HUE026179T2 - Készítmények és eljárások komplement C5 protein elleni antitestekhez - Google Patents
Készítmények és eljárások komplement C5 protein elleni antitestekhez Download PDFInfo
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- HUE026179T2 HUE026179T2 HUE09737379A HUE09737379A HUE026179T2 HU E026179 T2 HUE026179 T2 HU E026179T2 HU E09737379 A HUE09737379 A HU E09737379A HU E09737379 A HUE09737379 A HU E09737379A HU E026179 T2 HUE026179 T2 HU E026179T2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- General Chemical & Material Sciences (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (8)
- kôîtâpIecrserÎi OS- pro-tié'^t Szabadalmi igénypenlek1, Izeiéit menekkmáls hs»4n CS protein antitest, vagy ®gy antigén kötő fragment mely tt atáöhiakat tartalmazza: ||| egy ! , ΛΛδ síhdsfaá nel#2 lene SORI; egy& számú szekvenciával rendelkező nehéz lánc CDR2; és egy 3. számú szekvenciával rendelkező nehéz lene C DR.z és ni) egy 4. szêrnà s^yi^iá^l.rengted egy Ő, számú szekvermiávai mndélkeze könnyű lánc CORá; és egy §. számú szekvenciává i rendelkező könnyű lánc PORI, ahol az antitest vagy antigén kőié frsgmense a humán OS proteinhez felümti glazrnon fazanancta módszerrel mérve 1W!,í M; vagy arcnál kiseba Re értékkel kötődik. 2, % I. igénypont szerinti izolált monokionaiis antitest, vagy antigén kötő traimaos, mely tartalmaz egy, a ?. szama anhnosav-szakvénoiévat iagaiáfeő $0%, 90%,. fi%:, .9?%4.:98% vagy 99%-ban azonos szekveneiálú nehéz lánc vsoabs% régiót: és egy, aú, számú amleo-sav-eáekvencíées) legatáöh 80%, 80%, 95%, 97%, §8% vagy 99%-ban azonos szekveriemp kénnyődánc variábilis réglé!:,
- 3, Az % vagy 2, igénypont saatvtl Izolált iT^oo^nllis ahtlfest, vagy antigén koto bagmens,: mely tartalmaz egy 7. számú szekvsncmval rendelkező nenéz lánc variábilis régiét; és egy ö.
- 4., Az előző igénypontok bármelyike szerinti izolált monokionáks antitest, vagy ontígén konc tagmens, mely tartalmaz egy, a 9, számú ®S%, 96%, 87%, 91% vagy 99%*hao azonos szekvenciáid nehéz láncot; és egy, e 10, szama ammo^dv~ székveeclâvai iegaléhh 9®%,: 96%:, 97%,: 98% vagy 99%-ban azonos szekvenciám könnye láncot, ő:, A 4 Igénypont szeneit Izolált monokionális antitest vagy antigén kőto ímgmens, maiy *#*“ ialmaz agy 9. számú szekvenciával rendelkező nehéz láncot; és egy 10. számú szekvem.·^- :vai rstïdeik^zô· a Az as, Igénypontok bármelyike ezédni mmi ***** m m **» IWÂÉ ®mzéml mérve 20-206 pM ic^nei gátolja ax alternativ koraple^i^^t meszsntszls utat, ha barnán CS-tfett szegénykéd szérumot ΜϋΛ, amelyet 108 pM humán: Ca-tel Ätbttmfc^iyrm ?.· Az l-β. igénypontok bármelyike S2é*Mí enid^ vagy atâigm kom fragmens, ahoi m ami-téet· ggy humán vagy Mmém smittsi
- 8, Az 1Av: gényport.tok bármelyike szedne antitest ahor m. kifest egy IgG IzotipuS, 9. ®yà®fà$m készítmény, mely az előző igénypontok bármelyike szenna aniliestei vagy antigén kóló írsgmsnsi és egy gyógpx®fé:Sxabt@6 ekogadn^o horgozât tartalmaz. 16. ix0:iaitmiktetnsav>: :O5«iy aa t->8, igénypontok béam^M szeneit aatkestet; vagy artigen kóló fregmeosf tartalmazza. 11. A 10. igénypont: szerinti nukieinsav, mely a ?· szánta szekvenciával legalább OS *Á~bm azonos szekuenoiáló nehéz iá ne variábilis régiót tartalmazó poripepilosi, vagy a 8. számé szekvenciával legalább IS óiéban azonos szekvenciája könnyé lánc vaolbis régiét tétlék mázd pollpepíldet kódoló nukteotid szekvenosát tartalmakig. A 11, igénypont szerinti nukieinsav, aboi a nehéz ins variábilis régiót tartalmazó pellgeptidet kódoló nukiedkö szekvénolaa 11, színié szekvenciával rendelkezik, és a kény-nyé linó variábilis régiót tartalmazó gbíigéptldét kódoló nekleold szekvencia: a 12, számé szökve nciávebréndelkezik,
- 13. Vektor, mely a 10-12. igénypontok bármelyike szerinti nuklemsavat tartalmazza,:
- 14. Izolált gszdasejt, mely az 1-8. igénypontok bármelyike szerinti anflteet nehéz láncát és könnyű láncát kódoló rekombináns ONS szegmenseket tartalmaz: ahol a DNS szegmensek működőképesen: kspcsölödeak egy promoterbez, és a gszdasepen történő kifejeződésre képesek.
- 16, Az 1*8. igénypontok bármelyike szerinti aritest vagy antigén kötő fragment, vegye t, ÍS#^P«Pt s^Hhi15. Az 1*8. Igénypontok feármélylké szerinti antitest vagy antigén kötő fragmens, vagy a 9. igénypont kormi Járó maculons elváltozások:, asztma, sóim immun szívbetegség, sclerosis multiplex:, gyulladásos bélbeiegség, Isehaemiáseeperiüzlós sérülések, Barrsquer-Simons szindróma, systemás lupus, lupus erythematosus, psonaels, sclerosis multiplex,, .Afehàraer-kôr, giomerolbnephflti.s., paroxysmalls néciumalls hemoglobinuria rRNHy vagy klPGN b Vezetésében történő alkalmazásra.
- 17. Az 1-S. Igénypontok bármelyike szerinti antitest vagy antigén kötő fragmens, vagy a 9. igénypont szerinti gyógyászati készítmény az Immunrendszer és bemosziaikus rendszer extrasorporealls keringésével összefüggő rendellenességeinek csökkentésére szolgáié eljárásban történő· alkalmazásra, melynek során a rászoruló alanynak az antitestet vagy antigént, vagy a gyógyászati készítményt adagolok,
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US8635508P | 2008-08-05 | 2008-08-05 |
Publications (1)
Publication Number | Publication Date |
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HUE026179T2 true HUE026179T2 (hu) | 2016-05-30 |
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Family Applications (1)
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HUE09737379A HUE026179T2 (hu) | 2008-08-05 | 2009-08-03 | Készítmények és eljárások komplement C5 protein elleni antitestekhez |
Country Status (38)
Country | Link |
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US (5) | US8241628B2 (hu) |
EP (3) | EP2815766B1 (hu) |
JP (2) | JP5815403B2 (hu) |
KR (1) | KR101463296B1 (hu) |
CN (2) | CN104177495B (hu) |
AR (1) | AR072897A1 (hu) |
AU (1) | AU2009279197B2 (hu) |
BR (1) | BRPI0916668B1 (hu) |
CA (1) | CA2732782C (hu) |
CL (1) | CL2011000233A1 (hu) |
CO (1) | CO6351750A2 (hu) |
CR (2) | CR20110035A (hu) |
CU (1) | CU23978B1 (hu) |
DK (1) | DK2328616T3 (hu) |
EA (1) | EA027575B1 (hu) |
EC (1) | ECSP11010805A (hu) |
ES (2) | ES2643411T3 (hu) |
HK (4) | HK1203156A1 (hu) |
HN (1) | HN2011000357A (hu) |
HR (1) | HRP20150799T1 (hu) |
HU (1) | HUE026179T2 (hu) |
IL (1) | IL210768B (hu) |
JO (1) | JO3118B1 (hu) |
MA (1) | MA32535B1 (hu) |
MX (2) | MX356218B (hu) |
MY (1) | MY159396A (hu) |
NZ (2) | NZ590634A (hu) |
PE (1) | PE20110225A1 (hu) |
PL (1) | PL2328616T3 (hu) |
PT (1) | PT2328616E (hu) |
RS (1) | RS54113B1 (hu) |
SG (1) | SG10201405377XA (hu) |
SI (1) | SI2328616T1 (hu) |
SV (1) | SV2011003834A (hu) |
TW (2) | TWI417107B (hu) |
UA (1) | UA105009C2 (hu) |
WO (1) | WO2010015608A1 (hu) |
ZA (1) | ZA201100375B (hu) |
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