ATE305783T1 - Verwendung von diaminotrifluoromethylpyridinderivaten für die prevention und behandlung von lebererkrankungen - Google Patents
Verwendung von diaminotrifluoromethylpyridinderivaten für die prevention und behandlung von lebererkrankungenInfo
- Publication number
- ATE305783T1 ATE305783T1 AT01948938T AT01948938T ATE305783T1 AT E305783 T1 ATE305783 T1 AT E305783T1 AT 01948938 T AT01948938 T AT 01948938T AT 01948938 T AT01948938 T AT 01948938T AT E305783 T1 ATE305783 T1 AT E305783T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl
- prevention
- treatment
- liver disease
- Prior art date
Links
- UVPXDGMMAFWHMJ-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3,4-diamine Chemical class NC1=CC=NC(C(F)(F)F)=C1N UVPXDGMMAFWHMJ-UHFFFAOYSA-N 0.000 title abstract 2
- 208000019423 liver disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 125000004585 polycyclic heterocycle group Chemical group 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000024350 | 2000-02-01 | ||
| PCT/JP2001/000615 WO2001056569A1 (en) | 2000-02-01 | 2001-01-30 | Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305783T1 true ATE305783T1 (de) | 2005-10-15 |
Family
ID=18550354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01948938T ATE305783T1 (de) | 2000-02-01 | 2001-01-30 | Verwendung von diaminotrifluoromethylpyridinderivaten für die prevention und behandlung von lebererkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6664279B2 (de) |
| EP (1) | EP1252891B1 (de) |
| AT (1) | ATE305783T1 (de) |
| AU (1) | AU2001228862A1 (de) |
| DE (1) | DE60113808T2 (de) |
| TW (1) | TWI257864B (de) |
| WO (1) | WO2001056569A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101246568B1 (ko) * | 2006-06-09 | 2013-03-25 | 삼성전자주식회사 | 모바일 디스플레이 장치에서 가로 화면을 디스플레이하는방법과 장치 및 이를 포함하는 모바일 액정 표시 장치 |
| JP5584518B2 (ja) | 2009-05-28 | 2014-09-03 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤 |
| KR20200083500A (ko) | 2017-11-02 | 2020-07-08 | 이시하라 산교 가부시끼가이샤 | 서방성 의약 조성물 |
| WO2019167979A1 (ja) | 2018-03-01 | 2019-09-06 | 石原産業株式会社 | 保存安定性に優れた医薬組成物 |
| TWI858061B (zh) | 2019-05-15 | 2024-10-11 | 日商石原產業股份有限公司 | Ｎ－（２－乙基磺醯基胺基－５－三氟甲基－３－吡啶基）環己烷羧醯胺．一鈉鹽之無水合物結晶體 |
| CA3194011A1 (en) | 2020-09-29 | 2022-04-07 | Ishihara Sangyo Kaisha, Ltd. | Liquid-state pharmaceutical composition exhibiting excellent preservative effectiveness |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2777678B2 (ja) | 1990-06-11 | 1998-07-23 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子及びその製造方法 |
| ATE157969T1 (de) * | 1990-07-10 | 1997-09-15 | Ishihara Sangyo Kaisha | Diaminotrifluoromethylpyrimidinderivate, verfahren zu ihrer herstellung und diese enthaltende phospholipase-a2-inhibitoren |
| US5229403A (en) * | 1990-07-10 | 1993-07-20 | Ishihara Sangyo Kaisha Ltd. | Diaminotrifluoromethylpyridine derivatives and phospholipase A2 inhibitor containing them |
| JPH06239856A (ja) | 1993-02-15 | 1994-08-30 | Shin Nippon Yakuhin Kk | １，３−ベンゾオキサチオール−２−チオン誘導体 |
| JP3186365B2 (ja) | 1993-09-02 | 2001-07-11 | 日本油脂株式会社 | 肝疾患治療薬 |
| JPH10298076A (ja) | 1997-02-28 | 1998-11-10 | Ishihara Sangyo Kaisha Ltd | 抗癌剤 |
| ZA981430B (en) * | 1997-02-28 | 1998-08-24 | Ishihara Sangyo Kaisha | Anticancer composition |
| JPH11228563A (ja) | 1998-02-19 | 1999-08-24 | Dainippon Pharmaceut Co Ltd | ３−ヒドロキシ−２，３−ジヒドロベンゾフラン（又はベンゾチオフェン）誘導体及びそれを有効成分とする肝疾患治療薬 |
-
2001
- 2001-01-30 EP EP01948938A patent/EP1252891B1/de not_active Expired - Lifetime
- 2001-01-30 DE DE60113808T patent/DE60113808T2/de not_active Expired - Lifetime
- 2001-01-30 US US10/182,466 patent/US6664279B2/en not_active Expired - Lifetime
- 2001-01-30 WO PCT/JP2001/000615 patent/WO2001056569A1/ja not_active Ceased
- 2001-01-30 AU AU2001228862A patent/AU2001228862A1/en not_active Abandoned
- 2001-01-30 AT AT01948938T patent/ATE305783T1/de not_active IP Right Cessation
- 2001-01-31 TW TW090101938A patent/TWI257864B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20030018054A1 (en) | 2003-01-23 |
| US6664279B2 (en) | 2003-12-16 |
| DE60113808T2 (de) | 2006-05-18 |
| TWI257864B (en) | 2006-07-11 |
| AU2001228862A1 (en) | 2001-08-14 |
| WO2001056569A1 (en) | 2001-08-09 |
| EP1252891A4 (de) | 2003-05-14 |
| EP1252891B1 (de) | 2005-10-05 |
| EP1252891A1 (de) | 2002-10-30 |
| DE60113808D1 (de) | 2006-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |