AR109424A2 - Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteína quinasa akt - Google Patents

Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteína quinasa akt

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Publication number
AR109424A2
AR109424A2 ARP170102366A ARP170102366A AR109424A2 AR 109424 A2 AR109424 A2 AR 109424A2 AR P170102366 A ARP170102366 A AR P170102366A AR P170102366 A ARP170102366 A AR P170102366A AR 109424 A2 AR109424 A2 AR 109424A2
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Argentina
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alkyl
optionally substituted
cycloalkyl
phenyl
attached form
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ARP170102366A
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Array Biopharma Inc
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Publication of AR109424A2 publication Critical patent/AR109424A2/es

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Abstract

Un compuesto que tiene la fórmula (1) y sus tautómeros, enantiómeros resueltos, diastereómeros resueltos, solvatos, metabolitos y sales, en los cuales: R¹ es H, Me, Et, vinilo, CF₃, CHF₂ o CH₂F; R² es H o Me; R⁵ es H, Me, Et o CF₃; A es un resto de fórmula (2); G es fenilo sustituido en forma opcional con uno a cuatro grupos R⁹ o un heteroarilo de 5 - 6 miembros sustituido en forma opcional con un halógeno; R⁶ y R⁷ son de manera independiente H, OCH₃, (cicloalquil C₃₋₆)-(CH₂), (cicloalquil C₃₋₆)-(CH₂CH₂), V-(CH₂)₀₋₁ donde V es un heteroarilo de 5 - 6 miembros, W-(CH₂)₁₋₂ donde W es fenilo sustituido en forma opcional con F, Cl, Br, I, OMe, CF₃ o Me, cicloalquilo C₃₋₆ sustituido en forma opcional con alquilo C₁₋₃ u O(alquilo C₁₋₃), hidroxi-(cicloalquilo C₃₋₆), flúor-(cicloalquilo C₃₋₆), CH(CH₃)CH(OH)fenilo, heterociclo de 4 - 6 miembros sustituido en forma opcional con F, OH, alquilo C₁₋₃, ciclopropilmetilo o C(=O)(alquilo C₁₋₃) o alquilo C₁₋₆ sustituido en forma opcional con uno o más grupos seleccionados de manera independiente de OH, oxo, O(alquilo C₁₋₆), CN, F, NH₂, NH(alquilo C₁₋₆), N(alquil C₁₋₆)₂, ciclopropilo, fenilo, imidazolilo, piperidinilo, pirrolidinilo, morfolinilo, tetrahidrofuranilo, oxetanilo o tetrahidropiranilo, o R⁶ y R⁷ junto con el nitrógeno al cual están unidos forman un anillo heterocíclico de 4 - 7 miembros sustituido en forma opcional con uno o más grupos seleccionados de manera independiente de OH, halógeno, oxo, CF₃, CH₂CF₃, CH₃CH₂OH, O(alquilo C₁₋₃), C(=O)CH₃, NH₂, NHMe, N(Me)₂, S(O)₂CH₃, ciclopropilmetilo y alquilo C₁₋₃; Rᵃ y Rᵇ son H, o Rᵃ es H y Rᵇ y R⁶ junto con los átomos a los cuales estén unidos forman un anillo heterocíclico de 5 - 6 miembros que tiene uno o dos átomos de nitrógeno en el anillo; Rᶜ y Rᵈ son H o Me, o Rᶜ y Rᵈ junto con el átomo al cual están unidos forman un anillo ciclopropilo; R⁸ es H, Me, F u OH, o R⁸ y R⁶ junto con los átomos a los cuales están unidos forman un anillo heterocíclico de 5 - 6 miembros que tiene uno o dos átomos de nitrógeno en el anillo; cada R⁹ es de manera independiente halógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆, O-(alquilo C₁₋₆), CF₃, OCF₃, S(alquilo C₁₋₆), CN, OCH₂-fenilo, CH₂O-fenilo, NH₂, NH-(alquilo C₁₋₆), N-(alquil C₁₋₆)₂, piperidina, pirrolidina, CH₂F, CHF₂, OCH₂F, OCHF₂, OH, SO₂(alquilo C₁₋₆), C(O)NH₂, C(O)NH(alquilo C₁₋₆) y C(O)N(alquil C₁₋₆)₂; R¹⁰ es H o Me; y m, n y p son de manera independiente 0 ó 1.
ARP170102366A 2006-07-06 2017-08-25 Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteína quinasa akt AR109424A2 (es)

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ARP070103033A AR061842A1 (es) 2006-07-06 2007-07-06 Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteina quinasa akt
ARP130104510A AR093810A2 (es) 2006-07-06 2013-12-05 Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteina quinasa ak, sus usos, composiciones, kits y formas de dosificacion
ARP170102366A AR109424A2 (es) 2006-07-06 2017-08-25 Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteína quinasa akt

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ARP070103033A AR061842A1 (es) 2006-07-06 2007-07-06 Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteina quinasa akt
ARP130104510A AR093810A2 (es) 2006-07-06 2013-12-05 Pirimidil ciclopentanos hidroxilados y metoxilados como inhibidores de la proteina quinasa ak, sus usos, composiciones, kits y formas de dosificacion

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EP (4) EP2966065A3 (es)
JP (4) JP5266216B2 (es)
KR (5) KR101578877B1 (es)
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