HUP0302287A2 - Eljárás ciklopropánkarbonsav-észterek és származékaik előállítására - Google Patents

Eljárás ciklopropánkarbonsav-észterek és származékaik előállítására

Info

Publication number
HUP0302287A2
HUP0302287A2 HU0302287A HUP0302287A HUP0302287A2 HU P0302287 A2 HUP0302287 A2 HU P0302287A2 HU 0302287 A HU0302287 A HU 0302287A HU P0302287 A HUP0302287 A HU P0302287A HU P0302287 A2 HUP0302287 A2 HU P0302287A2
Authority
HU
Hungary
Prior art keywords
preparation
derivatives
acid esters
carboxylic acid
cyclopropanecarboxylic acid
Prior art date
Application number
HU0302287A
Other languages
English (en)
Inventor
Adrian Clark
Elfyn Jones
Ulf Larsson
Anna Minidis
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0013487A external-priority patent/GB0013487D0/en
Priority claimed from SE0002101A external-priority patent/SE0002101D0/xx
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0302287A2 publication Critical patent/HUP0302287A2/hu
Publication of HUP0302287A3 publication Critical patent/HUP0302287A3/hu
Publication of HU230303B1 publication Critical patent/HU230303B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/20—Compounds containing azido groups with azido groups acylated by carboxylic acids
    • C07C247/22—Compounds containing azido groups with azido groups acylated by carboxylic acids with the acylating carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/66—Acyl halides with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya új eljárás, bizonyos általános képletű vegyületek -ahol R egy vagy több halogénnel szubsztituált fenilcsoport; Y -OR1 az általános képletű csoport, amelyben R1 alkil-,cikloalkil- vagy szubsztituált bicikloheptil-csoport -ciklopropánkarbonsav-észterek és egyéb ciklopropánkarbonsav-származékok, (dimetil-szulfoxónium)-metilid és (dimetil-szulfónium)-metilid előállítására, és bizonyos ciklopropánkarbonsav-észterekgyógyászatilag hatásos vegyületek szintézisében intermedierkénthasználható vegyületek előállítására való alkalmazása. Ó
HU0302287A 2000-06-02 2001-05-31 Eljárás ciklopropánkarbonsav-észterek és származékaik előállítására HU230303B1 (hu)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0013487.4 2000-06-02
GB0013487A GB0013487D0 (en) 2000-06-02 2000-06-02 Novel process
SE0002101A SE0002101D0 (sv) 2000-06-06 2000-06-06 Novel Process
SE0002101-4 2000-06-06
PCT/SE2001/001240 WO2001092200A1 (en) 2000-06-02 2001-05-31 Process for the preparation of cyclopropyl carboxylic acid esters and derivatives

Publications (3)

Publication Number Publication Date
HUP0302287A2 true HUP0302287A2 (hu) 2003-10-28
HUP0302287A3 HUP0302287A3 (en) 2008-02-28
HU230303B1 HU230303B1 (hu) 2015-12-28

Family

ID=26244412

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302287A HU230303B1 (hu) 2000-06-02 2001-05-31 Eljárás ciklopropánkarbonsav-észterek és származékaik előállítására

Country Status (31)

Country Link
US (4) US7122695B2 (hu)
EP (4) EP2292582A3 (hu)
JP (2) JP4944344B2 (hu)
KR (1) KR100755170B1 (hu)
CN (2) CN1211344C (hu)
AR (2) AR028110A1 (hu)
AT (1) ATE386011T1 (hu)
AU (2) AU2001262875B2 (hu)
BG (4) BG65922B1 (hu)
BR (2) BRPI0111329B1 (hu)
CA (3) CA2641976C (hu)
CY (1) CY1108100T1 (hu)
CZ (2) CZ302384B6 (hu)
DE (1) DE60132771T2 (hu)
DK (1) DK1292561T3 (hu)
EE (1) EE05215B1 (hu)
ES (1) ES2300331T3 (hu)
HK (1) HK1052171B (hu)
HU (1) HU230303B1 (hu)
IL (4) IL152778A0 (hu)
IS (1) IS8828A (hu)
MX (1) MXPA02011794A (hu)
MY (2) MY140938A (hu)
NO (1) NO20025664D0 (hu)
NZ (2) NZ535112A (hu)
PL (1) PL205232B1 (hu)
PT (1) PT1292561E (hu)
SI (1) SI1292561T1 (hu)
SK (1) SK287215B6 (hu)
TW (1) TWI290549B (hu)
WO (1) WO2001092200A1 (hu)

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CN102796007B (zh) * 2012-08-14 2014-03-26 济南瑞丰医药科技有限公司 一种替卡格雷中间体的制备方法
CN102863341B (zh) * 2012-10-22 2014-05-07 南通大学 一种（1r,2s）-2-芳基环丙胺衍生物的化学合成方法
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
CN103739483B (zh) * 2013-12-23 2015-05-20 王桂霞 一种反式-(1r,2r)-2-(3,4-二氟苯基)-1-环丙烷甲酸的制备方法
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Publication number Publication date
HK1052171A1 (en) 2003-09-05
US20110190520A1 (en) 2011-08-04
CA2641976C (en) 2012-03-20
CY1108100T1 (el) 2014-02-12
MXPA02011794A (es) 2003-04-10
AR070510A2 (es) 2010-04-14
EP1760066A3 (en) 2008-09-10
NO20025664L (no) 2002-11-25
EP2292582A3 (en) 2011-11-02
EE200200666A (et) 2004-06-15
PT1292561E (pt) 2008-04-21
CA2746622A1 (en) 2001-12-06
PL205232B1 (pl) 2010-03-31
JP2003535072A (ja) 2003-11-25
US7906662B2 (en) 2011-03-15
EP2292582A2 (en) 2011-03-09
US20120130097A1 (en) 2012-05-24
BG110454A (bg) 2009-12-31
BG66157B1 (bg) 2011-09-30
HUP0302287A3 (en) 2008-02-28
CN102295555A (zh) 2011-12-28
SK16842002A3 (sk) 2003-06-03
BG65922B1 (bg) 2010-05-31
BG110635A (bg) 2010-08-31
BG66150B1 (bg) 2011-08-31
BR0111329A (pt) 2003-06-10
CA2641976A1 (en) 2001-12-06
DE60132771D1 (de) 2008-03-27
EE05215B1 (et) 2009-10-15
KR20030007827A (ko) 2003-01-23
EP1292561B1 (en) 2008-02-13
CZ20023916A3 (cs) 2003-05-14
KR100755170B1 (ko) 2007-09-04
AU2001262875B2 (en) 2006-08-10
EP2292591A3 (en) 2011-11-02
HK1052171B (zh) 2008-07-25
ATE386011T1 (de) 2008-03-15
BRPI0111329B1 (pt) 2018-05-29
ES2300331T3 (es) 2008-06-16
CZ302384B6 (cs) 2011-04-27
US20030120105A1 (en) 2003-06-26
IL214718A0 (en) 2011-09-27
NO20025664D0 (no) 2002-11-25
CZ301747B6 (cs) 2010-06-09
HU230303B1 (hu) 2015-12-28
IL193071A0 (en) 2009-02-11
CA2408591C (en) 2010-06-22
EP2292591A2 (en) 2011-03-09
JP2011236229A (ja) 2011-11-24
CN102295555B (zh) 2014-05-28
SK287215B6 (sk) 2010-03-08
JP4944344B2 (ja) 2012-05-30
NZ522639A (en) 2004-10-29
NZ535112A (en) 2006-04-28
CN1431992A (zh) 2003-07-23
EP1760066A2 (en) 2007-03-07
US8183412B2 (en) 2012-05-22
TWI290549B (en) 2007-12-01
WO2001092200A1 (en) 2001-12-06
CN1211344C (zh) 2005-07-20
BG110640A (bg) 2010-09-30
MY157627A (en) 2016-06-30
IL152778A (en) 2008-12-29
CA2746622C (en) 2014-01-21
IS8828A (is) 2009-06-05
MY140938A (en) 2010-02-12
AR028110A1 (es) 2003-04-23
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EP1292561A1 (en) 2003-03-19
SI1292561T1 (sl) 2008-06-30
BG107314A (bg) 2003-07-31
US20060258879A1 (en) 2006-11-16
DK1292561T3 (da) 2008-05-26
PL359268A1 (en) 2004-08-23
AU6287501A (en) 2001-12-11
IL193071A (en) 2011-12-29
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