HK1038040A1 - Non-endogenous, constitutively activated human g protein-coupled receptors - Google Patents
Non-endogenous, constitutively activated human g protein-coupled receptorsInfo
- Publication number
- HK1038040A1 HK1038040A1 HK01108940A HK01108940A HK1038040A1 HK 1038040 A1 HK1038040 A1 HK 1038040A1 HK 01108940 A HK01108940 A HK 01108940A HK 01108940 A HK01108940 A HK 01108940A HK 1038040 A1 HK1038040 A1 HK 1038040A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- endogenous
- sub
- sup
- codon
- gpcr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/170,496 US6555339B1 (en) | 1997-04-14 | 1998-10-13 | Non-endogenous, constitutively activated human protein-coupled receptors |
PCT/US1999/023938 WO2000022129A1 (fr) | 1998-10-13 | 1999-10-12 | Recepteurs couples a la proteine g humaine non endogenes et actives de façon constitutive |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1038040A1 true HK1038040A1 (en) | 2002-03-01 |
Family
ID=22620080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK01108940A HK1038040A1 (en) | 1998-10-13 | 2001-12-20 | Non-endogenous, constitutively activated human g protein-coupled receptors |
Country Status (15)
Country | Link |
---|---|
US (2) | US6555339B1 (fr) |
EP (1) | EP1121431B9 (fr) |
JP (2) | JP4685241B2 (fr) |
KR (1) | KR100598752B1 (fr) |
CN (1) | CN1329511C (fr) |
AT (1) | ATE318311T1 (fr) |
AU (5) | AU769987B2 (fr) |
CA (1) | CA2342314A1 (fr) |
DE (3) | DE69929993D1 (fr) |
DK (1) | DK1121431T5 (fr) |
ES (1) | ES2163384T3 (fr) |
HK (1) | HK1038040A1 (fr) |
IL (2) | IL141965A0 (fr) |
NZ (1) | NZ510331A (fr) |
WO (2) | WO2000022129A1 (fr) |
Families Citing this family (168)
Publication number | Priority date | Publication date | Assignee | Title |
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US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
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USRE42190E1 (en) | 1998-11-20 | 2011-03-01 | Arena Pharmaceuticals, Inc. | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors |
ATE366815T1 (de) * | 1998-11-20 | 2007-08-15 | Arena Pharm Inc | Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand |
US20030017528A1 (en) | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
US7816492B2 (en) * | 1998-11-20 | 2010-10-19 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors |
GB9903767D0 (en) * | 1999-02-18 | 1999-04-14 | Univ Glasgow | Receptor assay |
EP1235931A2 (fr) * | 1999-07-30 | 2002-09-04 | Millennium Pharmaceuticals, Inc. | Compositions, kits, et methodes de prevision, de diagnostic, de prevention, et de traitement de maladies des os et d'autres maladies |
JP4768946B2 (ja) * | 1999-11-17 | 2011-09-07 | アリーナ ファーマシューティカルズ, インコーポレイテッド | ヒトgタンパク質共役型受容体の内因性および非内因性型 |
AU5787901A (en) * | 1999-12-10 | 2001-07-09 | Astrazeneca Ab | Compound |
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GB0003898D0 (en) * | 2000-02-18 | 2000-04-05 | Glaxo Group Ltd | Assay |
EP1255779A2 (fr) * | 2000-02-18 | 2002-11-13 | Glaxo Group Limited | Identification de modulateurs de l'activite gpr41 ou gpr42 |
AU2001241778A1 (en) * | 2000-02-29 | 2001-09-12 | Millennium Pharmaceuticals, Inc. | Methods and compositions for the diagnosis and treatment of cardiovascular, hepatic, and bone disease |
US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
EP1149907A1 (fr) * | 2000-04-26 | 2001-10-31 | Aventis Pharma Deutschland GmbH | Récepteur EDG8, sa préparation ainsi que son utilisation |
KR100790329B1 (ko) * | 2000-04-26 | 2008-01-02 | 사노피-아벤티스 도이칠란트 게엠베하 | Edg8 수용체의 용도 |
EP1297127A2 (fr) * | 2000-05-03 | 2003-04-02 | AstraZeneca AB | Modulateurs du gpr22 comme agents de controle de l'appetit |
WO2001096567A1 (fr) * | 2000-06-15 | 2001-12-20 | Takeda Chemical Industries, Ltd. | Nouvelle proteine receptrice couplee a la proteine g et adn de ce recepteur |
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AU2001274562A1 (en) | 2000-06-21 | 2002-01-02 | Takeda Chemical Industries Ltd. | Ligand to gpr8 and dna thereof |
WO2002002767A1 (fr) * | 2000-07-04 | 2002-01-10 | Takeda Chemical Industries, Ltd. | Proteine de recepteur couple a la proteine g et adn correspondant |
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US7462457B2 (en) * | 2000-08-30 | 2008-12-09 | Johns Hopkins University School Of Medicine | Identification of activated receptors and ion channels |
WO2001027632A2 (fr) * | 2000-10-02 | 2001-04-19 | Biofocus Discovery Limited | Procede de prediction de mutations |
WO2002044368A1 (fr) * | 2000-11-30 | 2002-06-06 | Takeda Chemical Industries, Ltd. | Nouvelles proteines du recepteur couple a la proteine g et leurs adn |
GB0031527D0 (en) * | 2000-12-22 | 2001-02-07 | Smithkline Beecham Plc | New use |
US7241579B2 (en) | 2000-12-22 | 2007-07-10 | Smithkline Beecham Corporation | Method of screening for GPR40 ligands |
EP1412372A4 (fr) * | 2001-02-26 | 2005-08-24 | Arena Pharm Inc | Versions endogenes et non-endogenes des recepteurs humains couples a la proteine-g |
US6809104B2 (en) | 2001-05-04 | 2004-10-26 | Tularik Inc. | Fused heterocyclic compounds |
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JP2003018992A (ja) * | 2001-06-28 | 2003-01-21 | Inst Of Physical & Chemical Res | Pael受容体、Pael受容体発現細胞および動物、ならびにパーキンソン病治療薬のスクリーニング法 |
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