IL103320A - 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines - Google Patents

7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines

Info

Publication number
IL103320A
IL103320A IL10332092A IL10332092A IL103320A IL 103320 A IL103320 A IL 103320A IL 10332092 A IL10332092 A IL 10332092A IL 10332092 A IL10332092 A IL 10332092A IL 103320 A IL103320 A IL 103320A
Authority
IL
Israel
Prior art keywords
alkyl
amino
group
branched
straight
Prior art date
Application number
IL10332092A
Other languages
English (en)
Hebrew (he)
Other versions
IL103320A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL103320(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to IL11959092A priority Critical patent/IL119590A/xx
Publication of IL103320A0 publication Critical patent/IL103320A0/xx
Publication of IL103320A publication Critical patent/IL103320A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Moulding By Coating Moulds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL10332092A 1991-10-04 1992-10-01 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines IL103320A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL11959092A IL119590A (en) 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (2)

Publication Number Publication Date
IL103320A0 IL103320A0 (en) 1993-03-15
IL103320A true IL103320A (en) 1998-12-06

Family

ID=25092264

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines
IL11959092A IL119590A (en) 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates
IL11959096A IL119590A0 (en) 1991-10-04 1996-11-10 Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL11959092A IL119590A (en) 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates
IL11959096A IL119590A0 (en) 1991-10-04 1996-11-10 Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates

Country Status (28)

Country Link
EP (1) EP0536515B1 (fr)
JP (1) JP3186863B2 (fr)
KR (1) KR100269072B1 (fr)
CN (1) CN1048240C (fr)
AT (1) ATE211128T1 (fr)
AU (1) AU654049B2 (fr)
BR (1) BR1100853A (fr)
CA (1) CA2079692C (fr)
CL (1) CL2004001623A1 (fr)
CZ (2) CZ284159B6 (fr)
DE (4) DE69232302D1 (fr)
DK (1) DK0536515T3 (fr)
ES (1) ES2168254T3 (fr)
FI (1) FI114911B (fr)
HK (1) HK1011348A1 (fr)
HU (2) HU219973B (fr)
IL (3) IL103320A (fr)
LU (1) LU91279I2 (fr)
MX (1) MX9205532A (fr)
NL (1) NL300244I2 (fr)
NO (3) NO301472B1 (fr)
NZ (1) NZ244585A (fr)
PL (4) PL173311B1 (fr)
PT (1) PT536515E (fr)
SG (1) SG52361A1 (fr)
SK (2) SK284826B6 (fr)
TW (1) TW275616B (fr)
ZA (1) ZA927607B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
CA2183565A1 (fr) * 1994-02-17 1995-08-24 Wei-Guo Su Derives de 9-(amino-substitues)-alpha-6-deoxy-5-oxy tetracycline, leur preparation et leur utilisation comme antibiotiques
ATE323671T1 (de) 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EA200201046A1 (ru) 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
US6642270B2 (en) * 2000-05-15 2003-11-04 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
ATE544745T1 (de) * 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (fr) 2001-03-13 2002-09-18 Glaxo Group Limited Dérivés de tétracyclines et leur utilisation comme agents antibiotiques
CZ20032780A3 (cs) 2001-03-13 2004-01-14 Paratek Pharmaceuticals, Inc. 7,9- Substituované tetracyklinové sloučeniny
CA2444899C (fr) * 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
EP2332548A1 (fr) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines pour le traitement des accidents cérebrovasculaires
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
AU2003235759A1 (en) 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP1482926A4 (fr) * 2002-03-08 2006-04-12 Paratek Pharm Innc Composes a base de tetracycline a substitution aminomethyle
EP2319829A1 (fr) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Composés tétracyclines substitués em position 9
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
SI1753713T1 (sl) 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
CA2620600A1 (fr) * 2005-08-31 2007-03-08 Wyeth Derives de glycylcyclines substitues par 9-aminocarbonyle
EP2537934A3 (fr) 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Procédés de régulation de lýexpression des gènes ou produits génétiques utilisant des composés tétracyclines substitués
CA2706475C (fr) 2007-11-29 2016-05-03 Actelion Pharmaceuticals Ltd Derives d'acide phosphonique et leur utilisation en tant qu'antagonistes du recepteur p2y12
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202216656A (zh) 2008-05-23 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
SG10201806714PA (en) * 2008-08-08 2018-09-27 Tetraphase Pharmaceuticals Inc C7-fluoro substituted tetracycline compounds
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CA2761241C (fr) 2009-05-08 2018-02-27 Tetraphase Pharmaceuticals, Inc. Composes de tetracycline
CA2772386C (fr) 2009-08-28 2017-09-19 Tetraphase Pharmaceuticals, Inc. Composes tetracycline
CN102970992B (zh) 2010-05-12 2016-07-06 莱姆派克斯制药公司 四环素组合物
WO2013013504A1 (fr) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 Dérivé de tigécycline
BR112015004523B1 (pt) 2012-08-31 2020-08-04 Tetraphase Pharmaceuticals, Inc Compostos de tetraciclina, composições farmacêuticas e seus usos
EP3068370A2 (fr) 2013-11-12 2016-09-21 Galenicum Health S.L. Compositions pharmaceutiques stables
SG11201903327PA (en) 2016-10-19 2019-05-30 Tetraphase Pharmaceuticals Inc Crystalline forms of eravacycline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
JP3186863B2 (ja) 2001-07-11
HU9203110D0 (en) 1992-12-28
SG52361A1 (en) 1998-09-28
ES2168254T3 (es) 2002-06-16
JPH05255219A (ja) 1993-10-05
IL103320A0 (en) 1993-03-15
DE122006000058I1 (de) 2007-01-18
CN1072172A (zh) 1993-05-19
BR1100853A (pt) 1999-12-07
NO2017037I2 (no) 2017-08-01
FI114911B (fi) 2005-01-31
CZ309397A3 (cs) 1998-09-16
IL119590A (en) 1999-03-12
AU654049B2 (en) 1994-10-20
DK0536515T3 (da) 2002-04-08
KR930007894A (ko) 1993-05-20
TW275616B (fr) 1996-05-11
SK284826B6 (sk) 2005-12-01
EP0536515A1 (fr) 1993-04-14
NO2006015I1 (no) 2006-11-27
KR100269072B1 (ko) 2000-10-16
AU2618392A (en) 1993-04-08
PL176333B1 (pl) 1999-05-31
SK114999A3 (en) 2000-07-11
DE69232302D1 (de) 2002-01-31
FI924454A0 (fi) 1992-10-02
CN1048240C (zh) 2000-01-12
CA2079692A1 (fr) 1993-04-05
NO2006015I2 (no) 2011-03-14
HUT63145A (en) 1993-07-28
NL300244I1 (nl) 2007-01-02
SK280837B6 (sk) 2000-08-14
CL2004001623A1 (es) 2005-06-03
PL172282B1 (pl) 1997-08-29
DE122006000058I2 (de) 2007-09-13
EP0536515B1 (fr) 2001-12-19
SK298492A3 (en) 1995-03-08
PL175957B1 (pl) 1999-03-31
CZ284209B6 (cs) 1998-09-16
IL119590A0 (en) 1997-02-18
DE69232302T2 (de) 2002-08-14
NO2017037I1 (no) 2017-08-01
MX9205532A (es) 1993-04-01
HU211172A9 (en) 1995-11-28
FI924454A (fi) 1993-04-05
HU219973B (hu) 2001-10-28
CA2079692C (fr) 2004-06-08
HK1011348A1 (en) 1999-07-09
CZ284159B6 (cs) 1998-08-12
ATE211128T1 (de) 2002-01-15
CZ298492A3 (en) 1993-05-12
PL296143A1 (en) 1993-05-31
LU91279I2 (fr) 2006-12-11
PT536515E (pt) 2002-05-31
NO923857L (no) 1993-04-05
PL173311B1 (pl) 1998-02-27
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
NO301472B1 (no) 1997-11-03
NZ244585A (en) 1995-07-26
NO923857D0 (no) 1992-10-02
DE69232302T4 (de) 2003-02-13

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