HRP20110908T1 - Hidroksilirani i metoksilirani ciklopenta [d] pirimidini kao inhibitori kinaze akt proteina - Google Patents

Hidroksilirani i metoksilirani ciklopenta [d] pirimidini kao inhibitori kinaze akt proteina Download PDF

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Publication number
HRP20110908T1
HRP20110908T1 HR20110908T HRP20110908T HRP20110908T1 HR P20110908 T1 HRP20110908 T1 HR P20110908T1 HR 20110908 T HR20110908 T HR 20110908T HR P20110908 T HRP20110908 T HR P20110908T HR P20110908 T1 HRP20110908 T1 HR P20110908T1
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HR
Croatia
Prior art keywords
methyl
piperazin
hydroxy
cyclopenta
dihydro
Prior art date
Application number
HR20110908T
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English (en)
Croatian (hr)
Inventor
S. Mitchell Ian
F. Blake James
Xu Rui
C. Kallan Nicholas
Xiao Dengming
Lee Spencer Keith
R. Bencsik Josef
Liang Jun
Safina Brian
Zhang Birong
Chabot Christine
Do Steven
W. Wallace Eli
L. Banka Anna
T. Schlachter Stephen
Original Assignee
Array Biopharma
Genentech
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20110908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma, Genentech filed Critical Array Biopharma
Publication of HRP20110908T1 publication Critical patent/HRP20110908T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • AIDS & HIV (AREA)
HR20110908T 2006-07-06 2011-12-02 Hidroksilirani i metoksilirani ciklopenta [d] pirimidini kao inhibitori kinaze akt proteina HRP20110908T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
PCT/US2007/072885 WO2008006040A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
HRP20110908T1 true HRP20110908T1 (hr) 2012-02-29

Family

ID=38686743

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110908T HRP20110908T1 (hr) 2006-07-06 2011-12-02 Hidroksilirani i metoksilirani ciklopenta [d] pirimidini kao inhibitori kinaze akt proteina

Country Status (35)

Country Link
EP (4) EP2402325B1 (ko)
JP (4) JP5266216B2 (ko)
KR (5) KR101578877B1 (ko)
CN (2) CN102816124A (ko)
AR (3) AR061842A1 (ko)
AT (1) ATE524447T1 (ko)
AU (1) AU2007269060B2 (ko)
BR (3) BR122013028012B8 (ko)
CA (2) CA2836316A1 (ko)
CL (1) CL2007001993A1 (ko)
CO (1) CO6150161A2 (ko)
CR (1) CR10600A (ko)
CY (1) CY1112117T1 (ko)
DK (2) DK2402325T3 (ko)
ES (3) ES2554228T3 (ko)
HK (3) HK1160134A1 (ko)
HR (1) HRP20110908T1 (ko)
HU (1) HUE026237T2 (ko)
IL (2) IL196028A (ko)
IN (1) IN2014KN02886A (ko)
MA (1) MA31655B1 (ko)
MX (4) MX2008016202A (ko)
MY (1) MY147364A (ko)
NO (1) NO342346B1 (ko)
NZ (3) NZ597647A (ko)
PL (2) PL2049501T3 (ko)
PT (1) PT2049501E (ko)
RS (1) RS52212B (ko)
RU (2) RU2478632C2 (ko)
SG (4) SG188905A1 (ko)
SI (2) SI2402325T1 (ko)
TW (2) TW201332994A (ko)
UA (1) UA95641C2 (ko)
WO (1) WO2008006040A1 (ko)
ZA (1) ZA200900070B (ko)

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US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
BRPI0713555A2 (pt) 2006-07-06 2012-03-20 Array Biopharma, Inc. ciclopenta [d] pirimidinas como inibidores de akt protéina cinase
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WO2009089454A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
MX2010007546A (es) * 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
US8329709B2 (en) * 2008-01-09 2012-12-11 Genentech, Inc. 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors
NZ586346A (en) 2008-01-09 2012-02-24 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
CA2821378A1 (en) * 2010-12-23 2012-06-28 Genentech, Inc. Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
AU2012236134A1 (en) * 2011-04-01 2013-11-21 Genentech, Inc. Biomarkers for predicting sensitivity to cancer treatments
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