KR927002350A - 피리미딘 화합물 및 그의 약학적으로 허용되는 염류 - Google Patents

피리미딘 화합물 및 그의 약학적으로 허용되는 염류 Download PDF

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KR927002350A
KR927002350A KR1019920700487A KR920700487A KR927002350A KR 927002350 A KR927002350 A KR 927002350A KR 1019920700487 A KR1019920700487 A KR 1019920700487A KR 920700487 A KR920700487 A KR 920700487A KR 927002350 A KR927002350 A KR 927002350A
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South Korea
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group
pharmaceutically acceptable
hydrogen atom
salt
lower alkyl
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KR1019920700487A
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English (en)
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KR950007756B1 (ko
Inventor
아끼라 미즈찌
껜 이께다
유이찌로 고꾸분
까즈토시 호리꼬미
타다유끼 사사끼
아끼라 아와야
이꾸오 토미노
마사하루 이시구로
타꾸미 기타하라
노리아끼 기하라
Original Assignee
미쓰이세이야꾸 가부시끼가이샤
다께바야시 쇼오고
미쓰이세끼유 가가꾸고오교오 가부시끼가이샤
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Publication of KR927002350A publication Critical patent/KR927002350A/ko
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Publication of KR950007756B1 publication Critical patent/KR950007756B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

피리미딘 화합물 및 그의 약학적으로 허용되는 염류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(Ⅰ)
    ｛식중, X는 다음의 기
    (식중, R1,R1′는 동일하여도 달라도 좋고 수소원자, 저급알킬기, 벤질기, 페닐기 또는 저급알콕시카보닐),(식중, R2′및 R3′는 저급알킬임)또는
    (식중 R4′는 수소원자, 저급알킬기, 페닐기 또는 벤질기임)이고, Y는〔식중, R2는 수소원자 또는 저급알킬기, R3는 저급아씰기,
    (식중 R4는 수소원자, 트리후루오로메틸기, 수산기, 시아노기, 포밀기, 저급아씰기, 저급알콕시 카보닐기 또는 후루오르 슬포닐기임)
    임｝포 표시되는 피리미딘 화합물 또는 그 약학적으로 허용되는 염류.
  2. 제1항에 있어서, 약학적으로 허용되는 염이 염산염, 쉬화수소산염, 황산염, 중황산염, 인산염, 산성인산염, 초산염, 마레인산염, 후말산염, 호박산염, 젖산염, 주석산염, 안식향산염, 구연산염, 글루콘산염, 당산염, 메탈슬포산염, P-톨루엔슬폰산염, 나프탈린 슬폰산염 및 제4급 암모니움염으로 된 군에서 선택한 것인 피리미딘 화합물 또는 그 약학적으로 허용되는 염류.
  3. 제1항 기재의 화합물 또는 그 약학적으로 허용되는 염류를 유효성분으로 함유함을 특징으로 하는 신경질환용 치료약.
  4. 제3항에 있어서, 약학적으로 허용되는 염이 염산염, 쉬화수소산염, 황산염, 중황산염, 인산염, 산성인산염, 초산염, 마레인산염, 후말산염, 호박산염, 젖산염,주석산염, 안식향산염, 구연산염, 글루콘산염, 당산염, 메탄슬폰산염, P-톨루엔슬폰산염, 나프탈렌 슬폰산염 및 제4급 암모니움염으로 된 군에서 선택한 것인 신경질환용 치료약.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920700487A 1990-07-03 1991-07-03 피리미딘 화합물 및 그의 약학적으로 허용되는 염류 KR950007756B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17607790 1990-07-03
JP90-176077 1990-07-03
PCT/JP1991/000898 WO1992000970A1 (fr) 1990-07-03 1991-07-03 Compose de pyrimidine et sel pharmaceutiquement acceptable de ce compose

Publications (2)

Publication Number Publication Date
KR927002350A true KR927002350A (ko) 1992-09-03
KR950007756B1 KR950007756B1 (ko) 1995-07-14

Family

ID=16007319

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920700487A KR950007756B1 (ko) 1990-07-03 1991-07-03 피리미딘 화합물 및 그의 약학적으로 허용되는 염류

Country Status (7)

Country Link
US (1) US5358945A (ko)
EP (1) EP0489925B1 (ko)
KR (1) KR950007756B1 (ko)
AT (1) ATE139117T1 (ko)
CA (1) CA2065443A1 (ko)
DE (1) DE69120221T2 (ko)
WO (1) WO1992000970A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4406444A1 (de) 1994-02-28 1995-08-31 Huels Chemische Werke Ag Hydroxyl- und uretdiongruppenhaltige Polyadditionsprodukte und Verfahren zu ihrer Herstellung sowie deren Verwendung zur Herstellung abspaltfreier Polyurethan-Pulverlacke hoher Reaktivität und die danach hergestellten Polyurethan-Pulverlacke
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
US8949033B2 (en) * 2006-04-28 2015-02-03 The Chemo-Sero-Therapeutic Research Institute Method for quantification of neurotoxin
MX342326B (es) 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
ES2665619T3 (es) 2013-03-14 2018-04-26 Novartis Ag 3-Pirimidin-4-il-oxazolidin-2-onas como inhibidores de IDH mutante

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008235A (en) * 1975-03-07 1977-02-15 Sterling Drug Inc. N-[2-(pyridinyl)-4-pyrimidinyl]ureas
JPS56103178A (en) * 1980-01-22 1981-08-18 Mitsui Petrochem Ind Ltd Pyrimidinoaminomethylenemalonic cyclic ester and its preparation
FI70411C (fi) * 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
JPS5846084A (ja) * 1981-09-14 1983-03-17 Mitsui Petrochem Ind Ltd ピリミジノアミノメチレンマロン酸エステル及びその製法
JPS6281375A (ja) * 1985-10-04 1987-04-14 Teikoku Chem Ind Corp Ltd ４−アミノ−２−ピペラジニルピリミジンの製造方法
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
JP2537703B2 (ja) * 1991-02-27 1996-09-25 オリオン機械株式会社 熱交換器のフィンの構造

Also Published As

Publication number Publication date
CA2065443A1 (en) 1992-01-04
ATE139117T1 (de) 1996-06-15
DE69120221D1 (de) 1996-07-18
WO1992000970A1 (fr) 1992-01-23
US5358945A (en) 1994-10-25
EP0489925A4 (en) 1993-01-20
KR950007756B1 (ko) 1995-07-14
DE69120221T2 (de) 1996-11-21
EP0489925A1 (en) 1992-06-17
EP0489925B1 (en) 1996-06-12

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