ES8706159A1 - Procedimiento para la fabricacion de nuevos antibioticos de b-lactama - Google Patents

Procedimiento para la fabricacion de nuevos antibioticos de b-lactama

Info

Publication number
ES8706159A1
ES8706159A1 ES551071A ES551071A ES8706159A1 ES 8706159 A1 ES8706159 A1 ES 8706159A1 ES 551071 A ES551071 A ES 551071A ES 551071 A ES551071 A ES 551071A ES 8706159 A1 ES8706159 A1 ES 8706159A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
atom
formula
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551071A
Other languages
English (en)
Other versions
ES551071A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANKEI YAKUHIN KK
Nippon Pharmaceutical Development Institute Co
Original Assignee
SANKEI YAKUHIN KK
Nippon Pharmaceutical Development Institute Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANKEI YAKUHIN KK, Nippon Pharmaceutical Development Institute Co filed Critical SANKEI YAKUHIN KK
Publication of ES551071A0 publication Critical patent/ES551071A0/es
Publication of ES8706159A1 publication Critical patent/ES8706159A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE FABRICAR NUEVOS ANTIBIOTICOS DE B-LACTAMA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON EL ACIDO CARBOXILICO DE FORMULA (III) PARA OBTENER ANTIBIOTICOS DE B-LACTAMA DE FORMULA (I) DONDE A ES UN GRUPO DE FORMULAS -NHCO-, NHCONHCO Y OTRAS; R1 Y R2 SON UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR; R3 ES UN GRUPO PROTECTOR O UN GRUPO METOXI; X ES UN ATOMO DE HIDROGENO O UN GRUPO HIDROXILO, UN GRUPO HIDROXILO PROTEGIDO Y OTROS; N ES 1 O 2; Y ES UN GRUPO DE FORMULA (IV) O (V); R4 Y R5 SON ATOMOS DE HIDROGENO; Y Z ES UN ENLACE DIRECTO O UN GRUPO CARBONILO. TIENEN APLICACION PARA PREPARAR COMPUESTOS FARMACEUTICOS.
ES551071A 1985-01-21 1986-01-21 Procedimiento para la fabricacion de nuevos antibioticos de b-lactama Expired ES8706159A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP858785 1985-01-21
JP1198685 1985-01-25

Publications (2)

Publication Number Publication Date
ES551071A0 ES551071A0 (es) 1987-06-01
ES8706159A1 true ES8706159A1 (es) 1987-06-01

Family

ID=26343130

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551071A Expired ES8706159A1 (es) 1985-01-21 1986-01-21 Procedimiento para la fabricacion de nuevos antibioticos de b-lactama

Country Status (13)

Country Link
US (1) US4808711A (es)
EP (1) EP0189287B1 (es)
JP (1) JPS61267583A (es)
KR (1) KR930007417B1 (es)
AU (1) AU586215B2 (es)
CA (1) CA1277977C (es)
DE (1) DE3687279T2 (es)
DK (1) DK27486A (es)
ES (1) ES8706159A1 (es)
HU (1) HU202538B (es)
IL (1) IL77676A (es)
NZ (1) NZ214864A (es)
PH (1) PH22882A (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
EP0210815A3 (en) * 1985-07-25 1988-04-20 Beecham Group Plc 6-beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
FI872879A (fi) * 1986-07-21 1988-01-22 Sankei Yakuhin Kk --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes.
AT392969B (de) * 1986-11-17 1991-07-25 Sankei Yakuhin Kk Beta-lactamverbindungen, verfahren zu ihrer herstellung, dieselben enthaltende pharmazeutischepraeparate zur behandlung von durch bakterien verursachte infektionskrankheiten
DK170088A (da) * 1987-04-10 1988-10-11 Hoffmann La Roche Acylderivater
MC1921A1 (fr) * 1987-04-10 1989-04-06 Sankei Yakuhin Kk Derives acyles
NZ225383A (en) * 1987-08-07 1990-03-27 Sankei Yakuhin Kk Cephalosporin derivatives and pharmaceutical compositions
US5073550A (en) * 1987-08-14 1991-12-17 Hoffmann-La Roche Inc. Cephalosphorins with sulfur-containing oxyimino side chain
EP0303172A3 (de) * 1987-08-14 1991-05-15 F. Hoffmann-La Roche Ag Oxyimino-Cephalosporine
US5138066A (en) * 1987-08-14 1992-08-11 Hoffmann-La Roche, Inc. Intermediates for cephalosporins with sulfur-containing oxyimino side chain
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
EP0492277A3 (en) * 1990-12-20 1992-10-14 F. Hoffmann-La Roche Ag Cephalosporin derivatives
EP0550775A1 (en) * 1992-01-07 1993-07-14 F. Hoffmann-La Roche Ag Cephalosporin derivatives
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5599988A (en) * 1994-12-22 1997-02-04 Smithkline Beecham Corporation Large scale preparation of 2,4-dihydroxybenzaldehyde using a variation of the Vilsmeierhaack reaction and isolated intermediates
DE19654920A1 (de) * 1996-06-26 1998-01-08 Gruenenthal Gmbh Neue synthetische Catecholderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
EP2862569A1 (en) 2011-09-09 2015-04-22 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
KR102226197B1 (ko) 2013-03-15 2021-03-11 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1476312A (en) * 1974-06-03 1977-06-10 Beecham Group Ltd Penicillins and cephalosporins
US4091212A (en) * 1976-11-26 1978-05-23 E. R. Squibb & Sons, Inc. Hydrazinocarbonylamino cephalosporins 3-heterocyclicthio 7-hydrazinocarbonylamino acetylamino cephalosporins
JPS609719B2 (ja) * 1977-08-06 1985-03-12 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.

Also Published As

Publication number Publication date
DK27486D0 (da) 1986-01-20
CA1277977C (en) 1990-12-18
HUT41800A (en) 1987-05-28
KR860005824A (ko) 1986-08-13
NZ214864A (en) 1988-04-29
IL77676A (en) 1990-09-17
JPS61267583A (ja) 1986-11-27
KR930007417B1 (ko) 1993-08-10
AU586215B2 (en) 1989-07-06
DK27486A (da) 1986-07-22
EP0189287A2 (en) 1986-07-30
EP0189287B1 (en) 1992-12-16
US4808711A (en) 1989-02-28
ES551071A0 (es) 1987-06-01
DE3687279D1 (de) 1993-01-28
PH22882A (en) 1989-01-19
AU5244986A (en) 1986-07-24
EP0189287A3 (en) 1987-09-30
HU202538B (en) 1991-03-28
DE3687279T2 (de) 1993-05-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612