HK40183A - Cephalosporin antibiotics - Google Patents

Cephalosporin antibiotics

Info

Publication number
HK40183A
HK40183A HK401/83A HK40183A HK40183A HK 40183 A HK40183 A HK 40183A HK 401/83 A HK401/83 A HK 401/83A HK 40183 A HK40183 A HK 40183A HK 40183 A HK40183 A HK 40183A
Authority
HK
Hong Kong
Prior art keywords
cephalosporin antibiotics
cephalosporin
antibiotics
Prior art date
Application number
HK401/83A
Other languages
English (en)
Inventor
Cynthia Hilda O'callaghan
David George Hubert Livermore
Christopher Earle Newall
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of HK40183A publication Critical patent/HK40183A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HK401/83A 1978-05-26 1983-10-13 Cephalosporin antibiotics HK40183A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2291178 1978-05-26
GB2291378 1978-05-26

Publications (1)

Publication Number Publication Date
HK40183A true HK40183A (en) 1983-10-21

Family

ID=26256190

Family Applications (1)

Application Number Title Priority Date Filing Date
HK401/83A HK40183A (en) 1978-05-26 1983-10-13 Cephalosporin antibiotics

Country Status (27)

Country Link
US (2) US4258041A (de)
AR (2) AR229883A1 (de)
AT (1) AT370420B (de)
AU (1) AU524671B2 (de)
CA (1) CA1127633A (de)
CH (2) CH646178A5 (de)
DE (1) DE2921316C2 (de)
DK (1) DK157685C (de)
ES (2) ES480914A1 (de)
FI (2) FI67555C (de)
FR (2) FR2426695A1 (de)
HK (1) HK40183A (de)
IE (2) IE49173B1 (de)
IL (3) IL59793A (de)
IT (1) IT1116198B (de)
KE (1) KE3252A (de)
LU (1) LU81319A1 (de)
MY (1) MY8400017A (de)
NL (2) NL176855C (de)
NO (2) NO155347C (de)
NZ (2) NZ190558A (de)
PH (1) PH16961A (de)
PT (2) PT69669A (de)
SE (2) SE438507B (de)
SG (1) SG58382G (de)
SI (2) SI7911231A8 (de)
YU (2) YU41635B (de)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963542A (en) * 1976-09-08 1990-10-16 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
NL8003003A (nl) * 1979-05-25 1980-11-27 Glaxo Group Ltd Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
AU538653B2 (en) * 1979-10-02 1984-08-23 Glaxo Group Limited 7-(2-(2-amino thiazol-4-yl)-2-(carboxymethoxyimino) acetamioo)-3-(1-pyridiniammethyl)-ceph-3-em-4-carboxylate
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
FR2466469A1 (fr) * 1979-10-02 1981-04-10 Glaxo Group Ltd Bischlorhydrate de cephalosporine, son procede de preparation et ses applications, notamment en therapeutique
US4338313A (en) * 1979-10-12 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4332800A (en) * 1979-10-12 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
US4252802A (en) * 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
GR75711B (de) * 1980-06-30 1984-08-02 Sanofi Sa
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0046964B1 (de) * 1980-08-29 1986-08-20 Fujisawa Pharmaceutical Co., Ltd. Cephalosporinderivate und Verfahren zu ihrer Herstellung
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
US4427677A (en) 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS57144291A (en) * 1981-03-02 1982-09-06 Ajinomoto Co Inc Preparation of imidazoledicarboxylic acid derivative
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR75487B (de) * 1981-06-22 1984-07-23 Fujisawa Pharmaceutical Co
US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
US4436912A (en) 1981-09-08 1984-03-13 Eli Lilly And Company 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4382931A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company 3'-Substituted quinolinium cephalosporins
US4577014A (en) * 1981-09-08 1986-03-18 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4430499A (en) 1981-09-08 1984-02-07 Eli Lilly And Company 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido]cephalosporin antibiotics
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4388316A (en) * 1981-10-02 1983-06-14 Eli Lilly And Company Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins
US4450270A (en) * 1981-10-02 1984-05-22 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
EP0088183B1 (de) * 1981-11-13 1985-08-07 Glaxo Group Limited Thiazol-Derivate und ihre Verwendung bei der Herstellung von beta-Lactam-Antibiotika
US4510312A (en) * 1981-11-13 1985-04-09 Glaxo Group Limited Manufacture of antibiotics
US4474954A (en) * 1981-12-07 1984-10-02 Bristol-Myers Company Intermediates for cephalosporin derivatives
US4394503A (en) * 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
DE3375013D1 (en) * 1982-04-29 1988-02-04 Glaxo Group Ltd Thiazole derivative, process for its preparation and use in the preparation of beta-lactam antibiotics
JPS5910593A (ja) 1982-06-28 1984-01-20 Bristol Mayers Kenkyusho Kk セフアロスポリン誘導体
IL69246A (en) * 1982-08-07 1986-07-31 Tanabe Seiyaku Co 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ES8502863A1 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
EP0113568B1 (de) * 1982-12-27 1990-04-04 Eli Lilly And Company Zwischenverbindungen für die Herstellung von Ceftazidin und Verfahren zu ihrer Herstellung
EP0115770B2 (de) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazolderivate
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
DE3313816A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
US4540779A (en) * 1983-06-20 1985-09-10 Eli Lilly And Company Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
US4497811A (en) * 1983-07-01 1985-02-05 Seiji Shibahara 1-Oxadethiacephalosporin compound and antibacterial agent containing the _same
JPS6061528A (ja) * 1983-09-09 1985-04-09 ブリストル―マイヤーズ　スクイブ　カンパニー 嫌気性菌を包含する耐性バクテリアの処理法
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives
JPS60178891A (ja) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd セファロスポリン誘導体及び該誘導体を含有する医薬
GB8406218D0 (en) * 1984-03-09 1984-04-11 Glaxo Group Ltd Process
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
CA1236089A (en) * 1984-06-25 1988-05-03 Perry C. Heath Ceftazidime
US4616080A (en) * 1984-07-02 1986-10-07 Eli Lilly And Company Simplified process of forming crystalline ceftazidime pentahydrate
US4626534A (en) * 1984-07-23 1986-12-02 Eli Lilly And Company Pharmaceutical formulation
EP0175544A3 (de) * 1984-09-17 1987-06-03 Eli Lilly And Company Verfahren zur Herstellung von Cephalosporinzwischenverbindungen
US4659813A (en) * 1984-11-08 1987-04-21 Eli Lilly And Company Crystallization process for ceftazidime derivative
GB8504072D0 (en) * 1985-02-18 1985-03-20 Fujisawa Pharmaceutical Co Cephem compounds
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4692518A (en) * 1985-11-06 1987-09-08 Eli Lilly And Company Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound
JPS62175489A (ja) * 1986-01-29 1987-08-01 Sanwa Kagaku Kenkyusho:Kk 新規なセフアロスポリン誘導体及びその塩、これらの製法並びに該化合物を有効成分とする感染症治療剤
US5359057A (en) * 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
AT387022B (de) * 1986-06-04 1988-11-25 Biochemie Gmbh Verfahren zur herstellung einer neuen kristallinen form eines cefalosporinderivats
JPS63107989A (ja) * 1986-06-04 1988-05-12 Tanabe Seiyaku Co Ltd セファロスポリン化合物
IL82738A0 (en) * 1986-06-16 1987-12-20 Tanabe Seiyaku Co Cephalosporin compounds,their preparation and pharmaceutical compositions containing them
WO1988002001A1 (en) * 1986-09-10 1988-03-24 Biochemie Gesellschaft M.B.H. New stable crystalline form of an intermediate product of cephalosporine
US4954624A (en) * 1986-10-07 1990-09-04 Sandoz Ltd. Process for the production of cephalosporin derivatives
US5021564A (en) * 1987-02-02 1991-06-04 Eli Lilly And Company Process for preparing ceftazidime pentahydrate
ATE76874T1 (de) * 1987-02-02 1992-06-15 Lilly Co Eli Verfahren zur herstellung von ceftazidimepentahydrat.
DE3788279T2 (de) * 1987-06-25 1994-06-16 Banyu Pharma Co Ltd Kristalline cephalosporinzusammensetzungen, verfahren und zwischenprodukte für ihre herstellung.
GB8802622D0 (en) * 1988-02-05 1988-03-02 Glaxo Group Ltd Chemical compound
KR0159760B1 (ko) * 1988-12-27 1998-12-01 리로이 휘테커 아실화 방법
US5194604A (en) * 1990-06-29 1993-03-16 E. R. Squibb & Sons, Inc. Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
US5281589A (en) * 1991-06-15 1994-01-25 Cheil Foods & Chemicals, Inc. 3-fused pyridiniummethyl cephalosporins
KR100194994B1 (ko) * 1993-06-05 1999-06-15 손경식 새로운 세펨 화합물
US6472383B1 (en) 1994-04-25 2002-10-29 Smithkline Beecham P.L.C. Pharmaceutical formulations
NZ285085A (en) * 1994-04-25 1998-04-27 Smithkline Beecham Plc Penem composition, pharmaceutical formulation containing a beta-lactamase inhibiting penem and a beta-lactam antibiotic
AU2577495A (en) * 1994-05-23 1995-12-18 Korea Institute Of Science And Technology Cephalosporin compounds and processes for the preparation thereof
US5831085A (en) * 1997-01-16 1998-11-03 Lupin Laboratories Limited Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
IN189047B (de) 1998-06-01 2002-12-14 Ranbaxy Lab Ltd
US6930983B2 (en) * 2000-03-15 2005-08-16 Texas Instruments Incorporated Integrated circuits, systems, apparatus, packets and processes utilizing path diversity for media over packet applications
KR100342600B1 (ko) 2000-03-06 2002-07-04 한미정밀화학주식회사 신규한 티아졸 화합물 및 그의 제조 방법
KR100392409B1 (ko) 2000-03-20 2003-07-22 한미정밀화학주식회사 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법
US6911441B2 (en) * 2002-12-16 2005-06-28 Akzo Nobel N.V. Prolonged release pharmaceutical composition
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
CN101293891B (zh) * 2008-06-12 2011-01-12 齐鲁安替制药有限公司 头孢他啶中间体的制备方法
EP2862569A1 (de) 2011-09-09 2015-04-22 Cubist Pharmaceuticals, Inc. Verfahren zur Behandlung von intrapulmonalen Infektionen
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
KR20150126659A (ko) 2013-03-13 2015-11-12 세라밴스 바이오파마 안티바이오틱스 아이피, 엘엘씨 항생제 화합물의 히드로클로리드 염
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
EP3043797B1 (de) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Behandlung von infektionen mit ceftolozan/tazobactam bei personen mit beeinträchtigter nierenfunktion
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN106336418B (zh) * 2016-08-19 2019-02-01 上海上药新亚药业有限公司 一种头孢他啶盐酸盐的固相合成法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US4079178A (en) * 1971-05-14 1978-03-14 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
US4093803A (en) * 1971-05-14 1978-06-06 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4091209A (en) * 1971-05-14 1978-05-23 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
US4017515A (en) * 1971-05-14 1977-04-12 Glaxo Laboratories Limited α-(Etherified oximino) carboxylic acids and acid chlorides
US4064346A (en) * 1971-05-14 1977-12-20 Glaxo Laboratories Limited 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4144393A (en) * 1973-12-21 1979-03-13 Glaxo Laboratories Limited 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group
US4144392A (en) * 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4162360A (en) * 1973-12-21 1979-07-24 Glaxo Laboratories Limited 3-Carbamoyloxymethyl-7-substituted oximino acetamido cephalosporanic acid derivatives
US4060686A (en) * 1973-12-21 1977-11-29 Janice Bradshaw Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
GB1496757A (en) 1973-12-21 1978-01-05 Glaxo Lab Ltd Cephalosporin derivatives
US4032950A (en) * 1974-12-06 1977-06-28 Hughes Aircraft Company Liquid phase epitaxial process for growing semi-insulating gaas layers
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
JPS52125188A (en) 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
ZA781502B (en) 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
FR2384782A1 (fr) 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-acetoxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
HU184680B (en) 1977-04-02 1984-09-28 Hoechst Ag Process for producing ceph-3-eme-4-carboxylic acid derivatives containing amino-thiazolyl group in the side chain
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
GB1602725A (en) 1977-04-27 1981-11-18 Glaxo Operations Ltd 7-(a-oxyiminoacetamido)-ceph-3-em-4-carboxylic acid derivatives
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
US4394503A (en) * 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives

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SE8402887D0 (sv) 1984-05-28
IL59793A (en) 1982-08-31
FR2426695A1 (fr) 1979-12-21
NO791731L (no) 1979-11-27
FI801609A (fi) 1980-05-19
SG58382G (en) 1983-09-02
ES480914A1 (es) 1980-02-01
IE49172B1 (en) 1985-08-21
PH16961A (en) 1984-04-27
FR2426695B1 (de) 1982-06-11
SE8402887L (sv) 1984-05-28
NL7904122A (nl) 1979-11-28
YU41635B (en) 1987-12-31
DK216779A (da) 1979-11-27
AU4742279A (en) 1979-11-29
FI67555B (fi) 1984-12-31
IL57400A (en) 1982-08-31
PT69670A (en) 1979-06-01
NL176855C (nl) 1985-06-17
AT370420B (de) 1983-03-25
FI67705B (fi) 1985-01-31
NZ193326A (en) 1982-05-31
NL176855B (nl) 1985-01-16
CA1127633A (en) 1982-07-13
PT69669A (en) 1979-06-01
IE49173B1 (en) 1985-08-21
NO155347B (no) 1966-12-08
FI791678A (fi) 1979-11-27
DK157685C (da) 1990-07-09
US4600772A (en) 1986-07-15
FI67555C (fi) 1985-04-10
ES480915A1 (es) 1980-02-01
FR2445835B1 (de) 1983-06-03
IL59793A0 (en) 1980-06-30
ATA239281A (de) 1982-08-15
CH649556A5 (de) 1985-05-31
NL8001348A (nl) 1980-06-30
SI8212234A8 (en) 1997-06-30
DK157685B (da) 1990-02-05
YU43097B (en) 1989-02-28
CH646178A5 (de) 1984-11-15
IE791025L (en) 1979-11-26
FR2445835A1 (fr) 1980-08-01
AU524671B2 (en) 1982-09-30
AR229883A1 (es) 1983-12-30
IT1116198B (it) 1986-02-10
US4258041A (en) 1981-03-24
SE7904576L (sv) 1980-02-11
KE3252A (en) 1983-01-28
YU223482A (en) 1983-04-30
DE2921316C2 (de) 1982-09-16
IL57400A0 (en) 1979-09-30
SI7911231A8 (en) 1997-06-30
NZ190558A (en) 1982-05-31
NO155347C (no) 1987-03-18
NO850153L (no) 1979-11-27
AR228726A1 (es) 1983-04-15
MY8400017A (en) 1984-12-31
SE438507B (sv) 1985-04-22
FI67705C (fi) 1985-05-10
YU123179A (en) 1983-01-21
LU81319A1 (fr) 1979-09-11
DE2921316A1 (de) 1979-12-06
IE802453L (en) 1979-11-26

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