SK284826B6 - 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby - Google Patents

7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby Download PDF

Info

Publication number
SK284826B6
SK284826B6 SK1149-99A SK114999A SK284826B6 SK 284826 B6 SK284826 B6 SK 284826B6 SK 114999 A SK114999 A SK 114999A SK 284826 B6 SK284826 B6 SK 284826B6
Authority
SK
Slovakia
Prior art keywords
group
alkyl
amino
carbon atoms
substituted
Prior art date
Application number
SK1149-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK114999A3 (en
Inventor
Joseph J. Hlavka
Phaid-Eng Sum
Yakov Gluzman
Ving J. Lee
Adma A. Ross
Original Assignee
Wyeth Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK284826(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Holdings Corporation filed Critical Wyeth Holdings Corporation
Publication of SK114999A3 publication Critical patent/SK114999A3/sk
Publication of SK284826B6 publication Critical patent/SK284826B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Moulding By Coating Moulds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SK1149-99A 1991-10-04 1992-09-30 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby SK284826B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (2)

Publication Number Publication Date
SK114999A3 SK114999A3 (en) 2000-07-11
SK284826B6 true SK284826B6 (sk) 2005-12-01

Family

ID=25092264

Family Applications (2)

Application Number Title Priority Date Filing Date
SK2984-92A SK280837B6 (sk) 1991-10-04 1992-09-30 Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze
SK1149-99A SK284826B6 (sk) 1991-10-04 1992-09-30 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK2984-92A SK280837B6 (sk) 1991-10-04 1992-09-30 Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze

Country Status (28)

Country Link
EP (1) EP0536515B1 (fr)
JP (1) JP3186863B2 (fr)
KR (1) KR100269072B1 (fr)
CN (1) CN1048240C (fr)
AT (1) ATE211128T1 (fr)
AU (1) AU654049B2 (fr)
BR (1) BR1100853A (fr)
CA (1) CA2079692C (fr)
CL (1) CL2004001623A1 (fr)
CZ (2) CZ284159B6 (fr)
DE (4) DE69232302D1 (fr)
DK (1) DK0536515T3 (fr)
ES (1) ES2168254T3 (fr)
FI (1) FI114911B (fr)
HK (1) HK1011348A1 (fr)
HU (2) HU219973B (fr)
IL (3) IL119590A (fr)
LU (1) LU91279I2 (fr)
MX (1) MX9205532A (fr)
NL (1) NL300244I1 (fr)
NO (3) NO301472B1 (fr)
NZ (1) NZ244585A (fr)
PL (4) PL173311B1 (fr)
PT (1) PT536515E (fr)
SG (1) SG52361A1 (fr)
SK (2) SK280837B6 (fr)
TW (1) TW275616B (fr)
ZA (1) ZA927607B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
WO1995022529A1 (fr) * 1994-02-17 1995-08-24 Pfizer Inc. Derives de 9-(amino-substitues)-alpha-6-deoxy-5-oxy tetracycline, leur preparation et leur utilisation comme antibiotiques
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CA2672722C (fr) 1999-09-14 2013-11-05 Trustees Of Tufts College Techniques de preparation de tetracyclines substituees avec des solutions chimiques a base de metal de transition
CA2404628A1 (fr) * 2000-03-31 2001-10-11 Stuart B. Levy Composes de tetracycline substitues en 7 et en 9 par carbamate, uree, thio-uree, thiocarbamate et heteroaryl-amino
JP2003533504A (ja) * 2000-05-15 2003-11-11 パラテック ファーマシューティカルズ インコーポレイテッド ７置換型縮合環テトラサイクリン化合物
WO2002004406A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de monocycline 9-substitues
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (fr) 2001-03-13 2002-09-18 Glaxo Group Limited Dérivés de tétracyclines et leur utilisation comme agents antibiotiques
WO2002072506A2 (fr) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de 7-pyrollyl tetracycline et procedes d'utilisation associes
EP1955996A1 (fr) 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués en position 7, 9
WO2002085303A2 (fr) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
EP2329828A1 (fr) 2001-07-13 2011-06-08 Paratek Pharmaceuticals, Inc. Tetracyclines pour le traitement de l'ischémie
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
EP2995610A1 (fr) 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. Composés de tétracycline 4-dedimethylamino
CA2478335C (fr) * 2002-03-08 2011-05-10 Paratek Pharmaceuticals, Inc. Composes a base de tetracycline a substitution aminomethyle
EA201001081A1 (ru) 2003-07-09 2011-02-28 Пэрэтек Фамэсьютикэлс, Инк. Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
LT1753713T (lt) 2004-05-21 2016-11-25 President And Fellows Of Harvard College Tetraciklinų ir jų analogų sintezė
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AU2006285043A1 (en) * 2005-08-31 2007-03-08 Wyeth 9-aminocarbonylsubstituted derivatives of glycylcyclines
EP2537934A3 (fr) 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Procédés de régulation de lýexpression des gènes ou produits génétiques utilisant des composés tétracyclines substitués
MX2010005519A (es) 2007-11-29 2010-06-11 Actelion Pharmaceuticals Ltd Derivados de acido fosfonico y su uso como antagonista del receptor p2 y12.
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202216656A (zh) 2008-05-23 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
AU2009279473B2 (en) * 2008-08-08 2012-12-13 Tetraphase Pharmaceuticals, Inc. C7-fluoro substituted tetracycline compounds
WO2010126607A2 (fr) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
CA2761241C (fr) 2009-05-08 2018-02-27 Tetraphase Pharmaceuticals, Inc. Composes de tetracycline
PT2470500T (pt) * 2009-08-28 2018-01-09 Tetraphase Pharmaceuticals Inc Compostos de tetraciclina
MX347919B (es) 2010-05-12 2017-05-17 Rempex Pharmaceuticals Inc * Composiciones de tetraciclina.
WO2013013504A1 (fr) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 Dérivé de tigécycline
EA031523B1 (ru) 2012-08-31 2019-01-31 Тетрафейз Фармасьютикалс, Инк. Тетрациклиновые соединения
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions
PL3529236T3 (pl) 2016-10-19 2024-07-08 Tetraphase Pharmaceuticals, Inc. Krystaliczne formy erawacykliny

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
PL175957B1 (pl) 1999-03-31
IL119590A0 (en) 1997-02-18
EP0536515A1 (fr) 1993-04-14
CZ309397A3 (cs) 1998-09-16
NO2017037I2 (no) 2017-08-01
CN1072172A (zh) 1993-05-19
LU91279I2 (fr) 2006-12-11
ATE211128T1 (de) 2002-01-15
DE69232302T2 (de) 2002-08-14
NO2006015I1 (no) 2006-11-27
KR100269072B1 (ko) 2000-10-16
JP3186863B2 (ja) 2001-07-11
CL2004001623A1 (es) 2005-06-03
SK280837B6 (sk) 2000-08-14
NO2017037I1 (no) 2017-08-01
BR1100853A (pt) 1999-12-07
FI114911B (fi) 2005-01-31
HU9203110D0 (en) 1992-12-28
NO2006015I2 (no) 2011-03-14
MX9205532A (es) 1993-04-01
NO923857L (no) 1993-04-05
FI924454A (fi) 1993-04-05
ES2168254T3 (es) 2002-06-16
NZ244585A (en) 1995-07-26
HU219973B (hu) 2001-10-28
EP0536515B1 (fr) 2001-12-19
SG52361A1 (en) 1998-09-28
DE69232302T4 (de) 2003-02-13
AU654049B2 (en) 1994-10-20
NO923857D0 (no) 1992-10-02
PT536515E (pt) 2002-05-31
AU2618392A (en) 1993-04-08
PL296143A1 (en) 1993-05-31
IL119590A (en) 1999-03-12
CA2079692C (fr) 2004-06-08
DE69232302D1 (de) 2002-01-31
FI924454A0 (fi) 1992-10-02
SK114999A3 (en) 2000-07-11
DK0536515T3 (da) 2002-04-08
PL172282B1 (pl) 1997-08-29
DE122006000058I1 (de) 2007-01-18
TW275616B (fr) 1996-05-11
HUT63145A (en) 1993-07-28
NO301472B1 (no) 1997-11-03
KR930007894A (ko) 1993-05-20
CN1048240C (zh) 2000-01-12
CZ284209B6 (cs) 1998-09-16
CZ284159B6 (cs) 1998-08-12
HU211172A9 (en) 1995-11-28
DE122006000058I2 (de) 2007-09-13
PL173311B1 (pl) 1998-02-27
SK298492A3 (en) 1995-03-08
PL176333B1 (pl) 1999-05-31
CZ298492A3 (en) 1993-05-12
IL103320A0 (en) 1993-03-15
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
IL103320A (en) 1998-12-06
JPH05255219A (ja) 1993-10-05
NL300244I1 (nl) 2007-01-02
CA2079692A1 (fr) 1993-04-05
HK1011348A1 (en) 1999-07-09

Similar Documents

Publication Publication Date Title
SK284826B6 (sk) 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby
USRE40086E1 (en) Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines
US5834450A (en) 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5281628A (en) 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
JP3639313B2 (ja) 新規な７−（置換）−８−（置換）−９−（置換アミノ）−６−デメチル−６−デオキシテトラシクリン類
US20130029943A1 (en) Methods of Preparing Substituted Tetracyclines with Transition Metal-Based Chemistries
US20040033996A1 (en) Methods of preparing substituted tetracyclines with transition metal-based chemistries
AU2003220123A1 (en) Amino-methyl substituted tetracycline compounds
USRE40183E1 (en) 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
WO2003079983A2 (fr) Procedes de preparation de tetracyclines substituees avec des compositions chimiques a base de metal de transition
HU212267B (en) Process for preparing 9-nitro-7-(substituted)-6-demethyl-6-desoxytetracyclin derivatives

Legal Events

Date Code Title Description
MK4A Expiry of patent

Expiry date: 20120930