MX337843B - Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa. - Google Patents

Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Info

Publication number
MX337843B
MX337843B MX2011010569A MX2011010569A MX337843B MX 337843 B MX337843 B MX 337843B MX 2011010569 A MX2011010569 A MX 2011010569A MX 2011010569 A MX2011010569 A MX 2011010569A MX 337843 B MX337843 B MX 337843B
Authority
MX
Mexico
Prior art keywords
protein kinase
kinase inhibitors
pyrimidines
hydroxylated
akt protein
Prior art date
Application number
MX2011010569A
Other languages
English (en)
Inventor
Stephen T Schlachter
Eli M Wallace
Jun Liang
James F Blake
Ian S Mitchell
Rui Xu
Nicholas C Kallan
Dengming Xiao
Keith Lee Spencer
Josef R Bencsik
Brian Safina
Birong Zhang
Christine Chabot
Steven Do
Anna L Banka
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX337843(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX337843B publication Critical patent/MX337843B/es

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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

La presente invención proporciona compuestos, incluyendo sus enantiómeros resueltos, diestereómeros resueltos, solvatos y sales farmacéuticamente aceptables, que comprenden la Fórmula (I). También se proporcionan métodos de uso de los compuestos de esta invención como inhibidores de AKT proteína quinasa y para el tratamiento de enfermedades hiperproliferativas tales como cáncer. (ver fórmula (I)).
MX2011010569A 2006-07-06 2008-12-17 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa. MX337843B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
MX337843B true MX337843B (es) 2016-03-22

Family

ID=38686743

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2008016202A MX2008016202A (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2015013326A MX366319B (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2019008117A MX2019008117A (es) 2006-07-06 2008-12-17 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2011010569A MX337843B (es) 2006-07-06 2008-12-17 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2008016202A MX2008016202A (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2015013326A MX366319B (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2019008117A MX2019008117A (es) 2006-07-06 2008-12-17 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Country Status (35)

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EP (4) EP2399909B1 (es)
JP (4) JP5266216B2 (es)
KR (5) KR101578877B1 (es)
CN (2) CN102816124A (es)
AR (3) AR061842A1 (es)
AT (1) ATE524447T1 (es)
AU (1) AU2007269060B2 (es)
BR (3) BR122013028005B8 (es)
CA (2) CA2836316A1 (es)
CL (1) CL2007001993A1 (es)
CO (1) CO6150161A2 (es)
CR (1) CR10600A (es)
CY (1) CY1112117T1 (es)
DK (2) DK2402325T3 (es)
ES (3) ES2554252T3 (es)
HK (3) HK1160638A1 (es)
HR (1) HRP20110908T1 (es)
HU (1) HUE026237T2 (es)
IL (2) IL196028A (es)
IN (1) IN2014KN02886A (es)
MA (1) MA31655B1 (es)
MX (4) MX2008016202A (es)
MY (1) MY147364A (es)
NO (1) NO342346B1 (es)
NZ (3) NZ610633A (es)
PL (2) PL2402325T3 (es)
PT (1) PT2049501E (es)
RS (1) RS52212B (es)
RU (2) RU2478632C2 (es)
SG (4) SG10201802127UA (es)
SI (2) SI2402325T1 (es)
TW (2) TW201332994A (es)
UA (1) UA95641C2 (es)
WO (1) WO2008006040A1 (es)
ZA (1) ZA200900070B (es)

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