ES2120973T3 - Sal de diastereomero de acido quinolinmevalonico opticamente activo. - Google Patents

Sal de diastereomero de acido quinolinmevalonico opticamente activo.

Info

Publication number
ES2120973T3
ES2120973T3 ES92110636T ES92110636T ES2120973T3 ES 2120973 T3 ES2120973 T3 ES 2120973T3 ES 92110636 T ES92110636 T ES 92110636T ES 92110636 T ES92110636 T ES 92110636T ES 2120973 T3 ES2120973 T3 ES 2120973T3
Authority
ES
Spain
Prior art keywords
optically active
acid
chinolinmevalonic
diastereomer salt
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92110636T
Other languages
English (en)
Inventor
Yoshio Ohara
Mikio Suzuki
Yoshinobu Yanagawa
Hiroshi Iwasaki
Nobuhide Miyachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Application granted granted Critical
Publication of ES2120973T3 publication Critical patent/ES2120973T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PRESENTA UNA SAL DIASTEREOMERA DE UN ACIDO QUINOLINEMEVALONICO OPTICAMENTE ACTIVO DE LA FORMULA (()I (GRADOS) (+)II):
ES92110636T 1991-06-24 1992-06-24 Sal de diastereomero de acido quinolinmevalonico opticamente activo. Expired - Lifetime ES2120973T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15181091 1991-06-24
JP12727792A JP3528186B2 (ja) 1991-06-24 1992-05-20 光学活性キノリンメバロン酸のジアステレオマー塩

Publications (1)

Publication Number Publication Date
ES2120973T3 true ES2120973T3 (es) 1998-11-16

Family

ID=26463266

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92110636T Expired - Lifetime ES2120973T3 (es) 1991-06-24 1992-06-24 Sal de diastereomero de acido quinolinmevalonico opticamente activo.

Country Status (10)

Country Link
US (3) US5284953A (es)
EP (2) EP0742209A3 (es)
JP (1) JP3528186B2 (es)
KR (1) KR100208867B1 (es)
AT (1) ATE170513T1 (es)
CA (1) CA2072162C (es)
DE (1) DE69226822T2 (es)
DK (1) DK0520406T3 (es)
ES (1) ES2120973T3 (es)
TW (1) TW293007B (es)

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AU691582B2 (en) * 1994-02-25 1998-05-21 Daicel Chemical Industries Ltd. Process for producing optically active mevalonolactone compound
SI1148049T1 (en) 1995-07-17 2005-02-28 Warner-Lambert Company Crystalline R-(R*,R*)$-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- (phenylamino)carbonyl -1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
ES2183023T3 (es) * 1995-12-22 2003-03-16 Kowa Co Composicion farmaceutica estabilizada con un agente basico.
GB9614804D0 (en) * 1996-07-15 1996-09-04 Chiroscience Ltd Resolution process
IL135562A (en) 1997-12-19 2005-08-31 Warner Lambert Exp Ltd Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis
PT1099694E (pt) 1998-07-23 2005-10-31 Nissan Chemical Ind Ltd Processo para a preparacao de um derivado de quinolina e um intermediario para esse fim
KR100311645B1 (ko) * 1999-12-24 2001-10-12 이홍천 간판
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
IL158151A0 (en) * 2001-04-05 2004-03-28 Nissan Chemical Ind Ltd Method for preparing 7-quinolinyl-3, 5-dihydroxyhept-6-enoate
JP4783998B2 (ja) * 2001-05-15 2011-09-28 宇部興産株式会社 （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法
WO2003027073A1 (fr) * 2001-09-19 2003-04-03 Ube Industries, Ltd. Procede de production d'ester optiquement actif d'acide 7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoique
US6835838B2 (en) * 2002-01-28 2004-12-28 Novartis Ag Process for the manufacture of organic compounds
BR0307303A (pt) 2002-01-31 2005-01-11 Novartis Ag Processo para a fabricação de inibidores da hmg-coa redutase
WO2004026838A1 (en) * 2002-09-20 2004-04-01 Nissan Chemical Industries, Ltd. Method for producing a 3,5-dihydroxy-6-heptenoate
EP1592668A1 (en) * 2003-02-12 2005-11-09 Ciba SC Holding AG Crystalline forms of pitavastatin calcium
US20060276486A1 (en) * 2003-04-17 2006-12-07 Kowa Co., Ktd. Lklf/klf2 gene expression promoter
EP1722780A4 (en) * 2003-11-26 2008-12-17 Univ Duke METHOD FOR PREVENTING OR TREATING GLAUCOMA
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
EP1709008A1 (en) * 2004-01-19 2006-10-11 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
CN101220021B (zh) * 2007-01-12 2010-12-08 上海医药工业研究院 4-取代苯氧基喹啉类化合物及其中间体、制备方法和应用
WO2008111055A1 (en) * 2007-03-12 2008-09-18 In-Dot Ltd. Color sensing for a reader device and the like
WO2010027060A1 (ja) * 2008-09-05 2010-03-11 日産化学工業株式会社 ３，５－ジヒドロキシ－６－ヘプテン酸アミン塩類の製造方法
JP2013516459A (ja) 2010-01-20 2013-05-13 カディラ・ヘルスケア・リミテッド ピタバスタチン及び医薬として許容可能なそれらの塩の製造方法
JP2013536219A (ja) 2010-08-25 2013-09-19 カディラ・ヘルスケア・リミテッド ピタバスタチンカルシウムおよびその調製方法
WO2012063254A1 (en) * 2010-11-12 2012-05-18 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
KR101270586B1 (ko) 2010-11-26 2013-06-03 주식회사 아미노로직스 광학적으로 순수한 2,2'-디히드록시-1,1'-바이나프틸-3-카르복실산의 제조방법
WO2012140490A2 (en) 2011-04-11 2012-10-18 Aurobindo Pharma Limited Process for preparing quinoline derivative
JP2011173912A (ja) * 2011-04-28 2011-09-08 Ube Industries Ltd （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法
EP2751081B1 (en) 2011-09-12 2017-01-04 Farma GRS, d.o.o. Polymorphic form of pitavastatin calcium
JP2013103884A (ja) * 2011-11-10 2013-05-30 Daito Kk ピタバスタチンカルシウム塩の工業的製造方法
CN102653523A (zh) * 2011-12-17 2012-09-05 东莞达信生物技术有限公司 一种匹伐他汀钙重结晶制取方法
WO2013098773A1 (en) * 2011-12-28 2013-07-04 Dr. Reddy's Laboratories Limited Crystalline forms of pitavastatin calcium
CN102653524A (zh) * 2012-01-12 2012-09-05 东莞达信生物技术有限公司 一种匹伐他汀钙中间体的制备方法
US9676729B2 (en) 2013-03-29 2017-06-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Amine salts of pitavastatin and rosuvastatin
US9630906B2 (en) 2013-03-29 2017-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Amine salts of pitavastatin and rosuvastatin
CN103508949B (zh) * 2013-10-22 2015-12-09 黄河三角洲京博化工研究院有限公司 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法
JP6649263B2 (ja) * 2014-10-10 2020-02-19 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH576963A5 (es) * 1972-03-10 1976-06-30 Ciba Geigy Ag
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
DE3905908A1 (de) 1989-02-25 1990-09-06 Bayer Ag Substituierte chinoline, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE3925636A1 (de) * 1989-08-03 1991-02-07 Bayer Ag Imino-substituierte pyridine
EP0430129A3 (en) * 1989-11-30 1992-02-26 Tanabe Seiyaku Co., Ltd. Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor
JPH054943A (ja) * 1990-08-30 1993-01-14 Sagami Chem Res Center 光学活性β，δ−ジケト酸エステル及びその還元体

Also Published As

Publication number Publication date
TW293007B (es) 1996-12-11
EP0520406B1 (en) 1998-09-02
DE69226822T2 (de) 1999-02-11
CA2072162A1 (en) 1992-12-25
EP0520406A1 (en) 1992-12-30
KR100208867B1 (ko) 1999-07-15
DK0520406T3 (da) 1998-12-14
ATE170513T1 (de) 1998-09-15
DE69226822D1 (de) 1998-10-08
KR930000486A (ko) 1993-01-15
EP0742209A3 (en) 1997-05-14
US5473075A (en) 1995-12-05
JP3528186B2 (ja) 2004-05-17
CA2072162C (en) 2002-11-19
US5514804A (en) 1996-05-07
JPH05148237A (ja) 1993-06-15
US5284953A (en) 1994-02-08
EP0742209A2 (en) 1996-11-13

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