ATE239732T1 - Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung - Google Patents
Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendungInfo
- Publication number
- ATE239732T1 ATE239732T1 AT93921084T AT93921084T ATE239732T1 AT E239732 T1 ATE239732 T1 AT E239732T1 AT 93921084 T AT93921084 T AT 93921084T AT 93921084 T AT93921084 T AT 93921084T AT E239732 T1 ATE239732 T1 AT E239732T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- indole derivative
- production
- represents hydrogen
- medical application
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000004958 brain cell Anatomy 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25984192 | 1992-09-29 | ||
| PCT/JP1993/001388 WO1994007896A1 (en) | 1992-09-29 | 1993-09-29 | Indole derivative, process for producing the same, and medicinal use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239732T1 true ATE239732T1 (de) | 2003-05-15 |
Family
ID=17339733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93921084T ATE239732T1 (de) | 1992-09-29 | 1993-09-29 | Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6087369A (de) |
| EP (1) | EP0614898B1 (de) |
| JP (1) | JP3605825B2 (de) |
| KR (1) | KR100301093B1 (de) |
| CN (1) | CN1043766C (de) |
| AT (1) | ATE239732T1 (de) |
| AU (1) | AU672033B2 (de) |
| CA (1) | CA2124455C (de) |
| DE (1) | DE69332945T2 (de) |
| ES (1) | ES2199220T3 (de) |
| FI (1) | FI942499A (de) |
| NO (1) | NO941977L (de) |
| TW (1) | TW271440B (de) |
| WO (1) | WO1994007896A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU672033B2 (en) | 1992-09-29 | 1996-09-19 | Toray Industries, Inc. | Indole derivative, process for producing the same, and medicinal use thereof |
| US5464841A (en) * | 1993-11-08 | 1995-11-07 | Univ Minnesota | Use of delta opioid receptor antagonists to treat immunoregulatory disorders |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| SE9401728D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds II |
| US5578725A (en) * | 1995-01-30 | 1996-11-26 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5849731A (en) * | 1995-09-26 | 1998-12-15 | Toray Industries, Inc. | Indole derivatives and medical application thereof |
| US5994327A (en) * | 1995-11-17 | 1999-11-30 | Astra Ab | Process for the preparation of morphinans |
| WO1997025331A1 (en) | 1996-01-10 | 1997-07-17 | Smithkline Beecham S.P.A. | Heterocycle-condensed morphinoid derivatives (ii) |
| AU739367B2 (en) * | 1997-01-16 | 2001-10-11 | Toray Industries, Inc. | Indolomorphinan derivative and agent for curing and preventing cerebral disorder |
| AU6520198A (en) | 1997-03-31 | 1998-10-22 | Toray Industries, Inc. | Quinolinomorphinane derivatives and medicinal use thereof |
| US5986141A (en) * | 1998-09-29 | 1999-11-16 | Eastman Chemical Company | Process for the production of cyclopropanemethylamine |
| CA2383146C (en) * | 1999-08-24 | 2010-11-16 | Hiroshi Nagase | Therapeutic agent for neuropathic pain and neuropathic pain animal model |
| US8205237B2 (en) | 2000-09-14 | 2012-06-19 | Cox Ingemar J | Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet |
| US7232829B2 (en) | 2001-04-06 | 2007-06-19 | Regents Of The University Of Minnesota | Therapeutic compounds and methods |
| JP2004529161A (ja) | 2001-05-04 | 2004-09-24 | トゥラリック インコーポレイテッド | 縮合複素環式化合物 |
| US6809104B2 (en) | 2001-05-04 | 2004-10-26 | Tularik Inc. | Fused heterocyclic compounds |
| WO2003063779A2 (en) * | 2002-01-25 | 2003-08-07 | Regents Of The University Of Minnesota | Selective analgesic agents |
| CN1330651C (zh) | 2002-11-06 | 2007-08-08 | 安姆根有限公司 | 稠合杂环化合物 |
| EP1595541A1 (de) * | 2004-05-12 | 2005-11-16 | Alcasynn Pharmaceuticals Gmbh | Verwendung von Opioid-Rezeptor Antagonisten zur Vorbeugung und/oder Behandlung von Krankheiten die im zusammenhang mit den Angrifftspunkt Calcineurin stehen |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3631829A1 (de) * | 1986-09-19 | 1988-07-28 | Hoechst Ag | Klonierung und verwendung des transaminase gens-tyrb |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JP2906654B2 (ja) * | 1989-11-28 | 1999-06-21 | 東レ株式会社 | 免疫抑制剤及びその製造方法 |
| JPH04342529A (ja) * | 1991-05-21 | 1992-11-30 | Toray Ind Inc | 抗アレルギー剤 |
| US5225417A (en) * | 1992-01-21 | 1993-07-06 | G. D. Searle & Co. | Opioid agonist compounds |
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| US5352680A (en) * | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
| AU672033B2 (en) * | 1992-09-29 | 1996-09-19 | Toray Industries, Inc. | Indole derivative, process for producing the same, and medicinal use thereof |
| US5457208A (en) * | 1993-06-21 | 1995-10-10 | Regents Of The University Of Minnesota | Kappa opioid receptor antagonists |
| US5849731A (en) * | 1995-09-26 | 1998-12-15 | Toray Industries, Inc. | Indole derivatives and medical application thereof |
-
1993
- 1993-09-29 AU AU48341/93A patent/AU672033B2/en not_active Ceased
- 1993-09-29 EP EP93921084A patent/EP0614898B1/de not_active Expired - Lifetime
- 1993-09-29 DE DE69332945T patent/DE69332945T2/de not_active Expired - Fee Related
- 1993-09-29 CN CN93114196A patent/CN1043766C/zh not_active Expired - Fee Related
- 1993-09-29 CA CA002124455A patent/CA2124455C/en not_active Expired - Fee Related
- 1993-09-29 AT AT93921084T patent/ATE239732T1/de not_active IP Right Cessation
- 1993-09-29 KR KR1019940701818A patent/KR100301093B1/ko not_active IP Right Cessation
- 1993-09-29 ES ES93921084T patent/ES2199220T3/es not_active Expired - Lifetime
- 1993-09-29 JP JP50889694A patent/JP3605825B2/ja not_active Expired - Fee Related
- 1993-09-29 WO PCT/JP1993/001388 patent/WO1994007896A1/ja active IP Right Grant
- 1993-11-19 TW TW082109756A patent/TW271440B/zh active
-
1994
- 1994-05-27 NO NO941977A patent/NO941977L/no unknown
- 1994-05-27 FI FI942499A patent/FI942499A/fi unknown
-
1998
- 1998-08-18 US US09/135,580 patent/US6087369A/en not_active Expired - Fee Related
-
1999
- 1999-12-22 US US09/469,544 patent/US6291470B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994007896A1 (en) | 1994-04-14 |
| CA2124455C (en) | 2004-09-14 |
| AU672033B2 (en) | 1996-09-19 |
| EP0614898B1 (de) | 2003-05-07 |
| CA2124455A1 (en) | 1994-04-14 |
| CN1043766C (zh) | 1999-06-23 |
| DE69332945D1 (de) | 2003-06-12 |
| AU4834193A (en) | 1994-04-26 |
| US6087369A (en) | 2000-07-11 |
| NO941977D0 (no) | 1994-05-27 |
| TW271440B (de) | 1996-03-01 |
| FI942499A (fi) | 1994-07-27 |
| NO941977L (no) | 1994-07-29 |
| FI942499A0 (fi) | 1994-05-27 |
| KR100301093B1 (ko) | 2001-10-22 |
| EP0614898A1 (de) | 1994-09-14 |
| ES2199220T3 (es) | 2004-02-16 |
| JP3605825B2 (ja) | 2004-12-22 |
| DE69332945T2 (de) | 2004-05-19 |
| EP0614898A4 (de) | 1994-10-12 |
| CN1092425A (zh) | 1994-09-21 |
| US6291470B1 (en) | 2001-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |