MX2018012021A - Dispositivos de administracion de farmacos oculares implantables. - Google Patents

Dispositivos de administracion de farmacos oculares implantables.

Info

Publication number
MX2018012021A
MX2018012021A MX2018012021A MX2018012021A MX2018012021A MX 2018012021 A MX2018012021 A MX 2018012021A MX 2018012021 A MX2018012021 A MX 2018012021A MX 2018012021 A MX2018012021 A MX 2018012021A MX 2018012021 A MX2018012021 A MX 2018012021A
Authority
MX
Mexico
Prior art keywords
drug delivery
delivery devices
ocular drug
implantable ocular
outlet
Prior art date
Application number
MX2018012021A
Other languages
English (en)
Inventor
Erickson Signe
G Bachelder Bradley
E Campbell Randolph
W Sacherman Kevin
BOYETTE Jeremy
Original Assignee
Forsight Vision4 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forsight Vision4 Inc filed Critical Forsight Vision4 Inc
Publication of MX2018012021A publication Critical patent/MX2018012021A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Abstract

Se describen dispositivos implantables que tienen depósitos para la liberación sostenida de agentes terapéuticos. Los dispositivos están configurados para ser al menos parcialmente implantados en un ojo e incluyen una estructura de retención (105) y un elemento penetrable (115) acoplado a y que se extiende dentro de al menos una porción de la región extrema proximal del dispositivo. El dispositivo incluye un elemento de liberación de fármaco poroso (120) que está colocado en comunicación fluida con una salida del dispositivo y un depósito (130) que tiene un volumen configurado para contener uno o más agentes terapéuticos en comunicación fluida con la salida a través del elemento de liberación del fármaco poroso. El dispositivo se inserta al menos parcialmente a lo largo de un eje de inserción.
MX2018012021A 2016-04-05 2017-04-05 Dispositivos de administracion de farmacos oculares implantables. MX2018012021A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662318582P 2016-04-05 2016-04-05
PCT/US2017/026151 WO2017176886A1 (en) 2016-04-05 2017-04-05 Implantable ocular drug delivery devices

Publications (1)

Publication Number Publication Date
MX2018012021A true MX2018012021A (es) 2019-01-24

Family

ID=58610011

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012021A MX2018012021A (es) 2016-04-05 2017-04-05 Dispositivos de administracion de farmacos oculares implantables.

Country Status (13)

Country Link
US (2) US11617680B2 (es)
EP (2) EP3799844B1 (es)
JP (1) JP7009384B2 (es)
KR (1) KR20180133440A (es)
CN (2) CN113017981B (es)
AR (1) AR108177A1 (es)
AU (2) AU2017246889B2 (es)
BR (1) BR112018070383A2 (es)
CA (1) CA3019822A1 (es)
ES (1) ES2837524T3 (es)
IL (1) IL262062A (es)
MX (1) MX2018012021A (es)
WO (1) WO2017176886A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
WO2017087902A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
CN109431678B (zh) * 2018-12-17 2021-05-28 中国医学科学院北京协和医院 经巩膜药物传输系统
US20240024093A1 (en) * 2022-07-22 2024-01-25 SpyGlass Pharma, Inc. Intraocular drug delivery systems and methods of use
WO2024030672A1 (en) * 2022-08-05 2024-02-08 W. L. Gore & Associates, Inc. Medicament therapy delivery systems and methods

Family Cites Families (400)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2585815A (en) 1947-01-16 1952-02-12 Mclintock Duncan Menzies Injection syringe
US2564977A (en) 1949-01-19 1951-08-21 Hu Quang Hsi Medical injecting apparatus
US3232117A (en) 1962-09-14 1966-02-01 Roger Gilmont Instr Inc Micrometer buret
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3641237A (en) 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3831583A (en) 1971-03-05 1974-08-27 Univ California Implantable bulb for inflation of surgical implements
US3995635A (en) 1971-09-09 1976-12-07 Alza Corporation Ocular insert
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3845201A (en) 1972-04-24 1974-10-29 S Loucas Solid state ophthalmic medication delivery method
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3914402A (en) 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US4179497A (en) 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
US3902495A (en) 1974-01-28 1975-09-02 Cavitron Corp Flow control system
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949748A (en) 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US3926188A (en) 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4093708A (en) 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
NL188266C (nl) 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
US3977404A (en) 1975-09-08 1976-08-31 Alza Corporation Osmotic device having microporous reservoir
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4014333A (en) 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4111201A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for delivering selected beneficial agents having varying degrees of solubility
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4186184A (en) 1977-12-27 1980-01-29 Alza Corporation Selective administration of drug with ocular therapeutic system
US4220152A (en) 1978-05-08 1980-09-02 Pfizer Inc. Delivery system
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4309776A (en) 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4439198A (en) 1981-07-09 1984-03-27 University Of Illinois Foundation Biodegradable ocular insert for controlled delivery of ophthalmic medication
US4730013A (en) 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4475916A (en) 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4673405A (en) 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4883459A (en) 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4774091A (en) 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4712550A (en) 1985-04-08 1987-12-15 Sinnett Kevin B Retinal tack
US4693886A (en) 1985-04-22 1987-09-15 Alza Corporation Osmotic device with inert core
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
EP0201611A1 (de) 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
FR2582221B1 (fr) 1985-05-21 1987-09-25 Applied Precision Ltd Dispositif implantable d'injection chronique d'une substance, notamment therapeutique
US4840615A (en) 1985-09-30 1989-06-20 Mcghan Medical Corporation Self-sealing injection reservoir
US4781675A (en) 1985-11-27 1988-11-01 White Thomas C Infusion cannula
DE3672981D1 (de) 1985-11-27 1990-08-30 Thomas C White Gewebeimplantierbare fluessigkeitsverteileinrichtung.
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
ATE141166T1 (de) 1986-12-23 1996-08-15 Liposome Co Inc Guanidinaminoglycosid enthaltende liposome
US4781680A (en) 1987-03-02 1988-11-01 Vir Engineering Resealable injection site
US4853229A (en) 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
US4865846A (en) 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US5174999A (en) 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
WO1990007575A1 (en) 1988-12-30 1990-07-12 Anderson David M Stabilized microporous materials and hydrogel materials
US5141748A (en) 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US4979938A (en) 1989-05-11 1990-12-25 Iomed, Inc. Method of iontophoretically treating acne, furuncles and like skin disorders
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5092837A (en) 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5238687A (en) 1990-07-11 1993-08-24 Alza Corporation Delivery device with a protective sleeve
US5084021A (en) 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
AU650113B2 (en) 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5334189A (en) 1991-06-03 1994-08-02 Wade Stephen E Device for controlled diffusion of a chemical substance
US5766151A (en) * 1991-07-16 1998-06-16 Heartport, Inc. Endovascular system for arresting the heart
US5282829A (en) 1991-08-15 1994-02-01 United States Surgical Corporation Hollow body implants
FR2682090B1 (fr) 1991-10-03 1993-12-31 Holzstoff Holding Sa Systeme-reservoir pour diffusion prolongee d'un principe actif.
US5681572A (en) 1991-10-18 1997-10-28 Seare, Jr.; William J. Porous material product and process
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5770076A (en) 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5578042A (en) 1994-03-14 1996-11-26 Cumming; J. Stuart Ophthalmic kit and method for lens insertion
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
CA2204789C (en) 1994-11-10 2002-11-12 Paul Ashton Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5704915A (en) 1995-02-14 1998-01-06 Therex Limited Partnership Hemodialysis access device
US5554132A (en) 1995-03-30 1996-09-10 Abbott Laboratories Hand grip for use with syringe
WO1996036377A1 (en) 1995-05-14 1996-11-21 Optonol Ltd. Intraocular implant, delivery device, and method of implantation
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5989216A (en) 1995-06-29 1999-11-23 Sims Deltec, Inc. Access portal and method
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB2310149A (en) 1996-02-15 1997-08-20 Nomix Chipman Ltd Spray gun
US20090005864A1 (en) 1996-03-18 2009-01-01 Eggleston Harry C Modular intraocular implant
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
US5951512A (en) 1996-05-28 1999-09-14 Horizon Medical Products, Inc. Infusion port with modified drug reservoir
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
AU7533696A (en) 1996-12-13 1998-06-18 Ciba-Geigy Ag New materials
WO1998043611A1 (en) 1997-03-31 1998-10-08 Alza Corporation Diffusional implantable delivery system
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US5993414A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
FR2784296B1 (fr) 1998-09-18 2001-01-05 Imedex Biomateriaux Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
DE19948783C2 (de) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implantat
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
JP4851035B2 (ja) 1999-06-18 2012-01-11 アルコン ラボラトリーズ,インコーポレイティド アレルギー性眼疾患を処置するための局所的な眼マスト細胞安定剤
US6638263B1 (en) 1999-10-12 2003-10-28 Durect Corporation Regulation of drug delivery through flow diversion
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
EP1473003B1 (en) 1999-10-21 2008-11-19 Alcon, Inc. Drug delivery device
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20030212383A1 (en) 2001-01-05 2003-11-13 Dana Cote System and methods for reducing intraocular pressure
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
MXPA02006889A (es) 2000-01-12 2003-05-23 Becton Dickinson Co Sistemas y metodos para reducir la presion intraocular.
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
US7169444B2 (en) 2000-03-13 2007-01-30 Seiko Epson Corporation Method for treating surface of ink jet recording medium having recorded image
US7141152B2 (en) 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US6945969B1 (en) 2000-03-31 2005-09-20 Medtronic, Inc. Catheter for target specific drug delivery
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
JP4471568B2 (ja) 2000-08-30 2010-06-02 ジョンズ・ホプキンス・ユニバーシティ 眼内薬剤送達装置
US20020028330A1 (en) 2000-09-06 2002-03-07 Alcon Universal Ltd. Switchable tackiness coating compositions for ophthalmic implants
US6303290B1 (en) 2000-09-13 2001-10-16 The Trustees Of The University Of Pennsylvania Encapsulation of biomaterials in porous glass-like matrices prepared via an aqueous colloidal sol-gel process
JP2004517674A (ja) 2000-12-29 2004-06-17 ボシュ・アンド・ロム・インコーポレイテッド 徐放薬物送達装置
WO2002053130A2 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with coated drug cores
JP2004521882A (ja) 2001-01-03 2004-07-22 ボシュ・アンド・ロム・インコーポレイテッド 組立式透過性プラグを備えた徐放薬剤送達装置
CA2432203C (en) 2001-01-03 2008-03-25 Michael J. Brubaker Sustained release drug delivery devices with multiple agents
DE60219607T2 (de) 2001-01-09 2007-12-27 Microchips, Inc., Bedford Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
EP1365738A2 (en) 2001-01-26 2003-12-03 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
WO2003005951A2 (en) 2001-07-10 2003-01-23 Teva Pharmaceutical Industries Ltd. Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
DK1409065T3 (da) 2001-07-23 2007-05-21 Alcon Inc Oftalmisk medikamentafgivelsesanordning
DK1385452T3 (da) 2001-07-23 2007-01-15 Alcon Inc Anordning til tilförsel af et ophthalmisk medikament
MXPA04001076A (es) * 2001-08-03 2005-02-17 Glaucoma Res Technologies Inc Metodo e implante intraescleral para tratamiento de glaucoma y presbicia.
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
RU2311892C2 (ru) 2001-08-29 2007-12-10 КАРВАЛХО Рикардо А. П. ДЕ Имплантируемая и герметизируемая система для однонаправленной доставки терапевтических препаратов в ткани
AU2002341959A1 (en) 2001-10-04 2003-04-14 Case Western Reserve University Drug delivery devices and methods
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
EP1444338A4 (en) 2001-11-15 2007-07-04 Arryx Inc PASTILLE WITH SAMPLES
WO2003061625A2 (en) 2002-01-18 2003-07-31 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
CN1638743B (zh) 2002-03-11 2012-11-07 爱尔康公司 可植入药物的释放系统
US7074426B2 (en) 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
PL206379B1 (pl) 2002-07-15 2010-08-31 Alcon Ulegająca bioerozji kompozycja do wytwarzania błony do dostarczania leków oftalmicznych i zastosowanie
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US20040019325A1 (en) 2002-07-29 2004-01-29 Medrip Ltd. Syringe Pump
US7090681B2 (en) 2002-09-18 2006-08-15 Allergan, Inc. Methods and apparatus for delivery of ocular implants
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
WO2004028477A2 (en) 2002-09-29 2004-04-08 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
ATE451915T1 (de) * 2003-01-24 2010-01-15 Psivida Inc Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren
US7794437B2 (en) 2003-01-24 2010-09-14 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
US20060167435A1 (en) 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
US20060258000A1 (en) 2003-02-26 2006-11-16 Allen Jared W Use of steady-state oxygen gradients to modulate animal cell functions
US20050074497A1 (en) 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20050255144A1 (en) 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
JP2004315258A (ja) 2003-04-14 2004-11-11 Shin Etsu Handotai Co Ltd 単結晶の製造方法
EP1671624B1 (en) 2003-05-02 2010-08-11 SurModics, Inc. Delivery device for a controlled drug release of an active agent into the posterior section of the eye
JP4824549B2 (ja) 2003-05-02 2011-11-30 サーモディクス,インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
AU2004264839B2 (en) 2003-06-13 2009-06-04 Becton, Dickinson And Company Improved intra-dermal delivery of biologically active agents
US20040260381A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices and methods for forming stenting structures in situ
WO2004112653A2 (en) 2003-06-18 2004-12-29 D-Crown Ltd. Devices and methods for delivering and forming single and multiple stenting structures in situ
US20040260380A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices for delivering multiple stenting structures in situ
US8367410B2 (en) 2003-06-20 2013-02-05 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
AU2004258857A1 (en) 2003-07-10 2005-02-03 Alcon, Inc. Ophthalmic drug delivery device
FI120333B (fi) 2003-08-20 2009-09-30 Bioretec Oy Huokoinen lääketieteellinen väline ja menetelmä sen valmistamiseksi
EP1682132A1 (en) 2003-09-18 2006-07-26 Macusight, Inc. Transscleral delivery
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
AU2006225241B2 (en) 2003-09-24 2008-07-17 Tianda Pharmaceuticals (Australia) Pty Limited Medication Holder
WO2005028006A1 (en) 2003-09-24 2005-03-31 Medi-Stream Pty Ltd Medication holder
WO2005033798A2 (en) 2003-10-03 2005-04-14 University Of Washington Electrochemical micromanufacturing system and method
US7211272B2 (en) 2003-12-22 2007-05-01 Bausch & Lomb Incorporated Drug delivery device
AU2005214040B2 (en) 2004-02-12 2011-03-31 Neo Vista, Inc. Methods and apparatus for intraocular brachytherapy
US7276050B2 (en) 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
WO2005091922A2 (en) 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
US20060182783A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Sustained release intraocular drug delivery systems
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
WO2005110374A1 (en) 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
WO2006014434A2 (en) 2004-07-02 2006-02-09 Eliot Lazar Treatment medium delivery device and methods for delivery
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
CA2575622A1 (en) 2004-08-06 2006-02-09 Sopherion Therapeutics, Inc. Anti-angiogenic peptides and methods of use thereof
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
US20060104969A1 (en) 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US20060052754A1 (en) 2004-09-04 2006-03-09 Fields Douglas W Thumb trigger syringe pole
WO2006031532A2 (en) 2004-09-10 2006-03-23 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
EP2452670A1 (en) 2004-10-01 2012-05-16 Ramscor, Inc. Conveniently implantable sustained release drug compositions
EP1812030A4 (en) 2004-10-14 2009-01-14 Sopherion Therapeutics Inc ANTI-ANGIOGENIC PEPTIDES AND METHODS OF USE THEREOF
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US20060129215A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060154981A1 (en) 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
WO2006082588A2 (en) 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
WO2006102378A2 (en) 2005-03-21 2006-09-28 Macusight, Inc. Drug delivery systems for treatment of diseases or conditions
US20070077270A1 (en) 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
WO2006108054A2 (en) 2005-04-05 2006-10-12 The Ohio State University Diffusion delivery system and methods of fabrication
US20100168535A1 (en) 2006-04-12 2010-07-01 Mark Ries Robinson Methods and apparatuses related to blood analyte measurement system
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
WO2006127962A2 (en) 2005-05-25 2006-11-30 Becton, Dickinson And Comapny Particulate formulations for intradermal delivery of biologically active agents
ZA200710598B (en) 2005-06-17 2009-08-26 Dynamis Therapeutics Inc Treatment of inflammatory conditions
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
EP1928470A4 (en) 2005-08-02 2010-09-15 Bionaut Pharmaceuticals Inc HYPOXIC INDUCIBLE FACTOR-1 MODULATORS AND RELEVANT APPLICATIONS FOR THE TREATMENT OF EYE DISEASES
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
CA2622573A1 (en) 2005-09-16 2007-03-29 (Osi) Eyetech, Inc. Ophthalmic syringe
WO2007038453A2 (en) 2005-09-26 2007-04-05 Advanced Ocular Systems Limited Use of an anti-vascular endothelial growth factor (vegf) agent to ameliorate inflammation
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
US20080003219A1 (en) 2005-09-26 2008-01-03 Minu, L.L.C. Delivery of an ocular agent
US20070071756A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation
US20070072933A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an ocular agent
TW200732347A (en) 2005-10-06 2007-09-01 Trophogen Inc VEGF analogs and methods of use
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CA2625359A1 (en) 2005-10-11 2007-04-19 Blake Podaima Smart medical compliance method and system
AU2006304553A1 (en) 2005-10-14 2007-04-26 Alcon, Inc. Method for treating primary and secondary forms of glaucoma
US20080125406A1 (en) 2005-10-14 2008-05-29 Robin Alan L Method for Treating Primary and Secondary Forms of Glaucoma
DE602006017261D1 (de) 2005-11-29 2010-11-11 Glaxosmithkline Llc Behandlung von neovaskulären augenerkrankungen, wie z.b. maculadegeneration, angioiden streifen, uveitis und makulaödemen
JP4721425B2 (ja) 2005-12-01 2011-07-13 キヤノン株式会社 流体移動方法および流体移動装置
WO2007066339A1 (en) 2005-12-07 2007-06-14 Ramot At Tel Aviv University Ltd. Drug-delivering composite structures
US20070131611A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based article and associated method
US20070131610A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based apparatus and associated method
JP5388582B2 (ja) 2006-01-17 2014-01-15 トランセンド・メディカル・インコーポレイテッド 薬剤投与処置装置
ES2551782T3 (es) 2006-01-17 2015-11-23 Transcend Medical, Inc. Dispositivo para el tratamiento de glaucoma
US20080216736A1 (en) 2006-01-19 2008-09-11 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
US8979770B2 (en) 2006-02-24 2015-03-17 Merck Sharp & Dohme Corp. Extraction and diagnostic fluid devices, systems and methods of use
US7625927B2 (en) 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
TW200800230A (en) 2006-03-31 2008-01-01 Dynamis Therapeutics Inc Composition and method related to fructosamine-3-kinase inhibitors
BRPI0709663A2 (pt) 2006-03-31 2011-07-26 Qlt Plug Delivery Inc mÉtodos de liberaÇço de drogas, estruturas e composiÇÕes para um sistema nasolacrimal
JP2009534129A (ja) 2006-04-18 2009-09-24 カスケード オフタルミクス 眼圧減衰装置
EA013662B1 (ru) 2006-04-18 2010-06-30 Чжуншань Ботай Фармасьютик Инструментс Ко., Лтд. Асептический шприц
US7918814B2 (en) 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) * 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US20080124372A1 (en) 2006-06-06 2008-05-29 Hossainy Syed F A Morphology profiles for control of agent release rates from polymer matrices
EP2037882B1 (en) 2006-06-28 2014-12-10 SurModics, Inc. Combination degradable and non-degradable matrices for active agent delivery
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
US8104331B2 (en) 2006-07-19 2012-01-31 Noab Biodiscoveries Inc. Method and device to extract components contained in a fluid
US20080152694A1 (en) 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
US20080069854A1 (en) 2006-08-02 2008-03-20 Inframat Corporation Medical devices and methods of making and using
US20080125711A1 (en) * 2006-08-07 2008-05-29 Alpini Alfred A Catheter balloons with integrated non-distensible seals
JP2008054521A (ja) 2006-08-29 2008-03-13 Canon Inc 細胞培養処理装置及び細胞培養処理方法
US8821943B2 (en) 2006-09-12 2014-09-02 Board Of Regents Of The University Of Nebraska Methods and compositions for targeted delivery of therapeutic agents
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
JP5694664B2 (ja) 2006-09-29 2015-04-01 サーモディクス,インコーポレイティド 生分解性眼用インプラント及び眼の病気を治療する方法
TW200817039A (en) 2006-10-06 2008-04-16 Dynamis Therapeutics Inc Compositions and methods for skin lightening
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
WO2008052145A2 (en) 2006-10-25 2008-05-02 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
CA2667614A1 (en) 2006-10-25 2008-09-25 Revalesio Corporation Method of wound care and treatment
JP5748407B2 (ja) 2006-11-10 2015-07-15 グローコス コーポレーション ブドウ膜強膜シャント
US20080111282A1 (en) 2006-11-10 2008-05-15 Baojun Xie Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles
US20100286791A1 (en) 2006-11-21 2010-11-11 Goldsmith David S Integrated system for the ballistic and nonballistic infixion and retrieval of implants
US20090263346A1 (en) 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
JP2010511713A (ja) 2006-12-05 2010-04-15 ランデック コーポレイション 薬物送達
US20080154241A1 (en) 2006-12-07 2008-06-26 Burkstrand Michael J Latent stabilization of bioactive agents releasable from implantable medical articles
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
WO2008076544A2 (en) 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
CA2674076A1 (en) 2006-12-26 2008-07-10 Qlt Plug Delivery, Inc. Drug delivery implants for inhibition of optical defects
JP5201743B2 (ja) 2007-01-09 2013-06-05 フォヴェア ファルマシューティカル 眼内注射装置
CA2675121A1 (en) 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
WO2008116165A2 (en) 2007-03-21 2008-09-25 Next Safety, Inc. Methods and systems of delivering medication via inhalation
US20080249501A1 (en) 2007-04-09 2008-10-09 Medtronic Vascular, Inc. Methods for Simultaneous Injection and Aspiration of Fluids During a Medical Procedure
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
WO2008144919A1 (en) 2007-05-29 2008-12-04 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
WO2009023615A1 (en) 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
KR20100067099A (ko) 2007-09-07 2010-06-18 큐엘티 플러그 딜리버리, 인코포레이티드 눈물 임플랜트 검출
EP2207529B1 (en) 2007-09-07 2014-12-31 Mati Therapeutics Inc. Drug cores for sustained release of therapeutic agents
RU2482822C2 (ru) 2007-09-07 2013-05-27 Клт Инк. Инструменты для вставления и извлечения лакримальных имплантатов
US8308755B2 (en) 2007-09-24 2012-11-13 Ethicon Endo-Surgery, Inc. Elliptical retractor
GB0718737D0 (en) 2007-09-25 2007-11-07 Glaxo Group Ltd Antibodies
US20090214601A1 (en) 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
US20100100043A1 (en) 2007-10-05 2010-04-22 Racenet Danyel J Flexible Access Device For Use In Surgical Procedure
BRPI0817421A2 (pt) 2007-10-05 2015-06-16 Tyco Healthcare Fixador de vedação para uso em procedimentos cirúrgicos
US20100008997A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
CA2703648A1 (en) 2007-10-25 2009-04-30 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
WO2010062628A1 (en) 2008-10-27 2010-06-03 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100009008A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20100310665A1 (en) 2007-10-25 2010-12-09 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20100303918A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100004189A1 (en) 2007-10-25 2010-01-07 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20090263495A1 (en) 2007-10-25 2009-10-22 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20100303917A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating cystic fibrosis
CN101848701A (zh) 2007-11-05 2010-09-29 博士伦公司 水不混溶性物质作为药物递送的运载体
US8114883B2 (en) 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
EP2242464B2 (en) 2007-12-20 2017-03-01 University Of Southern California Apparatus for delivering therapeutic agents
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
ES2577502T3 (es) 2008-01-03 2016-07-15 University Of Southern California Dispositivos implantables de administración de fármacos y aparato para recargar los dispositivos
US20100305514A1 (en) 2008-01-10 2010-12-02 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009094466A2 (en) 2008-01-22 2009-07-30 University Of Florida Research Foundation, Inc. Contact lenses for extended release of bioactive agents containing diffusion attenuators
US8201752B2 (en) 2008-03-10 2012-06-19 Vapore, Inc. Low energy vaporization of liquids: apparatus and methods
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
WO2009117112A2 (en) 2008-03-21 2009-09-24 Novartis Ag Powder dispersion apparatus, method of making and using the apparatus, components that can be used on the apparatus and other devices, and various active agents
CA2720067C (en) 2008-03-31 2020-10-06 Altea Therapeutics Corporation Permeant delivery system and methods for use thereof
ES2452935T3 (es) 2008-04-04 2014-04-03 Nektar Therapeutics Dispositivo de aerosolización
EP2276508A4 (en) 2008-04-15 2011-12-28 Sarcode Bioscience Inc RELEASE OF LFA-1 ANTAGONISTS AGAINST THE GAS-DARM SYSTEM
WO2009134371A2 (en) 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
JP5901291B2 (ja) 2008-05-01 2016-04-06 リバルシオ コーポレイション 消化器障害を治療するための組成物および方法
JP2011519695A (ja) 2008-05-08 2011-07-14 リプレニッシュ パンプス, エルエルシー 植設可能な薬物送達デバイスおよびそのデバイスを充填する装置および方法
EP2891501B1 (en) 2008-05-08 2016-09-21 MiniPumps, LLC Methods of manufacture of drug-delivery pumps
EP2313770B1 (en) 2008-07-11 2019-09-04 Essen Instruments, Inc. d/b/a Essen BioScience, Inc. Multi-sample particle analyzer system and method for high throughput screening
US8979882B2 (en) 2008-07-21 2015-03-17 Arstasis, Inc. Devices, methods, and kits for forming tracts in tissue
US20100023033A1 (en) 2008-07-25 2010-01-28 Medtronic Vescular, Inc. Hydrodynamic Thrombectomy Catheter
US20100022943A1 (en) 2008-07-25 2010-01-28 Medtronic Vascular, Inc. Hydrodynamic Thrombectomy Catheter
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
DE102008054431B3 (de) 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
US20100174272A1 (en) * 2009-01-02 2010-07-08 Weiner Alan L In-situ refillable ophthalmic implant
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CN104887389B (zh) 2009-01-29 2017-06-23 弗赛特影像4股份有限公司 后段给药
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
WO2010125416A1 (en) 2009-04-27 2010-11-04 Raouf Rekik Drug delivery to the anterior and posterior segments of the eye
JP2012525396A (ja) 2009-04-27 2012-10-22 レバレジオ コーポレイション インスリン耐性および真性糖尿病を治療するための組成物および方法
AU2010248821A1 (en) 2009-05-15 2011-12-01 Arstasis, Inc. Devices, methods and kits for forming tracts in tissue
CN102655823B (zh) 2009-05-18 2016-04-20 多斯医学公司 药物洗脱眼植入物
WO2010141729A1 (en) 2009-06-03 2010-12-09 Forsight Labs, Llc Anterior segment drug delivery
WO2011008897A2 (en) 2009-07-14 2011-01-20 Board Of Regents, The University Of Texas System Methods for making controlled delivery devices having zero order kinetics
WO2011008986A2 (en) 2009-07-15 2011-01-20 California Institute Of Technology A method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves
CN102575298A (zh) 2009-08-14 2012-07-11 霍夫曼-拉罗奇有限公司 用于监测患者对vegf拮抗剂的响应的生物学标志物
US20120283316A1 (en) 2009-09-01 2012-11-08 Northwestern University Delivery of Therapeutic Agents Using Oligonucleotide-Modified Nanoparticles As Carriers
CA2811959A1 (en) 2009-09-21 2011-03-24 Harvard Bioscience, Inc. Methods and apparatus for introducing cells at a tissue site
ES2695907T3 (es) 2009-11-17 2019-01-11 Bard Inc C R Puerto de acceso sobremoldeado que incluye características de anclaje e identificación
JP2013515741A (ja) 2009-12-23 2013-05-09 サイヴィーダ ユーエス,インコーポレイテッド 持続放出性送達デバイス
US8821474B2 (en) * 2010-02-22 2014-09-02 Microsert Ltd. Slow release liquid drug delivery device
US8038650B2 (en) 2010-02-22 2011-10-18 Microsert Ltd. Slow release liquid drug delivery device
AR081364A1 (es) 2010-05-05 2012-08-29 Glaxo Wellcome Mfg Pte Ltd Composiciones farmaceuticas de pazopanib y metodos para su elaboracion
SI2600930T1 (sl) 2010-08-05 2021-08-31 Forsight Vision4, Inc. Injekcijska naprava za dajanje zdravila
JP6111194B2 (ja) 2010-08-05 2017-04-05 フォーサイト・ビジョン フォー・インコーポレーテッド 組み合わせ薬物送達方法および装置
CA2807508A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Subconjunctival implant for posterior segment drug delivery
LT2600812T (lt) 2010-08-05 2021-11-10 Forsight Vision4, Inc. Aparatas, skirtas akiai gydyti
US8864703B2 (en) 2010-10-05 2014-10-21 Alcon Research, Ltd. Drug introduction and placement system
WO2012065006A2 (en) 2010-11-11 2012-05-18 Forsight Vision4, Inc. Methods and apparatus to determine porous structures for drug delivery
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9668915B2 (en) * 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
EP2691127B1 (en) 2011-03-27 2021-01-13 Microsert Ltd Miniature implanted drug delivery devices and inserter systems for introducing such devices
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE
EP3903733A1 (en) 2011-09-16 2021-11-03 ForSight Vision4, Inc. Fluid exchange apparatus
US10010448B2 (en) * 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US20140336619A1 (en) 2013-05-13 2014-11-13 Abbott Cardiovascular Systems Inc. Ophthalmic shunt and method
US10376413B2 (en) 2013-10-27 2019-08-13 Microsert Ltd. Implantable drug delivery device and a system and method for deployment of such devices
US9445941B2 (en) 2013-11-07 2016-09-20 Drug Delivery Company, Llc Bioresorbable drug eluting intravitreal implant system and method
WO2015085234A1 (en) * 2013-12-06 2015-06-11 Forsight Vision4, Inc. Implantable therapeutic devices
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
EP3177289A4 (en) 2014-08-08 2018-03-21 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CN110478119B (zh) 2014-11-10 2022-04-15 弗赛特影像4股份有限公司 可膨胀药物递送装置和使用方法
WO2017087902A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use

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CA3019822A1 (en) 2017-10-12
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EP3799844A1 (en) 2021-04-07
US20190117454A1 (en) 2019-04-25
WO2017176886A1 (en) 2017-10-12
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AU2017246889A1 (en) 2018-10-25
CN113017981B (zh) 2023-07-25
AR108177A1 (es) 2018-07-25
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WO2017176886A8 (en) 2019-02-14
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CN109195556A (zh) 2019-01-11
US11617680B2 (en) 2023-04-04

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