HRP20180002T1 - Kompozicije i postupci za liječenje karcinoma - Google Patents
Kompozicije i postupci za liječenje karcinoma Download PDFInfo
- Publication number
- HRP20180002T1 HRP20180002T1 HRP20180002TT HRP20180002T HRP20180002T1 HR P20180002 T1 HRP20180002 T1 HR P20180002T1 HR P20180002T T HRP20180002T T HR P20180002TT HR P20180002 T HRP20180002 T HR P20180002T HR P20180002 T1 HRP20180002 T1 HR P20180002T1
- Authority
- HR
- Croatia
- Prior art keywords
- wee1
- inhibitor
- patient
- cancer
- pharmaceutically acceptable
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims 11
- 201000011510 cancer Diseases 0.000 title claims 11
- 239000000203 mixture Substances 0.000 title 1
- 101000621390 Homo sapiens Wee1-like protein kinase Proteins 0.000 claims 30
- 102100023037 Wee1-like protein kinase Human genes 0.000 claims 30
- 239000003112 inhibitor Substances 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 11
- 239000013068 control sample Substances 0.000 claims 8
- 230000014509 gene expression Effects 0.000 claims 7
- 101000687968 Homo sapiens Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Proteins 0.000 claims 4
- 102100024262 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Human genes 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013610 patient sample Substances 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000092 prognostic biomarker Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
1. Inhibitor WEE1 za upotrebu u liječenju pacijenta kome je dijagnostificiran karcinom povezan s WEE1 kinazom, pri čemu upotreba obuhvaća:
(a) mjerenje nivoa genske ekspresije PKMYT1 u biološkom uzorku koji sadrži karcinomske stanice dobivene od navedenog pacijenta i u kontrolnom uzorku;
(b) određivanje da li je nivo genske ekspresije u navedenom pacijentovom uzorku iznad ili ispod nivoa genske ekspresije u navedenom kontrolnom uzorku;
(c) odabir navedenog pacijenta za liječenje inhibitorom WEE1, gdje je nivo prognostičkog biomarkera iz navedenog pacijentovog uzorka ispod onog u kontrolnom uzorku; i
(d) primjenu inhibitora WEE 1 kod odabranog pacijenta.
2. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 1, gdje je navedeni kontrolni uzorak dobiven od jednog ili više subjekata koji nemaju bolest ili kod kojih nije dijagnostificiran karcinom povezan sa WEE1 kinazom.
3. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 1, gdje navedeni inhibitor WEE1 predstavlja WEE1-1, ili njegovu farmaceutski prihvatljivu sol, ili WEE1-2, ili njegovu farmaceutski prihvatljivu sol.
4. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 3, gdje navedeni inhibitor WEE1 predstavlja WEE1-1 ili njegovu farmaceutski prihvatljivu sol.
5. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 3, gdje navedeni inhibitor WEE1 predstavlja WEE1-2 ili njegovu farmaceutski prihvatljivu sol.
6. Inhibitor WEE1 za upotrebu u liječenju pacijenta oboljelog od karcinoma osjetljivog na liječenje inhibitorom WEE1 koja sadrži:
(a) mjerenje nivoa genske ekspresije PKMYT1 u biološkom uzorku koji sadrži karcinomske stanice dobivene od navedenog pacijenta i u kontrolnom uzorku;
(b) određivanje da li je nivo genske ekspresije u navedenom pacijentovom uzorku iznad ili ispod nivoa genske ekspresije u navedenom kontrolnom uzorku;
(c) identificiranje navedenog osjetljivog pacijenta za liječenje inhibitorom WEE1, gdje je nivo PKMYT1 iz navedenog pacijentovog uzorka ispod onog u kontrolnom uzorku; i
(d) primjenu inhibitora WEE1 kod osjetljivog pacijenta.
7. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 6, gdje je navedeni kontrolni uzorak dobiven od jednog ili više subjekata koji nemaju bolest ili kod kojih nije dijagnostificiran karcinom povezan sa WEE1 kinazom.
8. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 6, gdje navedeni inhibitor WEE1 predstavlja WEE1-1, ili njegovu farmaceutski prihvatljivu sol, ili WEE1-2, ili njegovu farmaceutski prihvatljivu sol.
9. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 8, gdje navedeni inhibitor WEE1 predstavlja WEE1-1, ili njegovu farmaceutski prihvatljivu sol.
10. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 8, gdje navedeni inhibitor WEE1 predstavlja WEE1-2, ili njegovu farmaceutski prihvatljivu sol.
11. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 6, gdje navedeni karcinom predstavlja karcinom povezan sa WEE1 kinazom odabran iz grupe koja se sastoji od karcinoma dojke, karcinoma pluća, karcinoma pankreasa, karcinoma debelog crijeva, karcinoma jajnika, akutne leukemije, kronične limfatične leukemije, kronične mijelocitne leukemije i Hodkinovog limfoma.
12. Inhibitor WEE1 za upotrebu u liječenju pacijenta s karcinomom povezanim s WEE1 kinazom, gdje inhibitor WEE1 predstavlja WEE1-1 ili njegovu farmaceutski prihvatljivu sol, ili WEE1-2 ili njegovu farmaceutski prihvatljivu sol, i gdje su karcinomske stanice navedenog pacijenta koji se treba liječiti naznačene niskom ekspresijom PKMYT1.
13. Inhibitor WEE1 za upotrebu prema patentnom zahtjevu 12 gdje inhibitor WEE1 predstavlja WEE1-1 ili njegovu farmaceutski prihvatljivu sol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730795P | 2012-11-28 | 2012-11-28 | |
| PCT/US2013/071377 WO2014085216A1 (en) | 2012-11-28 | 2013-11-22 | Compositions and methods for treating cancer |
| EP13858495.8A EP2925888B1 (en) | 2012-11-28 | 2013-11-22 | Compositions and methods for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180002T1 true HRP20180002T1 (hr) | 2018-02-09 |
Family
ID=50828365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180002TT HRP20180002T1 (hr) | 2012-11-28 | 2018-01-03 | Kompozicije i postupci za liječenje karcinoma |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9655899B2 (hr) |
| EP (1) | EP2925888B1 (hr) |
| JP (1) | JP6290237B2 (hr) |
| KR (1) | KR102161331B1 (hr) |
| AU (1) | AU2013352568B2 (hr) |
| BR (1) | BR112015012295A8 (hr) |
| CA (1) | CA2892361A1 (hr) |
| CY (1) | CY1119676T1 (hr) |
| DK (1) | DK2925888T3 (hr) |
| ES (1) | ES2651347T3 (hr) |
| HK (1) | HK1209798A1 (hr) |
| HR (1) | HRP20180002T1 (hr) |
| HU (1) | HUE035662T2 (hr) |
| LT (1) | LT2925888T (hr) |
| ME (1) | ME02925B (hr) |
| MX (1) | MX363243B (hr) |
| NO (1) | NO2941224T3 (hr) |
| PL (1) | PL2925888T3 (hr) |
| PT (1) | PT2925888T (hr) |
| RS (1) | RS56680B1 (hr) |
| RU (1) | RU2660349C2 (hr) |
| SI (1) | SI2925888T1 (hr) |
| WO (1) | WO2014085216A1 (hr) |
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| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| ES2704744T3 (es) | 2012-06-13 | 2019-03-19 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| CN109776525B (zh) | 2013-04-19 | 2022-01-21 | 因赛特控股公司 | 作为fgfr抑制剂的双环杂环 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2017078752A1 (en) * | 2015-11-06 | 2017-05-11 | The Penn State Research Foundation | Compositions and methods relating to cancer |
| US10280348B2 (en) * | 2017-01-31 | 2019-05-07 | Prc-Desoto International, Inc. | Low density aerospace compositions and sealants |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019074979A1 (en) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| EP3694509A4 (en) | 2017-10-09 | 2021-07-14 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AND THEIR USES |
| BR112020022392A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | formas sólidas de um inibidor de fgfr e processos para preparação das mesmas |
| MX2020011639A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| JP2022526831A (ja) | 2019-04-09 | 2022-05-26 | ニューベイション・バイオ・インコーポレイテッド | ヘテロ環式化合物およびその使用 |
| WO2020210383A1 (en) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2020210377A1 (en) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| IL291901A (en) | 2019-10-14 | 2022-06-01 | Incyte Corp | Bicyclyl heterocycles as fgr suppressors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| WO2021127046A1 (en) * | 2019-12-20 | 2021-06-24 | Recurium Ip Holdings, Llc | Combinations |
| KR20220119427A (ko) * | 2019-12-20 | 2022-08-29 | 리커리엄 아이피 홀딩스, 엘엘씨 | 조합 |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021202780A2 (en) * | 2020-04-01 | 2021-10-07 | Engine Biosciences Pte. Ltd. | Methods and compositions for treating cancer |
| CA3215903A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
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- 2013-11-22 JP JP2015544142A patent/JP6290237B2/ja active Active
- 2013-11-22 LT LTEP13858495.8T patent/LT2925888T/lt unknown
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- 2013-11-22 HU HUE13858495A patent/HUE035662T2/en unknown
- 2013-11-22 SI SI201330904T patent/SI2925888T1/en unknown
- 2013-11-22 PT PT138584958T patent/PT2925888T/pt unknown
- 2013-11-22 DK DK13858495.8T patent/DK2925888T3/en active
- 2013-11-22 ES ES13858495.8T patent/ES2651347T3/es active Active
- 2013-11-22 RS RS20171325A patent/RS56680B1/sr unknown
- 2013-11-22 PL PL13858495T patent/PL2925888T3/pl unknown
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- 2013-11-22 RU RU2015125575A patent/RU2660349C2/ru active
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2014
- 2014-01-02 NO NO14735382A patent/NO2941224T3/no unknown
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| PL2925888T3 (pl) | 2018-03-30 |
| RU2015125575A (ru) | 2017-01-10 |
| WO2014085216A1 (en) | 2014-06-05 |
| KR20150088257A (ko) | 2015-07-31 |
| RS56680B1 (sr) | 2018-03-30 |
| NO2941224T3 (hr) | 2018-07-28 |
| US9655899B2 (en) | 2017-05-23 |
| JP2016500110A (ja) | 2016-01-07 |
| MX2015006729A (es) | 2015-08-14 |
| BR112015012295A2 (pt) | 2017-07-11 |
| LT2925888T (lt) | 2018-01-10 |
| EP2925888A1 (en) | 2015-10-07 |
| SI2925888T1 (en) | 2018-02-28 |
| EP2925888B1 (en) | 2017-10-25 |
| US20160008361A1 (en) | 2016-01-14 |
| CA2892361A1 (en) | 2014-06-05 |
| HUE035662T2 (en) | 2018-05-28 |
| EP2925888A4 (en) | 2016-05-11 |
| KR102161331B1 (ko) | 2020-09-29 |
| MX363243B (es) | 2019-03-14 |
| AU2013352568A1 (en) | 2015-04-30 |
| AU2013352568B2 (en) | 2019-09-19 |
| DK2925888T3 (en) | 2017-12-18 |
| BR112015012295A8 (pt) | 2023-03-14 |
| ME02925B (me) | 2018-04-20 |
| CY1119676T1 (el) | 2018-04-04 |
| ES2651347T3 (es) | 2018-01-25 |
| RU2660349C2 (ru) | 2018-07-05 |
| PT2925888T (pt) | 2017-12-13 |
| HK1209798A1 (en) | 2016-04-08 |
| JP6290237B2 (ja) | 2018-03-07 |
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