HU228780B1 - Use of interleukin-18 inhibitors to inhibit tumor metastasis - Google Patents
Use of interleukin-18 inhibitors to inhibit tumor metastasis Download PDFInfo
- Publication number
- HU228780B1 HU228780B1 HU0202107A HUP0202107A HU228780B1 HU 228780 B1 HU228780 B1 HU 228780B1 HU 0202107 A HU0202107 A HU 0202107A HU P0202107 A HUP0202107 A HU P0202107A HU 228780 B1 HU228780 B1 HU 228780B1
- Authority
- HU
- Hungary
- Prior art keywords
- tree
- tree tree
- cells
- tel
- species
- Prior art date
Links
- 102000003810 Interleukin-18 Human genes 0.000 title description 12
- 108090000171 Interleukin-18 Proteins 0.000 title description 12
- 239000003112 inhibitor Substances 0.000 title description 9
- 206010027476 Metastases Diseases 0.000 title description 6
- 206010028980 Neoplasm Diseases 0.000 title description 6
- 230000009401 metastasis Effects 0.000 title description 6
- 230000000694 effects Effects 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 6
- 241001122767 Theaceae Species 0.000 claims 1
- ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 44
- 241000894007 species Species 0.000 description 18
- 241000699670 Mus sp. Species 0.000 description 12
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 9
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 9
- 102000004127 Cytokines Human genes 0.000 description 7
- 108090000695 Cytokines Proteins 0.000 description 7
- 241001529936 Murinae Species 0.000 description 7
- 102100040247 Tumor necrosis factor Human genes 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 235000013616 tea Nutrition 0.000 description 7
- 102000000589 Interleukin-1 Human genes 0.000 description 6
- 108010002352 Interleukin-1 Proteins 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 244000269722 Thea sinensis Species 0.000 description 5
- 239000003636 conditioned culture medium Substances 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- 230000001404 mediated effect Effects 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- FESBVLZDDCQLFY-UHFFFAOYSA-N sete Chemical compound [Te]=[Se] FESBVLZDDCQLFY-UHFFFAOYSA-N 0.000 description 4
- 239000002023 wood Substances 0.000 description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102000023732 binding proteins Human genes 0.000 description 3
- 108091008324 binding proteins Proteins 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 description 2
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 2
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 2
- 102000004557 Interleukin-18 Receptors Human genes 0.000 description 2
- 108010017537 Interleukin-18 Receptors Proteins 0.000 description 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 235000014510 cooky Nutrition 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 102000044166 interleukin-18 binding protein Human genes 0.000 description 2
- 108010070145 interleukin-18 binding protein Proteins 0.000 description 2
- 230000031037 interleukin-18 production Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 241000239290 Araneae Species 0.000 description 1
- 239000002947 C09CA04 - Irbesartan Substances 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 108090000426 Caspase-1 Proteins 0.000 description 1
- 102100035904 Caspase-1 Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 229910005900 GeTe Inorganic materials 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 101001057956 Homo sapiens 55 kDa erythrocyte membrane protein Proteins 0.000 description 1
- 101000837415 Homo sapiens DNA polymerase subunit gamma-2, mitochondrial Proteins 0.000 description 1
- 101001065272 Homo sapiens EGF-containing fibulin-like extracellular matrix protein 1 Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
- 101001072202 Homo sapiens Protein disulfide-isomerase Proteins 0.000 description 1
- 101000801228 Homo sapiens Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 1
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 102100035017 Interleukin-18-binding protein Human genes 0.000 description 1
- 101710205006 Interleukin-18-binding protein Proteins 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 201000003791 MALT lymphoma Diseases 0.000 description 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
- 244000305267 Quercus macrolepis Species 0.000 description 1
- 240000005499 Sasa Species 0.000 description 1
- 241000705082 Sialia Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 108700012920 TNF Proteins 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003305 autocrine Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000005422 blasting Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 230000004712 cancer cell adhesion Effects 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000002367 endolytic effect Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 206010016531 fetishism Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 102000057036 human EFEMP1 Human genes 0.000 description 1
- 230000002871 immunocytoma Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 108010027775 interleukin-1beta-converting enzyme inhibitor Proteins 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 description 1
- 229960002198 irbesartan Drugs 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 108700031196 mouse lisch-like Proteins 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000017448 oviposition Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108020003519 protein disulfide isomerase Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13104799A IL131047A0 (en) | 1999-07-22 | 1999-07-22 | Use of il-18 inhibitors |
| PCT/IL2000/000419 WO2001007480A2 (en) | 1999-07-22 | 2000-07-17 | Use of interleukin-18 inhibitors to inhibit tumor metastasis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0202107A2 HUP0202107A2 (en) | 2002-10-28 |
| HUP0202107A3 HUP0202107A3 (en) | 2005-01-28 |
| HU228780B1 true HU228780B1 (en) | 2013-05-28 |
Family
ID=11073044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202107A HU228780B1 (en) | 1999-07-22 | 2000-07-17 | Use of interleukin-18 inhibitors to inhibit tumor metastasis |
Country Status (31)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201305214A (zh) | 2000-02-10 | 2013-02-01 | Abbott Gmbh & Co Kg | 與人類間白素－１８結合之抗體，及其製法及用途 |
| EP1331943A4 (en) | 2000-10-11 | 2005-01-26 | Viron Therapeutics Inc | NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNOMODULATION |
| US7718368B2 (en) | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| KR101015682B1 (ko) * | 2002-10-08 | 2011-02-22 | 아레스 트레이딩 에스.에이. | Ｉｌ-18ｂｐ에 결합할 수 있고 제 2 사이토킨의 활성을저해할 수 있는 사이토킨의 용도 |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| PT1885753E (pt) | 2005-06-03 | 2011-10-06 | Ares Trading Sa | Produção de proteína recombinante de ligação a il-18 |
| CA2610804C (en) | 2005-06-10 | 2013-11-19 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| US9812033B2 (en) * | 2013-03-06 | 2017-11-07 | Venkatesh R. Chari | Tactile graphic display |
| WO2023178192A1 (en) | 2022-03-15 | 2023-09-21 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ299210A (en) * | 1992-09-02 | 2000-08-25 | Isis Pharmaceuticals Inc | Treating diseases characterised by changes in intercellular adhesion molecules using coding sequences hybridizable with those encoding proteins involved in synthesis of such molecules |
| US7141393B2 (en) * | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
| BR9810409A (pt) * | 1997-03-18 | 2000-08-22 | Basf Ag | Métodos e composições para a modulação de responsividade a corticosteróides |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
-
1999
- 1999-07-22 IL IL13104799A patent/IL131047A0/xx unknown
-
2000
- 2000-07-17 EE EEP200200032A patent/EE04838B1/xx unknown
- 2000-07-17 CZ CZ20020195A patent/CZ302114B6/cs not_active IP Right Cessation
- 2000-07-17 UA UA2002021472A patent/UA73745C2/uk unknown
- 2000-07-17 PT PT00944201T patent/PT1206274E/pt unknown
- 2000-07-17 DK DK00944201T patent/DK1206274T3/da active
- 2000-07-17 AT AT00944201T patent/ATE363288T1/de active
- 2000-07-17 JP JP2001512563A patent/JP4827352B2/ja not_active Expired - Lifetime
- 2000-07-17 CA CA2380216A patent/CA2380216C/en not_active Expired - Lifetime
- 2000-07-17 EA EA200200189A patent/EA005419B1/ru not_active IP Right Cessation
- 2000-07-17 WO PCT/IL2000/000419 patent/WO2001007480A2/en active IP Right Grant
- 2000-07-17 HU HU0202107A patent/HU228780B1/hu unknown
- 2000-07-17 DE DE1206274T patent/DE1206274T1/de active Pending
- 2000-07-17 SK SK88-2002A patent/SK287522B6/sk not_active IP Right Cessation
- 2000-07-17 BR BR0012675-6A patent/BR0012675A/pt not_active IP Right Cessation
- 2000-07-17 NZ NZ516535A patent/NZ516535A/en not_active IP Right Cessation
- 2000-07-17 DE DE60035049T patent/DE60035049T2/de not_active Expired - Lifetime
- 2000-07-17 KR KR1020027000682A patent/KR100682219B1/ko active IP Right Grant
- 2000-07-17 MX MXPA02000838A patent/MXPA02000838A/es active IP Right Grant
- 2000-07-17 TR TR2002/00169T patent/TR200200169T2/ unknown
- 2000-07-17 CN CNB008106894A patent/CN1173736C/zh not_active Expired - Lifetime
- 2000-07-17 ES ES00944201T patent/ES2186596T3/es not_active Expired - Lifetime
- 2000-07-17 AU AU58432/00A patent/AU782478B2/en not_active Expired
- 2000-07-17 EP EP00944201A patent/EP1206274B1/en not_active Expired - Lifetime
- 2000-07-17 PL PL353732A patent/PL202477B1/pl unknown
- 2000-07-21 AR ARP000103786A patent/AR024907A1/es unknown
-
2002
- 2002-01-11 NO NO20020153A patent/NO329827B1/no not_active IP Right Cessation
- 2002-01-16 ZA ZA200200390A patent/ZA200200390B/xx unknown
- 2002-01-16 BG BG106311A patent/BG65800B1/bg unknown
- 2002-01-17 IL IL147675A patent/IL147675A/en unknown
- 2002-11-11 HK HK02108154.3A patent/HK1048248B/zh not_active IP Right Cessation
-
2007
- 2007-07-06 US US11/825,548 patent/US7741276B2/en not_active Expired - Fee Related
- 2007-07-13 CY CY20071100938T patent/CY1107932T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Rolski et al. | Complexity of TNF-α signaling in heart disease | |
| Bureau et al. | Mechanisms of persistent NF-κB activity in the bronchi of an animal model of asthma | |
| Seki et al. | Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin | |
| Besser et al. | A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation | |
| Salamone et al. | High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow | |
| HU228780B1 (en) | Use of interleukin-18 inhibitors to inhibit tumor metastasis | |
| Maruyama et al. | Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter | |
| JP5759557B2 (ja) | 抗がん融合タンパク質 | |
| Wang et al. | Mechanisms of sex differences in TNFR2-mediated cardioprotection | |
| Yang et al. | Cynomorium songaricum induces spermatogenesis with glial cell-derived neurotrophic factor (GDNF) enhancement in rat testes | |
| EA010803B1 (ru) | Модифицированные белки буганины, цитотоксины и способы их применения | |
| Brown et al. | Carbonic anhydrase II promotes cardiomyocyte hypertrophy | |
| CN105246917A (zh) | 生产单克隆IgA抗体的方法 | |
| Brummell et al. | Biofortification of tomato (Solanum lycopersicum) fruit with the anticancer compound methylselenocysteine using a selenocysteine methyltransferase from a selenium hyperaccumulator | |
| US11041157B2 (en) | Slit2D2-HSA fusion protein and use thereof against tumours | |
| Wu et al. | Regression of human mammary adenocarcinoma by systemic administration of a recombinant gene encoding the hFlex-TRAIL fusion protein | |
| Wang et al. | Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice | |
| Lin et al. | Thrombin-induced CCAAT/enhancer-binding protein β activation and IL-8/CXCL8 expression via MEKK1, ERK, and p90 ribosomal S6 kinase 1 in lung epithelial cells | |
| Chang et al. | Hydrodynamics-based delivery of an interleukin-1 receptor II fusion gene ameliorates rat autoimmune myocarditis by inhibiting IL-1 and Th17 cell polarization | |
| Yoo et al. | STAMPing into mitochondria | |
| CN100358919C (zh) | 哺乳动物促乳素变体 | |
| Krishnan et al. | Introgression of leginsulin, a cysteine-rich protein, and high-protein trait from an Asian soybean plant introduction genotype into a North American experimental soybean line | |
| Potala et al. | Modified DT–IL2 fusion toxin targeting uniquely IL2Rα expressing leukemia cell lines–Construction and characterization | |
| Zhao et al. | Guanylyl cyclase/natriuretic peptide receptor-A gene disruption causes increased adrenal angiotensin II and aldosterone levels | |
| Kraynyak et al. | Plasmid-encoded interleukin-15 receptor α enhances specific immune responses induced by a DNA Vaccine in vivo |