HRP20211909T1 - Uređaj za liječenja oka - Google Patents

Uređaj za liječenja oka Download PDF

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Publication number
HRP20211909T1
HRP20211909T1 HRP20211909TT HRP20211909T HRP20211909T1 HR P20211909 T1 HRP20211909 T1 HR P20211909T1 HR P20211909T T HRP20211909T T HR P20211909TT HR P20211909 T HRP20211909 T HR P20211909T HR P20211909 T1 HRP20211909 T1 HR P20211909T1
Authority
HR
Croatia
Prior art keywords
chamber
container
vent
therapeutic agent
lumen
Prior art date
Application number
HRP20211909TT
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English (en)
Inventor
Eugene De Juan
Yair Alster
Kathleen Cogan Farinas
K. Angela Macfarlane
Cary J. Reich
Randolph E. Campbell
Signe Erickson
Original Assignee
Forsight Vision4, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Forsight Vision4, Inc. filed Critical Forsight Vision4, Inc.
Publication of HRP20211909T1 publication Critical patent/HRP20211909T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Radiation-Therapy Devices (AREA)

Claims (14)

1. Uređaj za liječenje oka (10) s terapijskim sredstvom (702, 110), naznačen time, da uređaj sadrži: - terapijski uređaj (100) koji je konfiguriran tako da se implantira u oko (10), pri čemu terapijski uređaj (100) sadrži: - komoru spremnika (130, 140) koja obuhvaća volumen spremnika koji se proteže između proksimalnog kraja i distalnog kraja komore spremnika (130, 140); i - čvrstu poroznu strukturu (150) koja je spojena s distalnim krajem komore spremnika (130, 140); i - injektor (701) koji je konfiguriran tako da ispunjava komoru spremnika (130, 140) s količinom terapijskog sredstva (702, 110), dok je terapijski uređaj (100) barem djelomično implantiran u oko (10), koji sadrži: - iglu (189, 189L) koja posjeduje injekcijski lumen (705, 189B) i odušni lumen (706, 189A); - injekcijsku komoru (702C) koja je konfigurirana tako da bude u fluidnoj komunikaciji s komorom spremnika (130, 140) preko injekcijskog lumena (705, 189B); - odušnu komoru (703C) koja je konfigurirana tako da bude u fluidnoj komunikaciji s komorom spremnika (130, 140) preko odušnog lumena (706, 189A); i - klip (501P) koji je pomičan unutar injekcijske komore (702C); pri čemu je injektor (701) konfiguriran tako da dostavlja količinu terapijskog sredstva (702, 110) u komoru spremnika (130, 140), bez dovođenja glavne doze lijeka iz komore spremnika (130, 140) u oko (10).
2. Uređaj prema patentnom zahtjevu 1, naznačen time, da odušna komora (703C) posjeduje protočni otpor koji je uglavnom manji nego što je to protočni otpor kroz čvrstu poroznu strukturu (150).
3. Uređaj prema patentnom zahtjevu 1, naznačen time, da je injektor (701) nadalje konfiguriran tako da odstranjuje fluid iz komore spremnika (130, 140) kroz odušni lumen (706, 189A) u odušnu komoru (703C).
4. Uređaj prema patentnom zahtjevu 3, naznačen time, da prva količina fluida (703) koja se nalazi u sadržaju komore spremnika (130, 140), protječe od komore spremnika (130, 140) u odušnu komoru (703C) kroz odušni lumen (706, 189A), nakon injektiranja druge količline fluida koji se nalazi u sadržaju injekcijske komore (702C), u komoru spremnika (130, 140) kroz injekcijski lumen (705, 189B).
5. Uređaj prema patentnom zahtjevu 1, naznačen time, da je injektor (701) konfiguriran tako da dostavlja količinu terapijskog sredstva (702, 110) u komoru spremnika (130, 140) s efikasnošću izmjene od barem 80%.
6. Uređaj prema patentnom zahtjevu 1, naznačen time, da je injektor (701) konfiguriran tako da dostavlja količinu terapijskog sredstva (702, 110) u komoru spremnika (130, 140) bez dostavljanja glavne doze lijeka iz komore spremnika (130, 140), zbog oduška koji ima uglavnom manji protočni otpor nego što je to protočni otpor čvrste porozne strukture (150), pri čemu je uređaj konfiguriran tako da dostavlja injekcijsku dozu terapijskog sredstva (702, 110) kroz terapijski uređaj (100) uporabom injektora (701), kada je protočni otpor oduška veći nego što je to protočni otpor čvrste porozne strukture (150).
7. Uređaj prema patentnom zahtjevu 6, naznačen time, da odušak je ventil (703V) koji je smješten između odušnog lumena (706, 189A) i odušne komore (703C), i time da se prvi dio količine terapijskog sredstva (702) dostavlja kroz čvrstu poroznu strukturu (150), nakon napredovanja klipa (701P) kroz injekcijsku komoru (702C) dok je ventil zatvoren.
8. Uređaj prema patentnom zahtjevu 7, naznačen time, da se drugi dio količine terapijskog sredstva (702, 110) zadržava u komori spremnika (130, 140) za ispuštanje u produljenom vremenskom razdoblju.
9. Uređaj prema patentnom zahtjevu 1, naznačen time, da je volumen spremnika manji nego volumen injekcijske komore (702C).
10. Uređaj prema patentnom zahtjevu 1, naznačen time, da se volumen spremnika komore spremnika (13) nalazi unutar raspona od oko 10 uL do oko 50 uL, ili od oko 10 uL do oko 200 uL.
11. Uređaj prema patentnom zahtjevu 1, naznačen time, da terapijsko sredstvo (702) jest ranibizumab.
12. Uređaj prema patentnom zahtjevu 11, naznačen time, da se ranibizumab nalazi u koncentraciji unutar raspona od 40 mg/mL do oko 200 mg/mL.
13. Uređaj prema patentnom zahtjevu 1, naznačen time, da komora spremnika (130, 140) je spremnik (140) koji se može proširivati i koji posjeduje prvu konfiguraciju uskog profila za plasiranje i drugu konfiguraciju proširenog profila nakon implantacije u oko.
14. Uređaj prema patentnom zahtjevu 13, naznačen time, da terapijski uređaj (100) sadrži fleksibilni pregradni materijal (160) koji je spojen s nosačem (160S), pri čemu se pregrada (160) i nosač (160S) mogu proširivati iz prve konfiguracije uskog profila u drugu konfiguraciju proširenog profila.
HRP20211909TT 2010-08-05 2011-08-05 Uređaj za liječenja oka HRP20211909T1 (hr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US37116910P 2010-08-05 2010-08-05
US37115410P 2010-08-05 2010-08-05
US37113610P 2010-08-05 2010-08-05
US40693410P 2010-10-26 2010-10-26
US40736110P 2010-10-27 2010-10-27
PCT/US2011/046870 WO2012019176A2 (en) 2010-08-05 2011-08-05 Implantable therapeutic device
EP11743753.3A EP2600812B1 (en) 2010-08-05 2011-08-05 Apparatus to treat an eye

Publications (1)

Publication Number Publication Date
HRP20211909T1 true HRP20211909T1 (hr) 2022-03-18

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Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20211909TT HRP20211909T1 (hr) 2010-08-05 2011-08-05 Uređaj za liječenja oka

Country Status (16)

Country Link
US (1) US9492315B2 (hr)
EP (2) EP3960134A1 (hr)
JP (2) JP5907966B2 (hr)
CN (1) CN103209664A (hr)
AU (3) AU2011285501B2 (hr)
CA (1) CA2807554C (hr)
DK (1) DK2600812T3 (hr)
ES (1) ES2894940T3 (hr)
HR (1) HRP20211909T1 (hr)
HU (1) HUE057267T2 (hr)
LT (1) LT2600812T (hr)
PL (1) PL2600812T3 (hr)
PT (1) PT2600812T (hr)
RS (1) RS62540B1 (hr)
SI (1) SI2600812T1 (hr)
WO (1) WO2012019176A2 (hr)

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