DE69332945D1 - Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung - Google Patents

Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung

Info

Publication number
DE69332945D1
DE69332945D1 DE69332945T DE69332945T DE69332945D1 DE 69332945 D1 DE69332945 D1 DE 69332945D1 DE 69332945 T DE69332945 T DE 69332945T DE 69332945 T DE69332945 T DE 69332945T DE 69332945 D1 DE69332945 D1 DE 69332945D1
Authority
DE
Germany
Prior art keywords
alkyl
production
represents hydrogen
medical application
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69332945T
Other languages
English (en)
Other versions
DE69332945T2 (de
Inventor
Hiroshi Nagase
Akira Mizusuna
Koji Kawai
Izumi Nakatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69332945D1 publication Critical patent/DE69332945D1/de
Publication of DE69332945T2 publication Critical patent/DE69332945T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE69332945T 1992-09-29 1993-09-29 Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung Expired - Fee Related DE69332945T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25984192 1992-09-29
JP25984192 1992-09-29
PCT/JP1993/001388 WO1994007896A1 (en) 1992-09-29 1993-09-29 Indole derivative, process for producing the same, and medicinal use thereof

Publications (2)

Publication Number Publication Date
DE69332945D1 true DE69332945D1 (de) 2003-06-12
DE69332945T2 DE69332945T2 (de) 2004-05-19

Family

ID=17339733

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332945T Expired - Fee Related DE69332945T2 (de) 1992-09-29 1993-09-29 Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung

Country Status (14)

Country Link
US (2) US6087369A (de)
EP (1) EP0614898B1 (de)
JP (1) JP3605825B2 (de)
KR (1) KR100301093B1 (de)
CN (1) CN1043766C (de)
AT (1) ATE239732T1 (de)
AU (1) AU672033B2 (de)
CA (1) CA2124455C (de)
DE (1) DE69332945T2 (de)
ES (1) ES2199220T3 (de)
FI (1) FI942499A (de)
NO (1) NO941977L (de)
TW (1) TW271440B (de)
WO (1) WO1994007896A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69332945T2 (de) * 1992-09-29 2004-05-19 Toray Industries, Inc. Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
EP0805157B1 (de) * 1995-09-26 2003-06-04 Toray Industries, Inc. Indolderivate und ihre medizinische verwendung
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
KR19990077125A (ko) * 1996-01-10 1999-10-25 파올로 비지, 엔리꼬 카쭐라니 헤테로고리-축합 모르핀 유도체 (ⅱ)
JP4110579B2 (ja) * 1997-01-16 2008-07-02 東レ株式会社 インドロモルヒナン誘導体および脳障害治療・予防剤
WO1998043977A1 (fr) * 1997-03-31 1998-10-08 Toray Industries, Inc. Derives de quinolinomorphinane et leur usage medical
US5986141A (en) * 1998-09-29 1999-11-16 Eastman Chemical Company Process for the production of cyclopropanemethylamine
EP1219624B1 (de) * 1999-08-24 2008-07-09 Toray Industries, Inc. Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes
US8205237B2 (en) 2000-09-14 2012-06-19 Cox Ingemar J Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
WO2002089729A2 (en) 2001-05-04 2002-11-14 Tularik Inc. Fused heterocyclic compounds
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
AU2003205332A1 (en) * 2002-01-25 2003-09-02 Philip S. Portoghese Selective analgesic agents
KR20050103184A (ko) 2002-11-06 2005-10-27 암젠 인코포레이션 융합된 헤테로사이클릭 화합물들
EP1595541A1 (de) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Verwendung von Opioid-Rezeptor Antagonisten zur Vorbeugung und/oder Behandlung von Krankheiten die im zusammenhang mit den Angrifftspunkt Calcineurin stehen
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631829A1 (de) * 1986-09-19 1988-07-28 Hoechst Ag Klonierung und verwendung des transaminase gens-tyrb
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
DE69332945T2 (de) * 1992-09-29 2004-05-19 Toray Industries, Inc. Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung
US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
EP0805157B1 (de) * 1995-09-26 2003-06-04 Toray Industries, Inc. Indolderivate und ihre medizinische verwendung

Also Published As

Publication number Publication date
ATE239732T1 (de) 2003-05-15
US6291470B1 (en) 2001-09-18
NO941977D0 (no) 1994-05-27
NO941977L (no) 1994-07-29
US6087369A (en) 2000-07-11
EP0614898B1 (de) 2003-05-07
EP0614898A1 (de) 1994-09-14
JP3605825B2 (ja) 2004-12-22
DE69332945T2 (de) 2004-05-19
CA2124455C (en) 2004-09-14
FI942499A0 (fi) 1994-05-27
KR100301093B1 (ko) 2001-10-22
TW271440B (de) 1996-03-01
FI942499A (fi) 1994-07-27
AU672033B2 (en) 1996-09-19
CN1092425A (zh) 1994-09-21
WO1994007896A1 (en) 1994-04-14
AU4834193A (en) 1994-04-26
CN1043766C (zh) 1999-06-23
EP0614898A4 (de) 1994-10-12
ES2199220T3 (es) 2004-02-16
CA2124455A1 (en) 1994-04-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee