HK183095A - Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof - Google Patents
Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereofInfo
- Publication number
- HK183095A HK183095A HK183095A HK183095A HK183095A HK 183095 A HK183095 A HK 183095A HK 183095 A HK183095 A HK 183095A HK 183095 A HK183095 A HK 183095A HK 183095 A HK183095 A HK 183095A
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyl
- opt
- pyrrolidinyl
- beta
- production
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58081443A JPS59205379A (ja) | 1983-05-09 | 1983-05-09 | 新規なβ−ラクタム化合物及びその製造法 |
JP58108472A JPS601186A (ja) | 1983-06-15 | 1983-06-15 | 新規なβ−ラクタム化合物及びその製造法 |
JP58127485A JPS6019787A (ja) | 1983-07-12 | 1983-07-12 | 新規なβ−ラクタム化合物及びその製造法 |
JP58166938A JPS6058987A (ja) | 1983-09-09 | 1983-09-09 | 新規なβ−ラクタム化合物およびその製造法 |
JP58212857A JPS60104088A (ja) | 1983-11-11 | 1983-11-11 | 新規なβ−ラクタム化合物およびその製造法 |
JP59023497A JPS60166683A (ja) | 1984-02-10 | 1984-02-10 | 新規なβ−ラクタム化合物及びその製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK183095A true HK183095A (en) | 1995-12-08 |
Family
ID=27549102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK183095A HK183095A (en) | 1983-05-09 | 1995-11-30 | Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof |
Country Status (9)
Country | Link |
---|---|
US (3) | US4933333A (fr) |
EP (1) | EP0126587B1 (fr) |
AT (1) | ATE121402T1 (fr) |
CA (1) | CA1283906C (fr) |
DE (1) | DE3486382T2 (fr) |
ES (1) | ES8600305A1 (fr) |
HK (1) | HK183095A (fr) |
MX (1) | MX9203063A (fr) |
NL (1) | NL950019I2 (fr) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (fr) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION |
JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | 1―置換カルバペネム―3―カルボン酸誘導体 |
EP0182213B1 (fr) * | 1984-11-08 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Dérivés de carbapénème et leur préparatIon |
FI81576C (fi) * | 1984-12-25 | 1990-11-12 | Sankyo Co | Foerfarande foer framstaellning av derivat av 6-(1-hydroxietyl)-2-(1,2-disubstituerade-4-pyrrolidinyltio)-2- karbapenem-3-karboxylsyra, vilka aer anvaendbara som laekemedel. |
US4806637A (en) * | 1986-03-17 | 1989-02-21 | Schering Corporation | 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates |
EP0243686B1 (fr) * | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Dérivés de bêta-lactame et leur préparation |
IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
ES2053508T3 (es) * | 1986-11-24 | 1994-08-01 | Fujisawa Pharmaceutical Co | Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos. |
US4925838A (en) * | 1988-03-18 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
US5242914A (en) * | 1988-04-01 | 1993-09-07 | Sankyo Company, Limited | 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics |
IE950607L (en) * | 1988-04-01 | 1989-10-01 | Sankyo Co | 2-(heterocyclylthio) carbapenem derivatives, their¹preparation and their use as antibiotics |
GB8811237D0 (en) * | 1988-05-12 | 1988-06-15 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
US4963544A (en) * | 1988-05-23 | 1990-10-16 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
US4876365A (en) * | 1988-12-05 | 1989-10-24 | Schering Corporation | Intermediate compounds for preparing penems and carbapenems |
DE69019610D1 (de) * | 1989-07-06 | 1995-06-29 | Banyu Pharma Co Ltd | Cyclische Derivate des Amidinylthiocarbapenems. |
GB8923844D0 (en) * | 1989-10-23 | 1989-12-13 | Fujisawa Pharmaceutical Co | Carbapenem compounds |
DE69013131T2 (de) * | 1989-12-29 | 1995-05-24 | Banyu Pharma Co Ltd | 2-(2-Cyclopropylpyrrolidin-4-ylthio)carbapenemderivate. |
US5227376A (en) * | 1990-02-14 | 1993-07-13 | Sumitomo Pharmaceuticals Co., Ltd. | β-lactam compounds and their production |
CA2036163C (fr) * | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Nouveaux composes de beta-lactame et leur production |
CA2036941A1 (fr) * | 1990-02-23 | 1991-08-24 | Isao Kawamoto | Derives du carbapenem ayant une action antibiotique, mode de preparation et d'utilisation |
GB9107363D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
US5554606A (en) * | 1990-03-12 | 1996-09-10 | Zeneca Limited | Antibiotic compounds |
TW198034B (fr) * | 1990-03-27 | 1993-01-11 | Manyu Seiyaku Kk | |
US5189158A (en) * | 1991-03-20 | 1993-02-23 | American Cyanamid Company | 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them |
GB9107341D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
CA2070305A1 (fr) * | 1991-06-04 | 1992-12-05 | Isao Kawamoto | Derives de 1-methylcarbapeneme; preparation et utilisation comme antibiotiques |
US5712267A (en) * | 1991-06-04 | 1998-01-27 | Sankyo Company,. Limited | Carbapenem derivatives, their preparation and their use as antibiotics |
JP3048196B2 (ja) * | 1991-06-20 | 2000-06-05 | 第一製薬株式会社 | カルバペネム誘導体 |
JP3091297B2 (ja) * | 1992-01-10 | 2000-09-25 | 住友製薬株式会社 | ピロリジン誘導体およびその製造方法 |
GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
CZ290002B6 (cs) * | 1992-03-11 | 2002-05-15 | Sankyo Company Limited | Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek |
CA2091309A1 (fr) * | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Composes antibiotiques |
GB9304156D0 (en) * | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
JP3233434B2 (ja) * | 1992-04-01 | 2001-11-26 | 塩野義製薬株式会社 | カルバペネム誘導体 |
EP0581501B1 (fr) * | 1992-07-21 | 1998-09-09 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
CA2099817A1 (fr) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Composes antibiotiques |
EP0581502B1 (fr) * | 1992-07-21 | 1998-10-21 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
CA2099811A1 (fr) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Composes antibiotiques |
CA2099818A1 (fr) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Composes antibiotiques |
EP0590885B1 (fr) * | 1992-09-28 | 2000-03-15 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
CA2106141A1 (fr) * | 1992-09-28 | 1994-03-29 | Michael J. Betts | Composes antibiotiques |
CA2106330A1 (fr) * | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Composes antibiotiques |
US5602118A (en) * | 1993-03-16 | 1997-02-11 | American Cyanamid Company | 2-thiosubstituted carbapenems |
AU4912393A (en) * | 1993-06-15 | 1994-12-22 | Dong Kook Pharmaceutical Co., Ltd. | 1-beta-methyl-2-thiolic carbapenem derivatives |
CA2155448A1 (fr) * | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibiteurs de la farnesyl-proteine-transferase |
GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
WO1997023483A1 (fr) * | 1995-12-21 | 1997-07-03 | Sankyo Company, Limited | Derives de 1-methylcarbapenem |
HUP9902149A3 (en) * | 1996-04-26 | 2002-01-28 | Sankyo Company Ltd Chuo Ku | 1-methylcarbapenem derivatives with antibacterial activity, use thereof, pharmaceutical compositions containing these compounds |
EP0923545A1 (fr) | 1996-08-17 | 1999-06-23 | Zeneca Limited | 3-mercaptopyrrolidines comme inhibiteurs de la farnesyle-proteine transferase |
AU725298B2 (en) * | 1996-10-28 | 2000-10-12 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
US6297231B1 (en) | 1996-10-28 | 2001-10-02 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
WO1998034936A1 (fr) * | 1997-02-07 | 1998-08-13 | Kyoto Pharmaceutical Industries, Ltd. | Composes de carbapenem, leur utilisation et composes intermediaires de celui-ci |
US6143885A (en) * | 1997-08-27 | 2000-11-07 | Merck & Co., Inc. | Preparation of beta-methyl carbapenem intermediates |
WO1999014218A1 (fr) * | 1997-09-13 | 1999-03-25 | Korea Institute Of Science And Technology | Derives de carbapenem et leur procede de preparation |
BR9910098A (pt) | 1998-05-01 | 2000-12-26 | Kyoto Pharma Ind | Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos |
US6271222B1 (en) * | 1998-05-28 | 2001-08-07 | Merck & Co., Inc. | Penem antibacterial compounds, compositions and methods of treatment |
WO2001044186A1 (fr) * | 1999-12-16 | 2001-06-21 | Sumitomo Pharmaceuticals Company, Limited | Derives de guanidine substitues |
GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
GB9930317D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
KR100345465B1 (ko) * | 2000-07-05 | 2002-07-26 | 한국과학기술연구원 | 신규 1-베타메틸카바페넴 유도체 및 그의 제조방법 |
US6444829B1 (en) * | 2000-07-19 | 2002-09-03 | Hoffmann-La Roche Inc. | Pyrrolidine compounds |
JP4068452B2 (ja) | 2000-07-19 | 2008-03-26 | エフ.ホフマン−ラ ロシュ アーゲー | エンドセリン変換酵素阻害剤としてのピロリジン誘導体 |
HUP0400444A3 (en) * | 2001-05-21 | 2007-02-28 | Kyoto Pharmaceutical Ind | Carbapenem compound, pharmaceutical compositions containing them and their use |
USRE40794E1 (en) | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
PT1474426E (pt) * | 2001-09-26 | 2011-10-07 | Merck Sharp & Dohme | Processo para o fabrico de compostos de carbapenema |
JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
DK1713823T3 (da) | 2004-01-30 | 2010-03-08 | Medivir Ab | HCV NS-3 serinproteaseinhibitorer |
SE0400199D0 (sv) * | 2004-01-30 | 2004-01-30 | Medivir Ab | HCV Protease inhbitors |
US20070249827A1 (en) * | 2004-06-02 | 2007-10-25 | Sandoz Ag | Meropenem Intermediatein in Crystalling Form |
US7632828B2 (en) | 2004-06-10 | 2009-12-15 | Fob Synthesis, Inc. | Gram-positive carbapenem antibacterials and processes for their preparation |
WO2006035300A2 (fr) * | 2004-09-30 | 2006-04-06 | Ranbaxy Laboratories Limited | Procede de preparation de meropenem |
WO2007004028A2 (fr) * | 2005-06-30 | 2007-01-11 | Ranbaxy Laboratories Limited | Procedes de preparation de penemes et de leurs intermediaires |
PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
US20070197781A1 (en) * | 2005-07-29 | 2007-08-23 | Neera Tewari | Processes for the preparation of carbapenems |
DK1926732T3 (da) | 2005-09-05 | 2013-12-09 | Ranbaxy Lab Ltd | Fremgangsmåde til fremstillingen af carbapenemforbindelser |
BRPI0616563A2 (pt) * | 2005-09-15 | 2012-12-25 | Orchid Chemicals & Pharm Ltd | processo melhorado para a preparaÇço de antibiàtico betalactÂmico |
CN100422184C (zh) * | 2006-03-14 | 2008-10-01 | 深圳市海滨制药有限公司 | 美罗培南的制备方法 |
WO2007104221A1 (fr) * | 2006-03-14 | 2007-09-20 | Shenzhen Haibin Pharmaceutical Co., Ltd. | Procédé de préparation de méropénem |
CN100347175C (zh) * | 2006-03-14 | 2007-11-07 | 深圳市海滨制药有限公司 | 一种β-甲基碳青霉烯中间体的制备方法 |
CN101410398B (zh) * | 2006-03-28 | 2013-01-23 | 株式会社钟化 | 碳青霉素烯化合物的改良制备方法 |
CN101041632A (zh) * | 2007-04-28 | 2007-09-26 | 浙江耐司康药业有限公司 | 一种培南类药物支链中间体——硫醇衍生物的制备方法 |
CN101323615B (zh) * | 2007-06-11 | 2010-10-13 | 山东轩竹医药科技有限公司 | 含有甲酰胺杂环磺酰胺巯基吡咯烷的培南衍生物 |
CN101333217A (zh) * | 2007-06-26 | 2008-12-31 | 黄振华 | 1-甲基碳青霉烯抗生素 |
CN101333219B (zh) * | 2007-06-26 | 2010-10-13 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺苯烷基杂环的培南衍生物 |
JP5406181B2 (ja) | 2007-06-28 | 2014-02-05 | ケービーピー・バイオサイエンシズ・カンパニー・リミテッド | 新規カルバペネム誘導体 |
CN101367809B (zh) * | 2007-06-28 | 2011-04-27 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰肼的培南衍生物 |
CN101848911A (zh) * | 2007-09-20 | 2010-09-29 | 国际药品工业株式会社 | 碳青霉烯类抗生素的合成中间体的酸加成盐及其制备方法 |
US20090082327A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched meropenem |
US20090216010A1 (en) * | 2008-02-22 | 2009-08-27 | Wei-Hong Tseng | Crystalline carbapenem compound and produced method thereof |
EP2098525A1 (fr) | 2008-02-26 | 2009-09-09 | Savior Lifetec Corporation | Composé de carbapenem cristallin et son procédé de production |
US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
US8841444B2 (en) * | 2008-07-30 | 2014-09-23 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
CN101817837A (zh) * | 2009-02-13 | 2010-09-01 | 山东轩竹医药科技有限公司 | 含有氮杂双环的碳青霉烯衍生物 |
MX2011009532A (es) | 2009-03-13 | 2011-10-24 | Daewoong Bio Inc | Metodo mejorado para preparar meropenem usando polvo de zinc. |
EP2477993B1 (fr) | 2009-09-15 | 2015-06-24 | Nabriva Therapeutics AG | Acide clavulanique substitué |
WO2011048583A1 (fr) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Procédé pour la préparation de composés de carbapénème |
US8318716B2 (en) | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
CA2802529C (fr) | 2010-06-18 | 2019-10-29 | Woo-Baeg Choi | Agents antibacteriens de carbapenem avec activite anti-gram negatif |
EP2773456B1 (fr) * | 2011-10-31 | 2019-04-17 | Dow Technology Investments LLC | Procédés de fabrication de catalyseurs d'époxydation et procédés d'époxydation les utilisant |
WO2014070774A1 (fr) * | 2012-10-29 | 2014-05-08 | Southern Methodist University | Procédés de génération de composés de carbapénem résistants à la bêta-lactamase |
KR101331762B1 (ko) | 2012-12-28 | 2013-11-20 | 주식회사 대웅제약 | 메로페넴의 삼수화물의 제조방법 |
KR102144777B1 (ko) | 2013-06-19 | 2020-08-18 | 제이더블유중외제약 주식회사 | 결정형 메로페넴 삼수화물의 제조방법 |
CN103894210B (zh) * | 2014-04-29 | 2015-08-12 | 西安凯立化工有限公司 | 一种可套用的美罗培南合成用钯炭催化剂 |
MA43791A (fr) | 2016-03-16 | 2018-11-28 | Merck Sharp & Dohme | Composés de carbapénème |
EP3269718A1 (fr) | 2016-07-12 | 2018-01-17 | Evonik Degussa GmbH | Prodédé pour la déprotection d'un carbapénème par hydrogénation catalytique hétérogène avec hydrogène en présence d'un amine organique |
WO2018071358A1 (fr) * | 2016-10-10 | 2018-04-19 | The Johns Hopkins University | Agents antibactériens contre d, d- et l, d-transpeptidases |
US10933051B2 (en) | 2017-06-09 | 2021-03-02 | Fob Synthesis, Inc. | Carbapenem compounds and compositions for the treatment of bacterial infections |
CN111960984B (zh) * | 2020-09-11 | 2023-04-28 | 江西如益科技发展有限公司 | 一种合成多尼培南侧链中间体的制备方法 |
CN114163371B (zh) * | 2021-12-21 | 2024-05-14 | 天津市敬业精细化工有限公司 | 一种美罗培南侧链光学异构体及其制备方法和应用、美罗培南侧链杂质的检测方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
EP0003960B1 (fr) * | 1978-02-02 | 1983-06-29 | Ciba-Geigy Ag | Composés thia-aza substitués en position 6, leur préparation et compositions pharmaceutiques les contenant |
DE2966497D1 (en) * | 1978-10-24 | 1984-01-26 | Merck & Co Inc | 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds |
DE2965394D1 (en) * | 1978-11-01 | 1983-06-16 | Sanraku Ocean Co | Process for producing antibiotic beta-lactam compounds |
JPS5625110A (en) * | 1978-12-18 | 1981-03-10 | Bristol Myers Co | Antibacterial |
DK165280A (da) * | 1979-04-19 | 1980-10-20 | Merck & Co Inc | Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaaden |
US4383946A (en) * | 1980-03-27 | 1983-05-17 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals |
DE3169567D1 (en) * | 1980-10-25 | 1985-05-02 | Beecham Group Plc | The preparation of beta-lactam antibiotics |
JPS5778883A (en) * | 1980-11-05 | 1982-05-17 | Toshiaki Betsumiya | Solid puzzle |
EP0057565A1 (fr) * | 1981-02-04 | 1982-08-11 | Beecham Group Plc | Bêta-lactames à activité antibiotique, leur préparation et leur application |
EP0061231A1 (fr) * | 1981-02-04 | 1982-09-29 | Beecham Group Plc | Procédé pour la préparation de dérivés de l'azabicyclo-(3.2.0) heptène-2 |
JPS57176988A (en) * | 1981-04-09 | 1982-10-30 | Sankyo Co Ltd | Penam-3-carboxylic acid derivative and its preparation |
ES8404184A1 (es) * | 1981-08-03 | 1984-04-16 | Merck & Co Inc | Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados. |
US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
EP0089139A2 (fr) * | 1982-03-16 | 1983-09-21 | Beecham Group Plc | Antibiotiques, leur préparation et leur utilisation |
JPS58157788A (ja) * | 1982-03-16 | 1983-09-19 | Sankyo Co Ltd | β−ラクタム化合物の製造法 |
JPS5913757A (ja) * | 1982-07-14 | 1984-01-24 | Sankyo Co Ltd | 3−メルカプトピロリジン誘導体及びその製法 |
JPS5916892A (ja) * | 1982-07-19 | 1984-01-28 | Sankyo Co Ltd | カルバペネム−3−カルボン酸誘導体およびその製法 |
CA1283906C (fr) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION |
JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | 1―置換カルバペネム―3―カルボン酸誘導体 |
EP0182213B1 (fr) * | 1984-11-08 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Dérivés de carbapénème et leur préparatIon |
US4806637A (en) * | 1986-03-17 | 1989-02-21 | Schering Corporation | 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates |
IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
-
1984
- 1984-05-03 CA CA000453478A patent/CA1283906C/fr not_active Expired - Lifetime
- 1984-05-09 ES ES532741A patent/ES8600305A1/es not_active Expired
- 1984-05-09 DE DE3486382T patent/DE3486382T2/de not_active Expired - Lifetime
- 1984-05-09 EP EP84303128A patent/EP0126587B1/fr not_active Expired - Lifetime
- 1984-05-09 AT AT84303128T patent/ATE121402T1/de active
-
1987
- 1987-10-08 US US07/106,035 patent/US4933333A/en not_active Expired - Fee Related
- 1987-10-08 US US07/106,036 patent/US4943569A/en not_active Expired - Lifetime
-
1990
- 1990-05-21 US US07/525,817 patent/US5122604A/en not_active Expired - Lifetime
-
1992
- 1992-06-19 MX MX9203063A patent/MX9203063A/es unknown
-
1995
- 1995-09-12 NL NL950019C patent/NL950019I2/nl unknown
- 1995-11-30 HK HK183095A patent/HK183095A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX9203063A (es) | 1992-07-01 |
NL950019I2 (nl) | 1997-03-03 |
US4933333A (en) | 1990-06-12 |
EP0126587B1 (fr) | 1995-04-19 |
ES532741A0 (es) | 1985-10-16 |
EP0126587A1 (fr) | 1984-11-28 |
ATE121402T1 (de) | 1995-05-15 |
ES8600305A1 (es) | 1985-10-16 |
US5122604A (en) | 1992-06-16 |
DE3486382D1 (de) | 1995-05-24 |
US4943569A (en) | 1990-07-24 |
DE3486382T2 (de) | 1995-08-17 |
NL950019I1 (fr) | 1995-11-01 |
CA1283906C (fr) | 1991-05-07 |
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