DE69712784D1 - Säureadditionssalze einer optisch aktiven piperidinverbindung und verfahren zu seiner herstellung - Google Patents

Säureadditionssalze einer optisch aktiven piperidinverbindung und verfahren zu seiner herstellung

Info

Publication number
DE69712784D1
DE69712784D1 DE69712784T DE69712784T DE69712784D1 DE 69712784 D1 DE69712784 D1 DE 69712784D1 DE 69712784 T DE69712784 T DE 69712784T DE 69712784 T DE69712784 T DE 69712784T DE 69712784 D1 DE69712784 D1 DE 69712784D1
Authority
DE
Germany
Prior art keywords
production
acid addition
addition salts
optically active
piperidine compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69712784T
Other languages
English (en)
Other versions
DE69712784T2 (de
Inventor
Jun-Ichiro Kita
Hiroshi Fujiwara
Shinji Takamura
Ryuzo Yoshioka
Yasuhiko Ozaki
Shin-Ichi Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Ube Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27341269&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69712784(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP34785196A external-priority patent/JP3157117B2/ja
Priority claimed from JP34785396A external-priority patent/JP3157118B2/ja
Application filed by Tanabe Seiyaku Co Ltd, Ube Industries Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of DE69712784D1 publication Critical patent/DE69712784D1/de
Publication of DE69712784T2 publication Critical patent/DE69712784T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DE69712784T 1996-12-26 1997-12-25 Säureadditionssalze einer optisch aktiven piperidinverbindung und verfahren zu seiner herstellung Expired - Lifetime DE69712784T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP34785196A JP3157117B2 (ja) 1996-12-26 1996-12-26 ピペリジン誘導体の光学分割方法
JP34785396A JP3157118B2 (ja) 1996-12-26 1996-12-26 アシルアミノ酸を用いるピペリジン誘導体の光学分割方法
JP34789596 1996-12-26
PCT/JP1997/004826 WO1998029409A1 (fr) 1996-12-26 1997-12-25 Sels d'addition acides de compose de piperidine optiquement actif et procede de production associe

Publications (2)

Publication Number Publication Date
DE69712784D1 true DE69712784D1 (de) 2002-06-27
DE69712784T2 DE69712784T2 (de) 2002-11-21

Family

ID=27341269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69712784T Expired - Lifetime DE69712784T2 (de) 1996-12-26 1997-12-25 Säureadditionssalze einer optisch aktiven piperidinverbindung und verfahren zu seiner herstellung

Country Status (16)

Country Link
US (3) US6307052B1 (de)
EP (1) EP0949260B1 (de)
KR (1) KR100515227B1 (de)
CN (2) CN1098262C (de)
AT (1) ATE217872T1 (de)
AU (1) AU7890698A (de)
CA (1) CA2275987C (de)
DE (1) DE69712784T2 (de)
DK (1) DK0949260T3 (de)
ES (1) ES2173499T3 (de)
HK (1) HK1022477A1 (de)
ID (1) ID21985A (de)
MY (1) MY118016A (de)
PT (1) PT949260E (de)
TW (1) TW486475B (de)
WO (1) WO1998029409A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8112101A (en) * 2000-08-08 2002-02-18 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines
CA2463579A1 (en) 2001-10-16 2003-04-24 Hypnion, Inc. Treatment of cns disorders using cns target modulators
US7189757B2 (en) * 2001-10-16 2007-03-13 Hypnion, Inc. Treatment of sleep disorders using CNS target modulators
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
KR20040064687A (ko) * 2001-12-21 2004-07-19 도오레 화인케미칼 가부시키가이샤 광학 활성 시스 피페리딘 유도체의 제조법
AU2003216726A1 (en) * 2002-01-17 2003-07-30 Atofina Supramolecular polymers
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
KR101016595B1 (ko) * 2002-07-31 2011-02-22 센주 세이야꾸 가부시키가이샤 수성액제 및 광안정화된 수성액제
AU2003261748B2 (en) 2002-08-29 2006-11-23 Taisho Pharmaceutical Co., Ltd. Benzenesulfonate of 4-fluoro-2-cyanopyrrolidine derivative
WO2008002583A1 (en) 2006-06-28 2008-01-03 Amgen Inc. Glycine transporter-1 inhibitors
KR100878698B1 (ko) 2007-04-05 2009-01-13 한미약품 주식회사 결정형의 베포타스틴 금속염 수화물, 이의 제조방법 및이를 포함하는 약학 조성물
KR100879409B1 (ko) * 2007-06-11 2009-01-19 한미약품 주식회사 (ｓ)-베포타스틴의 제조방법 및 이에 사용되는 중간체
CN102026970B (zh) * 2007-11-21 2013-07-31 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4抑制剂
KR101307712B1 (ko) * 2008-12-02 2013-09-11 한미사이언스 주식회사 결정형의 베포타스틴 금속염 수화물, 이의 제조방법 및 이를 포함하는 약학 조성물
KR101132949B1 (ko) * 2009-09-08 2012-04-10 경희대학교 산학협력단 베포타스틴 살리실산염, 이의 제조방법 및 이를 유효성분으로 포함하는 항히스타민 또는 항알레르기용 약학적 조성물
KR101146009B1 (ko) 2009-10-01 2012-05-15 동인화학 주식회사 광학 분리에 의한 활성 피페리딘 화합물의 제조방법
JP2011195500A (ja) * 2010-03-19 2011-10-06 Tokuyama Corp （ｓ）−４−［４−［（４−クロロフェニル）（２−ピリジル）メトキシ］ピペリジノ］ブタン酸一ベンゼンスルホン酸塩の製造方法
CN101928278B (zh) * 2010-08-23 2013-06-05 浙江燎原药业有限公司 (s)-4-[(4-氯苯基)(吡啶-2-基)甲氧基]哌啶羟基苯丙酸盐及其应用
CN103269687B (zh) 2011-01-04 2016-09-14 伊斯塔制药公司 贝托斯汀组合物
CN102675283B (zh) * 2012-05-17 2013-08-14 上海右手医药科技开发有限公司 一种酸性条件下缩合制备贝托斯汀的新方法
TWI455933B (zh) * 2012-08-10 2014-10-11 Everlight Chem Ind Corp 貝他斯汀或其苯磺酸鹽之製法及其使用之中間體
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
WO2014134510A1 (en) 2013-02-28 2014-09-04 Dermira, Inc. Glycopyrrolate salts
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN104031029A (zh) * 2013-03-08 2014-09-10 重庆华邦制药有限公司 单一光学异构体的2-[(4-氯苯基)(哌啶-4-氧基)甲基]吡啶的合成方法
CN104119314B (zh) * 2013-04-23 2018-01-12 重庆华邦制药有限公司 一种稳定的苯磺酸贝他斯汀晶体及其制备方法
CN104003978B (zh) * 2014-06-18 2016-01-20 江苏联环药业股份有限公司 贝他斯汀或其消旋化合物的工业化制备方法
CN104151295B (zh) * 2014-08-26 2015-12-30 山东川成医药股份有限公司 一种2-[(4-氯苯基)(4-哌啶基氧基)甲基]吡啶的合成方法
CN106117183B (zh) * 2016-06-24 2019-08-02 合肥久诺医药科技有限公司 一种高纯度苯磺贝他斯汀的精制方法
CN106938995B (zh) * 2017-01-17 2019-05-28 宜昌人福药业有限责任公司 一种眼科药物苯磺酸贝他斯汀的不对称合成方法
CN106946847B (zh) * 2017-03-27 2019-06-21 福建省微生物研究所 一种贝他斯汀重要中间体的制备方法
CN108727335A (zh) * 2018-08-07 2018-11-02 福建省微生物研究所 一种苯磺贝他斯汀的纯化方法
CN111116556B (zh) * 2019-12-26 2021-11-02 北京鑫开元医药科技有限公司 一种(r)-2-[(4-氯苯基)(4-哌啶氧基)甲基]吡啶的制备方法
CN113480521B (zh) * 2021-07-12 2024-04-16 成都丽凯手性技术有限公司 一种苯磺酸贝他斯汀全合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5345759A (en) * 1976-10-07 1978-04-24 Takasago Thermal Eng Co Lts Formation method for spot clean zone
JPS6336480A (ja) * 1986-07-31 1988-02-17 Hitachi Seiki Co Ltd 部品図の寸法表示自動作画装置
US4730827A (en) * 1986-11-21 1988-03-15 Williams George R Hand rehabilitation device
JPS63225465A (ja) 1987-03-13 1988-09-20 Jeol Ltd 走査電子顕微鏡等の集束レンズ
JPS6413090A (en) * 1987-07-07 1989-01-17 Ube Industries Xanthine derivative
JPS6413090U (de) * 1987-07-13 1989-01-24
JPH01242574A (ja) * 1988-03-25 1989-09-27 Ube Ind Ltd 含窒素縮合環を有するピペリジン及びピペラジン誘導体、その製造方法並びにそれを含む薬学的組成物
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
CA2035147A1 (en) * 1990-02-08 1991-08-09 Kousuke Yasuda Thiazine (or oxazine) derivatives and preparation thereof
JP2624372B2 (ja) * 1990-11-15 1997-06-25 宇部興産株式会社 ジアリールメトキシピペリジン誘導体
JPH04225465A (ja) 1990-12-27 1992-08-14 Hitachi Ltd 文書作成装置
JPH05345759A (ja) * 1991-08-08 1993-12-27 Kaken Pharmaceut Co Ltd ピペリジン誘導体
JPH06135958A (ja) * 1992-10-28 1994-05-17 Tanabe Seiyaku Co Ltd ベンゾシクロヘプテン誘導体及びその製法
JPH06239742A (ja) * 1992-12-03 1994-08-30 Tanabe Seiyaku Co Ltd 排尿障害の予防・治療剤
JP2787973B2 (ja) * 1993-05-28 1998-08-20 宇部興産株式会社 ピペリジン中間体の精製法
JPH1025465A (ja) 1996-07-10 1998-01-27 Toshiba Chem Corp 耐熱性フィルム接着剤組成物
JPH10182635A (ja) * 1996-12-26 1998-07-07 Ube Ind Ltd 光学活性ピペリジン誘導体及びその製造方法
IT1293941B1 (it) 1997-02-13 1999-03-11 Orthofix Srl Attrezzo ortopedico particolarmente per la correzione chirurgica di deformazioni ossee
JP3252741B2 (ja) * 1997-02-21 2002-02-04 宇部興産株式会社 光学活性ピペリジン化合物のラセミ化方法
US6319176B1 (en) * 1999-07-28 2001-11-20 Hampton Fitness Products, Ltd. Weightlifting plate
USD474517S1 (en) * 2002-01-18 2003-05-13 Technical Knockout, Inc. Barbell weight plate

Also Published As

Publication number Publication date
US6780877B2 (en) 2004-08-24
US7282589B2 (en) 2007-10-16
TW486475B (en) 2002-05-11
ID21985A (id) 1999-08-19
DK0949260T3 (da) 2002-09-09
DE69712784T2 (de) 2002-11-21
CN1098262C (zh) 2003-01-08
EP0949260A1 (de) 1999-10-13
ES2173499T3 (es) 2002-10-16
KR100515227B1 (ko) 2005-09-16
PT949260E (pt) 2002-09-30
CN1231478C (zh) 2005-12-14
MY118016A (en) 2004-08-30
KR20000062337A (ko) 2000-10-25
US6307052B1 (en) 2001-10-23
CA2275987A1 (en) 1998-07-09
AU7890698A (en) 1998-07-31
US20040220226A1 (en) 2004-11-04
US20020026054A1 (en) 2002-02-28
ATE217872T1 (de) 2002-06-15
EP0949260A4 (de) 2000-03-15
EP0949260B1 (de) 2002-05-22
WO1998029409A1 (fr) 1998-07-09
CN1446812A (zh) 2003-10-08
HK1022477A1 (en) 2000-08-11
CN1242013A (zh) 2000-01-19
CA2275987C (en) 2006-12-19

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