BR9305435A - Processo para determinação de peptídeos correspondendo a epítopos imunologicamente importantes e seu uso em um processo para determinação de anticorpos ou peptídeos biotinilados correspondendo a epítopos imunologicamente importantes, processo para preparação dos mesmos e composições contendo os mesmos - Google Patents
Processo para determinação de peptídeos correspondendo a epítopos imunologicamente importantes e seu uso em um processo para determinação de anticorpos ou peptídeos biotinilados correspondendo a epítopos imunologicamente importantes, processo para preparação dos mesmos e composições contendo os mesmosInfo
- Publication number
- BR9305435A BR9305435A BR9305435A BR9305435A BR9305435A BR 9305435 A BR9305435 A BR 9305435A BR 9305435 A BR9305435 A BR 9305435A BR 9305435 A BR9305435 A BR 9305435A BR 9305435 A BR9305435 A BR 9305435A
- Authority
- BR
- Brazil
- Prior art keywords
- determining
- peptides corresponding
- immunologically important
- important epitopes
- preparing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92400598 | 1992-03-06 | ||
PCT/EP1993/000517 WO1993018054A2 (en) | 1992-03-06 | 1993-03-08 | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9305435A true BR9305435A (pt) | 1994-12-27 |
Family
ID=8211622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9305435A BR9305435A (pt) | 1992-03-06 | 1993-03-08 | Processo para determinação de peptídeos correspondendo a epítopos imunologicamente importantes e seu uso em um processo para determinação de anticorpos ou peptídeos biotinilados correspondendo a epítopos imunologicamente importantes, processo para preparação dos mesmos e composições contendo os mesmos |
Country Status (16)
Country | Link |
---|---|
US (3) | US5891640A (pt) |
EP (2) | EP0589004B2 (pt) |
JP (2) | JP3443809B2 (pt) |
KR (3) | KR20030096423A (pt) |
AT (2) | ATE364621T1 (pt) |
AU (1) | AU671623B2 (pt) |
BR (1) | BR9305435A (pt) |
CA (1) | CA2102301C (pt) |
DE (2) | DE69324751T3 (pt) |
DK (2) | DK0589004T4 (pt) |
ES (2) | ES2133392T5 (pt) |
GR (1) | GR3030595T3 (pt) |
NZ (2) | NZ249838A (pt) |
PT (1) | PT891982E (pt) |
SG (1) | SG77551A1 (pt) |
WO (1) | WO1993018054A2 (pt) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US7413537B2 (en) * | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
AU8740491A (en) * | 1990-09-28 | 1992-04-28 | Protein Engineering Corporation | Proteinaceous anti-dental plaque agents |
ES2138784T3 (es) * | 1990-12-14 | 2000-01-16 | Innogenetics Nv | Antigenos sinteticos para la deteccion de anticuerpos contra el virus de la hepatitis c. |
ES2330052T3 (es) * | 1991-03-01 | 2009-12-03 | Dyax Corporation | Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas. |
US5773211A (en) * | 1991-07-10 | 1998-06-30 | Abbott Laboratories | Differentiation of HTLV-I and HTLV-II using synthetic peptides |
US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
JP2723360B2 (ja) * | 1992-05-29 | 1998-03-09 | ハワード・フローレイ・インスティテュート・オブ・エクスペリメンタル・フィジオロジー・アンド・メディスン | オリゴヌクレオチド−ポリアミドコンジュゲート |
IT1270941B (it) * | 1993-05-12 | 1997-05-26 | Sorin Biomedica Spa | Peptidi di hcv e loro usi. |
DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
US5885771A (en) * | 1993-10-29 | 1999-03-23 | Srl, Inc. | Antigenic peptide compound and immunoassay |
DK0992580T3 (da) | 1993-11-04 | 2005-07-11 | Innogenetics Nv | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
AU1443695A (en) * | 1993-12-20 | 1995-07-10 | Abbott Laboratories | Differentiation of htlv-i and htlv-ii using synthetic peptides |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
GB9410044D0 (en) * | 1994-05-19 | 1994-07-06 | Int Murex Tech Corp | Assay |
US6303574B1 (en) | 1994-07-22 | 2001-10-16 | The University Of North Carolina At Chapel Hill | Scr SH3 binding peptides and methods of isolating and using same |
US6184205B1 (en) * | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
CA2195648A1 (en) * | 1994-07-25 | 1996-02-08 | Christoph Seidel | Metal chelate-labelled peptides |
WO1996003423A1 (de) * | 1994-07-25 | 1996-02-08 | Boehringer Mannheim Gmbh | Hapten-markierte peptide |
JPH09503396A (ja) | 1994-07-29 | 1997-04-08 | インノジェネティクス・エヌ・ブイ | 診断用及び治療用の精製c型肝炎ウイルスエンベロープ蛋白 |
JP3665371B2 (ja) * | 1994-08-31 | 2005-06-29 | 株式会社先端生命科学研究所 | C型肝炎ウイルス感染又はグループ判定のためのエピトープキメラ抗原ペプチド、その製法、及びそれを使用する感染又はグループ判定法 |
FR2731225B1 (fr) * | 1995-03-03 | 2003-10-31 | Pasteur Institut | Peptides de glycoproteine transmembranaire d'enveloppe et de proteine de capside du retrovirus humain du type hiv-1 et peptides presentant avec eux une parente immunologique |
EP1849869A3 (fr) * | 1994-10-20 | 2011-05-18 | Institut Pasteur | Séquences nucléotidiques d'antigènes rétroviraux VIH-1 groupe (ou sous-groupe) 0 |
AU780017B2 (en) * | 1994-10-20 | 2005-02-24 | Institut Pasteur | Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens |
DE19504302A1 (de) * | 1995-02-09 | 1996-08-14 | Boehringer Mannheim Gmbh | Methode zur serologischen Typisierung mittels typspezifischer Antigene |
DE19505262C2 (de) * | 1995-02-16 | 1998-06-18 | Behring Diagnostics Gmbh | Retrovirus aus der HIV-Gruppe und dessen Verwendung |
WO1996027012A1 (en) * | 1995-03-02 | 1996-09-06 | Akzo Nobel N.V. | Specific hiv-1 group o antigens |
US6309820B1 (en) | 1995-04-07 | 2001-10-30 | University Of North Carolina At Chapel Hill | Polypeptides having a functional domain of interest and methods of identifying and using same |
WO1996031625A1 (en) * | 1995-04-07 | 1996-10-10 | Cytogen Corporation | Polypeptides having a functional domain of interest and methods of identifying and using same |
WO1996034013A1 (fr) * | 1995-04-28 | 1996-10-31 | Srl, Inc. | Compose peptidique antigenique et methode de dosage immunologique |
US6110465A (en) * | 1995-06-07 | 2000-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines |
JPH0967395A (ja) * | 1995-08-31 | 1997-03-11 | S R L:Kk | 抗原ペプチド化合物および免疫学的測定方法 |
DE19534988A1 (de) * | 1995-09-21 | 1997-03-27 | Forssmann Wolf Georg | Verfahren zur Herstellung und Anwendung synthetischer, biotinylierter Peptide |
JP2002171972A (ja) * | 1996-10-14 | 2002-06-18 | Chemo Sero Therapeut Res Inst | 肝炎ウイルスエピトープ |
US6270777B1 (en) * | 1996-12-20 | 2001-08-07 | University Technologies International Inc. | Conserved metalloprotease epitopes |
FR2765688B1 (fr) | 1997-07-04 | 1999-09-10 | Pasteur Institut | Reactif de detection et de suivi des infections provoquees par le virus d'epstein-barr et ses applications |
EP1028972B1 (en) | 1997-11-06 | 2010-09-29 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes |
EP0947525A1 (en) | 1998-03-27 | 1999-10-06 | Innogenetics N.V. | Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue |
EP1115847A1 (en) | 1998-09-25 | 2001-07-18 | Children's Medical Center Corporation | Short peptides which selectively modulate the activity of protein kinases |
SE9903031D0 (sv) * | 1999-08-27 | 1999-08-27 | Eurodiagnostica Ab | Peptide mixture and vaccine against a chronic viral infection |
IT1310160B1 (it) * | 1999-09-03 | 2002-02-11 | Invicta S P A | Zaino con schienale provvisto di lamina elastica |
JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
EP1436627A2 (en) * | 2001-10-05 | 2004-07-14 | Novozymes A/S | Kit for predicting binding of a specific antibody to a potential immunogen and method of screening |
CN100479859C (zh) * | 2002-03-20 | 2009-04-22 | 厦门大学 | 一种针对靶的空间变构现象筛选可抑制和/或激活所述靶生物活性的物质的方法 |
CA2525640C (en) * | 2003-04-11 | 2014-10-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Multiple antigenic peptide assay for detection of hiv or siv type retroviruses |
US7604804B2 (en) | 2004-02-09 | 2009-10-20 | University Of Maryland Biotechnology Institute | Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120 |
US20070073039A1 (en) * | 2005-09-29 | 2007-03-29 | Chisari Francis V | Peptides that inhibit viral infections |
US8865398B2 (en) * | 2006-09-01 | 2014-10-21 | Abbott Laboratories | Combination hepatitis C virus antigen and antibody detection method |
EP2196804A4 (en) * | 2007-10-05 | 2010-09-15 | Kaneka Corp | MARKED PEPTIDE WITH IMMOBILOBULIN BINDING ACTIVITY AND / OR AN IMMUNE LOBULIN COMPLEX AND METHOD FOR DETECTING OR REVIEWING IMMUNE LOBULIN WITH THE AID OF PEPTIDE |
JP5707326B2 (ja) * | 2008-09-02 | 2015-04-30 | アンティジェン・エクスプレス・インコーポレーテッドAntigen Express,Inc. | ヒトパピローマウイルス/Ii−keyのハイブリッドおよびその使用方法 |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
SG11201506804VA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
EP2989120A4 (en) | 2013-04-25 | 2017-04-19 | Carmel-Haifa University Economic Corp. | Synthetic anti-inflammatory peptides and use thereof |
JP6312225B2 (ja) * | 2013-12-27 | 2018-04-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | タンパク質に対するペプチドバインダーの系統的探索、成熟化、および伸長 |
CN108474795B (zh) | 2015-04-20 | 2021-10-29 | 豪夫迈·罗氏有限公司 | 经由系统发现、成熟和延伸过程鉴定的针对蛋白质的特异性肽结合剂 |
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AP56A (en) * | 1987-01-30 | 1989-09-26 | Smithkline Biologicals S A | Hepatitis B virus surface antigens and hybrid antigehs containing them. |
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ATE120234T1 (de) | 1988-06-09 | 1995-04-15 | Innogenetics Nv | Hiv-3-retrovirus und seine verwendung. |
DE3901857A1 (de) * | 1989-01-23 | 1990-07-26 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von hiv 2 antikoerpern |
SU1612264A1 (ru) * | 1989-03-01 | 1990-12-07 | Институт биоорганической химии им.М.М.Шемякина | Способ твердофазного иммуноферментного определени антител к вирусу иммунодефицита человека и меченный биотином синтетический пептид дл его осуществлени |
HUT54896A (en) * | 1989-03-17 | 1991-04-29 | Chiron Corp | Process for producing aquous diagnosticum and vaccine of nanbv |
US5120662A (en) * | 1989-05-09 | 1992-06-09 | Abbott Laboratories | Multilayer solid phase immunoassay support and method of use |
EP0438332B1 (fr) * | 1990-01-16 | 1998-04-08 | Orgenics Ltd. | Peptides dérivant de la glycoprotéine d'enveloppe de virus HIV, leurs applications à la détection d'une infection due à ces virus et à la vaccination contre le SIDA |
KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
EP0445801A3 (en) * | 1990-03-08 | 1992-07-01 | Kuraray Co., Ltd. | Peptide and its use |
EP0448095A1 (en) * | 1990-03-21 | 1991-09-25 | Wolf, Hans Joachim, Prof. Dr. | Subregion of the retroviral ENV protein, DNA sequences encoding it and compositions for the diagnosis, prevention or therapy of retrovirus infections |
CA2047792C (en) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
DK0770679T4 (da) * | 1990-11-03 | 2010-05-10 | Siemens Healthcare Diagnostics | HCV-specifikke peptider, sammensætninger dertil og anvendelse deraf |
ES2138784T3 (es) * | 1990-12-14 | 2000-01-16 | Innogenetics Nv | Antigenos sinteticos para la deteccion de anticuerpos contra el virus de la hepatitis c. |
US5574132A (en) * | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
WO1992022571A1 (en) * | 1991-06-13 | 1992-12-23 | Baxter Diagnostics Inc. | Immunoassay for non-a non-b hepatitis |
CA2107732C (en) | 1992-10-06 | 2003-04-08 | Lutz G. Gurtler | Retrovirus from the hiv group and its use |
-
1993
- 1993-03-08 BR BR9305435A patent/BR9305435A/pt not_active IP Right Cessation
- 1993-03-08 PT PT98202777T patent/PT891982E/pt unknown
- 1993-03-08 KR KR10-1999-7012596A patent/KR20030096423A/ko not_active Application Discontinuation
- 1993-03-08 AT AT98202777T patent/ATE364621T1/de active
- 1993-03-08 AT AT93906490T patent/ATE179716T1/de not_active IP Right Cessation
- 1993-03-08 DE DE69324751T patent/DE69324751T3/de not_active Expired - Lifetime
- 1993-03-08 EP EP93906490A patent/EP0589004B2/en not_active Expired - Lifetime
- 1993-03-08 DK DK93906490T patent/DK0589004T4/da active
- 1993-03-08 EP EP98202777A patent/EP0891982B1/en not_active Expired - Lifetime
- 1993-03-08 US US08/146,028 patent/US5891640A/en not_active Expired - Lifetime
- 1993-03-08 JP JP51533493A patent/JP3443809B2/ja not_active Expired - Lifetime
- 1993-03-08 SG SG9605107A patent/SG77551A1/en unknown
- 1993-03-08 NZ NZ249838A patent/NZ249838A/en active IP Right Revival
- 1993-03-08 KR KR1019930703359A patent/KR100257941B1/ko not_active IP Right Cessation
- 1993-03-08 CA CA002102301A patent/CA2102301C/en not_active Expired - Lifetime
- 1993-03-08 US US08/723,425 patent/US6165730A/en not_active Expired - Lifetime
- 1993-03-08 DK DK98202777T patent/DK0891982T3/da active
- 1993-03-08 DE DE69334148T patent/DE69334148T2/de not_active Expired - Lifetime
- 1993-03-08 WO PCT/EP1993/000517 patent/WO1993018054A2/en active IP Right Grant
- 1993-03-08 NZ NZ299048A patent/NZ299048A/en not_active IP Right Cessation
- 1993-03-08 ES ES93906490T patent/ES2133392T5/es not_active Expired - Lifetime
- 1993-03-08 ES ES98202777T patent/ES2287969T3/es not_active Expired - Lifetime
- 1993-03-08 AU AU37463/93A patent/AU671623B2/en not_active Expired
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1998
- 1998-02-28 KR KR1019980701532A patent/KR100259223B1/ko not_active IP Right Cessation
- 1998-07-09 US US09/112,206 patent/US6210903B1/en not_active Expired - Lifetime
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1999
- 1999-06-23 GR GR990401678T patent/GR3030595T3/el unknown
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2003
- 2003-04-11 JP JP2003107716A patent/JP2004002379A/ja active Pending
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