CN115925922A - 抗-c5抗体及使用方法 - Google Patents

抗-c5抗体及使用方法 Download PDF

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Publication number
CN115925922A
CN115925922A CN202211023851.9A CN202211023851A CN115925922A CN 115925922 A CN115925922 A CN 115925922A CN 202211023851 A CN202211023851 A CN 202211023851A CN 115925922 A CN115925922 A CN 115925922A
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CN
China
Prior art keywords
antibody
seq
amino acid
hvr
acid sequence
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Pending
Application number
CN202211023851.9A
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English (en)
Chinese (zh)
Inventor
类家庆直
三瓶全次郎
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Publication of CN115925922A publication Critical patent/CN115925922A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
CN202211023851.9A 2016-06-17 2017-06-16 抗-c5抗体及使用方法 Pending CN115925922A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2016120325 2016-06-17
JP2016-120325 2016-06-17
CN201780036916.4A CN109312326B (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
PCT/JP2017/022253 WO2017217524A1 (en) 2016-06-17 2017-06-16 Anti-c5 antibodies and methods of use

Related Parent Applications (1)

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CN201780036916.4A Division CN109312326B (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

Publications (1)

Publication Number Publication Date
CN115925922A true CN115925922A (zh) 2023-04-07

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201780036916.4A Active CN109312326B (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211023851.9A Pending CN115925922A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法
CN202211018018.5A Pending CN115960223A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

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CN201780036916.4A Active CN109312326B (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202211018018.5A Pending CN115960223A (zh) 2016-06-17 2017-06-16 抗-c5抗体及使用方法

Country Status (19)

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EP (1) EP3472316A4 (es)
JP (3) JP6202774B1 (es)
KR (2) KR102226975B1 (es)
CN (3) CN109312326B (es)
AU (1) AU2017285763B2 (es)
BR (1) BR112018075688A2 (es)
CA (1) CA3021956A1 (es)
CL (1) CL2018003573A1 (es)
CR (1) CR20190013A (es)
EA (1) EA201990018A1 (es)
IL (2) IL300611A (es)
MX (2) MX2018015030A (es)
MY (1) MY187848A (es)
PE (1) PE20190394A1 (es)
PH (1) PH12018502354A1 (es)
SG (2) SG10201800265UA (es)
TW (4) TWI807666B (es)
UA (1) UA126561C2 (es)
WO (1) WO2017217524A1 (es)

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EP3689912A1 (en) 2007-09-26 2020-08-05 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
EP4238993A3 (en) 2008-04-11 2023-11-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
SG11201607165YA (en) 2014-12-19 2016-09-29 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
UA124734C2 (uk) 2016-06-14 2021-11-10 Рідженерон Фармасьютікалз, Інк. Антитіло проти с5 і його застосування
AU2017285763B2 (en) * 2016-06-17 2024-02-01 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies and methods of use
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8
CA3078362A1 (en) * 2017-10-04 2019-04-11 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-c5 antibodies for treatment of patients with membranoproliferative glomerulonephritis
JP2021506241A (ja) 2017-12-13 2021-02-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 抗c5抗体組み合わせ物およびその使用
JP2021536509A (ja) * 2018-09-06 2021-12-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ヒト化抗c5抗体とその利用
MX2021012997A (es) * 2019-04-24 2022-03-04 Univ Pennsylvania Anticuerpos anti-c5 humanizados bifuncionales y proteínas de fusión del factor h y usos de los mismos.
CN113563467A (zh) * 2020-04-28 2021-10-29 上海普铭生物科技有限公司 针对人补体蛋白c5的抗体及其应用

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JP4958387B2 (ja) 2001-08-17 2012-06-20 ジェネンテック, インコーポレイテッド C5bの形成を妨害することなくc5及びc5aに結合する補体経路阻害剤
JP4333939B2 (ja) 2001-08-27 2009-09-16 ロード・コーポレーション トロリ線の吊架装置
DE10253331A1 (de) 2002-11-14 2004-06-03 Symrise Gmbh & Co. Kg Verwendung von trans-Pellitori als Aromastoff
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EP4238993A3 (en) * 2008-04-11 2023-11-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
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KR20110122011A (ko) 2010-05-03 2011-11-09 황보철종 매장 포인트 통합 관리 시스템 및 그 방법
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KR101638931B1 (ko) * 2013-01-31 2016-07-12 서울대학교산학협력단 보체 관련 질환의 예방 및 치료를 위한 c5 항체 및 방법
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NZ631007A (en) * 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
SG11201607165YA (en) * 2014-12-19 2016-09-29 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
EP3390442B1 (en) * 2015-12-18 2023-11-08 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use
AU2017285763B2 (en) * 2016-06-17 2024-02-01 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies and methods of use

Also Published As

Publication number Publication date
JP2018009021A (ja) 2018-01-18
JP7032077B2 (ja) 2022-03-08
TWI610941B (zh) 2018-01-11
PH12018502354A1 (en) 2019-09-23
EP3472316A1 (en) 2019-04-24
KR102226975B1 (ko) 2021-03-11
SG10201800265UA (en) 2018-02-27
TW202337903A (zh) 2023-10-01
MX2018015030A (es) 2019-04-22
SG11201705584VA (en) 2018-05-30
CN109312326B (zh) 2022-09-09
KR101852739B1 (ko) 2018-04-30
CL2018003573A1 (es) 2019-02-01
BR112018075688A2 (pt) 2019-04-02
RU2019100222A (ru) 2020-07-17
AU2017285763B2 (en) 2024-02-01
KR20190009273A (ko) 2019-01-28
TW202239766A (zh) 2022-10-16
TW201809000A (zh) 2018-03-16
MY187848A (en) 2021-10-26
CN115960223A (zh) 2023-04-14
MX2023001360A (es) 2023-02-27
EA201990018A1 (ru) 2019-08-30
PE20190394A1 (es) 2019-03-13
CR20190013A (es) 2019-03-05
JP2017226655A (ja) 2017-12-28
IL300611A (en) 2023-04-01
TWI807666B (zh) 2023-07-01
UA126561C2 (uk) 2022-11-02
CN109312326A (zh) 2019-02-05
CA3021956A1 (en) 2017-12-21
RU2019100222A3 (es) 2020-11-05
WO2017217524A1 (en) 2017-12-21
JP6202774B1 (ja) 2017-09-27
EP3472316A4 (en) 2020-01-08
AU2017285763A1 (en) 2018-11-08
IL263657A (en) 2019-01-31
TWI789369B (zh) 2023-01-11
TW201808996A (zh) 2018-03-16
JP2022091748A (ja) 2022-06-21

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