HUE035168T2 - Modified animal erythropoietin polypeptides and their applications - Google Patents

Modified animal erythropoietin polypeptides and their applications Download PDF

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Publication number
HUE035168T2
HUE035168T2 HUE09816953A HUE09816953A HUE035168T2 HU E035168 T2 HUE035168 T2 HU E035168T2 HU E09816953 A HUE09816953 A HU E09816953A HU E09816953 A HUE09816953 A HU E09816953A HU E035168 T2 HUE035168 T2 HU E035168T2
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HU
Hungary
Prior art keywords
limited
amino acid
fepo
protein
amino acids
Prior art date
Application number
HUE09816953A
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English (en)
Hungarian (hu)
Inventor
Feng Tian
Putnam Anna-Maria Hays
Frank Song
Stephanie Chu
Joseph Sheffer
Richard Barnett
Marc Siladi
Kyle Atkinson
Darin Lee
Peter CANNING
Original Assignee
Ambrx Inc
Elanco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42060418&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE035168(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ambrx Inc, Elanco Us Inc filed Critical Ambrx Inc
Publication of HUE035168T2 publication Critical patent/HUE035168T2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HUE09816953A 2008-09-26 2009-09-25 Modified animal erythropoietin polypeptides and their applications HUE035168T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10067908P 2008-09-26 2008-09-26
US10069208P 2008-09-26 2008-09-26

Publications (1)

Publication Number Publication Date
HUE035168T2 true HUE035168T2 (en) 2018-05-02

Family

ID=42060418

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE09816953A HUE035168T2 (en) 2008-09-26 2009-09-25 Modified animal erythropoietin polypeptides and their applications

Country Status (23)

Country Link
US (4) US8278418B2 (fr)
EP (2) EP2342223B1 (fr)
JP (1) JP5694171B2 (fr)
KR (1) KR101647164B1 (fr)
CN (2) CN102232085A (fr)
AU (1) AU2009296397B2 (fr)
BR (2) BR122012024318A2 (fr)
CA (1) CA2737026C (fr)
CL (1) CL2011000613A1 (fr)
CO (1) CO6362016A2 (fr)
DK (1) DK2342223T3 (fr)
EA (1) EA019653B1 (fr)
ES (1) ES2631915T3 (fr)
HU (1) HUE035168T2 (fr)
IL (1) IL211600A (fr)
MX (2) MX2011003272A (fr)
NZ (2) NZ601659A (fr)
PE (1) PE20110832A1 (fr)
PL (1) PL2342223T3 (fr)
PT (1) PT2342223T (fr)
UA (1) UA106731C2 (fr)
WO (1) WO2010036964A2 (fr)
ZA (1) ZA201102716B (fr)

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KR101647164B1 (ko) * 2008-09-26 2016-08-09 암브룩스, 인코포레이티드 변형된 동물 에리트로포이에틴 폴리펩티드 및 이의 용도
CA2773596C (fr) * 2009-09-15 2017-11-28 Kaneka Corporation Erythropoietine modifiee a laquelle une molecule a chaine longue soluble dans l'eau est ajoutee
CA2775012A1 (fr) * 2009-09-23 2011-03-31 Biogenerix Ag Procede de purification d'une erythropoietine (epo) humaine recombinee, epo ainsi purifiee et compositions pharmaceutiques la contenant
MX346786B (es) 2010-08-17 2017-03-31 Ambrx Inc Polipeptidos de relaxina modificados y sus usos.
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
US9732132B2 (en) 2011-01-14 2017-08-15 Vanderbilt University Therapeutic compositions and methods for disorders associated with neuronal degeneration
CN103534355A (zh) 2011-03-04 2014-01-22 英特瑞克斯顿股份有限公司 条件性表达蛋白质的载体
KR102004558B1 (ko) 2011-07-29 2019-07-26 아벨라스 바이오사이언시즈 인코포레이티드 선택적 전달 분자 및 사용 방법
US10800856B2 (en) * 2012-06-07 2020-10-13 Ambrx, Inc. Prostate-specific membrane antigen antibody drug conjugates
KR102363779B1 (ko) * 2013-01-30 2022-02-15 아벨라스 바이오사이언시즈 인코포레이티드 선택적 전달 분자 및 사용 방법
EP3194429A4 (fr) * 2014-09-18 2018-06-13 Askgene Pharma, Inc. Nouveaux agonistes du récepteur de l'érythropoïétine de félins
US11319359B2 (en) 2015-04-17 2022-05-03 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
JP6877408B2 (ja) * 2015-08-31 2021-05-26 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ペット治療用ａａｖ−ｅｐｏ
JP6800633B2 (ja) * 2016-07-04 2020-12-16 株式会社カネカ 非ヒト動物において腎機能の低下を抑制する方法
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US20190352609A1 (en) * 2017-01-05 2019-11-21 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Method for preparing reticulocyte simulating particles and platelet simulating particles, and reference control
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
CA3061340A1 (fr) 2017-04-25 2018-11-01 Temple Otorongo Llc Composition pharmaceutique comprenant du tryptophane et un derive de phyllokinine destinee a etre utilisee dans le traitement de troubles psychiatriques et psychologiques
JP2020522263A (ja) * 2017-06-06 2020-07-30 キンドレッド バイオサイエンシズ インコーポレイテッド 獣医学的使用のためのエリスロポエチンおよびアナログ
CN113423721A (zh) * 2018-12-12 2021-09-21 金德雷德生物科学股份有限公司 兽用促红细胞生成素类似物
CA3133652A1 (fr) * 2019-04-01 2020-10-08 Genentech, Inc. Compositions et procedes de stabilisation de formulations contenant des proteines
WO2020214926A1 (fr) 2019-04-17 2020-10-22 Dmc Global Inc. Procédé et système d'identification d'une limite de liaison entre une liaison sonore et une liaison faible dans un article multicouche
RU2770425C2 (ru) * 2020-06-15 2022-04-18 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ получения иммуноглобулина противооспенного из сыворотки крови лошадей
US20230355712A1 (en) * 2020-09-28 2023-11-09 ScoutBio, Inc. Composition and uses thereof
WO2022159414A1 (fr) 2021-01-22 2022-07-28 University Of Rochester Érythropoïétine pour un dysfonctionnement gastrointestinal
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method

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