ES2147167T1 - Procedimiento de identificacion de moduladores de receptores de membrana de superficie celular util para el tratamiento de enfermedades. - Google Patents

Procedimiento de identificacion de moduladores de receptores de membrana de superficie celular util para el tratamiento de enfermedades.

Info

Publication number
ES2147167T1
ES2147167T1 ES98918196T ES98918196T ES2147167T1 ES 2147167 T1 ES2147167 T1 ES 2147167T1 ES 98918196 T ES98918196 T ES 98918196T ES 98918196 T ES98918196 T ES 98918196T ES 2147167 T1 ES2147167 T1 ES 2147167T1
Authority
ES
Spain
Prior art keywords
diseases
treatment
receptor modulators
surface membrane
membrane receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES98918196T
Other languages
English (en)
Inventor
Dominic P Behan
Derek Chalmers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES2147167T1 publication Critical patent/ES2147167T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LOS RECEPTORES SUPERFICIALES CELULARES EXISTEN EN EQUILIBRIO ENTRE UN ESTADO INACTIVO Y OTRO ACTIVO. HASTA LA FECHA, LOS PLANTEAMIENTOS DE LA TECNICA ANTERIOR PARA ESTUDIAR LA FUNCION DE LOS RECEPTORES Y DETECTAR LOS RECEPTORES PARA NUEVOS FARMACOS SE CENTRABAN EN IDENTIFICAR PREVIAMENTE EL LIGANDO ENDOGENO PARA EL RECEPTOR (O UN SUSTITUTO SINTETICO) Y DESPUES IDENTIFICAR LOS ANTAGONISTAS DEL RECEPTOR EXISTENTE EN UNA CONFORMACION ESTRUCTURAL INACTIVA. AHORA SE HA RECONOCIDO QUE PUEDE OBTENERSE INFORMACION MUY VALIOSA PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR RECEPTORES, DE FORMA DIRECTA, IDENTIFICANDO LOS COMPUESTOS QUE ACTUAN COMO AGONISTAS INVERSOS PARA LAS FORMAS CONSTITUTIVAMENTE ACTIVADAS DE LOS RECEPTORES; ES DECIR, AQUELLOS EN LOS QUE EL EQUILIBRIO SE HA DESPLAZADO HACIA EL ESTADO ACTIVO. SE UTILIZAN PROCEDIMIENTOS PARA ACTIVAR CONSTITUTIVAMENTE LOS RECEPTORES PARA ESPECIFICAR LA CODIFICACION DE INFORMACION GENETICA PARA LOS RECEPTORES QUE POSTERIORMENTE SE EXPRESA EN SISTEMAS DE EXPRESION APROPIADOS. LOS ANALISIS QUE MIDEN LA RESPUESTA CELULAR PRODUCIDA POR COMPUESTOS QUE ACTUAN SOBRE LOS RECEPTORES, PUEDEN IDENTIFICAR TANTO LOS AGONISTAS INVERSOS COMO LOS AGONISTAS DEL RECEPTOR. LA EXPLORACION DE ALTA CAPACIDAD PUEDE UTILIZARSE PARA IDENTIFICAR RAPIDAMENTE ESTOS COMPUESTOS. UNA CARACTERISTICA ESPECIALMENTE RELEVANTE ES QUE LOS MODULADORES DE LA ACCION RECEPTORA PUEDEN IDENTIFICARSE SIN NINGUN CONOCIMIENTO PREVIO DEL LIGANDO ENDOGENO O DE LA FUNCION DEL RECEPTOR. EL PROCEDIMIENTO DE ESTA INVENCION ES ESPECIALMENTE APLICABLE A LOS RECEPTORES HUERFANOS.
ES98918196T 1997-04-14 1998-04-14 Procedimiento de identificacion de moduladores de receptores de membrana de superficie celular util para el tratamiento de enfermedades. Pending ES2147167T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83944997A 1997-04-14 1997-04-14

Publications (1)

Publication Number Publication Date
ES2147167T1 true ES2147167T1 (es) 2000-09-01

Family

ID=25279763

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98918196T Pending ES2147167T1 (es) 1997-04-14 1998-04-14 Procedimiento de identificacion de moduladores de receptores de membrana de superficie celular util para el tratamiento de enfermedades.

Country Status (11)

Country Link
US (1) US20060240523A1 (es)
EP (1) EP0965041B1 (es)
AT (1) ATE423313T1 (es)
AU (1) AU743259B2 (es)
CA (1) CA2279881C (es)
DE (2) DE965041T1 (es)
DK (1) DK0965041T3 (es)
ES (1) ES2147167T1 (es)
IL (1) IL130880A (es)
NZ (1) NZ336479A (es)
WO (1) WO1998046995A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) * 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US6653086B1 (en) 1998-04-14 2003-11-25 Arena Pharmaceuticals, Inc. Endogenous constitutively activated G protein-coupled orphan receptors
JP2002521681A (ja) * 1998-07-31 2002-07-16 アリーナ・フアーマシユーチカルズ・インコーポレーテツド 内因性の構成的に活性化されるｇタンパク質−共役オーファン受容体
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
WO2000040725A1 (en) * 1998-12-28 2000-07-13 Takeda Chemical Industries, Ltd. Screening method
AU5787901A (en) * 1999-12-10 2001-07-09 Astrazeneca Ab Compound
EP1290449A1 (en) * 2000-05-03 2003-03-12 AstraZeneca AB Use of the g protein coupled receptor gpr3 to identify apetite control agents
DE10123958A1 (de) * 2001-05-17 2002-11-28 Aventis Pharma Gmbh Verfahren zur Identifizierung von Liganden für G protein coupled receptors
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
AU2004241193B2 (en) 2003-05-20 2011-03-10 The University Court Of The University Of Glasgow Materials and methods relating to G-protein coupled receptor oligomers
US9952202B2 (en) 2013-03-14 2018-04-24 Galapagos Nv Methods of identifying compounds for the treatment of fibrosis by using S1PR5
US20190216891A1 (en) 2016-03-06 2019-07-18 Yeda Research And Development Co., Ltd. Method for modulating myelination
GB201803079D0 (en) * 2018-02-26 2018-04-11 Autolus Ltd Cell

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE220421T1 (de) * 1990-02-26 2002-07-15 Univ Leland Stanford Junior Identifizierung und expression von insekten- steroidrezeptor-dns-sequenzen
DE69232876D1 (de) * 1991-10-01 2003-01-30 Us Gov Health & Human Serv Ein verfahren zur identifikation von liganden und ligandantagonisten
ES2085247T1 (es) * 1992-09-25 1996-06-01 Synaptic Pharma Corp Receptores adrenergicos alfa 1 humanos que codifican dna y sus utilizaciones.
AU1173995A (en) * 1993-11-10 1995-05-29 Arch Development Corporation Ubiquitous nuclear receptor: compositions and methods
US5573944A (en) * 1994-07-22 1996-11-12 President And Fellows Of Harvard College Yeast cell expressing heterologous receptor kinase
EP0862614A1 (en) * 1995-09-20 1998-09-09 Molecular Geriatrics Corporation Yeast receptor and g-protein fusion protein
IL124808A0 (en) * 1995-12-11 1999-01-26 New England Medical Center Inc Assay for and uses of peptide hormone receptor ligands
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
AU733007B2 (en) * 1996-09-24 2001-05-03 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US5891720A (en) * 1997-04-17 1999-04-06 Millennium Pharmaceuticals, Inc. Isolated DNA encoding a novel human G-protein coupled receptor
US5955308A (en) * 1997-06-18 1999-09-21 Smithkline Beecham Corporation cDNA clone HEAOD54 that encodes a human 7-transmembrane receptor
AU1450900A (en) * 1998-10-21 2000-05-08 Arch Development Corporation Methods of treatment of type 2 diabetes

Also Published As

Publication number Publication date
IL130880A (en) 2004-03-28
CA2279881C (en) 2009-12-22
EP0965041B1 (en) 2009-02-18
DE69840568D1 (de) 2009-04-02
WO1998046995A1 (en) 1998-10-22
DE965041T1 (de) 2000-11-09
DK0965041T3 (da) 2009-05-25
AU743259B2 (en) 2002-01-24
AU7116698A (en) 1998-11-11
CA2279881A1 (en) 1998-10-22
EP0965041A1 (en) 1999-12-22
EP0965041A4 (en) 2003-01-02
US20060240523A1 (en) 2006-10-26
NZ336479A (en) 2001-10-26
IL130880A0 (en) 2001-01-28
ATE423313T1 (de) 2009-03-15

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