * 1994-05-10 1998-03-31 ザ ジェネラル ホスピタル コーポレーション Ｃ型肝炎ウイルスのアンチセンス阻害
JP3217600B2 (ja) 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
AU3241095A (en) * 1994-07-29 1996-03-04 Chiron Corporation Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same
JPH09503396A (ja) 1994-07-29 1997-04-08 インノジェネティクス・エヌ・ブイ 診断用及び治療用の精製ｃ型肝炎ウイルスエンベロープ蛋白
CA2195312A1 (en) 1994-07-29 1996-02-15 Mark Selby Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
US6235888B1 (en) 1994-10-05 2001-05-22 The General Hospital Corporation Hepatitis C virus vaccine
PT804584E (pt) 1994-10-21 2002-11-29 Innogenetics Nv Sequencias de virus da hepatite c genotipo 7 e sua utilizacao como agentes profilacticos terapeuticos e de diagnostico
ES2168456T3 (es) * 1995-01-16 2002-06-16 North Sydney Area Health Serv Peptidos que afectan a los linfocitos t.
KR970010787A (ko) * 1995-08-14 1997-03-27 성재갑 B형 간염 바이러스 표면항원과 c형 간염 바이러스 외피 단백질의 융합 단백질 및 이를 포함하는 혼합 백신
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
GB9517926D0 (en) 1995-09-01 1995-11-01 Biocine Spa Binding protein
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US5851759A (en) * 1996-04-19 1998-12-22 Chiron Corporation Heteroduplex tracking assay (HTA) for genotyping HCV
IT1284635B1 (it) * 1996-04-24 1998-05-21 Clonit Spa Metodo per la rivelazione di acidi nucleici amplificati e kit per il suo uso.
JP3715027B2 (ja) 1996-05-07 2005-11-09 シスメックス株式会社 Ｃ型肝炎ウイルス感染症診断薬
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
FR2760458B1 (fr) * 1997-03-05 1999-04-23 Bio Merieux Peptide structural antigenique, composes antigenique et immunogene et utilisations dans la detection, la prevention et le traitement d'une infection par le vhc
AU7471698A (en) 1997-05-06 1998-11-27 Chiron Corporation Intracellular production of hepatitis c e1 and e2 truncated polypeptides
AU9363398A (en) 1997-10-06 1999-04-27 Chiron S.P.A. Hepatitis c receptor protein cd81
CA2689696C (en) 1999-02-26 2013-08-06 Novartis Vaccines And Diagnostics, Inc. Microemulsions with adsorbed macromolecules and microparticles
PT1154793E (pt) 1999-02-26 2010-12-21 Novartis Vaccines & Diagnostic Utilização de bioadesivos e adjuvantes para a administração de antigénios nas mucosas
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
AU2001272945A1 (en) * 2000-06-15 2001-12-24 Chiron Corporation Immunoassays for anti-hcv antibodies
EP1178116A1 (en) * 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
WO2002014362A2 (en) 2000-08-17 2002-02-21 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
EP1399183B1 (en) 2001-05-31 2010-06-30 Novartis Vaccines and Diagnostics, Inc. Chimeric alphavirus replicon particles
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
US7049060B2 (en) * 2001-11-05 2006-05-23 Ortho-Clinical Diagnostics, Inc. HCV anti-core monoclonal antibodies
AU2003215316A1 (en) 2002-02-20 2003-09-09 Chiron Corporation Microparticles with adsorbed polypeptide-containing molecules
US7598421B2 (en) 2002-05-08 2009-10-06 Ucl Biomedica Plc Materials for the delivery of biologically-active material to cells
FR2839555B1 (fr) * 2002-05-10 2007-07-27 Bio Rad Pasteur Procede de detection simultanee d'un antigene et d'un anticorps d'un microorganisme infectieux
FR2839722A1 (fr) 2002-05-17 2003-11-21 Bio Merieux Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c
EP1546414B1 (en) 2002-09-09 2008-10-08 Novartis Vaccines and Diagnostics, Inc. Hcv assay
US7927840B2 (en) 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
CA3081071A1 (en) 2002-10-16 2004-04-29 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
WO2004060396A2 (en) 2002-12-27 2004-07-22 Chiron Corporation Immunogenic compositions containing phospholpid
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
PT1592441E (pt) 2003-02-06 2012-05-21 Aduro Biotech Listeria atenuada relativamente à entrada em células não patogénicas, vacinas compreendendo a listeria e métodos para sua utilização
KR101173871B1 (ko) 2003-02-06 2012-08-16 앤저 테라퓨틱스 인코퍼레이티드 변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
WO2006070028A1 (es) * 2004-12-23 2006-07-06 Berthet Francois Xavier Composiciones y procedimientos para detectar infección patógena
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
EP2612679A1 (en) 2004-07-29 2013-07-10 Novartis Vaccines and Diagnostics, Inc. Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
WO2006024020A2 (en) 2004-08-27 2006-03-02 Novartis Vaccines And Diagnostics Inc. Hcv non-structural protein mutants and uses thereof
WO2006039326A2 (en) * 2004-09-29 2006-04-13 The Administrators Of The Tulane Educational Fund Inhibitors of hepatitits c virus
WO2007031867A2 (en) 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-stru tural ns3/4a fusion gene
EP2138483B1 (en) 2007-03-20 2011-05-18 Terumo Kabushiki Kaisha Oxidative color-developing compounds, salts thereof, process for production of the same, reagent compositions and test tools made by using the same
US20090214593A1 (en) 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
US8815253B2 (en) 2007-12-07 2014-08-26 Novartis Ag Compositions for inducing immune responses
CA2724649A1 (en) 2008-05-19 2009-11-26 Anza Therapeutics, Inc. Compositions comprising prfa* mutant listeria and methods of use thereof
US20120100171A1 (en) 2009-03-09 2012-04-26 William Henry Hapten-carrier conjugates with bacterial toxins having a signal peptide as carrier and their use in immunogenic compositions
CA2766907A1 (en) 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
JP6025721B2 (ja) 2010-07-06 2016-11-16 ノバルティス アーゲー カチオン性水中油型エマルジョン
RU2606846C2 (ru) 2011-07-06 2017-01-10 Новартис Аг Эмульсии типа "масло в воде", которые содержат нуклеиновые кислоты
ES2702318T3 (es) 2011-07-06 2019-02-28 Glaxosmithkline Biologicals Sa Emulsiones catiónicas de aceite en agua
AU2012322704B2 (en) 2011-10-11 2017-09-07 Novartis Ag Recombinant self-replicating polycistronic RNA molecules
RU2667429C2 (ru) * 2013-05-10 2018-09-19 Соединенные Штаты Америки, В Лице Секретаря, Департамента Здравоохранения И Социального Обеспечения Сша Композиции и способы для одновременного обнаружения hcv антигена/антитела
RU2568872C1 (ru) * 2014-10-15 2015-11-20 Игорь Геннадьевич Сивов Лекарственное средство для лечения вирусного гепатита с
BR112017010180B1 (pt) 2014-11-27 2022-10-04 Kimberly-Clark Worldwide, Inc Método para detectar a presença de norovírus, e, dispositivo de ensaio de fluxo contínuo para detecção de norovírus em uma amostra
WO2016160046A1 (en) 2015-03-27 2016-10-06 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
CN109071665B (zh) 2016-04-18 2022-11-01 塞德斯医疗公司 结合人cd40的激动性抗体及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542016A (en) * 1981-03-27 1985-09-17 Institut Merieux Non-a non-b hepatitis surface antigen useful for the preparation of vaccines and methods of use
US4702909A (en) * 1982-05-05 1987-10-27 Louisiana State University A & M Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent
US4870026A (en) * 1982-09-16 1989-09-26 The General Hospital Corporation Non-A, non-B. hepatitis, virus, methods of identification purification, characterization, diagnosis and immunization
US5032511A (en) * 1987-03-31 1991-07-16 Mitsubishi Kasei Corporation DNA fragments coding for antigens specific to non-A non-B hepatitis, expression vectors containing said DNA fragments, transformants and process for producing said antigens
AU624105B2 (en) * 1987-11-18 1992-06-04 Novartis Vaccines And Diagnostics, Inc. Nanbv diagnostics and vaccines
EP0318216B2 (en) * 1987-11-18 2001-08-29 Chiron Corporation NANBV diagnostics
WO1989012641A1 (en) * 1988-06-17 1989-12-28 Genelabs Incorporated Enterically transmitted non-a/non-b hepatitis viral agent
WO1990000597A1 (en) * 1988-07-06 1990-01-25 Genelabs Incorporated Post-transfusion, non-a, non-b hepatitis virus and antigens
JP2696116B2 (ja) * 1988-09-30 1998-01-14 財団法人阪大微生物病研究会 非ａ非ｂ肝炎患者の血清と抗原抗体反応するペプチド、及び該ペプチドをコードするｄｎａ
HUT54896A (en) * 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv

Also Published As

Publication number Publication date
FI107619B (fi) 2001-09-14
EP1034785A3 (en) 2004-06-02
EP1394255A3 (en) 2004-06-02
AU666766B2 (en) 1996-02-22
IE20060607A1 (en) 2006-09-20
JP2009292819A (ja) 2009-12-17
IE20060608A1 (en) 2006-09-20
JP3171792B2 (ja) 2001-06-04
JPH04504715A (ja) 1992-08-20
GR910300016T1 (en) 1991-11-15
JP2006111632A (ja) 2006-04-27
ES2228297T1 (es) 2005-04-16
DE388232T1 (de) 1991-05-02
NO904712L (no) 1990-10-30
ES2020152T4 (es) 2006-11-16
FI905591A0 (fi) 1990-11-12
HU902814D0 (en) 1991-03-28
PT93480A (pt) 1990-11-07
JPH09215497A (ja) 1997-08-19
JP2007332148A (ja) 2007-12-27
AU4750493A (en) 1994-01-20
IL93764A0 (en) 1990-12-23
DE69034182D1 (de) 2005-03-03
PT93480B (pt) 1997-07-31
EP0388232A1 (en) 1990-09-19
KR920700045A (ko) 1992-02-19
JPH07101986A (ja) 1995-04-18
JPH07145194A (ja) 1995-06-06
AU4750593A (en) 1993-12-16
FI107610B (fi) 2001-09-14
AU5278390A (en) 1990-10-22
EP0388232B1 (en) 2005-01-12
KR0167125B1 (en) 1999-05-01
CA2012482A1 (en) 1990-09-17
HU211981A9 (en) 1996-01-29
HUT54896A (en) 1991-04-29
NO904712D0 (no) 1990-10-30
WO1990011089A1 (en) 1990-10-04
KR0185373B1 (ko) 1999-05-01
AU4750693A (en) 1993-12-16
JPH10295389A (ja) 1998-11-10
DE03016585T1 (de) 2005-03-31
FI106211B (fi) 2000-12-15
JP2009275046A (ja) 2009-11-26
JP2007254475A (ja) 2007-10-04
JP2693908B2 (ja) 1997-12-24
MY110260A (en) 1998-03-31
AU640920B2 (en) 1993-09-09
EP1034785A2 (en) 2000-09-13
DE69034182T2 (de) 2005-12-15
FI20002014A (fi) 2000-09-13
JP2000039434A (ja) 2000-02-08
ES2020152A4 (es) 1991-08-01
HU225068B1 (en) 2006-05-29
NO303941B1 (no) 1998-09-28
UA50829C2 (uk) 2002-11-15
CA2012482C (en) 2004-11-23
JP2809987B2 (ja) 1998-10-15
ES2020152T3 (es) 2005-07-16
ATE286979T1 (de) 2005-01-15
FI20002013A (fi) 2000-09-13
JPH10309197A (ja) 1998-11-24
JP2656995B2 (ja) 1997-09-24
AU666767B2 (en) 1996-02-22
DK0388232T3 (da) 2005-02-07
JP2006169233A (ja) 2006-06-29
EP1394255A2 (en) 2004-03-03
AU666576B2 (en) 1996-02-15
EP0388232B9 (en) 2005-10-26

Similar Documents

Publication Publication Date Title
IL93764A (en) Polynucleotides capable of hybridizing to a genomic sequence of hepatitis c virus, polypeptides encoded thereby and methods and kits using said polynucleotides or polypeptides
WO1994025601A3 (en) New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
GR3030641T3 (en) Process for typing of hcv isolates.
HUT69609A (en) Hcv genomic sequences for diagnostics and therapeutics
NZ505880A (en) IL-18 receptor polypeptides
DE69434116D1 (en) Hepatitis-c virus typ 4,5 und 6
CA2102702A1 (en) Vitamin K-Dependent Carboxylase
CA2163641A1 (en) Multiple sclerosis virus
WO1995021858A3 (en) Mosaic polypeptide and methods for detecting the hepatitis e virus
WO1999055366A8 (en) Chimeras of hepatitis c virus and bovine viral diarrhea virus
EP1236800A3 (en) Nucleic acids encoding interferon alpha 2, containing single nucleotide polymorphisms and methods of use thereof
EP1010759A4 (en) GENE OF NON-B, NON-C, NON-G HEPATITIS VIRUS, CORRESPONDING POLYNUCLEOTIDE, POLYPEPTIDE AND VIRION, METHOD FOR SEPARATING THE VIRION, AND METHOD FOR DETECTING THE VIRUS
WO2002020771A3 (en) Nucleotide sequences coding for the hisc2 gene
TH35121C3 (th) วิธีสำหรับการเพาะเลี้ยงขนาดใหญ่ของเซลล์ที่ผลิตรีคอมบิแนนท์อิริโธรพอยอิทินของมนุษย์
Lichenstein et al. Nucleic acid encoding N-acetylmuramidase M 1
IL88420A (en) Polypeptide comprising an amino acid sequence encoded by the hepatitis C virus genome a composition comprising said polypeptide immunoassays using said polypeptide antibodies against said polypeptide a DNA polynucleotide encoding said polypeptide kits comprising said polypeptide or said polynucleotide and a method for performing a reaction using said polynucleotide
TH60654A (th) ลำดับนิวคลีโอไทด์ที่มีรหัสสำหรับจีน 1ysR2

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
EXP Patent expired