ES2152902B1 - Procedimiento de obtencion de venlafaxina - Google Patents
Procedimiento de obtencion de venlafaxinaInfo
- Publication number
- ES2152902B1 ES2152902B1 ES009901686A ES9901686A ES2152902B1 ES 2152902 B1 ES2152902 B1 ES 2152902B1 ES 009901686 A ES009901686 A ES 009901686A ES 9901686 A ES9901686 A ES 9901686A ES 2152902 B1 ES2152902 B1 ES 2152902B1
- Authority
- ES
- Spain
- Prior art keywords
- venlafaxine
- obtaining procedure
- venlafaxin
- general formula
- physiologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Procedimiento para la obtención de venlafaxina y/o sus sales de adición fisiológicamente aceptables, que consiste en hacer reaccionar un compuesto de fórmula general (II), en la que R es un grupo alquilo C{Sub, 1}-C{sub, l0}, arilo, aralquilo o cicloalquilo de 3 a 6 átomos de carbono, con un compuesto organomagnesiano de fórmula general (III), en la que X significa un átomo de halógeno y, si se desea, se forma una sal de la venlafaxina obtenida mediante su reacción con un ácido fisiológicamente aceptable. **FORMULA 01** .
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901686A ES2152902B1 (es) | 1999-07-27 | 1999-07-27 | Procedimiento de obtencion de venlafaxina |
US10/048,107 US6506941B1 (en) | 1999-07-27 | 2000-07-17 | Venlafaxine production process |
ES00945958T ES2226877T3 (es) | 1999-07-27 | 2000-07-17 | Procedimiento para la preparacion de venlafaxina. |
DK00945958T DK1213279T3 (da) | 1999-07-27 | 2000-07-17 | Fremgangsmåde til fremstilling af venlafaxin |
SI200030552T SI1213279T1 (en) | 1999-07-27 | 2000-07-17 | Venlafaxine production process |
EP00945958A EP1213279B1 (en) | 1999-07-27 | 2000-07-17 | Venlafaxine production process |
IL14766800A IL147668A0 (en) | 1999-07-27 | 2000-07-17 | A process for the preparation of venlafaxin |
PT00945958T PT1213279E (pt) | 1999-07-27 | 2000-07-17 | Processo para a preparacao de venlafaxina |
AT00945958T ATE276229T1 (de) | 1999-07-27 | 2000-07-17 | Herstellungsverfahren für venlafaxin |
PCT/ES2000/000255 WO2001007397A1 (es) | 1999-07-27 | 2000-07-17 | Procedimiento de obtencion de venlafaxina |
DE60013861T DE60013861T2 (de) | 1999-07-27 | 2000-07-17 | Herstellungsverfahren für venlafaxin |
CA002380854A CA2380854A1 (en) | 1999-07-27 | 2000-07-17 | A process for the preparation of venlafaxin |
AU59874/00A AU5987400A (en) | 1999-07-27 | 2000-07-17 | Venlafaxine production process |
IL147668A IL147668A (en) | 1999-07-27 | 2002-01-16 | Process for the preparation of venlafaxin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901686A ES2152902B1 (es) | 1999-07-27 | 1999-07-27 | Procedimiento de obtencion de venlafaxina |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2152902A1 ES2152902A1 (es) | 2001-02-01 |
ES2152902B1 true ES2152902B1 (es) | 2001-08-16 |
Family
ID=8309382
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901686A Expired - Fee Related ES2152902B1 (es) | 1999-07-27 | 1999-07-27 | Procedimiento de obtencion de venlafaxina |
ES00945958T Expired - Lifetime ES2226877T3 (es) | 1999-07-27 | 2000-07-17 | Procedimiento para la preparacion de venlafaxina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00945958T Expired - Lifetime ES2226877T3 (es) | 1999-07-27 | 2000-07-17 | Procedimiento para la preparacion de venlafaxina. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6506941B1 (es) |
EP (1) | EP1213279B1 (es) |
AT (1) | ATE276229T1 (es) |
AU (1) | AU5987400A (es) |
CA (1) | CA2380854A1 (es) |
DE (1) | DE60013861T2 (es) |
DK (1) | DK1213279T3 (es) |
ES (2) | ES2152902B1 (es) |
IL (2) | IL147668A0 (es) |
PT (1) | PT1213279E (es) |
SI (1) | SI1213279T1 (es) |
WO (1) | WO2001007397A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040186310A1 (en) * | 2001-06-22 | 2004-09-23 | Kim Keun-Sik | Process for preparation of cyclohexanol derivatives |
AR039163A1 (es) | 2002-03-28 | 2005-02-09 | Synthon Bv | Besilato de venlafaxina |
WO2003082805A1 (en) | 2002-03-28 | 2003-10-09 | Synthon B.V. | Low water-soluble venlafaxine salts |
WO2007047972A2 (en) * | 2005-10-19 | 2007-04-26 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of highly pure 1-[2-dimethylamino-(4-methoxyphenyl) ethyl]cyclohexanol hydrochloride |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US20080081067A1 (en) * | 2006-10-03 | 2008-04-03 | Gupta Manishkumar | Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof |
WO2011007136A2 (en) * | 2009-07-16 | 2011-01-20 | Cipla Limited | Process for the preparation of o-desmethyl venlafaxine and intermediate for use therein |
CN115650863A (zh) * | 2022-09-05 | 2023-01-31 | 上海博纳赛恩医药研发有限公司 | 制备文拉法辛盐酸盐的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8802131A1 (es) * | 1982-12-13 | 1988-04-01 | American Home Prod | Un procedimiento para la produccion de derivados de feniletilamina. |
GB8902209D0 (en) * | 1989-02-01 | 1989-03-22 | Wyeth John And Brother Limited | Preparation of cyclohexanol derivatives and novel thioamide intermediates |
-
1999
- 1999-07-27 ES ES009901686A patent/ES2152902B1/es not_active Expired - Fee Related
-
2000
- 2000-07-17 IL IL14766800A patent/IL147668A0/xx active IP Right Grant
- 2000-07-17 CA CA002380854A patent/CA2380854A1/en not_active Abandoned
- 2000-07-17 ES ES00945958T patent/ES2226877T3/es not_active Expired - Lifetime
- 2000-07-17 WO PCT/ES2000/000255 patent/WO2001007397A1/es active IP Right Grant
- 2000-07-17 AT AT00945958T patent/ATE276229T1/de not_active IP Right Cessation
- 2000-07-17 EP EP00945958A patent/EP1213279B1/en not_active Expired - Lifetime
- 2000-07-17 DE DE60013861T patent/DE60013861T2/de not_active Expired - Fee Related
- 2000-07-17 US US10/048,107 patent/US6506941B1/en not_active Expired - Fee Related
- 2000-07-17 DK DK00945958T patent/DK1213279T3/da active
- 2000-07-17 AU AU59874/00A patent/AU5987400A/en not_active Abandoned
- 2000-07-17 PT PT00945958T patent/PT1213279E/pt unknown
- 2000-07-17 SI SI200030552T patent/SI1213279T1/xx unknown
-
2002
- 2002-01-16 IL IL147668A patent/IL147668A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE60013861T2 (de) | 2005-09-29 |
CA2380854A1 (en) | 2001-02-01 |
DK1213279T3 (da) | 2005-01-10 |
EP1213279A1 (en) | 2002-06-12 |
DE60013861D1 (de) | 2004-10-21 |
WO2001007397A1 (es) | 2001-02-01 |
ATE276229T1 (de) | 2004-10-15 |
PT1213279E (pt) | 2005-01-31 |
ES2226877T3 (es) | 2005-04-01 |
IL147668A0 (en) | 2002-08-14 |
US6506941B1 (en) | 2003-01-14 |
ES2152902A1 (es) | 2001-02-01 |
AU5987400A (en) | 2001-02-13 |
SI1213279T1 (en) | 2005-04-30 |
IL147668A (en) | 2006-08-20 |
EP1213279B1 (en) | 2004-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20100528 |