DE69226822D1 - Diastereomeres Salz von optisch aktiver Chinolinmevalonsäure - Google Patents
Diastereomeres Salz von optisch aktiver ChinolinmevalonsäureInfo
- Publication number
- DE69226822D1 DE69226822D1 DE69226822T DE69226822T DE69226822D1 DE 69226822 D1 DE69226822 D1 DE 69226822D1 DE 69226822 T DE69226822 T DE 69226822T DE 69226822 T DE69226822 T DE 69226822T DE 69226822 D1 DE69226822 D1 DE 69226822D1
- Authority
- DE
- Germany
- Prior art keywords
- optically active
- diastereomeric salt
- mevalonic acid
- active quinoline
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15181091 | 1991-06-24 | ||
| JP12727792A JP3528186B2 (ja) | 1991-06-24 | 1992-05-20 | 光学活性キノリンメバロン酸のジアステレオマー塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69226822D1 true DE69226822D1 (de) | 1998-10-08 |
| DE69226822T2 DE69226822T2 (de) | 1999-02-11 |
Family
ID=26463266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69226822T Expired - Lifetime DE69226822T2 (de) | 1991-06-24 | 1992-06-24 | Diastereomeres Salz von optisch aktiver Chinolinmevalonsäure |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5284953A (de) |
| EP (2) | EP0520406B1 (de) |
| JP (1) | JP3528186B2 (de) |
| KR (1) | KR100208867B1 (de) |
| AT (1) | ATE170513T1 (de) |
| CA (1) | CA2072162C (de) |
| DE (1) | DE69226822T2 (de) |
| DK (1) | DK0520406T3 (de) |
| ES (1) | ES2120973T3 (de) |
| TW (1) | TW293007B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69526784T2 (de) * | 1994-02-25 | 2002-09-05 | Daicel Chem | Verfahren zur herstellung von optisch aktiven mevalonolactonen |
| SK284202B6 (sk) | 1995-07-17 | 2004-10-05 | Warner-Lambert Company | Kryštalické formy I, II a IV atorvastatínu, to je semivápenatej soli kyseliny [R-(R*,R*)]-2-(4-fluórfenyl)-beta,delta-dihydroxy- 5-(1-metyletyl)-3-fenyl-4-(fenylamino)karbonyl]-1H-pyrol-1- heptánovej, alebo jeho hydrátu, farmaceutické kompozície obsahujúce uvedené kryštalické formy a kryštalické formy na použitie ako liečivo |
| RU2142790C1 (ru) * | 1995-12-22 | 1999-12-20 | Кова Компани Лтд | Фармацевтическая композиция, стабилизированная основным агентом |
| GB9614804D0 (en) * | 1996-07-15 | 1996-09-04 | Chiroscience Ltd | Resolution process |
| PL193678B1 (pl) | 1997-12-19 | 2007-03-30 | Warner Lambert Exp Ltd | Sposób wytwarzania cis-1,3-diolu, synergiczna kombinacja oraz zastosowanie synergicznej kombinacji |
| CN1107670C (zh) | 1998-07-23 | 2003-05-07 | 日产化学工业株式会社 | 喹啉衍生物的制备方法及中间体 |
| KR100311645B1 (ko) * | 1999-12-24 | 2001-10-12 | 이홍천 | 간판 |
| GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| UA76984C2 (en) * | 2001-04-05 | 2006-10-16 | Nissan Chemical Ind Ltd | A method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate |
| JP4783998B2 (ja) * | 2001-05-15 | 2011-09-28 | 宇部興産株式会社 | （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法 |
| WO2003027073A1 (en) * | 2001-09-19 | 2003-04-03 | Ube Industries, Ltd. | Process for producing optically active 7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoic acid ester |
| US6835838B2 (en) * | 2002-01-28 | 2004-12-28 | Novartis Ag | Process for the manufacture of organic compounds |
| KR20040081161A (ko) | 2002-01-31 | 2004-09-20 | 노파르티스 아게 | ＨＭＧ-ＣｏＡ 환원효소 억제제의 제조 방법 |
| WO2004026838A1 (en) * | 2002-09-20 | 2004-04-01 | Nissan Chemical Industries, Ltd. | Method for producing a 3,5-dihydroxy-6-heptenoate |
| CA2785954A1 (en) * | 2003-02-12 | 2004-08-26 | Nissan Chemical Industries, Ltd. | Crystalline forms of pitavastatin calcium |
| JP4719572B2 (ja) * | 2003-04-17 | 2011-07-06 | 興和株式会社 | Ｌｋｌｆ／ｋｌｆ２遺伝子発現促進剤 |
| WO2005053683A1 (en) * | 2003-11-26 | 2005-06-16 | Duke University | A method of preventing or treating glaucoma |
| TWI328006B (en) * | 2003-12-26 | 2010-08-01 | Nissan Chemical Ind Ltd | Crystal form of quinoline compound and process for its production |
| EP1709008A1 (de) * | 2004-01-19 | 2006-10-11 | Ranbaxy Laboratories Limited | Salze von hmg-coa-reduktase-inhibitoren und deren verwendung |
| CN101220021B (zh) * | 2007-01-12 | 2010-12-08 | 上海医药工业研究院 | 4-取代苯氧基喹啉类化合物及其中间体、制备方法和应用 |
| US20100044441A1 (en) * | 2007-03-12 | 2010-02-25 | Moshe Cohen | Color sensing for a reader device and the like |
| WO2010027060A1 (ja) * | 2008-09-05 | 2010-03-11 | 日産化学工業株式会社 | ３，５－ジヒドロキシ－６－ヘプテン酸アミン塩類の製造方法 |
| US20120022102A1 (en) | 2010-01-20 | 2012-01-26 | Cadila Healthcare Limited | Method for preparation of pitavastatin and its pharmaceutical acceptable salts thereof |
| US9034901B2 (en) | 2010-08-25 | 2015-05-19 | Cadila Healthcare Limited | Pitavastatin calcium and process for its preparation |
| EP3178812A1 (de) * | 2010-11-12 | 2017-06-14 | Hetero Research Foundation | Neuartige polymorphe von pitavastatin-calcium |
| KR101270586B1 (ko) * | 2010-11-26 | 2013-06-03 | 주식회사 아미노로직스 | 광학적으로 순수한 2,2'-디히드록시-1,1'-바이나프틸-3-카르복실산의 제조방법 |
| WO2012140490A2 (en) | 2011-04-11 | 2012-10-18 | Aurobindo Pharma Limited | Process for preparing quinoline derivative |
| JP2011173912A (ja) * | 2011-04-28 | 2011-09-08 | Ube Industries Ltd | （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法 |
| EA024991B1 (ru) | 2011-09-12 | 2016-11-30 | ФАРМА ДжРС, Д.О.О. | Полиморфная форма питавастатина кальция |
| JP2013103884A (ja) * | 2011-11-10 | 2013-05-30 | Daito Kk | ピタバスタチンカルシウム塩の工業的製造方法 |
| CN102653523A (zh) * | 2011-12-17 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙重结晶制取方法 |
| WO2013098773A1 (en) * | 2011-12-28 | 2013-07-04 | Dr. Reddy's Laboratories Limited | Crystalline forms of pitavastatin calcium |
| CN102653524A (zh) * | 2012-01-12 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙中间体的制备方法 |
| US9676729B2 (en) | 2013-03-29 | 2017-06-13 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Amine salts of pitavastatin and rosuvastatin |
| CN105189458A (zh) * | 2013-03-29 | 2015-12-23 | 中化帝斯曼制药有限公司荷兰公司 | 匹伐他汀和罗素伐他汀的胺盐 |
| CN103508949B (zh) * | 2013-10-22 | 2015-12-09 | 黄河三角洲京博化工研究院有限公司 | 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH603587A5 (de) * | 1972-03-10 | 1978-08-31 | Ciba Geigy Ag | |
| US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| DE3905908A1 (de) * | 1989-02-25 | 1990-09-06 | Bayer Ag | Substituierte chinoline, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| DE3925636A1 (de) * | 1989-08-03 | 1991-02-07 | Bayer Ag | Imino-substituierte pyridine |
| EP0430129A3 (en) * | 1989-11-30 | 1992-02-26 | Tanabe Seiyaku Co., Ltd. | Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor |
| JPH054943A (ja) * | 1990-08-30 | 1993-01-14 | Sagami Chem Res Center | 光学活性β，δ−ジケト酸エステル及びその還元体 |
-
1992
- 1992-05-20 JP JP12727792A patent/JP3528186B2/ja not_active Expired - Lifetime
- 1992-06-12 TW TW081104622A patent/TW293007B/zh active
- 1992-06-23 US US07/902,863 patent/US5284953A/en not_active Expired - Lifetime
- 1992-06-23 CA CA002072162A patent/CA2072162C/en not_active Expired - Lifetime
- 1992-06-24 KR KR1019920011018A patent/KR100208867B1/ko not_active IP Right Cessation
- 1992-06-24 ES ES92110636T patent/ES2120973T3/es not_active Expired - Lifetime
- 1992-06-24 EP EP92110636A patent/EP0520406B1/de not_active Expired - Lifetime
- 1992-06-24 EP EP96107815A patent/EP0742209A3/de not_active Withdrawn
- 1992-06-24 DE DE69226822T patent/DE69226822T2/de not_active Expired - Lifetime
- 1992-06-24 DK DK92110636T patent/DK0520406T3/da active
- 1992-06-24 AT AT92110636T patent/ATE170513T1/de active
-
1993
- 1993-09-20 US US08/123,117 patent/US5473075A/en not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/450,383 patent/US5514804A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2120973T3 (es) | 1998-11-16 |
| DK0520406T3 (da) | 1998-12-14 |
| JPH05148237A (ja) | 1993-06-15 |
| JP3528186B2 (ja) | 2004-05-17 |
| CA2072162A1 (en) | 1992-12-25 |
| EP0520406B1 (de) | 1998-09-02 |
| CA2072162C (en) | 2002-11-19 |
| DE69226822T2 (de) | 1999-02-11 |
| US5514804A (en) | 1996-05-07 |
| EP0742209A2 (de) | 1996-11-13 |
| TW293007B (de) | 1996-12-11 |
| EP0742209A3 (de) | 1997-05-14 |
| US5473075A (en) | 1995-12-05 |
| EP0520406A1 (de) | 1992-12-30 |
| KR930000486A (ko) | 1993-01-15 |
| ATE170513T1 (de) | 1998-09-15 |
| KR100208867B1 (ko) | 1999-07-15 |
| US5284953A (en) | 1994-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R071 | Expiry of right |
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