DE69120221D1 - Pyrimidin-verbindung und ihr pharmazeutisch annehmbares salz - Google Patents

Pyrimidin-verbindung und ihr pharmazeutisch annehmbares salz

Info

Publication number
DE69120221D1
DE69120221D1 DE69120221T DE69120221T DE69120221D1 DE 69120221 D1 DE69120221 D1 DE 69120221D1 DE 69120221 T DE69120221 T DE 69120221T DE 69120221 T DE69120221 T DE 69120221T DE 69120221 D1 DE69120221 D1 DE 69120221D1
Authority
DE
Germany
Prior art keywords
pyrimidine compound
acceptable salt
neural diseases
represents substituted
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69120221T
Other languages
English (en)
Other versions
DE69120221T2 (de
Inventor
Akira Mizuchi
Ken Ikeda
Yuichiro Kokubun
Kazutoshi Horikomi
Tadayuki Sasaki
Akira Awaya
Ikuo Tomino
Masaharu Ishiguro
Takumi Kitahara
Noriaki Kihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP MITSUI PHA
Original Assignee
Mitsui Pharmaceuticals Inc
Mitsui Petrochemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Pharmaceuticals Inc, Mitsui Petrochemical Industries Ltd filed Critical Mitsui Pharmaceuticals Inc
Publication of DE69120221D1 publication Critical patent/DE69120221D1/de
Application granted granted Critical
Publication of DE69120221T2 publication Critical patent/DE69120221T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69120221T 1990-07-03 1991-07-03 Pyrimidin-verbindung und ihr pharmazeutisch annehmbares salz Expired - Fee Related DE69120221T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17607790 1990-07-03
PCT/JP1991/000898 WO1992000970A1 (fr) 1990-07-03 1991-07-03 Compose de pyrimidine et sel pharmaceutiquement acceptable de ce compose

Publications (2)

Publication Number Publication Date
DE69120221D1 true DE69120221D1 (de) 1996-07-18
DE69120221T2 DE69120221T2 (de) 1996-11-21

Family

ID=16007319

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69120221T Expired - Fee Related DE69120221T2 (de) 1990-07-03 1991-07-03 Pyrimidin-verbindung und ihr pharmazeutisch annehmbares salz

Country Status (7)

Country Link
US (1) US5358945A (de)
EP (1) EP0489925B1 (de)
KR (1) KR950007756B1 (de)
AT (1) ATE139117T1 (de)
CA (1) CA2065443A1 (de)
DE (1) DE69120221T2 (de)
WO (1) WO1992000970A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4406444A1 (de) 1994-02-28 1995-08-31 Huels Chemische Werke Ag Hydroxyl- und uretdiongruppenhaltige Polyadditionsprodukte und Verfahren zu ihrer Herstellung sowie deren Verwendung zur Herstellung abspaltfreier Polyurethan-Pulverlacke hoher Reaktivität und die danach hergestellten Polyurethan-Pulverlacke
US7101869B2 (en) * 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
WO2007125604A1 (ja) * 2006-04-28 2007-11-08 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 神経毒素の定量方法
PE20141581A1 (es) 2011-09-27 2014-11-14 Novartis Ag 3-pirmidin-4-il-oxazolidin-2-onas como inhibidores de la idh mutante
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
PE20151939A1 (es) 2013-03-14 2016-01-08 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008235A (en) * 1975-03-07 1977-02-15 Sterling Drug Inc. N-[2-(pyridinyl)-4-pyrimidinyl]ureas
JPS56103178A (en) * 1980-01-22 1981-08-18 Mitsui Petrochem Ind Ltd Pyrimidinoaminomethylenemalonic cyclic ester and its preparation
FI70411C (fi) * 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
JPS5846084A (ja) * 1981-09-14 1983-03-17 Mitsui Petrochem Ind Ltd ピリミジノアミノメチレンマロン酸エステル及びその製法
JPS6281375A (ja) * 1985-10-04 1987-04-14 Teikoku Chem Ind Corp Ltd ４−アミノ−２−ピペラジニルピリミジンの製造方法
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
JP2537703B2 (ja) * 1991-02-27 1996-09-25 オリオン機械株式会社 熱交換器のフィンの構造

Also Published As

Publication number Publication date
US5358945A (en) 1994-10-25
ATE139117T1 (de) 1996-06-15
KR950007756B1 (ko) 1995-07-14
WO1992000970A1 (fr) 1992-01-23
EP0489925A1 (de) 1992-06-17
EP0489925B1 (de) 1996-06-12
KR927002350A (ko) 1992-09-03
DE69120221T2 (de) 1996-11-21
EP0489925A4 (en) 1993-01-20
CA2065443A1 (en) 1992-01-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP MITSUI PHA

8339 Ceased/non-payment of the annual fee