HUE026179T2 - Készítmények és eljárások komplement C5 protein elleni antitestekhez - Google Patents

Készítmények és eljárások komplement C5 protein elleni antitestekhez Download PDF

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Publication number
HUE026179T2
HUE026179T2 HUE09737379A HUE09737379A HUE026179T2 HU E026179 T2 HUE026179 T2 HU E026179T2 HU E09737379 A HUE09737379 A HU E09737379A HU E09737379 A HUE09737379 A HU E09737379A HU E026179 T2 HUE026179 T2 HU E026179T2
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antibody
human
seq
antibodies
binding
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HUE09737379A
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Beate Diefenbach-Streiber
Adina Eberth
Braydon Charles Guild
Yong-In Kim
Michael Roguska
Igor Splawski
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Novartis Ag
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Claims (8)

  1. kôîtâpIecrserÎi OS- pro-tié'^t Szabadalmi igénypenlek
    1, Izeiéit menekkmáls hs»4n CS protein antitest, vagy ®gy antigén kötő fragment mely tt atáöhiakat tartalmazza: ||| egy ! , ΛΛδ síhdsfaá nel#2 lene SORI; egy& számú szekvenciával rendelkező nehéz lánc CDR2; és egy 3. számú szekvenciával rendelkező nehéz lene C DR.z és ni) egy 4. szêrnà s^yi^iá^l.rengted egy Ő, számú szekvermiávai mndélkeze könnyű lánc CORá; és egy §. számú szekvenciává i rendelkező könnyű lánc PORI, ahol az antitest vagy antigén kőié frsgmense a humán OS proteinhez felümti glazrnon fazanancta módszerrel mérve 1W!,í M; vagy arcnál kiseba Re értékkel kötődik. 2, % I. igénypont szerinti izolált monokionaiis antitest, vagy antigén kötő traimaos, mely tartalmaz egy, a ?. szama anhnosav-szakvénoiévat iagaiáfeő $0%, 90%,. fi%:, .9?%4.:98% vagy 99%-ban azonos szekveneiálú nehéz lánc vsoabs% régiót: és egy, aú, számú amleo-sav-eáekvencíées) legatáöh 80%, 80%, 95%, 97%, §8% vagy 99%-ban azonos szekveriemp kénnyődánc variábilis réglé!:,
  2. 3, Az % vagy 2, igénypont saatvtl Izolált iT^oo^nllis ahtlfest, vagy antigén koto bagmens,: mely tartalmaz egy 7. számú szekvsncmval rendelkező nenéz lánc variábilis régiét; és egy ö.
  3. 4., Az előző igénypontok bármelyike szerinti izolált monokionáks antitest, vagy ontígén konc tagmens, mely tartalmaz egy, a 9, számú ®S%, 96%, 87%, 91% vagy 99%*hao azonos szekvenciáid nehéz láncot; és egy, e 10, szama ammo^dv~ székveeclâvai iegaléhh 9®%,: 96%:, 97%,: 98% vagy 99%-ban azonos szekvenciám könnye láncot, ő:, A 4 Igénypont szeneit Izolált monokionális antitest vagy antigén kőto ímgmens, maiy *#*“ ialmaz agy 9. számú szekvenciával rendelkező nehéz láncot; és egy 10. számú szekvem.·^- :vai rstïdeik^zô· a Az as, Igénypontok bármelyike ezédni mmi ***** m m **» IWÂÉ ®mzéml mérve 20-206 pM ic^nei gátolja ax alternativ koraple^i^^t meszsntszls utat, ha barnán CS-tfett szegénykéd szérumot ΜϋΛ, amelyet 108 pM humán: Ca-tel Ätbttmfc^iyrm ?.· Az l-β. igénypontok bármelyike S2é*Mí enid^ vagy atâigm kom fragmens, ahoi m ami-téet· ggy humán vagy Mmém smittsi
  4. 8, Az 1Av: gényport.tok bármelyike szedne antitest ahor m. kifest egy IgG IzotipuS, 9. ®yà®fà$m készítmény, mely az előző igénypontok bármelyike szenna aniliestei vagy antigén kóló írsgmsnsi és egy gyógpx®fé:Sxabt@6 ekogadn^o horgozât tartalmaz. 16. ix0:iaitmiktetnsav>: :O5«iy aa t->8, igénypontok béam^M szeneit aatkestet; vagy artigen kóló fregmeosf tartalmazza. 11. A 10. igénypont: szerinti nukieinsav, mely a ?· szánta szekvenciával legalább OS *Á~bm azonos szekuenoiáló nehéz iá ne variábilis régiót tartalmazó poripepilosi, vagy a 8. számé szekvenciával legalább IS óiéban azonos szekvenciája könnyé lánc vaolbis régiét tétlék mázd pollpepíldet kódoló nukteotid szekvenosát tartalmakig. A 11, igénypont szerinti nukieinsav, aboi a nehéz ins variábilis régiót tartalmazó pellgeptidet kódoló nukiedkö szekvénolaa 11, színié szekvenciával rendelkezik, és a kény-nyé linó variábilis régiót tartalmazó gbíigéptldét kódoló nekleold szekvencia: a 12, számé szökve nciávebréndelkezik,
  5. 13. Vektor, mely a 10-12. igénypontok bármelyike szerinti nuklemsavat tartalmazza,:
  6. 14. Izolált gszdasejt, mely az 1-8. igénypontok bármelyike szerinti anflteet nehéz láncát és könnyű láncát kódoló rekombináns ONS szegmenseket tartalmaz: ahol a DNS szegmensek működőképesen: kspcsölödeak egy promoterbez, és a gszdasepen történő kifejeződésre képesek.
  7. 16, Az 1*8. igénypontok bármelyike szerinti aritest vagy antigén kötő fragment, vegye t, ÍS#^P«Pt s^Hhi
    15. Az 1*8. Igénypontok feármélylké szerinti antitest vagy antigén kötő fragmens, vagy a 9. igénypont kormi Járó maculons elváltozások:, asztma, sóim immun szívbetegség, sclerosis multiplex:, gyulladásos bélbeiegség, Isehaemiáseeperiüzlós sérülések, Barrsquer-Simons szindróma, systemás lupus, lupus erythematosus, psonaels, sclerosis multiplex,, .Afehàraer-kôr, giomerolbnephflti.s., paroxysmalls néciumalls hemoglobinuria rRNHy vagy klPGN b Vezetésében történő alkalmazásra.
  8. 17. Az 1-S. Igénypontok bármelyike szerinti antitest vagy antigén kötő fragmens, vagy a 9. igénypont szerinti gyógyászati készítmény az Immunrendszer és bemosziaikus rendszer extrasorporealls keringésével összefüggő rendellenességeinek csökkentésére szolgáié eljárásban történő· alkalmazásra, melynek során a rászoruló alanynak az antitestet vagy antigént, vagy a gyógyászati készítményt adagolok,
HUE09737379A 2008-08-05 2009-08-03 Készítmények és eljárások komplement C5 protein elleni antitestekhez HUE026179T2 (hu)

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