AT388729B - Alpha-alkyl-4-amino-3-chinolinmethanole und 1-(4-aralkylamino-3-chinolinyl)-alkanone, ein verfahren zur ihrer herstellung und deren verwendung - Google Patents

Alpha-alkyl-4-amino-3-chinolinmethanole und 1-(4-aralkylamino-3-chinolinyl)-alkanone, ein verfahren zur ihrer herstellung und deren verwendung

Info

Publication number
AT388729B
AT388729B AT0260187A AT260187A AT388729B AT 388729 B AT388729 B AT 388729B AT 0260187 A AT0260187 A AT 0260187A AT 260187 A AT260187 A AT 260187A AT 388729 B AT388729 B AT 388729B
Authority
AT
Austria
Prior art keywords
loweralkyl
hydrogen
chinolinmethanole
chinolinyl
alkanone
Prior art date
Application number
AT0260187A
Other languages
English (en)
Other versions
ATA260187A (de
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ATA260187A publication Critical patent/ATA260187A/de
Application granted granted Critical
Publication of AT388729B publication Critical patent/AT388729B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
AT0260187A 1986-08-25 1987-10-08 Alpha-alkyl-4-amino-3-chinolinmethanole und 1-(4-aralkylamino-3-chinolinyl)-alkanone, ein verfahren zur ihrer herstellung und deren verwendung AT388729B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/899,584 US4789678A (en) 1986-08-25 1986-08-25 Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds

Publications (2)

Publication Number Publication Date
ATA260187A ATA260187A (de) 1989-01-15
AT388729B true AT388729B (de) 1989-08-25

Family

ID=25411249

Family Applications (2)

Application Number Title Priority Date Filing Date
AT87112131T ATE67189T1 (de) 1986-08-25 1987-08-21 Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AT0260187A AT388729B (de) 1986-08-25 1987-10-08 Alpha-alkyl-4-amino-3-chinolinmethanole und 1-(4-aralkylamino-3-chinolinyl)-alkanone, ein verfahren zur ihrer herstellung und deren verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT87112131T ATE67189T1 (de) 1986-08-25 1987-08-21 Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Country Status (19)

Country Link
US (1) US4789678A (de)
EP (1) EP0258755B1 (de)
JP (1) JPS6360968A (de)
KR (1) KR880002834A (de)
AT (2) ATE67189T1 (de)
AU (1) AU589029B2 (de)
CA (1) CA1297111C (de)
DE (1) DE3772905D1 (de)
DK (1) DK441187A (de)
ES (1) ES2029812T3 (de)
FI (1) FI86299C (de)
GR (1) GR3003299T3 (de)
HU (1) HU199425B (de)
IL (1) IL83629A (de)
NO (1) NO873568L (de)
NZ (1) NZ221543A (de)
PH (1) PH25571A (de)
PT (1) PT85583B (de)
ZA (1) ZA876254B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581382B1 (fr) * 1985-05-06 1987-06-26 Sanofi Sa Derives n-(quinolyl) glycinamides, leur procede de preparation et leur application therapeutique en tant que psychotropes
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
US4743601A (en) * 1987-07-13 1988-05-10 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-1,4-oxazino(2,3-C)quinolines
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5019574A (en) * 1988-09-30 1991-05-28 Chugai Seiyaku Kabushiki Kaisha 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
US5110815A (en) * 1990-12-03 1992-05-05 Hoechst-Roussel Pharmaceuticals Inc. 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use
GB9122051D0 (en) * 1991-10-17 1991-11-27 Univ Nottingham Medicines
US5493027A (en) * 1993-01-22 1996-02-20 Board Of Regents, The University Of Texas System Anticonvulsive agents and uses thereof
YU19302A (sh) * 1999-09-22 2004-11-25 Aventis Pharma Deutschland Gmbh. 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena
EP2178842A2 (de) 2007-08-22 2010-04-28 Abbott GmbH & Co. KG 4-benzylaminochinoline, pharmazeutische zusammensetzungen, die diese enthalten, und ihre verwendung
ES2397764T3 (es) 2008-04-01 2013-03-11 Abbott Gmbh & Co. Kg Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2014521682A (ja) 2011-08-05 2014-08-28 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー アミノクロマン、アミノチオクロマンおよびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用
EP2780328A1 (de) 2011-11-18 2014-09-24 Abbvie Deutschland GmbH & Co. KG N-substituierte aminobenzocyclohepten-, aminotetralin-, aminoindan- und phenylalkylaminderivate, diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische verwendung
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015055771A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2016004936A (es) 2013-10-17 2016-12-20 Abbvie Deutschland Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545636A1 (de) * 1964-11-10 1969-12-11 Bristol Myers Co Verfahren zur Herstellung von therapeutisch wirksamen 2-Chinolinmethanolen
US4421920A (en) * 1981-01-16 1983-12-20 Rhone-Poulenc Sante Process for the preparation of 4-amino-chloroquinolines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785165A (en) * 1953-12-22 1957-03-12 Abbott Lab Preparation of 4-aminoquinoline
US4180670A (en) * 1977-02-02 1979-12-25 John Wyeth & Brother Limited Amino pyridine derivatives
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545636A1 (de) * 1964-11-10 1969-12-11 Bristol Myers Co Verfahren zur Herstellung von therapeutisch wirksamen 2-Chinolinmethanolen
US4421920A (en) * 1981-01-16 1983-12-20 Rhone-Poulenc Sante Process for the preparation of 4-amino-chloroquinolines

Also Published As

Publication number Publication date
DK441187A (da) 1988-02-26
FI873631A0 (fi) 1987-08-21
DE3772905D1 (de) 1991-10-17
ES2029812T3 (es) 1992-10-01
PT85583B (pt) 1990-05-31
AU7734387A (en) 1988-02-25
AU589029B2 (en) 1989-09-28
KR880002834A (ko) 1988-05-11
EP0258755A1 (de) 1988-03-09
IL83629A (en) 1992-02-16
GR3003299T3 (en) 1993-02-17
HU199425B (en) 1990-02-28
ATA260187A (de) 1989-01-15
ATE67189T1 (de) 1991-09-15
DK441187D0 (da) 1987-08-24
FI86299B (fi) 1992-04-30
US4789678A (en) 1988-12-06
PH25571A (en) 1991-08-08
IL83629A0 (en) 1988-01-31
JPS6360968A (ja) 1988-03-17
NZ221543A (en) 1990-09-26
NO873568D0 (no) 1987-08-24
ZA876254B (en) 1988-04-27
FI86299C (fi) 1992-08-10
NO873568L (no) 1988-02-26
EP0258755B1 (de) 1991-09-11
HUT45503A (en) 1988-07-28
PT85583A (en) 1987-09-01
FI873631A7 (fi) 1988-02-26
CA1297111C (en) 1992-03-10

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Legal Events

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ELJ Ceased due to non-payment of the annual fee