DK1292561T3 - Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater - Google Patents

Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater

Info

Publication number
DK1292561T3
DK1292561T3 DK01937110T DK01937110T DK1292561T3 DK 1292561 T3 DK1292561 T3 DK 1292561T3 DK 01937110 T DK01937110 T DK 01937110T DK 01937110 T DK01937110 T DK 01937110T DK 1292561 T3 DK1292561 T3 DK 1292561T3
Authority
DK
Denmark
Prior art keywords
derivatives
preparation
acid esters
cyclopropylcarboxylic acid
cyclopropylcarboxylic
Prior art date
Application number
DK01937110T
Other languages
English (en)
Inventor
Adrian Clark
Elfyn Jones
Ulf Larsson
Anna Minidis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0013487A external-priority patent/GB0013487D0/en
Priority claimed from SE0002101A external-priority patent/SE0002101D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1292561T3 publication Critical patent/DK1292561T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/20—Compounds containing azido groups with azido groups acylated by carboxylic acids
    • C07C247/22—Compounds containing azido groups with azido groups acylated by carboxylic acids with the acylating carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/66—Acyl halides with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK01937110T 2000-06-02 2001-05-31 Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater DK1292561T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0013487A GB0013487D0 (en) 2000-06-02 2000-06-02 Novel process
SE0002101A SE0002101D0 (sv) 2000-06-06 2000-06-06 Novel Process
PCT/SE2001/001240 WO2001092200A1 (en) 2000-06-02 2001-05-31 Process for the preparation of cyclopropyl carboxylic acid esters and derivatives

Publications (1)

Publication Number Publication Date
DK1292561T3 true DK1292561T3 (da) 2008-05-26

Family

ID=26244412

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01937110T DK1292561T3 (da) 2000-06-02 2001-05-31 Fremgangsmåde til fremstillingen af cyclopropylcarboxylsyreestere og -derivater

Country Status (31)

Country Link
US (4) US7122695B2 (da)
EP (4) EP2292591A3 (da)
JP (2) JP4944344B2 (da)
KR (1) KR100755170B1 (da)
CN (2) CN1211344C (da)
AR (2) AR028110A1 (da)
AT (1) ATE386011T1 (da)
AU (2) AU6287501A (da)
BG (4) BG65922B1 (da)
BR (2) BR0111329A (da)
CA (3) CA2746622C (da)
CY (1) CY1108100T1 (da)
CZ (2) CZ302384B6 (da)
DE (1) DE60132771T2 (da)
DK (1) DK1292561T3 (da)
EE (1) EE05215B1 (da)
ES (1) ES2300331T3 (da)
HK (1) HK1052171B (da)
HU (1) HU230303B1 (da)
IL (4) IL152778A0 (da)
IS (1) IS8828A (da)
MX (1) MXPA02011794A (da)
MY (2) MY140938A (da)
NO (1) NO20025664L (da)
NZ (2) NZ535112A (da)
PL (1) PL205232B1 (da)
PT (1) PT1292561E (da)
SI (1) SI1292561T1 (da)
SK (1) SK287215B6 (da)
TW (1) TWI290549B (da)
WO (1) WO2001092200A1 (da)

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GB0615620D0 (en) * 2006-08-05 2006-09-13 Astrazeneca Ab A process for the preparation of optically active intermediates
GB0615619D0 (en) * 2006-08-05 2006-09-13 Astrazeneca Ab Chemical process for preparation of intermediates
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EP2340252B1 (en) 2008-09-09 2015-11-11 AstraZeneca AB A process for preparing [1s- ]1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ]-3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino]- 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d]pyrimidin-3-yl]-5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates
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CN102796007B (zh) * 2012-08-14 2014-03-26 济南瑞丰医药科技有限公司 一种替卡格雷中间体的制备方法
CN103588674B (zh) * 2012-08-14 2015-02-11 上海医药工业研究院 一种具有光学活性的环丙烷酰阱化合物、其制备和应用
CN102863341B (zh) * 2012-10-22 2014-05-07 南通大学 一种（1r,2s）-2-芳基环丙胺衍生物的化学合成方法
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
CN103739483B (zh) * 2013-12-23 2015-05-20 王桂霞 一种反式-(1r,2r)-2-(3,4-二氟苯基)-1-环丙烷甲酸的制备方法
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
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CN106496178A (zh) * 2016-10-19 2017-03-15 青岛辰达生物科技有限公司 一种替卡格雷中间体及其制备方法
CN107141236B (zh) * 2017-04-24 2019-03-22 台州职业技术学院 替卡格雷中间体(1r,2r)-2-(3,4-二氟代苯基)环丙烷腈的新合成方法
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Also Published As

Publication number Publication date
ATE386011T1 (de) 2008-03-15
CN102295555B (zh) 2014-05-28
EP2292591A3 (en) 2011-11-02
BR0111329A (pt) 2003-06-10
EE05215B1 (et) 2009-10-15
IS8828A (is) 2009-06-05
EP1760066A3 (en) 2008-09-10
US7906662B2 (en) 2011-03-15
NO20025664D0 (no) 2002-11-25
CZ20023916A3 (cs) 2003-05-14
US20030120105A1 (en) 2003-06-26
NO20025664L (no) 2002-11-25
CN1431992A (zh) 2003-07-23
IL193071A (en) 2011-12-29
JP2011236229A (ja) 2011-11-24
DE60132771T2 (de) 2009-02-05
PT1292561E (pt) 2008-04-21
BG110635A (bg) 2010-08-31
US8183412B2 (en) 2012-05-22
KR100755170B1 (ko) 2007-09-04
US20120130097A1 (en) 2012-05-24
IL152778A0 (en) 2003-06-24
HUP0302287A2 (hu) 2003-10-28
PL205232B1 (pl) 2010-03-31
NZ535112A (en) 2006-04-28
US20110190520A1 (en) 2011-08-04
CN1211344C (zh) 2005-07-20
IL152778A (en) 2008-12-29
US7122695B2 (en) 2006-10-17
BRPI0111329B1 (pt) 2018-05-29
MXPA02011794A (es) 2003-04-10
EP2292582A3 (en) 2011-11-02
AU2001262875B2 (en) 2006-08-10
CA2641976C (en) 2012-03-20
BG66150B1 (bg) 2011-08-31
BG66157B1 (bg) 2011-09-30
KR20030007827A (ko) 2003-01-23
JP4944344B2 (ja) 2012-05-30
US20060258879A1 (en) 2006-11-16
WO2001092200A1 (en) 2001-12-06
NZ522639A (en) 2004-10-29
BG65922B1 (bg) 2010-05-31
BG107314A (bg) 2003-07-31
EP1292561A1 (en) 2003-03-19
SK16842002A3 (sk) 2003-06-03
HUP0302287A3 (en) 2008-02-28
CA2641976A1 (en) 2001-12-06
MY157627A (en) 2016-06-30
ES2300331T3 (es) 2008-06-16
EP2292582A2 (en) 2011-03-09
SI1292561T1 (sl) 2008-06-30
JP2003535072A (ja) 2003-11-25
HU230303B1 (hu) 2015-12-28
EE200200666A (et) 2004-06-15
TWI290549B (en) 2007-12-01
CY1108100T1 (el) 2014-02-12
DE60132771D1 (de) 2008-03-27
CZ301747B6 (cs) 2010-06-09
EP1760066A2 (en) 2007-03-07
AR070510A2 (es) 2010-04-14
HK1052171B (zh) 2008-07-25
CA2746622C (en) 2014-01-21
EP2292591A2 (en) 2011-03-09
SK287215B6 (sk) 2010-03-08
BG110454A (bg) 2009-12-31
CN102295555A (zh) 2011-12-28
IL193071A0 (en) 2009-02-11
PL359268A1 (en) 2004-08-23
CZ302384B6 (cs) 2011-04-27
IL214718A0 (en) 2011-09-27
CA2408591C (en) 2010-06-22
AU6287501A (en) 2001-12-11
EP1292561B1 (en) 2008-02-13
HK1052171A1 (en) 2003-09-05
BG66158B1 (bg) 2011-09-30
CA2746622A1 (en) 2001-12-06
MY140938A (en) 2010-02-12
AR028110A1 (es) 2003-04-23
CA2408591A1 (en) 2001-12-06
BG110640A (bg) 2010-09-30

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