HK1206073A1 - Mutations associated with resistance to inhibitors of brutons tyrosine kinase (btk) (btk) - Google Patents

Mutations associated with resistance to inhibitors of brutons tyrosine kinase (btk) (btk)

Info

Publication number
HK1206073A1
HK1206073A1 HK15106636.0A HK15106636A HK1206073A1 HK 1206073 A1 HK1206073 A1 HK 1206073A1 HK 15106636 A HK15106636 A HK 15106636A HK 1206073 A1 HK1206073 A1 HK 1206073A1
Authority
HK
Hong Kong
Prior art keywords
btk
inhibitors
resistance
tyrosine kinase
mutations associated
Prior art date
Application number
HK15106636.0A
Other languages
English (en)
Chinese (zh)
Inventor
Betty Y Chang
Joseph J Buggy
Susanne M Steggerda
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of HK1206073A1 publication Critical patent/HK1206073A1/xx

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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
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HK15106636.0A 2012-07-24 2015-07-10 Mutations associated with resistance to inhibitors of brutons tyrosine kinase (btk) (btk) HK1206073A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261675303P 2012-07-24 2012-07-24
US201261682688P 2012-08-13 2012-08-13
US201361780652P 2013-03-13 2013-03-13
PCT/US2013/051741 WO2014018567A1 (en) 2012-07-24 2013-07-23 Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)

Publications (1)

Publication Number Publication Date
HK1206073A1 true HK1206073A1 (en) 2015-12-31

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HK15106636.0A HK1206073A1 (en) 2012-07-24 2015-07-10 Mutations associated with resistance to inhibitors of brutons tyrosine kinase (btk) (btk)

Country Status (11)

Country Link
US (1) US10954567B2 (ja)
EP (2) EP2877598A1 (ja)
JP (2) JP6575950B2 (ja)
KR (2) KR20150032340A (ja)
CN (1) CN104704129A (ja)
AU (1) AU2013293087B2 (ja)
BR (1) BR112015001690A2 (ja)
CA (1) CA2879570A1 (ja)
HK (1) HK1206073A1 (ja)
MX (2) MX2015001081A (ja)
WO (1) WO2014018567A1 (ja)

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US20150184249A1 (en) 2015-07-02
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AU2013293087B2 (en) 2017-08-31
WO2014018567A1 (en) 2014-01-30
CA2879570A1 (en) 2014-01-30
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BR112015001690A2 (pt) 2017-11-07

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