HK1022477A1 - Acid-addition salts of optically active piperidine compound and process for producing the same - Google Patents

Acid-addition salts of optically active piperidine compound and process for producing the same

Info

Publication number
HK1022477A1
HK1022477A1 HK00101619A HK00101619A HK1022477A1 HK 1022477 A1 HK1022477 A1 HK 1022477A1 HK 00101619 A HK00101619 A HK 00101619A HK 00101619 A HK00101619 A HK 00101619A HK 1022477 A1 HK1022477 A1 HK 1022477A1
Authority
HK
Hong Kong
Prior art keywords
producing
same
acid
addition salts
optically active
Prior art date
Application number
HK00101619A
Other languages
English (en)
Inventor
Jun-Ichiro Kita
Hiroshi Fujiwara
Shinji Takamura
Ryuzo Yoshioka
Yasuhiko Ozaki
Shin-Ichi Yamada
Original Assignee
Ube Industries
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27341269&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1022477(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP34785196A external-priority patent/JP3157117B2/ja
Priority claimed from JP34785396A external-priority patent/JP3157118B2/ja
Application filed by Ube Industries, Tanabe Seiyaku Co filed Critical Ube Industries
Publication of HK1022477A1 publication Critical patent/HK1022477A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK00101619A 1996-12-26 2000-03-16 Acid-addition salts of optically active piperidine compound and process for producing the same HK1022477A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP34785196A JP3157117B2 (ja) 1996-12-26 1996-12-26 ピペリジン誘導体の光学分割方法
JP34785396A JP3157118B2 (ja) 1996-12-26 1996-12-26 アシルアミノ酸を用いるピペリジン誘導体の光学分割方法
JP34789596 1996-12-26
PCT/JP1997/004826 WO1998029409A1 (fr) 1996-12-26 1997-12-25 Sels d'addition acides de compose de piperidine optiquement actif et procede de production associe

Publications (1)

Publication Number Publication Date
HK1022477A1 true HK1022477A1 (en) 2000-08-11

Family

ID=27341269

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00101619A HK1022477A1 (en) 1996-12-26 2000-03-16 Acid-addition salts of optically active piperidine compound and process for producing the same

Country Status (16)

Country Link
US (3) US6307052B1 (de)
EP (1) EP0949260B1 (de)
KR (1) KR100515227B1 (de)
CN (2) CN1098262C (de)
AT (1) ATE217872T1 (de)
AU (1) AU7890698A (de)
CA (1) CA2275987C (de)
DE (1) DE69712784T2 (de)
DK (1) DK0949260T3 (de)
ES (1) ES2173499T3 (de)
HK (1) HK1022477A1 (de)
ID (1) ID21985A (de)
MY (1) MY118016A (de)
PT (1) PT949260E (de)
TW (1) TW486475B (de)
WO (1) WO1998029409A1 (de)

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CN101928278B (zh) * 2010-08-23 2013-06-05 浙江燎原药业有限公司 (s)-4-[(4-氯苯基)(吡啶-2-基)甲氧基]哌啶羟基苯丙酸盐及其应用
CN103269687B (zh) 2011-01-04 2016-09-14 伊斯塔制药公司 贝托斯汀组合物
CN102675283B (zh) * 2012-05-17 2013-08-14 上海右手医药科技开发有限公司 一种酸性条件下缩合制备贝托斯汀的新方法
TWI455933B (zh) * 2012-08-10 2014-10-11 Everlight Chem Ind Corp 貝他斯汀或其苯磺酸鹽之製法及其使用之中間體
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US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN104031029A (zh) * 2013-03-08 2014-09-10 重庆华邦制药有限公司 单一光学异构体的2-[(4-氯苯基)(哌啶-4-氧基)甲基]吡啶的合成方法
CN104119314B (zh) * 2013-04-23 2018-01-12 重庆华邦制药有限公司 一种稳定的苯磺酸贝他斯汀晶体及其制备方法
CN104003978B (zh) * 2014-06-18 2016-01-20 江苏联环药业股份有限公司 贝他斯汀或其消旋化合物的工业化制备方法
CN104151295B (zh) * 2014-08-26 2015-12-30 山东川成医药股份有限公司 一种2-[(4-氯苯基)(4-哌啶基氧基)甲基]吡啶的合成方法
CN106117183B (zh) * 2016-06-24 2019-08-02 合肥久诺医药科技有限公司 一种高纯度苯磺贝他斯汀的精制方法
CN106938995B (zh) * 2017-01-17 2019-05-28 宜昌人福药业有限责任公司 一种眼科药物苯磺酸贝他斯汀的不对称合成方法
CN106946847B (zh) * 2017-03-27 2019-06-21 福建省微生物研究所 一种贝他斯汀重要中间体的制备方法
CN108727335A (zh) * 2018-08-07 2018-11-02 福建省微生物研究所 一种苯磺贝他斯汀的纯化方法
CN111116556B (zh) * 2019-12-26 2021-11-02 北京鑫开元医药科技有限公司 一种(r)-2-[(4-氯苯基)(4-哌啶氧基)甲基]吡啶的制备方法
CN113480521B (zh) * 2021-07-12 2024-04-16 成都丽凯手性技术有限公司 一种苯磺酸贝他斯汀全合成方法

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Also Published As

Publication number Publication date
TW486475B (en) 2002-05-11
ES2173499T3 (es) 2002-10-16
DE69712784T2 (de) 2002-11-21
US20040220226A1 (en) 2004-11-04
CA2275987A1 (en) 1998-07-09
DE69712784D1 (de) 2002-06-27
PT949260E (pt) 2002-09-30
CA2275987C (en) 2006-12-19
MY118016A (en) 2004-08-30
US6307052B1 (en) 2001-10-23
CN1242013A (zh) 2000-01-19
AU7890698A (en) 1998-07-31
WO1998029409A1 (fr) 1998-07-09
CN1231478C (zh) 2005-12-14
EP0949260A4 (de) 2000-03-15
CN1098262C (zh) 2003-01-08
CN1446812A (zh) 2003-10-08
EP0949260A1 (de) 1999-10-13
DK0949260T3 (da) 2002-09-09
KR20000062337A (ko) 2000-10-25
US20020026054A1 (en) 2002-02-28
ID21985A (id) 1999-08-19
US6780877B2 (en) 2004-08-24
US7282589B2 (en) 2007-10-16
KR100515227B1 (ko) 2005-09-16
EP0949260B1 (de) 2002-05-22
ATE217872T1 (de) 2002-06-15

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Effective date: 20171224