PE20151939A1 - 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante - Google Patents

3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante

Info

Publication number
PE20151939A1
PE20151939A1 PE2015001929A PE2015001929A PE20151939A1 PE 20151939 A1 PE20151939 A1 PE 20151939A1 PE 2015001929 A PE2015001929 A PE 2015001929A PE 2015001929 A PE2015001929 A PE 2015001929A PE 20151939 A1 PE20151939 A1 PE 20151939A1
Authority
PE
Peru
Prior art keywords
oxazolidin
pyrimidin
onas
inhibitors
formula
Prior art date
Application number
PE2015001929A
Other languages
English (en)
Inventor
Thomas Raymond Caferro
Zhuoliang Chen
Young Shin Cho
Abran Q Costales
Julian Roy Levell
Gang Liu
Qian Zhao
Martin Sendzik
Cynthia Shafer
Michael David Shultz
James Sutton
Yaping Wang
James R Manning
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20151939A1 publication Critical patent/PE20151939A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere al desarroolo de derivados de 3-pirimidin-4-il-oxazolidin-2-ona de formula (I), o una sal farmaceuticamente aceptable del mismo, en donde R1, R2a, R2b y R3-R7 se definen en la presente. La invencion tambien se refiere a composiciones que contienen un compuesto de la formula (I) y al uso de tales compuestos en la inhibicion de proteinas IDH mutantes que tienen una actividad neomorfica. La invencion se refiere ademas al uso de un compuesto de la formula (I) en el tratamiento de enfermedades o trastornos asociados con tales proteinas IDH mutantes incluyendo pero sin limitar a, trastornos de proliferacion celular como el cancer
PE2015001929A 2013-03-14 2014-03-12 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante PE20151939A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783210P 2013-03-14 2013-03-14
US201361892131P 2013-10-17 2013-10-17

Publications (1)

Publication Number Publication Date
PE20151939A1 true PE20151939A1 (es) 2016-01-08

Family

ID=50382516

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015001929A PE20151939A1 (es) 2013-03-14 2014-03-12 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante

Country Status (29)

Country Link
US (4) US9434719B2 (es)
EP (1) EP2970240B1 (es)
JP (1) JP6387360B2 (es)
KR (1) KR20150131224A (es)
CN (1) CN105263929B (es)
AP (1) AP2015008707A0 (es)
AR (1) AR095311A1 (es)
AU (1) AU2014229313B2 (es)
BR (1) BR112015023412A8 (es)
CA (1) CA2903979A1 (es)
CL (1) CL2015002472A1 (es)
CR (1) CR20150491A (es)
CU (1) CU20150119A7 (es)
DO (1) DOP2015000240A (es)
EA (1) EA028033B1 (es)
ES (1) ES2665619T3 (es)
GE (1) GEP201706699B (es)
HK (1) HK1213251A1 (es)
IL (1) IL240972A0 (es)
MX (1) MX355945B (es)
NI (1) NI201500128A (es)
PE (1) PE20151939A1 (es)
PH (1) PH12015502018A1 (es)
SG (1) SG11201507063YA (es)
TN (1) TN2015000392A1 (es)
TW (1) TW201444831A (es)
UY (1) UY35470A (es)
WO (1) WO2014141104A1 (es)
ZA (1) ZA201506452B (es)

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