CN109312326B - 抗-c5抗体及使用方法 - Google Patents

抗-c5抗体及使用方法 Download PDF

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Publication number
CN109312326B
CN109312326B CN201780036916.4A CN201780036916A CN109312326B CN 109312326 B CN109312326 B CN 109312326B CN 201780036916 A CN201780036916 A CN 201780036916A CN 109312326 B CN109312326 B CN 109312326B
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antibody
seq
hvr
antibodies
sequence
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CN109312326A (zh
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类家庆直
三瓶全次郎
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Priority to CN202211023851.9A priority Critical patent/CN115925922A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201780036916.4A 2016-06-17 2017-06-16 抗-c5抗体及使用方法 Active CN109312326B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202211023851.9A CN115925922A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211018018.5A CN115960223A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-120325 2016-06-17
JP2016120325 2016-06-17
PCT/JP2017/022253 WO2017217524A1 (en) 2016-06-17 2017-06-16 Anti-c5 antibodies and methods of use

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202211023851.9A Division CN115925922A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211018018.5A Division CN115960223A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

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CN109312326A CN109312326A (zh) 2019-02-05
CN109312326B true CN109312326B (zh) 2022-09-09

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CN201780036916.4A Active CN109312326B (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211018018.5A Pending CN115960223A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211023851.9A Pending CN115925922A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

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CN202211018018.5A Pending CN115960223A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211023851.9A Pending CN115925922A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

Country Status (19)

Country Link
EP (1) EP3472316A4 (es)
JP (4) JP6202774B1 (es)
KR (2) KR101852739B1 (es)
CN (3) CN109312326B (es)
AU (1) AU2017285763B2 (es)
BR (1) BR112018075688A2 (es)
CA (1) CA3021956A1 (es)
CL (1) CL2018003573A1 (es)
CR (1) CR20190013A (es)
EA (1) EA201990018A1 (es)
IL (2) IL300611A (es)
MX (2) MX2018015030A (es)
MY (1) MY187848A (es)
PE (2) PE20240825A1 (es)
PH (1) PH12018502354A1 (es)
SG (2) SG11201705584VA (es)
TW (4) TWI789369B (es)
UA (1) UA126561C2 (es)
WO (1) WO2017217524A1 (es)

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ES2568436T3 (es) 2006-03-31 2016-04-29 Chugai Seiyaku Kabushiki Kaisha Procedimiento para controlar la farmacocinética en sangre de anticuerpos
BRPI0817294A2 (pt) 2007-09-26 2015-03-17 Chugai Pharmaceutical Co Ltd Método de modificação do ponto isoelétrico de anticorpo via substituição de aminoácido em cdr.
MX2010011184A (es) 2008-04-11 2011-01-20 Chugai Pharmaceutical Co Ltd Molecula de union de antigeno capaz de unir repetidamente a dos o mas moleculas de antigeno.
CN108715614A (zh) 2010-11-30 2018-10-30 中外制药株式会社 与多分子的抗原重复结合的抗原结合分子
ES2899894T3 (es) 2014-12-19 2022-03-15 Chugai Pharmaceutical Co Ltd Anticuerpos anti-C5 y métodos de uso
JP7102353B2 (ja) 2016-06-14 2022-07-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗c5抗体及びそれらの使用
CN109312326B (zh) * 2016-06-17 2022-09-09 中外制药株式会社 抗-c5抗体及使用方法
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8
KR20200059279A (ko) * 2017-10-04 2020-05-28 알렉시온 파마슈티칼스, 인코포레이티드 막증식성 사구체신염을 갖는 환자의 치료를 위한 항-c5 항체의 투여량 및 투여
WO2019118556A1 (en) 2017-12-13 2019-06-20 Regeneron Pharmaceuticals, Inc. Anti-c5 antibody combinations and uses thereof
US20220177556A1 (en) * 2018-09-06 2022-06-09 The Trustees Of The University Of Pennsylvania Humanized anti-c5 antibodies and uses thereof
BR112021021176A2 (pt) * 2019-04-24 2021-12-28 Kira Pharmaceuticals Us Llc Proteína de fusão, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indivíduo e para reduzir a atividade de um sistema de complemento de um indivíduo, célula, e, animal não humano geneticamente modificado
CN113563467A (zh) * 2020-04-28 2021-10-29 上海普铭生物科技有限公司 针对人补体蛋白c5的抗体及其应用
EP4181958A4 (en) * 2020-07-15 2024-03-06 Biosion, Inc. C5-BINDING ANTIBODIES AND USES THEREOF

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WO2010015608A1 (en) * 2008-08-05 2010-02-11 Novartis Ag Compositions and methods for antibodies targeting complement protein c5
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WO2015134894A1 (en) * 2014-03-07 2015-09-11 Alexion Pharmaceuticals, Inc. Anti-c5 antibodies having improved pharmacokinetics
WO2016098356A1 (en) * 2014-12-19 2016-06-23 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use

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JP4333939B2 (ja) 2001-08-27 2009-09-16 ロード・コーポレーション トロリ線の吊架装置
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ES2969440T3 (es) * 2015-12-18 2024-05-20 Chugai Pharmaceutical Co Ltd Anticuerpos anti-C5 y métodos de uso
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WO1995029697A1 (en) * 1994-05-02 1995-11-09 Alexion Pharmaceuticals, Inc. Methods and compositions for the treatment of glomerulonephritis and other inflammatory diseases
WO2010015608A1 (en) * 2008-08-05 2010-02-11 Novartis Ag Compositions and methods for antibodies targeting complement protein c5
WO2011111007A2 (en) * 2010-03-11 2011-09-15 Rinat Neuroscience Corporation ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
WO2014160958A1 (en) * 2013-03-29 2014-10-02 Alexion Pharmaceuticals, Inc. Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
WO2015134894A1 (en) * 2014-03-07 2015-09-11 Alexion Pharmaceuticals, Inc. Anti-c5 antibodies having improved pharmacokinetics
WO2016098356A1 (en) * 2014-12-19 2016-06-23 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use

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Publication number Publication date
RU2019100222A3 (es) 2020-11-05
TW201808996A (zh) 2018-03-16
CN115925922A (zh) 2023-04-07
CA3021956A1 (en) 2017-12-21
CL2018003573A1 (es) 2019-02-01
MX2023001360A (es) 2023-02-27
MX2018015030A (es) 2019-04-22
RU2019100222A (ru) 2020-07-17
JP2022091748A (ja) 2022-06-21
JP7032077B2 (ja) 2022-03-08
CN115960223A (zh) 2023-04-14
WO2017217524A1 (en) 2017-12-21
IL300611A (en) 2023-04-01
BR112018075688A2 (pt) 2019-04-02
PE20190394A1 (es) 2019-03-13
SG10201800265UA (en) 2018-02-27
KR20190009273A (ko) 2019-01-28
TW202239766A (zh) 2022-10-16
TW201809000A (zh) 2018-03-16
TWI789369B (zh) 2023-01-11
AU2017285763B2 (en) 2024-02-01
TWI610941B (zh) 2018-01-11
IL263657A (en) 2019-01-31
EP3472316A4 (en) 2020-01-08
JP2018009021A (ja) 2018-01-18
AU2017285763A1 (en) 2018-11-08
PE20240825A1 (es) 2024-04-18
TWI807666B (zh) 2023-07-01
UA126561C2 (uk) 2022-11-02
TW202337903A (zh) 2023-10-01
JP6202774B1 (ja) 2017-09-27
SG11201705584VA (en) 2018-05-30
KR102226975B1 (ko) 2021-03-11
KR101852739B1 (ko) 2018-04-30
JP2017226655A (ja) 2017-12-28
JP2024102181A (ja) 2024-07-30
CN109312326A (zh) 2019-02-05
PH12018502354A1 (en) 2019-09-23
MY187848A (en) 2021-10-26
CR20190013A (es) 2019-03-05
EA201990018A1 (ru) 2019-08-30
EP3472316A1 (en) 2019-04-24

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