IL60312A - Replicable bacterial plasmids method for obtention thereof and method of producing human growth hormone - Google Patents

Replicable bacterial plasmids method for obtention thereof and method of producing human growth hormone

Info

Publication number
IL60312A
IL60312A IL60312A IL6031280A IL60312A IL 60312 A IL60312 A IL 60312A IL 60312 A IL60312 A IL 60312A IL 6031280 A IL6031280 A IL 6031280A IL 60312 A IL60312 A IL 60312A
Authority
IL
Israel
Prior art keywords
obtention
growth hormone
human growth
producing human
bacterial plasmids
Prior art date
Application number
IL60312A
Other languages
English (en)
Other versions
IL60312A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26733870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL60312(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to IL69492A priority Critical patent/IL69492A/xx
Publication of IL60312A0 publication Critical patent/IL60312A0/xx
Priority to IL69492A priority patent/IL69492A0/xx
Publication of IL60312A publication Critical patent/IL60312A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
IL60312A 1979-07-05 1980-06-15 Replicable bacterial plasmids method for obtention thereof and method of producing human growth hormone IL60312A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL69492A IL69492A (en) 1979-07-05 1980-06-15 Expression plasmid having a tandem lac promotor system
IL69492A IL69492A0 (en) 1979-07-05 1983-08-14 Microbial expression of quasisynthetic genes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/055,126 US4342832A (en) 1979-07-05 1979-07-05 Method of constructing a replicable cloning vehicle having quasi-synthetic genes

Publications (2)

Publication Number Publication Date
IL60312A0 IL60312A0 (en) 1980-09-16
IL60312A true IL60312A (en) 1985-04-30

Family

ID=26733870

Family Applications (3)

Application Number Title Priority Date Filing Date
IL69492A IL69492A (en) 1979-07-05 1980-06-15 Expression plasmid having a tandem lac promotor system
IL60312A IL60312A (en) 1979-07-05 1980-06-15 Replicable bacterial plasmids method for obtention thereof and method of producing human growth hormone
IL69492A IL69492A0 (en) 1979-07-05 1983-08-14 Microbial expression of quasisynthetic genes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL69492A IL69492A (en) 1979-07-05 1980-06-15 Expression plasmid having a tandem lac promotor system

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL69492A IL69492A0 (en) 1979-07-05 1983-08-14 Microbial expression of quasisynthetic genes

Country Status (42)

Country Link
US (7) US4342832A (no)
EP (1) EP0022242B1 (no)
JP (4) JPH0612996B2 (no)
KR (2) KR830003574A (no)
AR (1) AR244341A1 (no)
AT (1) ATE82324T1 (no)
AU (2) AU533697B2 (no)
BE (1) BE884012A (no)
BG (1) BG41135A3 (no)
BR (1) BR8008736A (no)
CA (2) CA1164375A (no)
CH (1) CH661939A5 (no)
CS (3) CS250652B2 (no)
DD (3) DD210071A5 (no)
DE (3) DE3050722C2 (no)
DK (2) DK173503B1 (no)
EG (1) EG14819A (no)
ES (2) ES8105386A1 (no)
FI (2) FI802030A (no)
FR (2) FR2460330B1 (no)
GB (2) GB2121047B (no)
GR (1) GR69320B (no)
HK (3) HK87584A (no)
IE (3) IE50461B1 (no)
IL (3) IL69492A (no)
IT (1) IT1131393B (no)
KE (3) KE3451A (no)
MX (1) MX172674B (no)
MY (3) MY8500765A (no)
NL (1) NL930114I2 (no)
NO (2) NO167673C (no)
NZ (2) NZ194043A (no)
OA (1) OA06562A (no)
PH (1) PH19814A (no)
PL (1) PL149278B1 (no)
PT (1) PT71487A (no)
RO (1) RO93374B (no)
SG (1) SG56984G (no)
WO (1) WO1981000114A1 (no)
YU (3) YU163580A (no)
ZA (1) ZA803600B (no)
ZW (1) ZW14180A1 (no)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4898830A (en) * 1979-07-05 1990-02-06 Genentech, Inc. Human growth hormone DNA
US6455275B1 (en) 1980-02-25 2002-09-24 The Trustees Of Columbia University In The City Of New York DNA construct for producing proteinaceous materials in eucaryotic cells
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4711843A (en) * 1980-12-31 1987-12-08 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
IL59690A (en) * 1980-03-24 1983-11-30 Yeda Res & Dev Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
IE53166B1 (en) * 1980-08-05 1988-08-03 Searle & Co Synthetic urogastrone gene,corresponding plasmid recombinants,transformed cells,production thereof and urogastrone expression
US7101981B1 (en) 1980-08-26 2006-09-05 Regents Of The University Of California Bovine growth hormone recombinantly produced in E. coli
US4725549A (en) * 1980-09-22 1988-02-16 The Regents Of The University Of California Human and rat prolactin and preprolactin cloned genes
GR81946B (no) * 1980-09-25 1984-12-12 Genentech Inc
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS57181098A (en) * 1981-04-30 1982-11-08 Japan Found Cancer Novel recombinant dna
US4810645A (en) * 1981-08-14 1989-03-07 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
NZ201918A (en) * 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US4880910A (en) * 1981-09-18 1989-11-14 Genentech, Inc. Terminal methionyl bovine growth hormone and its use
US5254463A (en) * 1981-09-18 1993-10-19 Genentech, Inc. Method for expression of bovine growth hormone
US5236831A (en) * 1981-12-29 1993-08-17 Kiowa Hakko Kogyo Co., Ltd. Amino acid synthesis in corynebacteria using E. coli genes
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US4665160A (en) * 1982-03-22 1987-05-12 Genentech, Inc. Novel human growth hormone like protein HGH-V encoded in the human genome
US4446235A (en) * 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
DE3380262D1 (en) * 1982-05-25 1989-08-31 Lilly Co Eli Cloning vectors for expression of exogenous protein
US4778759A (en) * 1982-07-09 1988-10-18 Boyce, Thompson Institute For Plant Research, Inc. Genetic engineering in cyanobacteria
US4891315A (en) * 1982-10-25 1990-01-02 American Cyanamid Company Production of herpes simplex viral porteins
WO1984000775A1 (en) * 1982-08-10 1984-03-01 Univ Columbia The use of eucaryotic promoter sequences in the production of proteinaceous materials
US4530904A (en) * 1982-09-03 1985-07-23 Eli Lilly And Company Method for conferring bacteriophage resistance to bacteria
WO1984001150A1 (en) * 1982-09-16 1984-03-29 Amgen Avian growth hormones
CA1209501A (en) * 1982-09-16 1986-08-12 Nikos Panayotatos Expression vector
US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
JPS59106297A (ja) * 1982-12-07 1984-06-19 Rikagaku Kenkyusho ヒト生長ホルモンのカルボキシ末端遺伝子の合成法
US5618697A (en) * 1982-12-10 1997-04-08 Novo Nordisk A/S Process for preparing a desired protein
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US4634678A (en) * 1982-12-13 1987-01-06 Molecular Genetics Research And Development Limited Partnership Plasmid cloning and expression vectors for use in microorganisms
GB8303383D0 (en) * 1983-02-08 1983-03-16 Biogen Nv Sequences recombinant dna molecules
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
US5242798A (en) * 1983-07-21 1993-09-07 Scripps Clinic And Research Foundation Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
US4900811A (en) * 1983-07-21 1990-02-13 Scripps Clinic And Research Foundation Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
JPS60137291A (ja) * 1983-12-26 1985-07-20 Takeda Chem Ind Ltd 発現ベクター
CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
CA1272144A (en) * 1984-06-29 1990-07-31 Tamio Mizukami Fish growth hormone polypeptide
US5489529A (en) * 1984-07-19 1996-02-06 De Boer; Herman A. DNA for expression of bovine growth hormone
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
DE3586386T2 (de) * 1984-10-05 1993-01-14 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
NZ213759A (en) * 1984-10-19 1989-01-27 Genentech Inc Lhrh-ctp protein conjugates influencing prolactin fsh and lh release
US4645829A (en) * 1984-10-29 1987-02-24 Monsanto Company Method for separating polypeptides
US4861868A (en) 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
DK151585D0 (da) * 1985-04-03 1985-04-03 Nordisk Gentofte Dna-sekvens
EP0200986B2 (en) * 1985-04-25 1998-03-11 F. Hoffmann-La Roche Ag Recombinant human interleukin-1
AU6131086A (en) * 1985-07-05 1987-01-30 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US5041381A (en) 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
US4892764A (en) * 1985-11-26 1990-01-09 Loctite Corporation Fiber/resin composites, and method of making the same
US5552528A (en) 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
US5827826A (en) * 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
ES2061524T3 (es) * 1986-05-07 1994-12-16 Eniricerche Spa Un vector plasmidico para la expresion en bacillus y empleado para la clonacion del gen estructural que codifica la hormona de crecimiento humana y un metodo para la produccion de la hormona.
EP0252588A3 (en) * 1986-05-12 1989-07-12 Smithkline Beecham Corporation Process for the isolation and purification of p. falciparum cs protein expressed in recombinant e. coli, and its use as a vaccine
US4806239A (en) * 1986-11-28 1989-02-21 Envirotech Corporation Apparatus for shifting filter plates in a filter press
JPS63159244A (ja) * 1986-12-23 1988-07-02 三菱マテリアル株式会社 二層の押出成形珪酸質―石灰質系成形品の製造方法
WO1988005079A1 (en) * 1986-12-31 1988-07-14 Lucky, Ltd. Method for the production of salmon growth hormone using a synthetic gene
EP0329710A1 (en) * 1987-01-07 1989-08-30 Allied Corporation Microbial production of peptide oligomers
US4977089A (en) * 1987-01-30 1990-12-11 Eli Lilly And Company Vector comprising signal peptide-encoding DNA for use in Bacillus and other microorganisms
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins
FR2624835B2 (fr) * 1987-08-05 1990-09-07 Hassevelde Roger Support ergonomique a creme glacee, a cuillere integree, transformable en tout autre objet apres son utilisation premiere
US5268267A (en) * 1987-08-21 1993-12-07 The General Hospital Corporation Method for diagnosing small cell carcinoma
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura
JPH0231042U (no) * 1988-08-19 1990-02-27
US5130422A (en) * 1988-08-29 1992-07-14 Monsanto Company Variant somatotropin-encoding DNA
ATE154364T1 (de) 1988-09-02 1997-06-15 Univ Rockefeller Makrophagenabgeleiteter entzündungsmediator(mip- 2)
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5082767A (en) * 1989-02-27 1992-01-21 Hatfield G Wesley Codon pair utilization
US5075227A (en) * 1989-03-07 1991-12-24 Zymogenetics, Inc. Directional cloning
US4960301A (en) * 1989-03-27 1990-10-02 Fry Steven A Disposable liner for pickup truck beds
US5164180A (en) 1989-05-18 1992-11-17 Mycogen Corporation Bacillus thuringiensis isolates active against lepidopteran pests
US5266477A (en) * 1990-02-02 1993-11-30 Pitman-Moore, Inc. Monoclonal antibodies which differentiate between native and modified porcine somatotropins
CA2041446A1 (en) 1990-05-15 1991-11-16 August J. Sick Bacillus thuringiensis genes encoding novel dipteran-active toxins
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
US5202119A (en) * 1991-06-28 1993-04-13 Genentech, Inc. Method of stimulating immune response
US5744139A (en) * 1991-06-28 1998-04-28 University Of Tennessee Research Corporation Insulin-like growth factor I (IGF-1) induced improvement of depressed T4/T8 ratios
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
HUT67319A (en) * 1991-08-30 1995-03-28 Life Medical Sciences Inc Compositions for treating wounds
US5317012A (en) * 1991-10-04 1994-05-31 The University Of Tennessee Research Corporation Human growth hormone induced improvement in depressed T4/T8 ratio
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
AU5446494A (en) * 1992-10-22 1994-05-09 Sloan-Kettering Institute For Cancer Research Growth hormone fragment hgh 108-129
DE69435280D1 (de) 1993-03-10 2010-04-15 Glaxosmithkline Llc Phosphodiesterase des menschlichen Gehirns und Screening-Verfahren
FR2738842B1 (fr) * 1995-09-15 1997-10-31 Rhone Poulenc Rorer Sa Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US5760187A (en) * 1996-02-22 1998-06-02 Mitsui Toatsu Chemicals, Inc. Purification process of a human growth hormone
JP3794748B2 (ja) * 1996-03-04 2006-07-12 第一アスビオファーマ株式会社 メタノール代謝系を有する微生物の培養法
US6503729B1 (en) 1996-08-22 2003-01-07 The Board Of Trustees Of The University Of Illinois Selected polynucleotide and polypeptide sequences of the methanogenic archaeon, methanococcus jannashii
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
EP1007069A1 (en) * 1996-11-01 2000-06-14 Smithkline Beecham Corporation Novel coding sequences
US6068991A (en) * 1997-12-16 2000-05-30 Bristol-Myers Squibb Company High expression Escherichia coli expression vector
PT1040192E (pt) 1997-12-18 2006-12-29 Monsanto Technology Llc Plantas transgénicas resistentes a insectos e métodos para melhoramento da actividade 8-endotoxina contra insectos
US6087128A (en) 1998-02-12 2000-07-11 Ndsu Research Foundation DNA encoding an avian E. coli iss
ES2317665T3 (es) 1998-03-31 2009-04-16 Tonghua Gantech Biotechnology Ltd. Proteina quimerica que contiene una secuencia de tipo chaperona intramolecular y su aplicacion a la produccion de insulina.
US6512162B2 (en) 1998-07-10 2003-01-28 Calgene Llc Expression of eukaryotic peptides in plant plastids
US6271444B1 (en) 1998-07-10 2001-08-07 Calgene Llc Enhancer elements for increased translation in plant plastids
DE19940751A1 (de) 1998-08-28 2000-03-02 Febit Ferrarius Biotech Gmbh Lichtemissions-Detektionseinrichtung
ATE456652T1 (de) 1999-02-19 2010-02-15 Febit Holding Gmbh Verfahren zur herstellung von polymeren
US6946265B1 (en) 1999-05-12 2005-09-20 Xencor, Inc. Nucleic acids and proteins with growth hormone activity
US6187750B1 (en) 1999-08-25 2001-02-13 Everyoung Technologies, Inc. Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
AT408721B (de) 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
GB9924351D0 (en) * 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
US6562790B2 (en) 2000-02-05 2003-05-13 Chein Edmund Y M Hormone therapy methods and hormone products for abating coronary artery blockage
JP2003530847A (ja) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
US6995246B1 (en) * 2000-10-19 2006-02-07 Akzo Nobel N.V. Methods for removing suspended particles from soluble protein solutions
ATE416784T1 (de) 2000-12-01 2008-12-15 Takeda Pharmaceutical Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
WO2002046435A2 (en) * 2000-12-05 2002-06-13 Alexion Pharmaceuticals, Inc. Engineered plasmids and their use for in situ production of genes
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
US20030143191A1 (en) * 2001-05-25 2003-07-31 Adam Bell Chemokine beta-1 fusion proteins
US6720538B2 (en) * 2001-06-18 2004-04-13 Homedics, Inc. Thermostat variation compensating knob
ES2516041T3 (es) 2001-10-10 2014-10-30 Ratiopharm Gmbh Remodelación y glicoconjugación de la hormona del crecimiento humano (hGH)
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
WO2003059934A2 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
EP1463751B1 (en) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Albumin fusion proteins
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
TWI281864B (en) * 2002-11-20 2007-06-01 Pharmacia Corp N-terminally monopegylated human growth hormone conjugates and process for their preparation
RU2357750C2 (ru) 2002-12-31 2009-06-10 Элтус Фармасьютикалз Инк. Кристаллы человеческого гормона роста и способы их получения
MXPA05008785A (es) * 2003-02-19 2005-10-18 Pharmacia Corp Esteres de polietilen glicol activados.
EP1625157A2 (en) * 2003-05-09 2006-02-15 Pharmexa A/S Immunogenic human tnf alpha analogues with reduced cytotoxicity and methods of their preparation
MXPA06008507A (es) 2004-02-02 2008-02-13 Ambrx Inc Cuatro polipeptidos en haz helicoidal humanos modificados y sus usos.
DE602004031982D1 (de) * 2004-06-23 2011-05-05 Usv Ltd Chimeres, von den placenta- und hypophysenisoformen abgeleitetes humanes wachstumshormon und verfahren zur gewinnung der chimere
US8282921B2 (en) * 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US20060024288A1 (en) * 2004-08-02 2006-02-02 Pfizer Inc. tRNA synthetase fragments
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
WO2006071840A2 (en) * 2004-12-22 2006-07-06 Ambrx, Inc. Formulations of human growth hormone comprising a non-naturally encoded amino acid
AU2005323106B2 (en) 2004-12-22 2010-07-29 Ambrx, Inc. Methods for expression and purification of recombinant human growth hormone
CN103690936A (zh) * 2004-12-22 2014-04-02 Ambrx公司 经修饰的人类生长激素
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US7576053B2 (en) 2005-06-13 2009-08-18 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders
US8030271B2 (en) * 2005-07-05 2011-10-04 Emisphere Technologies, Inc. Compositions and methods for buccal delivery of human growth hormone
WO2007019646A1 (en) * 2005-08-19 2007-02-22 University Of Technology, Sydney Liver-directed gene therapy
ES2547554T3 (es) 2005-11-16 2015-10-07 Ambrx, Inc. Métodos y composiciones que comprenden aminoácidos no naturales
AU2006330833A1 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
DE102006039479A1 (de) 2006-08-23 2008-03-06 Febit Biotech Gmbh Programmierbare Oligonukleotidsynthese
EP2486916B1 (en) 2006-12-18 2015-04-01 Ajinomoto Althea, Inc. Human growth hormone formulations
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
US20090093019A1 (en) * 2007-04-27 2009-04-09 Phelps Jamie P Production and in vivo assembly of soluble recombinant icosahedral virus-like particles
AU2007352618B2 (en) 2007-05-02 2013-07-18 Boehringer Ingelheim Animal Health USA Inc. DNA plasmids having improved expression and stability
AU2008275911A1 (en) * 2007-07-19 2009-01-22 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University Self- anchoring MEMS intrafascicular neural electrode
US7939447B2 (en) * 2007-10-26 2011-05-10 Asm America, Inc. Inhibitors for selective deposition of silicon containing films
MX344166B (es) 2008-02-08 2016-12-07 Ambrx Inc Leptina-polipeptidos modificados y sus usos.
BRPI0911780B1 (pt) 2008-04-29 2021-10-05 Ascendis Pharma Endocrinology Division A/S Composição farmacêutica compreendendo compostos peguilados de hormônio de crescimento humano recombinante, e profármaco
CN102171341A (zh) 2008-04-30 2011-08-31 格兰达利斯有限公司 高纯度质粒dna制备物及其制备方法
US8425914B2 (en) * 2008-06-25 2013-04-23 Braasch Biotech Llc Methods for enhanced somatostatin immunogenicity in the treatment of obesity
DK2303314T3 (da) * 2008-06-25 2014-01-13 Braasch Biotech Llc Chloramphenicol-acetyltransferase (cat)-defekt somatostatin-fusionsprotein og anvendelser deraf til kvæg
CN102348715B (zh) 2009-02-03 2017-12-08 阿穆尼克斯运营公司 延伸重组多肽和包含该延伸重组多肽的组合物
US8703717B2 (en) * 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
WO2010094772A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
CN102741275B (zh) 2009-08-24 2016-08-03 阿穆尼克斯运营公司 凝血因子ix组合物及其制备和使用方法
CA2784793A1 (en) 2009-12-21 2011-07-21 Ambrx, Inc. Modified bovine somatotropin polypeptides and their uses
BR112012015597A2 (pt) 2009-12-21 2017-01-31 Ambrx Inc peptídeos de somatotropina suínos modificados e seus usos
WO2011103325A1 (en) 2010-02-17 2011-08-25 Elona Biotechnologies Methods for preparing human growth hormone
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
RU2473556C1 (ru) * 2011-07-14 2013-01-27 Закрытое акционерное общество "ГЕНЕРИУМ" Промышленный способ получения и очистки рекомбинантного гормона роста человека из телец включения
WO2013119880A1 (en) 2012-02-07 2013-08-15 Global Bio Therapeutics Usa, Inc. Compartmentalized method of nucleic acid delivery and compositions and uses thereof
EP4194465A1 (en) 2012-02-15 2023-06-14 Bioverativ Therapeutics Inc. Factor viii compositions and methods of making and using same
AU2013204636B2 (en) 2012-02-15 2016-04-14 Bioverativ Therapeutics Inc. Recombinant Factor VIII proteins
RU2014143029A (ru) 2012-03-26 2016-05-20 Проньютриа, Инк. Заряженные питательные белки и способы их применения
JP2015513904A (ja) 2012-03-26 2015-05-18 プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ， Ｉｎｃ． 栄養断片、タンパク質、および方法
WO2013148328A1 (en) 2012-03-26 2013-10-03 Pronutria, Inc. Nutritive proteins and methods
JP2015519878A (ja) 2012-03-26 2015-07-16 プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ， Ｉｎｃ． 栄養断片、タンパク質、および方法
US9457096B2 (en) 2012-07-06 2016-10-04 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
CN105813579B (zh) 2013-08-08 2019-05-07 全球生物疗法有限公司 用于微创手术过程的夹具装置和其应用
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
US20160219910A1 (en) 2013-09-25 2016-08-04 Pronutria, Inc. Compositions and Formulations for Maintaining and Increasing Muscle Mass, Strength, and Performance and Methods of Production and Use Thereof
WO2017024060A1 (en) 2015-08-03 2017-02-09 Biogen Ma Inc. Factor ix fusion proteins and methods of making and using same
WO2017189432A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
KR20210024082A (ko) 2018-06-25 2021-03-04 제이씨알 파마 가부시키가이샤 단백질 함유 수성 액제
CN109486847B (zh) * 2018-12-17 2021-03-02 江南大学 基于人工串联启动子的枯草芽孢杆菌高效诱导表达系统

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853832A (en) * 1971-04-27 1974-12-10 Harmone Res Foundation Synthetic human pituitary growth hormone and method of producing it
US3853833A (en) * 1971-04-27 1974-12-10 Hormone Res Foundation Synthetic human growth-promoting and lactogenic hormones and method of producing same
GB1521032A (en) * 1974-08-08 1978-08-09 Ici Ltd Biological treatment
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
NL7607683A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4190495A (en) * 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
US4363877B1 (en) * 1977-09-23 1998-05-26 Univ California Recombinant dna transfer vectors
CH630089A5 (de) * 1977-09-09 1982-05-28 Ciba Geigy Ag Verfahren zur herstellung von siliciummodifizierten imidyl-phthalsaeurederivaten.
JPS5449837A (en) * 1977-09-19 1979-04-19 Kobashi Kogyo Kk Safety apparatus of soil block making machine
US4407948A (en) * 1977-09-23 1983-10-04 The Regents Of The University Of California Purification of nucleotide sequences suitable for expression in bacteria
ZA782933B (en) * 1977-09-23 1979-05-30 Univ California Purification of nucleotide sequences suitable for expression in bacteria
US4321365A (en) * 1977-10-19 1982-03-23 Research Corporation Oligonucleotides useful as adaptors in DNA cloning, adapted DNA molecules, and methods of preparing adaptors and adapted molecules
CH655935B (no) * 1977-11-08 1986-05-30
BR7807288A (pt) * 1977-11-08 1979-06-12 Genentech Inc Processo para sintese de polinucleotidos
AT373279B (de) * 1977-11-08 1984-01-10 Genentech Inc Verfahren zur herstellung eines rekombinationsclonbildungstraegers
GR72861B (no) * 1977-11-08 1983-12-13 Genentech Inc
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4356270A (en) * 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4652525A (en) * 1978-04-19 1987-03-24 The Regents Of The University Of California Recombinant bacterial plasmids containing the coding sequences of insulin genes
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
FI792481A (fi) * 1978-08-11 1980-02-12 Univ California Syntes av enkaroytiskt protein genom anvaendning av mikro-organismer
DE2963374D1 (en) * 1978-10-10 1982-09-09 Univ Leland Stanford Junior Recombinant dna, method for preparing it and production of foreign proteins by unicellular hosts containing it
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
IE52036B1 (en) * 1979-05-24 1987-05-27 Univ California Non-passageable viruses
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
US4898830A (en) * 1979-07-05 1990-02-06 Genentech, Inc. Human growth hormone DNA
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
GR70279B (no) * 1979-09-12 1982-09-03 Univ California
IL59690A (en) * 1980-03-24 1983-11-30 Yeda Res & Dev Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it
GR79124B (no) * 1982-12-22 1984-10-02 Genentech Inc
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms

Also Published As

Publication number Publication date
NL930114I1 (nl) 1993-10-18
KE3446A (en) 1984-10-05
US5424199A (en) 1995-06-13
JPS5621596A (en) 1981-02-28
CS250655B2 (en) 1987-05-14
CS270884A2 (en) 1987-07-16
MY8500763A (en) 1985-12-31
DD157343A5 (de) 1982-11-03
AU574351B2 (en) 1988-07-07
BR8008736A (pt) 1981-04-28
IE50460B1 (en) 1986-04-30
RO93374A (ro) 1988-01-30
DE3050725C2 (no) 1988-03-10
DK97381A (da) 1981-03-04
IL69492A0 (en) 1983-11-30
NO167674C (no) 1991-11-27
GB2121047B (en) 1984-06-06
BG41135A3 (en) 1987-04-15
HK87584A (en) 1984-11-16
ES493149A0 (es) 1981-05-16
IE50462B1 (en) 1986-04-30
FR2460330B1 (fr) 1985-07-19
GB2055382B (en) 1983-10-19
NO167674B (no) 1991-08-19
DD210070A5 (de) 1984-05-30
GB2055382A (en) 1981-03-04
PT71487A (en) 1980-08-01
CA1202256A (en) 1986-03-25
BE884012A (fr) 1980-12-29
KE3450A (en) 1984-10-05
YU121283A (en) 1984-02-29
JPH02478A (ja) 1990-01-05
US4342832A (en) 1982-08-03
AU533697B2 (en) 1983-12-08
WO1981000114A1 (en) 1981-01-22
NZ201312A (en) 1983-09-30
NO167673C (no) 1991-11-27
NO810608L (no) 1981-02-20
DK173503B1 (da) 2001-01-15
NL930114I2 (nl) 1994-10-17
KR870000701B1 (ko) 1987-04-07
KE3451A (en) 1984-10-05
KR830003574A (ko) 1983-06-21
GR69320B (no) 1982-05-14
SG56984G (en) 1985-03-08
JPH05268970A (ja) 1993-10-19
CA1164375A (en) 1984-03-27
CH661939A5 (de) 1987-08-31
IE801214L (en) 1981-01-05
JPH0612996B2 (ja) 1994-02-23
CS254973B2 (en) 1988-02-15
FI802030A (fi) 1981-01-06
OA06562A (fr) 1981-07-31
YU121183A (en) 1984-02-29
CS250652B2 (en) 1987-05-14
DD210071A5 (de) 1984-05-30
ZA803600B (en) 1981-07-29
JPH0648987B2 (ja) 1994-06-29
JP2622479B2 (ja) 1997-06-18
YU163580A (en) 1984-02-29
DK251490A (da) 1990-10-18
PH19814A (en) 1986-07-08
US5795745A (en) 1998-08-18
DK251490D0 (da) 1990-10-18
IL69492A (en) 1985-04-30
IE842193L (en) 1981-01-05
MX172674B (es) 1994-01-06
NO167673B (no) 1991-08-19
US4634677A (en) 1987-01-06
IT1131393B (it) 1986-06-18
JPH08242881A (ja) 1996-09-24
US4601980A (en) 1986-07-22
ATE82324T1 (de) 1992-11-15
IT8023070A0 (it) 1980-06-26
GB2121047A (en) 1983-12-14
DE3023627A1 (de) 1981-01-22
FI850198A0 (fi) 1985-01-16
HK87484A (en) 1984-11-16
DK172132B1 (da) 1997-11-24
NZ194043A (en) 1983-09-30
EP0022242B1 (en) 1992-11-11
ES8205265A1 (es) 1982-06-01
IE50461B1 (en) 1986-04-30
ZW14180A1 (en) 1980-09-10
FR2460330A1 (fr) 1981-01-23
MY8500764A (en) 1985-12-31
EG14819A (en) 1985-03-31
IL60312A0 (en) 1980-09-16
MY8500765A (en) 1985-12-31
AU1838883A (en) 1984-01-05
NO860680L (no) 1981-02-20
EP0022242A2 (en) 1981-01-14
FR2518572B1 (fr) 1985-08-23
DE3050722C2 (no) 1987-09-24
FR2518572A1 (fr) 1983-06-24
PL149278B1 (en) 1990-01-31
PL225376A1 (en) 1983-07-18
HK87384A (en) 1984-11-16
RO93374B (ro) 1988-01-31
AU5949880A (en) 1981-01-15
ES8105386A1 (es) 1981-05-16
AR244341A1 (es) 1993-10-29
ES499043A0 (es) 1982-06-01
FI850198L (fi) 1985-01-16
EP0022242A3 (en) 1982-04-07
AU2583484A (en) 1984-07-12
US4604359A (en) 1986-08-05
US4658021A (en) 1987-04-14

Similar Documents

Publication Publication Date Title
IL60312A (en) Replicable bacterial plasmids method for obtention thereof and method of producing human growth hormone
JPS5615762A (en) Method and device for controlling growth of tissue
ZA892366B (en) Antiinflammatory skin moisturizing composition and method of preparing same
IL59880A (en) Human le form interferon proteins,method of producing same and formulations comprising them
EP0249993A3 (en) Method of and apparatus for making bread
DE3169454D1 (en) Process for the preparation of a composition for promoting the growth of hair
BG41134A3 (en) Method for cloning and expression of desoxynucleotide sequence coding human pregrowth hormone
GB2196008B (en) Process for preparing ophthalmological collagen coverings and coverings prepared thereby
DE3379379D1 (en) Method of producing human epidermal growth factor
DE2856901D2 (de) Form of implant medicament and preparation process
JPS52133989A (en) Novel aminopiperidines and method of their preparation and medical composition thereof
BG46981A1 (en) Method for preparing of human leucocytaric alpha- 2- interferon
DE3063904D1 (en) Growth promotant controlled release formulations and method of treatment
AR244216A1 (es) Iminofeniltiazolidinas, procedimiento de preparacion y metodo de uso.
EP0320239A3 (en) Method of preparation of inoculum sections for plant tissue culture
GB2083824B (en) Process for the production of human growth hormone
IL87264A0 (en) Artificial skin and method for its production
JPS53101397A (en) Novel imidazo*1*55b*pyridazine process for preparing same medical composition containing same and therapeutic method using same
AU7804187A (en) Intrauterine catheter apparatus and method of use
AU8961082A (en) Proless and apparatus for promoting growth of biomass
EP0219295A3 (en) Process for producing human growth hormone
JPS5672629A (en) Uniformly warming method and apparatus of greenhouse
GB2091739B (en) Purification of human growth hormone
PH25495A (en) Method of controlling tobacco use
SU694493A1 (ru) -Формилвинилацетат и способ его получени