TWI610941B - 抗c5抗體及使用方法 - Google Patents

抗c5抗體及使用方法 Download PDF

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Publication number
TWI610941B
TWI610941B TW106120143A TW106120143A TWI610941B TW I610941 B TWI610941 B TW I610941B TW 106120143 A TW106120143 A TW 106120143A TW 106120143 A TW106120143 A TW 106120143A TW I610941 B TWI610941 B TW I610941B
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TW
Taiwan
Prior art keywords
antibody
sequence
identification number
sequence identification
antibodies
Prior art date
Application number
TW106120143A
Other languages
English (en)
Chinese (zh)
Other versions
TW201808996A (zh
Inventor
類家慶直
三瓶全次郎
Original Assignee
中外製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 中外製藥股份有限公司 filed Critical 中外製藥股份有限公司
Application granted granted Critical
Publication of TWI610941B publication Critical patent/TWI610941B/zh
Publication of TW201808996A publication Critical patent/TW201808996A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
TW106120143A 2016-06-17 2017-06-16 抗c5抗體及使用方法 TWI610941B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016120325 2016-06-17
JP2016-120325 2016-06-17

Publications (2)

Publication Number Publication Date
TWI610941B true TWI610941B (zh) 2018-01-11
TW201808996A TW201808996A (zh) 2018-03-16

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Family Applications (4)

Application Number Title Priority Date Filing Date
TW111107923A TWI807666B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW112120479A TW202337903A (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW106141573A TWI789369B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW106120143A TWI610941B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
TW111107923A TWI807666B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW112120479A TW202337903A (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW106141573A TWI789369B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法

Country Status (19)

Country Link
EP (1) EP3472316A4 (es)
JP (3) JP6202774B1 (es)
KR (2) KR102226975B1 (es)
CN (3) CN109312326B (es)
AU (1) AU2017285763B2 (es)
BR (1) BR112018075688A2 (es)
CA (1) CA3021956A1 (es)
CL (1) CL2018003573A1 (es)
CR (1) CR20190013A (es)
EA (1) EA201990018A1 (es)
IL (2) IL300611A (es)
MX (2) MX2018015030A (es)
MY (1) MY187848A (es)
PE (1) PE20190394A1 (es)
PH (1) PH12018502354A1 (es)
SG (2) SG10201800265UA (es)
TW (4) TWI807666B (es)
UA (1) UA126561C2 (es)
WO (1) WO2017217524A1 (es)

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EP3689912A1 (en) 2007-09-26 2020-08-05 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
EP4238993A3 (en) 2008-04-11 2023-11-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
SG11201607165YA (en) 2014-12-19 2016-09-29 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
UA124734C2 (uk) 2016-06-14 2021-11-10 Рідженерон Фармасьютікалз, Інк. Антитіло проти с5 і його застосування
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8
CA3078362A1 (en) * 2017-10-04 2019-04-11 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-c5 antibodies for treatment of patients with membranoproliferative glomerulonephritis
JP2021506241A (ja) 2017-12-13 2021-02-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 抗c5抗体組み合わせ物およびその使用
JP2021536509A (ja) * 2018-09-06 2021-12-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ヒト化抗c5抗体とその利用
MX2021012997A (es) * 2019-04-24 2022-03-04 Univ Pennsylvania Anticuerpos anti-c5 humanizados bifuncionales y proteínas de fusión del factor h y usos de los mismos.
CN113563467A (zh) * 2020-04-28 2021-10-29 上海普铭生物科技有限公司 针对人补体蛋白c5的抗体及其应用

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EP4238993A3 (en) * 2008-04-11 2023-11-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI789369B (zh) * 2016-06-17 2023-01-11 日商中外製藥股份有限公司 抗c5抗體及使用方法
TWI807666B (zh) * 2016-06-17 2023-07-01 日商中外製藥股份有限公司 抗c5抗體及使用方法

Also Published As

Publication number Publication date
JP2018009021A (ja) 2018-01-18
JP7032077B2 (ja) 2022-03-08
PH12018502354A1 (en) 2019-09-23
EP3472316A1 (en) 2019-04-24
KR102226975B1 (ko) 2021-03-11
SG10201800265UA (en) 2018-02-27
TW202337903A (zh) 2023-10-01
MX2018015030A (es) 2019-04-22
SG11201705584VA (en) 2018-05-30
CN109312326B (zh) 2022-09-09
KR101852739B1 (ko) 2018-04-30
CL2018003573A1 (es) 2019-02-01
BR112018075688A2 (pt) 2019-04-02
RU2019100222A (ru) 2020-07-17
AU2017285763B2 (en) 2024-02-01
KR20190009273A (ko) 2019-01-28
TW202239766A (zh) 2022-10-16
TW201809000A (zh) 2018-03-16
MY187848A (en) 2021-10-26
CN115960223A (zh) 2023-04-14
MX2023001360A (es) 2023-02-27
CN115925922A (zh) 2023-04-07
EA201990018A1 (ru) 2019-08-30
PE20190394A1 (es) 2019-03-13
CR20190013A (es) 2019-03-05
JP2017226655A (ja) 2017-12-28
IL300611A (en) 2023-04-01
TWI807666B (zh) 2023-07-01
UA126561C2 (uk) 2022-11-02
CN109312326A (zh) 2019-02-05
CA3021956A1 (en) 2017-12-21
RU2019100222A3 (es) 2020-11-05
WO2017217524A1 (en) 2017-12-21
JP6202774B1 (ja) 2017-09-27
EP3472316A4 (en) 2020-01-08
AU2017285763A1 (en) 2018-11-08
IL263657A (en) 2019-01-31
TWI789369B (zh) 2023-01-11
TW201808996A (zh) 2018-03-16
JP2022091748A (ja) 2022-06-21

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