MX2018015030A - Anticuerpos anti-c5 y metodos de uso. - Google Patents
Anticuerpos anti-c5 y metodos de uso.Info
- Publication number
- MX2018015030A MX2018015030A MX2018015030A MX2018015030A MX2018015030A MX 2018015030 A MX2018015030 A MX 2018015030A MX 2018015030 A MX2018015030 A MX 2018015030A MX 2018015030 A MX2018015030 A MX 2018015030A MX 2018015030 A MX2018015030 A MX 2018015030A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- present
- provides
- antibodies
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La invención se refiere a anticuerpos anti-C5 y métodos para usarse. En algunas modalidades, un anticuerpo anti-C5 aislado de la presente invención se une a un epítopo dentro de la cadena beta de C5 con mayor afinidad a un pH neutro que a un pH ácido. La invención también proporciona ácidos nucleicos aislados que codifican un anticuerpo anti-C5 de la presente invención. La invención también proporciona células hospederas que comprenden un ácido nucleico de la presente invención. La invención también proporciona un método para producir un anticuerpo que comprende cultivar una célula hospedera de la presente invención a fin de producir el anticuerpo. La invención proporciona además un método para producir un anticuerpo anti-C5 que comprende inmunizar un animal contra un polipéptido que comprende el dominio MG1-MG2 de la cadena beta de C5. Los anticuerpos anti-C5 de la presente invención se pueden usar como medicamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016120325 | 2016-06-17 | ||
| PCT/JP2017/022253 WO2017217524A1 (en) | 2016-06-17 | 2017-06-16 | Anti-c5 antibodies and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018015030A true MX2018015030A (es) | 2019-04-22 |
Family
ID=59969459
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015030A MX2018015030A (es) | 2016-06-17 | 2017-06-16 | Anticuerpos anti-c5 y metodos de uso. |
| MX2023001360A MX2023001360A (es) | 2016-06-17 | 2018-12-04 | Anticuerpos anti-c5 y metodos de uso. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023001360A MX2023001360A (es) | 2016-06-17 | 2018-12-04 | Anticuerpos anti-c5 y metodos de uso. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP3472316A4 (es) |
| JP (3) | JP6202774B1 (es) |
| KR (2) | KR102226975B1 (es) |
| CN (3) | CN115925922A (es) |
| AU (1) | AU2017285763B2 (es) |
| BR (1) | BR112018075688A2 (es) |
| CA (1) | CA3021956A1 (es) |
| CL (1) | CL2018003573A1 (es) |
| CR (1) | CR20190013A (es) |
| EA (1) | EA201990018A1 (es) |
| IL (2) | IL300611A (es) |
| MX (2) | MX2018015030A (es) |
| MY (1) | MY187848A (es) |
| PE (1) | PE20190394A1 (es) |
| PH (1) | PH12018502354A1 (es) |
| SG (2) | SG10201800265UA (es) |
| TW (4) | TWI610941B (es) |
| UA (1) | UA126561C2 (es) |
| WO (1) | WO2017217524A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3056568T3 (da) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR102469853B1 (ko) | 2008-04-11 | 2022-11-22 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| RU2746356C2 (ru) | 2014-12-19 | 2021-04-12 | Чугаи Сейяку Кабусики Кайся | Антитела к с5 и способы их применения |
| US10633434B2 (en) | 2016-06-14 | 2020-04-28 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibodies |
| MY187848A (en) * | 2016-06-17 | 2021-10-26 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| CN116251182A (zh) | 2016-08-05 | 2023-06-13 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| MX2020003619A (es) * | 2017-10-04 | 2020-10-28 | Alexion Pharma Inc | Dosificacion y administracion de los anticuerpos anti-c5 para el tratamiento de los pacientes con glomerulonefritis membranoproliferativa. |
| AU2018383751A1 (en) | 2017-12-13 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibody combinations and uses thereof |
| US20220177556A1 (en) * | 2018-09-06 | 2022-06-09 | The Trustees Of The University Of Pennsylvania | Humanized anti-c5 antibodies and uses thereof |
| MX2021012997A (es) * | 2019-04-24 | 2022-03-04 | Univ Pennsylvania | Anticuerpos anti-c5 humanizados bifuncionales y proteínas de fusión del factor h y usos de los mismos. |
| CN113563467A (zh) * | 2020-04-28 | 2021-10-29 | 上海普铭生物科技有限公司 | 针对人补体蛋白c5的抗体及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0230985Y2 (es) | 1985-07-08 | 1990-08-21 | ||
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| WO2002102110A1 (en) | 2001-06-12 | 2002-12-19 | Telefonaktiebolaget Lm Ericsson (Publ) | Synchronisation in a umts terrestrial radio access network (utran) |
| CN100391537C (zh) | 2001-08-17 | 2008-06-04 | 建南德克公司 | 结合至c5和c5a但不阻止c5b形成的补体途径抑制剂 |
| JP4333939B2 (ja) | 2001-08-27 | 2009-09-16 | ロード・コーポレーション | トロリ線の吊架装置 |
| DE10253331A1 (de) | 2002-11-14 | 2004-06-03 | Symrise Gmbh & Co. Kg | Verwendung von trans-Pellitori als Aromastoff |
| US7267849B2 (en) | 2004-03-02 | 2007-09-11 | Nitto Denko Corporation | Compensator for liquid crystal display |
| KR20080069889A (ko) | 2007-03-20 | 2008-07-29 | (주)화도 | 폴리에틸렌 관 |
| JP2010521194A (ja) * | 2007-03-22 | 2010-06-24 | ノバルティス アーゲー | Ｃ５抗原およびその使用 |
| WO2008126921A1 (ja) | 2007-04-11 | 2008-10-23 | Sekisui Chemical Co., Ltd. | 架橋ポリビニルアセタール樹脂の製造方法及び架橋ポリビニルアセタール樹脂 |
| KR102469853B1 (ko) * | 2008-04-11 | 2022-11-22 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| EA027575B1 (ru) * | 2008-08-05 | 2017-08-31 | Новартис Аг | Антитело или его антигенсвязывающий фрагмент, связывающий человеческий белок с5, содержащая их композиция, нуклеиновая кислота, кодирующая антитело или его антигенсвязывающий фрагмент, содержащие эту кислоту вектор и клетка-хозяин и применение антитела или его антигенсвязывающего фрагмента |
| KR20100054403A (ko) | 2008-11-14 | 2010-05-25 | 삼성전자주식회사 | 온라인 공동 작문 장치 및 방법 |
| WO2011111007A2 (en) * | 2010-03-11 | 2011-09-15 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| TW201206466A (en) * | 2010-03-11 | 2012-02-16 | Rinat Neuroscience Corp | Antibodies with pH dependent antigen binding |
| KR20110111007A (ko) | 2010-04-02 | 2011-10-10 | 이화여자대학교 산학협력단 | Ｌ／ｄ 광학변환 및 광학분할을 위한 옥타하이드로-바이나프톨 유도체 |
| KR20110122011A (ko) | 2010-05-03 | 2011-11-09 | 황보철종 | 매장 포인트 통합 관리 시스템 및 그 방법 |
| WO2014028354A1 (en) * | 2012-08-13 | 2014-02-20 | Regeneron Pharmaceuticals, Inc. | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
| CA2899589C (en) * | 2013-01-31 | 2022-02-22 | Seoul National University R & Db Foundation | C5 antibody and method for preventing and treating complement-related diseases |
| ES2768648T3 (es) * | 2013-03-29 | 2020-06-23 | Alexion Pharma Inc | Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento |
| NZ711451A (en) * | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| RU2746356C2 (ru) * | 2014-12-19 | 2021-04-12 | Чугаи Сейяку Кабусики Кайся | Антитела к с5 и способы их применения |
| PL3390442T3 (pl) * | 2015-12-18 | 2024-03-18 | Chugai Seiyaku Kabushiki Kaisha | Przeciwciała anty-c5 i sposoby ich stosowania |
| MY187848A (en) * | 2016-06-17 | 2021-10-26 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
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2017
- 2017-06-16 MY MYPI2018002581A patent/MY187848A/en unknown
- 2017-06-16 EA EA201990018A patent/EA201990018A1/ru unknown
- 2017-06-16 KR KR1020187010179A patent/KR102226975B1/ko active IP Right Grant
- 2017-06-16 CN CN202211023851.9A patent/CN115925922A/zh active Pending
- 2017-06-16 UA UAA201810992A patent/UA126561C2/uk unknown
- 2017-06-16 TW TW106120143A patent/TWI610941B/zh active
- 2017-06-16 TW TW111107923A patent/TWI807666B/zh active
- 2017-06-16 WO PCT/JP2017/022253 patent/WO2017217524A1/en active Application Filing
- 2017-06-16 CN CN201780036916.4A patent/CN109312326B/zh active Active
- 2017-06-16 CA CA3021956A patent/CA3021956A1/en active Pending
- 2017-06-16 CN CN202211018018.5A patent/CN115960223A/zh active Pending
- 2017-06-16 TW TW106141573A patent/TWI789369B/zh active
- 2017-06-16 TW TW112120479A patent/TW202337903A/zh unknown
- 2017-06-16 AU AU2017285763A patent/AU2017285763B2/en active Active
- 2017-06-16 IL IL300611A patent/IL300611A/en unknown
- 2017-06-16 SG SG10201800265UA patent/SG10201800265UA/en unknown
- 2017-06-16 JP JP2017118226A patent/JP6202774B1/ja active Active
- 2017-06-16 CR CR20190013A patent/CR20190013A/es unknown
- 2017-06-16 KR KR1020177020545A patent/KR101852739B1/ko active IP Right Grant
- 2017-06-16 PE PE2018003148A patent/PE20190394A1/es unknown
- 2017-06-16 SG SG11201705584VA patent/SG11201705584VA/en unknown
- 2017-06-16 MX MX2018015030A patent/MX2018015030A/es unknown
- 2017-06-16 EP EP17813418.5A patent/EP3472316A4/en active Pending
- 2017-06-16 BR BR112018075688-1A patent/BR112018075688A2/pt unknown
- 2017-08-28 JP JP2017162934A patent/JP7032077B2/ja active Active
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2018
- 2018-11-08 PH PH12018502354A patent/PH12018502354A1/en unknown
- 2018-12-04 MX MX2023001360A patent/MX2023001360A/es unknown
- 2018-12-12 IL IL263657A patent/IL263657A/en unknown
- 2018-12-12 CL CL2018003573A patent/CL2018003573A1/es unknown
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2022
- 2022-02-24 JP JP2022026406A patent/JP2022091748A/ja active Pending
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