IL123171A - Process for the preparation of substituted 2-oxazolidinone derivatives and a non-solvated 2-oxazolidinone derivative - Google Patents

Process for the preparation of substituted 2-oxazolidinone derivatives and a non-solvated 2-oxazolidinone derivative

Info

Publication number
IL123171A
IL123171A IL12317196A IL12317196A IL123171A IL 123171 A IL123171 A IL 123171A IL 12317196 A IL12317196 A IL 12317196A IL 12317196 A IL12317196 A IL 12317196A IL 123171 A IL123171 A IL 123171A
Authority
IL
Israel
Prior art keywords
oxazolidinone
solvated
substituted
preparation
derivative
Prior art date
Application number
IL12317196A
Other languages
English (en)
Other versions
IL123171A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to IL156733A priority Critical patent/IL156733A/en
Publication of IL123171A0 publication Critical patent/IL123171A0/xx
Priority to IL14803002A priority patent/IL148030A0/xx
Publication of IL123171A publication Critical patent/IL123171A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
IL12317196A 1995-08-07 1996-08-02 Process for the preparation of substituted 2-oxazolidinone derivatives and a non-solvated 2-oxazolidinone derivative IL123171A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL156733A IL156733A (en) 1995-08-07 1996-08-02 Process for the preparation of 2-oxazolidinone derivatives, intermediates for such a process and their preparation and use in the preparation of preparations for medical use
IL14803002A IL148030A0 (en) 1995-08-07 2002-02-06 Process for the purification of (s)-4-{[3-(dimethylamino)ethyl]-1h-indol-5-yl] methyl}-2-oxazolidinone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9516145.1A GB9516145D0 (en) 1995-08-07 1995-08-07 Improved chemical synthesis
PCT/GB1996/001885 WO1997006162A1 (en) 1995-08-07 1996-08-02 One pot synthesis of 2-oxazolidinone derivatives

Publications (2)

Publication Number Publication Date
IL123171A0 IL123171A0 (en) 1998-09-24
IL123171A true IL123171A (en) 2003-10-31

Family

ID=10778867

Family Applications (4)

Application Number Title Priority Date Filing Date
IL148030A IL148030A (en) 1995-08-07 1996-08-02 Process for purification (S) - 4 - {[3 - (2 - (dimethylamino) ethyl] - H1 - indole - 5 - ile] methyl} -2 - oxazolidinone
IL12317196A IL123171A (en) 1995-08-07 1996-08-02 Process for the preparation of substituted 2-oxazolidinone derivatives and a non-solvated 2-oxazolidinone derivative
IL156733A IL156733A (en) 1995-08-07 1996-08-02 Process for the preparation of 2-oxazolidinone derivatives, intermediates for such a process and their preparation and use in the preparation of preparations for medical use
IL14803002A IL148030A0 (en) 1995-08-07 2002-02-06 Process for the purification of (s)-4-{[3-(dimethylamino)ethyl]-1h-indol-5-yl] methyl}-2-oxazolidinone

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL148030A IL148030A (en) 1995-08-07 1996-08-02 Process for purification (S) - 4 - {[3 - (2 - (dimethylamino) ethyl] - H1 - indole - 5 - ile] methyl} -2 - oxazolidinone

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL156733A IL156733A (en) 1995-08-07 1996-08-02 Process for the preparation of 2-oxazolidinone derivatives, intermediates for such a process and their preparation and use in the preparation of preparations for medical use
IL14803002A IL148030A0 (en) 1995-08-07 2002-02-06 Process for the purification of (s)-4-{[3-(dimethylamino)ethyl]-1h-indol-5-yl] methyl}-2-oxazolidinone

Country Status (34)

Country Link
US (2) US6084103A (ja)
EP (2) EP0843672B1 (ja)
JP (6) JP3729503B2 (ja)
KR (1) KR100670704B1 (ja)
CN (3) CN1092657C (ja)
AR (2) AR006515A1 (ja)
AT (2) ATE325121T1 (ja)
AU (1) AU718413B2 (ja)
BR (1) BR9609830A (ja)
CA (2) CA2227039C (ja)
CZ (2) CZ293050B6 (ja)
DE (2) DE69636107T2 (ja)
DK (2) DK0843672T3 (ja)
ES (2) ES2261545T3 (ja)
GB (1) GB9516145D0 (ja)
HK (2) HK1047094B (ja)
HU (1) HU229966B1 (ja)
IL (4) IL148030A (ja)
IN (2) IN185148B (ja)
MX (1) MX9801044A (ja)
MY (1) MY117571A (ja)
NO (2) NO311690B1 (ja)
NZ (1) NZ315040A (ja)
PL (1) PL188805B1 (ja)
PT (2) PT843672E (ja)
RO (2) RO121816B1 (ja)
RU (1) RU2167875C2 (ja)
SI (2) SI0843672T1 (ja)
SK (1) SK285052B6 (ja)
TR (1) TR199800182T1 (ja)
TW (1) TW358811B (ja)
UA (1) UA53625C2 (ja)
WO (1) WO1997006162A1 (ja)
ZA (1) ZA966711B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5851400A (en) * 1999-07-09 2001-01-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of aniline derivatives
ES2204302B2 (es) 2002-08-07 2005-03-01 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
EP1711493A2 (en) * 2004-02-06 2006-10-18 CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement Crystalline forms of zolmitriptan
WO2006055964A2 (en) * 2004-11-19 2006-05-26 Teva Pharmaceutical Industries Ltd. Zolmitriptan crystal forms
US8143052B2 (en) 2005-08-25 2012-03-27 Ube Industries, Ltd. Process for preparing optically active (S or R)-α amino acid and (R or S)-α amino acid ester in one phase organic reaction medium
EP1981860B1 (en) * 2006-01-19 2011-05-25 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
WO2008007390A2 (en) * 2006-07-10 2008-01-17 Natco Pharma Limited An improved process for purification of zolmitriptan
WO2008018090A2 (en) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd An improved process for the preparation of zolmitriptan
CZ301538B6 (cs) * 2007-02-26 2010-04-07 Zentiva, A. S. Zpusob prípravy zolmitriptanu
CZ2007158A3 (cs) * 2007-02-26 2008-10-22 Zentiva, A. S. Zpusob prípravy zolmitriptanu
CA2701414A1 (en) 2007-10-03 2009-04-09 Generics [Uk] Limited Process for the preparation of zolmitriptan, salts and solvates thereof
CN101230047B (zh) * 2008-02-04 2010-08-04 江苏中威药业有限公司 一种4-取代手性噁唑烷酮类化合物的制备方法
EP2387993B1 (en) * 2010-05-21 2012-11-07 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Orally disintegrating tablets of zolmitriptan and process for preparing the same
CN101948443B (zh) * 2010-08-17 2012-08-22 河南师范大学 一种简单、高效合成4-取代噁唑烷酮衍生物的方法
EP2691396B1 (en) 2011-03-30 2016-08-10 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
WO2013057739A2 (en) * 2011-09-02 2013-04-25 Emcure Pharmaceuticals Limited An improved process for preparation of zolmitriptan
CN102964270B (zh) * 2012-11-21 2015-01-07 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法
CN103275075B (zh) * 2013-06-24 2015-01-07 成都天台山制药有限公司 佐米曲普坦及其制备方法
WO2016037072A2 (en) * 2014-09-04 2016-03-10 Brown University Enopeptin analogas and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
AU646871B2 (en) * 1990-06-07 1994-03-10 Astrazeneca Uk Limited Therapeutic heterocyclic compounds
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US6025374A (en) * 1994-12-06 2000-02-15 Merck Sharp & Dohme, Ltd. Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists

Also Published As

Publication number Publication date
HU229966B1 (hu) 2015-03-30
CA2572508A1 (en) 1997-02-20
JP2006077025A (ja) 2006-03-23
RU2167875C2 (ru) 2001-05-27
NZ315040A (en) 2000-01-28
MY117571A (en) 2004-07-31
HK1047094B (zh) 2006-10-13
CN1244579C (zh) 2006-03-08
NO980522D0 (no) 1998-02-06
AU6663496A (en) 1997-03-05
DE69636107T2 (de) 2007-05-03
NO20005187L (no) 1998-02-06
IL148030A (en) 2010-05-17
PT1227095E (pt) 2006-08-31
JPH11513023A (ja) 1999-11-09
HUP9900188A3 (en) 1999-11-29
US6084103A (en) 2000-07-04
EP1227095A2 (en) 2002-07-31
PT843672E (pt) 2003-03-31
CZ301603B6 (cs) 2010-04-28
DE69636107D1 (de) 2006-06-08
GB9516145D0 (en) 1995-10-04
CA2227039A1 (en) 1997-02-20
US6160123A (en) 2000-12-12
EP1227095B1 (en) 2006-05-03
NO20005187D0 (no) 2000-10-16
SK285052B6 (sk) 2006-05-04
CN1403455A (zh) 2003-03-19
DK0843672T3 (da) 2003-02-17
SI0843672T1 (en) 2003-04-30
IL156733A0 (en) 2004-02-08
TR199800182T1 (xx) 1998-05-21
MX9801044A (es) 1998-05-31
EP0843672A1 (en) 1998-05-27
ES2185790T3 (es) 2003-05-01
CN1092657C (zh) 2002-10-16
CN1201460A (zh) 1998-12-09
CA2227039C (en) 2007-12-04
IL123171A0 (en) 1998-09-24
DE69624825D1 (de) 2002-12-19
CZ293050B6 (cs) 2004-01-14
UA53625C2 (uk) 2003-02-17
AR006515A1 (es) 1999-09-08
PL324881A1 (en) 1998-06-22
DE69624825T2 (de) 2003-09-04
JP3729503B2 (ja) 2005-12-21
SK15498A3 (en) 1998-06-03
ATE227723T1 (de) 2002-11-15
JP2002097178A (ja) 2002-04-02
DK1227095T3 (da) 2006-07-31
HK1047094A1 (en) 2003-02-07
BR9609830A (pt) 1999-03-09
SI1227095T1 (sl) 2006-08-31
JP2006225406A (ja) 2006-08-31
IL156733A (en) 2007-07-04
CN1317480A (zh) 2001-10-17
AU718413B2 (en) 2000-04-13
AR046236A2 (es) 2005-11-30
ATE325121T1 (de) 2006-06-15
RO119618B1 (ro) 2005-01-28
IN185148B (ja) 2000-11-25
ZA966711B (en) 1997-02-18
CN1142904C (zh) 2004-03-24
CA2572508C (en) 2010-03-30
PL188805B1 (pl) 2005-04-29
RO121816B1 (ro) 2008-05-30
JP2002308858A (ja) 2002-10-23
JP4634286B2 (ja) 2011-02-16
EP1227095A3 (en) 2003-11-19
WO1997006162A1 (en) 1997-02-20
KR19990036165A (ko) 1999-05-25
CZ35298A3 (cs) 1998-06-17
JP2002037786A (ja) 2002-02-06
HUP9900188A2 (hu) 1999-05-28
NO311690B1 (no) 2002-01-07
KR100670704B1 (ko) 2007-07-11
NO311691B1 (no) 2002-01-07
NO980522L (no) 1998-02-06
HK1009129A1 (en) 1999-05-28
IL148030A0 (en) 2002-09-12
IN189756B (ja) 2003-04-19
ES2261545T3 (es) 2006-11-16
TW358811B (en) 1999-05-21
JP3739678B2 (ja) 2006-01-25
EP0843672B1 (en) 2002-11-13

Similar Documents

Publication Publication Date Title
IL123171A (en) Process for the preparation of substituted 2-oxazolidinone derivatives and a non-solvated 2-oxazolidinone derivative
IL115315A (en) Process for the preparation of non-solvated crystalline forms of benzothiophene derivatives
IL117659A0 (en) Acetamide derivative process for preparing the same and a pharmaceutical composition containing the same
EG25852A (en) Teracyclic derivatives process of preparation
PL322277A1 (en) Derivatives of pyrazol-4-ylobenzoyl
HUP9901085A3 (en) A process for preparing aza-cyclohexapeptide derivatives
HUP9900947A3 (en) Process for the preparation of piperidine derivatives, intermediates and preparation thereof
PL324451A1 (en) Derivatives of diphenylmethylenepiperidine
HUP9900318A3 (en) Process for preparing 4-aryl-piperidine derivatives
AU5898596A (en) A process for the preparation of lercanidipine hydrochloride
GR3032600T3 (en) Process for the production of imidazo-benzodiazepine derivatives
HUP9904034A3 (en) New process for the preparation of phenylimidazolidine derivatives
PL325517A1 (en) Derivatives of benzothiazolone
EP0722949A3 (en) Process for the preparation of cyclopentadienyl compounds and compounds produced by the process
HUP9903701A3 (en) Process for the preparation of 2-chlorothiazole derivatives, intermediates and preparation thereof
IL117574A0 (en) Processes for the preparation of cyclobutanone derivatives
HUP9903481A3 (en) Process for the preparation of 1-aryl-1-cyanocyclobutane derivatives
IL118992A0 (en) Process and intermediates for preparing norbenzomorphan derivatives
EG20800A (en) Process for preparing of benzophenonehudazone derivatives and insecticides
SG44059A1 (en) Process for preparing acetoxyazetidinone derivative and intermediate thereof
EG21612A (en) Process for preparing of naphtoqunone derivatives
EP0752419A3 (de) Verfahren zur Herstellung von N-substituierten 4-Ketoprolin-Derivaten
AU4191396A (en) A process for the preparation of benzimidazole derivatives
AU1163795A (en) Hirudin derivatives and a process for their preparation
ZA968604B (en) A process for the preparation of alpha-chloromethylphenyl-acetic acid derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired