DE68919378T2 - Thienotriazolodiazepine und ihre pharmazeutische Verwendung. - Google Patents

Thienotriazolodiazepine und ihre pharmazeutische Verwendung.

Info

Publication number
DE68919378T2
DE68919378T2 DE68919378T DE68919378T DE68919378T2 DE 68919378 T2 DE68919378 T2 DE 68919378T2 DE 68919378 T DE68919378 T DE 68919378T DE 68919378 T DE68919378 T DE 68919378T DE 68919378 T2 DE68919378 T2 DE 68919378T2
Authority
DE
Germany
Prior art keywords
thienotriazolodiazepines
pharmaceutical use
paf
pharmaceutically
spedification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68919378T
Other languages
English (en)
Other versions
DE68919378D1 (de
Inventor
Minoru Moriwaki
Youichi Akiyama
Ken-Ichi Demizu
Hiroshi Mikashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of DE68919378D1 publication Critical patent/DE68919378D1/de
Application granted granted Critical
Publication of DE68919378T2 publication Critical patent/DE68919378T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE68919378T 1988-05-17 1989-05-16 Thienotriazolodiazepine und ihre pharmazeutische Verwendung. Expired - Fee Related DE68919378T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11971388 1988-05-17

Publications (2)

Publication Number Publication Date
DE68919378D1 DE68919378D1 (de) 1994-12-22
DE68919378T2 true DE68919378T2 (de) 1995-03-30

Family

ID=14768268

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68919378T Expired - Fee Related DE68919378T2 (de) 1988-05-17 1989-05-16 Thienotriazolodiazepine und ihre pharmazeutische Verwendung.

Country Status (8)

Country Link
US (1) US4910194A (de)
EP (1) EP0342587B1 (de)
JP (1) JPH0641471B2 (de)
KR (1) KR910007978B1 (de)
AT (1) ATE114154T1 (de)
CA (1) CA1322367C (de)
DE (1) DE68919378T2 (de)
ES (1) ES2068216T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
FR2659332B1 (fr) * 1990-03-08 1994-04-29 Adit Et Cie Nouvelles pyrrolo [1,2-a] thieno [3,2-f] diazepines [1,4], leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
EP0995752A4 (de) 1997-06-25 2001-08-16 Nikken Chemicals Co Ltd Tirazolo-1,4-diazepin-derivate und sie enthaltende medizinische zubereitung
US6252756B1 (en) * 1998-09-18 2001-06-26 Illinois Tool Works Inc. Low voltage modular room ionization system
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (de) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendung
EP2721031B1 (de) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendungen
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
CA2952830C (en) 2014-06-20 2022-11-01 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3777541D1 (de) * 1986-11-17 1992-04-23 Yoshitomi Pharmaceutical Paf-antagonistische thienotriazoldiazepin-verbindungen und deren pharmazeutische anwendung.

Also Published As

Publication number Publication date
JPH0641471B2 (ja) 1994-06-01
KR910007978B1 (ko) 1991-10-05
DE68919378D1 (de) 1994-12-22
EP0342587A2 (de) 1989-11-23
JPH0249787A (ja) 1990-02-20
CA1322367C (en) 1993-09-21
US4910194A (en) 1990-03-20
ATE114154T1 (de) 1994-12-15
ES2068216T3 (es) 1995-04-16
EP0342587A3 (de) 1991-05-22
KR890017252A (ko) 1989-12-15
EP0342587B1 (de) 1994-11-17

Similar Documents

Publication Publication Date Title
HU913283D0 (en) Process for the production of hydroximethyl-(methylene-cyclopentyl)-purines and pirimidines, their medically usable salts, and of medical preparations containing them
DE69321525D1 (de) Morphinan-derivate und medizinische verwendung
ES8705886A1 (es) Un metodo para preparar un derivadode tiazolidin-diona
BR0211228A (pt) Composto, composição farmacêutica e seus usos
ATE81009T1 (de) N-acetyl-3-fluoroneuraminsaeure als antivirales arzneimittel.
LV12457A (lv) Acil-piperazinil-pirimidinu atvasinajumi to iegusana un izmantosana par medikamentiem
ATE110071T1 (de) Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DE68919378T2 (de) Thienotriazolodiazepine und ihre pharmazeutische Verwendung.
ATE141605T1 (de) Thienotriazoldiazepinverbindungen und deren pharmazeutische anwendungen
ATE92489T1 (de) Imid-derivate, ihre herstellung und verwendung.
DE68922035D1 (de) Glyzerin-Derivat und dessen pharmazeutische Verwendung.
DE3872425D1 (de) Substituierte tetrahydroisochinolin-verbindungen, ihre herstellung und diese enthaltende pharmazeutische mittel.
ATE144515T1 (de) Pyridylthiazolidinsäureamid-derivate, ihre herstellung und therapeutische verwendungen
ATE75399T1 (de) Therapeutikum zur behandlung von magengeschwueren.
ATE88176T1 (de) 2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
EP0299076A4 (en) 5-hydroxyindole-3-carboxamide compound and medicinal use thereof
DE3884878T2 (de) Uricosuretische Zusammensetzung.
ATE81466T1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
NO933199L (no) Heteroarenylpiperaziner, fremgangsmåte for deres fremstilling og anvendelse derav som legemidler
ATE81465T1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
TH13808EX (th) อนุพันธ์ของพิเพอแรซิน และอนุพันธ์ของพิเพอริดิน

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WELFIDE CORP., OSAKA, JP

8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI PHARMA CORP., OSAKA, JP

8339 Ceased/non-payment of the annual fee