FI96947C - Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi

Info

Publication number
FI96947C
FI96947C FI891980A FI891980A FI96947C FI 96947 C FI96947 C FI 96947C FI 891980 A FI891980 A FI 891980A FI 891980 A FI891980 A FI 891980A FI 96947 C FI96947 C FI 96947C
Authority
FI
Finland
Prior art keywords
cis
acid derivatives
halocyclopropyl
preparation
pyridonecarboxylic acid
Prior art date
Application number
FI891980A
Other languages
English (en)
Swedish (sv)
Other versions
FI891980A (fi
FI891980A0 (fi
FI96947B (fi
Inventor
Isao Hayakawa
Youichi Kimura
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of FI891980A0 publication Critical patent/FI891980A0/fi
Publication of FI891980A publication Critical patent/FI891980A/fi
Publication of FI96947B publication Critical patent/FI96947B/fi
Application granted granted Critical
Publication of FI96947C publication Critical patent/FI96947C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI891980A 1988-04-27 1989-04-26 Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi FI96947C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP10462588 1988-04-27
JP10462588 1988-04-27
JP29698488 1988-11-24
JP29698488 1988-11-24

Publications (4)

Publication Number Publication Date
FI891980A0 FI891980A0 (fi) 1989-04-26
FI891980A FI891980A (fi) 1989-10-28
FI96947B FI96947B (fi) 1996-06-14
FI96947C true FI96947C (fi) 1996-09-25

Family

ID=26445063

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891980A FI96947C (fi) 1988-04-27 1989-04-26 Menetelmä terapeuttisesti aktiivisten N1-(1,2-cis-2-halogeenisyklopropyyli)substituoitujen pyridonikarboksyylihappojohdannaisten valmistamiseksi

Country Status (26)

Country Link
US (4) US5587386A (fi)
EP (1) EP0341493B1 (fi)
JP (5) JP2714597B2 (fi)
KR (1) KR0184614B1 (fi)
CN (1) CN1033751C (fi)
AT (1) ATE182145T1 (fi)
AU (1) AU625414B2 (fi)
BG (1) BG61122B2 (fi)
CA (1) CA1340801C (fi)
DE (1) DE68929030T2 (fi)
DK (1) DK175467B1 (fi)
ES (1) ES2135372T3 (fi)
FI (1) FI96947C (fi)
GR (1) GR3031365T3 (fi)
HK (1) HK1002108A1 (fi)
HU (1) HU211136A9 (fi)
IL (1) IL90062A (fi)
LV (1) LV10092B (fi)
MY (1) MY105136A (fi)
NO (1) NO175939C (fi)
NZ (1) NZ228893A (fi)
PT (1) PT90377B (fi)
RU (1) RU2075475C1 (fi)
SG (1) SG48036A1 (fi)
UA (1) UA29378C2 (fi)
YU (1) YU48432B (fi)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
CN1054980A (zh) * 1990-02-19 1991-10-02 杏林制药株式会社 具有旋光活性的8-甲氧基喹诺酮羧酸衍生物，它们的制备方法以及它们的中间体
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
WO1992021659A1 (en) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative
EP0641339B1 (en) * 1991-06-19 1999-09-15 Pfizer Inc. Azaspiro quinolone antibacterial agents
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
MX9700497A (es) * 1994-07-18 1997-04-30 Ube Industries Derivado de acido trifluorometilquinolinocarboxilico.
KR100389773B1 (ko) * 1995-02-02 2003-10-23 다이이찌 세이야꾸 가부시기가이샤 헤테로사이클릭화합물
PT816355E (pt) * 1995-02-07 2003-09-30 Daiichi Seiyaku Co Derivados espiro-heterociclicos
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
US6121285A (en) * 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
JP4040091B2 (ja) * 1995-11-22 2008-01-30 第一三共株式会社 置換アミノシクロアルキルピロリジン誘導体
CA2242242C (en) * 1996-02-09 2001-08-07 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
ID16655A (id) * 1996-04-24 1997-10-30 Daiichi Seiyaku Co Turunan-turunan sikloalkilaminometilpirolidina
WO1998024781A1 (fr) * 1996-12-04 1998-06-11 Daiichi Pharmaceutical Co., Ltd. Derives d'aminomethylpyrrolidine substitue
CN1173971C (zh) * 1998-11-24 2004-11-03 第一制药株式会社 环烷基取代的氨甲基吡咯烷衍生物
EP1182202B1 (en) 1999-03-10 2004-06-02 Daiichi Pharmaceutical Co., Ltd. Aminomethylpyrrolidine derivatives having aromatic substituents
RU2270695C2 (ru) 1999-03-17 2006-02-27 Дайити Фармасьютикал Ко., Лтд. Фармацевтическая композиция
US7176313B2 (en) * 2000-02-09 2007-02-13 Daiichi Pharmaceutical Co., Ltd. Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
WO2001072738A1 (fr) * 2000-03-31 2001-10-04 Daiichi Pharmaceutical Co., Ltd. Derive d'acide quinolone-carboxylique
PT1277471E (pt) * 2000-04-24 2008-08-26 Daiichi Sankyo Co Ltd Preparação líquida estável compreendendo sitafloxacina
CN1214792C (zh) 2000-08-08 2005-08-17 第一制药株式会社 吸收性很好的固体制剂
RU2004136997A (ru) * 2002-05-17 2005-06-27 Дайити Фармасьютикал Ко., Лтд. (JP) Способ получения производных хинолонкарбоновой кислоты
ATE488489T1 (de) * 2003-01-07 2010-12-15 Daiichi Sankyo Co Ltd Verfahren zur reduktiven deshalogenierung
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
EP1757598A4 (en) 2004-05-13 2010-07-21 Daiichi Seiyaku Co SUBSTITUTED PYRROLIDINE DERIVATIVE
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
WO2006123767A1 (ja) * 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited 不斉四置換炭素原子含有化合物の製法
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) * 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
CA2674369C (en) 2007-01-05 2012-04-03 Daiichi Sankyo Company, Limited Fused substituted aminopyrrolidine derivative
JP5414395B2 (ja) 2008-07-11 2014-02-12 住友化学株式会社 （１ｓ，２ｒ）−２−クロロ−２−フルオロシクロプロパンカルボン酸の製造方法
FR2961207B1 (fr) * 2010-06-09 2013-01-18 Oreal Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes
CN103467448B (zh) * 2013-09-18 2015-04-15 浙江司太立制药股份有限公司 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
EP2957561A1 (en) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
CN105330590B (zh) * 2015-10-15 2018-09-25 广州市朗启医药科技有限责任公司 西他沙星五元环侧链中间体的制备方法
CN109912504B (zh) * 2019-04-04 2020-11-10 山东省联合农药工业有限公司 一种喹啉羧酸类化合物及其制备方法与用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0191185B1 (en) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Quinoline-carboxylic acid derivatives
AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4657913A (en) 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4735949A (en) 1986-02-18 1988-04-05 Warner-Lambert Company Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
AU5123690A (en) * 1989-03-13 1990-09-13 Bristol-Myers Squibb Company 5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
WO2001072738A1 (fr) 2000-03-31 2001-10-04 Daiichi Pharmaceutical Co., Ltd. Derive d'acide quinolone-carboxylique
EP1757598A4 (en) * 2004-05-13 2010-07-21 Daiichi Seiyaku Co SUBSTITUTED PYRROLIDINE DERIVATIVE

Also Published As

Publication number Publication date
DK175467B1 (da) 2004-11-01
EP0341493A2 (en) 1989-11-15
RU2075475C1 (ru) 1997-03-20
SG48036A1 (en) 1998-04-17
KR0184614B1 (ko) 1999-05-01
HU211136A9 (en) 1995-10-30
NZ228893A (en) 1990-06-26
DK205789D0 (da) 1989-04-27
FI891980A (fi) 1989-10-28
AU3370289A (en) 1989-11-02
PT90377A (pt) 1989-11-10
KR900016205A (ko) 1990-11-12
DE68929030T2 (de) 2000-03-23
US5587386A (en) 1996-12-24
GR3031365T3 (en) 2000-01-31
LV10092B (en) 1995-02-20
US5767127A (en) 1998-06-16
JP2917010B2 (ja) 1999-07-12
HK1002108A1 (en) 1998-07-31
NO891698D0 (no) 1989-04-25
IL90062A0 (en) 1989-12-15
FI891980A0 (fi) 1989-04-26
EP0341493A3 (en) 1990-12-19
USRE41149E1 (en) 2010-02-23
CN1037507A (zh) 1989-11-29
AU625414B2 (en) 1992-07-09
NO891698L (no) 1989-10-30
IL90062A (en) 1994-10-07
PT90377B (pt) 1994-09-30
FI96947B (fi) 1996-06-14
JPH11124380A (ja) 1999-05-11
CN1033751C (zh) 1997-01-08
EP0341493B1 (en) 1999-07-14
UA29378C2 (uk) 2000-11-15
JPH02231475A (ja) 1990-09-13
JPH1067779A (ja) 1998-03-10
CA1340801C (en) 1999-10-26
MY105136A (en) 1994-08-30
JPH07300416A (ja) 1995-11-14
YU87589A (en) 1990-12-31
ES2135372T3 (es) 1999-11-01
DE68929030D1 (de) 1999-08-19
JPH11124367A (ja) 1999-05-11
JP2903292B2 (ja) 1999-06-07
US6031102A (en) 2000-02-29
ATE182145T1 (de) 1999-07-15
DK205789A (da) 1989-10-28
BG61122B2 (bg) 1996-11-29
NO175939C (no) 1995-01-04
YU48432B (sh) 1998-07-10
JP2714597B2 (ja) 1998-02-16
NO175939B (no) 1994-09-26

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Legal Events

Date Code Title Description
BB Publication of examined application
TC Name/ company changed in patent

Owner name: DAIICHI PHARMACEUTICAL CO., LTD.

FG Patent granted

Owner name: DAIICHI PHARMACEUTICAL CO., LTD.

MA Patent expired