NL7515179A - Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity - Google Patents

Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Info

Publication number
NL7515179A
NL7515179A NL7515179A NL7515179A NL7515179A NL 7515179 A NL7515179 A NL 7515179A NL 7515179 A NL7515179 A NL 7515179A NL 7515179 A NL7515179 A NL 7515179A NL 7515179 A NL7515179 A NL 7515179A
Authority
NL
Netherlands
Prior art keywords
opt
substd
aryl
halo
alkyl
Prior art date
Application number
NL7515179A
Other languages
Dutch (nl)
Original Assignee
Delmar Chem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delmar Chem filed Critical Delmar Chem
Priority to NL7515179A priority Critical patent/NL7515179A/en
Publication of NL7515179A publication Critical patent/NL7515179A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

4-Aryl-amino-hydroxypiperidines of formula (I) are new together with their acid-addn. salts (where R' is H,alkyl, alkenyl, alkynyl, aralkyl, acyl, 2-6C alkylamino opt. substd. by one or two alkyls or opt. substd. by alkylene to complete a satd. N-heterocycle; a gp. where R7 and R8 are H, phenyl opt. substd. by halo, or alkyl; or R7 + R8 and the attached N-atom form a 6 or 7-membered heterocyclic ring opt. contg. an O-atom; n is 1, 2, 3 or 4; a gp. -(CH2)n. CO2H; a gp. where X is H or halo; one of R2 and R3 is CN, free NH2 or a radical derived from it; the other is a free or protected OH; or R2 is where R3 is free or protected OH; or R2 + R3 and the attached C atoms form an oxazepin ring; Ar is aryl opt. substd. by one or more alkyl, alkoxy, halo or CF3). One subgp. has antidepressant activity, another gp. has local anaesthetic and antiarrhythmic activity. Other activities in the gp. include antihistamine, anticholinergic, spasmolytic, and diuretic activity.
NL7515179A 1975-12-30 1975-12-30 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity NL7515179A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7515179A NL7515179A (en) 1975-12-30 1975-12-30 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7515179A NL7515179A (en) 1975-12-30 1975-12-30 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Publications (1)

Publication Number Publication Date
NL7515179A true NL7515179A (en) 1977-07-04

Family

ID=19825110

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7515179A NL7515179A (en) 1975-12-30 1975-12-30 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Country Status (1)

Country Link
NL (1) NL7515179A (en)

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