ES8301233A1 - Un procedimiento para la preparacion de antibioticos de b-lactama. - Google Patents
Un procedimiento para la preparacion de antibioticos de b-lactama.Info
- Publication number
- ES8301233A1 ES8301233A1 ES498823A ES498823A ES8301233A1 ES 8301233 A1 ES8301233 A1 ES 8301233A1 ES 498823 A ES498823 A ES 498823A ES 498823 A ES498823 A ES 498823A ES 8301233 A1 ES8301233 A1 ES 8301233A1
- Authority
- ES
- Spain
- Prior art keywords
- beta
- preparation
- containing compounds
- lactam containing
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000003952 β-lactams Chemical class 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- -1 beta -Lactam compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ANTIBIOTICOS DE LACTAMA, DE FORMULA GENERAL (I), DONDE R ES UN RADICAL QUE FORMA CON EL CO UN GRUPO ACIDO CARBOXILICO O UNA SAL O UN ESTER; R ES HIDROGENO O UN RADICAL ORGANICO; N ES CERO O UNO; R Y R SON INDEPENDIENTE HIDROGENO O ALQUILO; X ES ALQUILENO; E Y ES AMINO O AMINO SUSTITUIDO. CONSISTE EN SOMETER A UNA REACCION DE ELIMINACION CON FORMACION DE ANILLO, A UN ESTER DE UN COMPUESTO DE FORMULA (II), DONDE A , A Y A SON INDEPENDIENTEMENTE FENILO O METOXIFENILO; Y R , R , R , X E Y TIENEN LOS SIGNIFICADOS YA INDICADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8002565 | 1980-01-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8301233A1 true ES8301233A1 (es) | 1982-12-01 |
ES498823A0 ES498823A0 (es) | 1982-12-01 |
Family
ID=10510891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES498823A Granted ES498823A0 (es) | 1980-01-25 | 1981-01-26 | Un procedimiento para la preparacion de antibioticos de b-lactama. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4428961A (es) |
EP (1) | EP0033209B1 (es) |
JP (1) | JPS56120684A (es) |
AU (1) | AU6659081A (es) |
DE (1) | DE3164021D1 (es) |
DK (1) | DK33281A (es) |
ES (1) | ES498823A0 (es) |
ZA (1) | ZA81483B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0072121A1 (en) * | 1981-08-08 | 1983-02-16 | Beecham Group Plc | Beta-lactam antibiotics |
JPH0869073A (ja) * | 1994-08-30 | 1996-03-12 | Konica Corp | ハロゲン化銀カラー写真感光材料 |
ZA985672B (en) * | 1997-06-30 | 1999-11-25 | Procter & Gamble | Multi-directionally extensible sanitary napkin. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4146610A (en) | 1974-03-28 | 1979-03-27 | Beecham Group Limited | Antibiotics mm13902 |
NL7704040A (nl) | 1976-04-28 | 1977-11-01 | Merck & Co Inc | Werkwijze voor het bereiden van nieuwe anti- biotica. |
DE2808563A1 (de) * | 1977-03-05 | 1978-09-07 | Beecham Group Ltd | Derivate der 3-thio-6-(1-hydroxyaethyl)-7-oxo-1-aza-bicyclo eckige klammer auf 3.2.0 eckige klammer zu hept-2-en- 2-carbonsaeure, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
PT68527A (en) * | 1977-09-15 | 1978-10-01 | Merck & Co Inc | Process for the preparation of o-,n-and carboxyl derivati-ves of thienamycin sulfoxide and sulfone |
AU531084B2 (en) * | 1977-10-19 | 1983-08-11 | Merck & Co., Inc. | Azetidine derivatives |
US4263314A (en) | 1978-01-19 | 1981-04-21 | Beecham Group Limited | β-Lactam antibiotics, a process for their preparation and their use in pharmaceutical compositions |
EP0003740B1 (en) * | 1978-01-19 | 1982-01-27 | Beecham Group Plc | Beta-lactam antibiotics, a process for their preparation and pharmaceutical compositions containing them |
EP0004132A1 (en) * | 1978-03-04 | 1979-09-19 | Beecham Group Plc | Esters of beta-lactam antibiotics, a process for their preparation pharmaceutical compositions containing them and the compounds for use as antibacterial agents |
US4255441A (en) | 1978-03-14 | 1981-03-10 | Beecham Group Limited | β-Lactam antibiotics, a process for their prepaeration and their use in pharmaceutical compositions |
EP0008888B1 (en) * | 1978-08-23 | 1983-09-21 | Beecham Group Plc | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them |
-
1981
- 1981-01-19 EP EP81300224A patent/EP0033209B1/en not_active Expired
- 1981-01-19 DE DE8181300224T patent/DE3164021D1/de not_active Expired
- 1981-01-23 US US06/227,765 patent/US4428961A/en not_active Expired - Fee Related
- 1981-01-23 DK DK33281A patent/DK33281A/da not_active Application Discontinuation
- 1981-01-23 AU AU66590/81A patent/AU6659081A/en not_active Abandoned
- 1981-01-23 ZA ZA00810483A patent/ZA81483B/xx unknown
- 1981-01-26 JP JP1072481A patent/JPS56120684A/ja active Pending
- 1981-01-26 ES ES498823A patent/ES498823A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
ZA81483B (en) | 1982-02-24 |
EP0033209B1 (en) | 1984-06-13 |
EP0033209A1 (en) | 1981-08-05 |
JPS56120684A (en) | 1981-09-22 |
AU6659081A (en) | 1981-07-30 |
ES498823A0 (es) | 1982-12-01 |
DE3164021D1 (en) | 1984-07-19 |
DK33281A (da) | 1981-07-26 |
US4428961A (en) | 1984-01-31 |
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