PT88526A - L-dopa derivatives or their acid addition salts process for producing same and their use - Google Patents
L-dopa derivatives or their acid addition salts process for producing same and their useInfo
- Publication number
- PT88526A PT88526A PT88526A PT8852688A PT88526A PT 88526 A PT88526 A PT 88526A PT 88526 A PT88526 A PT 88526A PT 8852688 A PT8852688 A PT 8852688A PT 88526 A PT88526 A PT 88526A
- Authority
- PT
- Portugal
- Prior art keywords
- optionally substituted
- acid addition
- addition salts
- denotes
- producing same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23429987 | 1987-09-18 | ||
| JP3126088 | 1988-02-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT88526A true PT88526A (pt) | 1988-10-01 |
| PT88526B PT88526B (pt) | 1992-11-30 |
Family
ID=26369718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT88526A PT88526B (pt) | 1987-09-18 | 1988-09-16 | Processo de producao de derivados de l-dopa, dos seus sais de adicao de acido e de composicoes farmaceuticas contendo os mesmos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4966915A (pt) |
| EP (1) | EP0309827B1 (pt) |
| JP (1) | JPH02138A (pt) |
| KR (1) | KR890005031A (pt) |
| CN (1) | CN1032785A (pt) |
| AT (1) | ATE71083T1 (pt) |
| AU (1) | AU2234088A (pt) |
| CA (1) | CA1316180C (pt) |
| DE (1) | DE3867403D1 (pt) |
| DK (1) | DK517588A (pt) |
| IL (1) | IL87765A0 (pt) |
| PT (1) | PT88526B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2314189T3 (es) * | 2002-02-15 | 2009-03-16 | Darpharma, Inc. | Profarmacos monoester y diester asimetricamente sustituidos de los agonistas del receptor d1 de dopamina. |
| US7101912B2 (en) | 2002-12-06 | 2006-09-05 | Xenoport, Inc. | Carbidopa prodrugs and derivatives, and compositions and uses thereof |
| US7471862B2 (en) | 2002-12-19 | 2008-12-30 | Corning Cable Systems, Llc | Dry fiber optic cables and assemblies |
| US6970629B2 (en) | 2002-12-19 | 2005-11-29 | Corning Cable Systems Llc | Optical tube assembly having a dry insert and methods of making the same |
| US20090190890A1 (en) | 2002-12-19 | 2009-07-30 | Freeland Riley S | Fiber optic cable having a dry insert and methods of making the same |
| IL154318A (en) | 2003-02-06 | 2010-05-31 | Sarah Herzog Memorial Hospital | Pharmaceutical compositions for the treatment of movement disorders |
| ZA200610042B (en) | 2004-06-04 | 2008-06-25 | Xenoport Inc | Levodopa prodrugs, and compositions and uses thereof |
| US7323585B2 (en) | 2004-06-04 | 2008-01-29 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| BRPI0619425A2 (pt) * | 2005-12-05 | 2011-10-04 | Xenoport Inc | mesilato de pró-fármaco de levedopa, composição farmacêutica, método de preparar (2s)-2- amino-3-(3,4-diidróxi fenil) propanoato de mesilato de (2r)-2- fenil carbonilóxi propila e uso do referido composto |
| US7829592B2 (en) * | 2006-12-21 | 2010-11-09 | Xenoport, Inc. | Catechol protected levodopa diester prodrugs, compositions, and methods of use |
| WO2008076458A1 (en) | 2006-12-21 | 2008-06-26 | Xenoport, Inc. | Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use |
| US8399513B2 (en) | 2008-10-20 | 2013-03-19 | Xenoport, Inc. | Levodopa prodrug mesylate hydrate |
| CA2740017A1 (en) | 2008-10-20 | 2010-04-29 | Xenoport, Inc. | Methods of synthesizing a levodopa ester prodrug |
| KR101025612B1 (ko) * | 2008-11-10 | 2011-03-30 | 한국해양연구원 | 신규 화합물인 Ｒａｍａｌｉｎ 및 그 용도 |
| US8435562B2 (en) | 2009-11-09 | 2013-05-07 | Xenoport, Inc. | Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use |
| BR112012018256A8 (pt) | 2010-03-04 | 2017-12-19 | Orion Corp | método de tratamento de doença de parkinson |
| CN103694127B (zh) * | 2013-12-30 | 2015-04-01 | 上海交通大学 | 链霉菌属菌种所产的化合物及该化合物的制备方法和应用 |
| PT3209302T (pt) | 2014-10-21 | 2019-07-19 | Abbvie Inc | Profármacos de carbidopa e l-dopa e a sua utilização para tratar doença de parkinson |
| EP3291872A4 (en) | 2015-05-06 | 2019-02-13 | SynAgile Corporation | PHARMACEUTICAL SUSPENSIONS WITH ACTIVE SUBSTANCES, DEVICES FOR THEIR ADMINISTRATION AND METHOD FOR THEIR USE |
| WO2019097120A1 (en) | 2017-11-16 | 2019-05-23 | Orion Corporation | New use and pharmaceutical dosage forms |
| US20220213128A1 (en) * | 2021-01-03 | 2022-07-07 | RockGen Therapeutics LLC | L-Dopa Enhanced with a Neuroprotective Agent as a Therapy for Parkinson's Disease |
| WO2023064783A1 (en) * | 2021-10-11 | 2023-04-20 | The Johns Hopkins University | Dopa and caffiec acid analogs as novel gcpii inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US393923A (en) * | 1888-12-04 | Samuel preston | ||
| US2868818A (en) * | 1953-12-15 | 1959-01-13 | Merck & Co Inc | Alpha methyl phenylalanines |
| US3725470A (en) * | 1969-05-14 | 1973-04-03 | Hoffmann La Roche | Amino acid derivatives |
| CH562199A5 (pt) * | 1970-10-30 | 1975-05-30 | Hoffmann La Roche | |
| BE793426A (fr) * | 1971-12-28 | 1973-06-28 | Lannacher Heilmittel G M B H | Derives de phenylalanine |
| US3983138A (en) * | 1973-09-25 | 1976-09-28 | Merck & Co., Inc. | Amino acid esters |
| US3939253A (en) * | 1973-11-02 | 1976-02-17 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease |
| US3891696A (en) * | 1973-11-02 | 1975-06-24 | Interx Research Corp | Novel, transient pro-drug forms of l-dopa |
| US4401676A (en) * | 1977-06-01 | 1983-08-30 | Merck & Co., Inc. | Novel α-amino acids |
| US4311706A (en) * | 1980-01-22 | 1982-01-19 | Interx Research Corporation | Novel dopa/dopamine prodrugs |
-
1988
- 1988-09-10 JP JP63227086A patent/JPH02138A/ja active Granted
- 1988-09-14 CA CA000577320A patent/CA1316180C/en not_active Expired - Fee Related
- 1988-09-15 IL IL87765A patent/IL87765A0/xx unknown
- 1988-09-16 AT AT88115183T patent/ATE71083T1/de active
- 1988-09-16 US US07/245,348 patent/US4966915A/en not_active Expired - Fee Related
- 1988-09-16 EP EP88115183A patent/EP0309827B1/en not_active Expired - Lifetime
- 1988-09-16 KR KR1019880012032A patent/KR890005031A/ko not_active Application Discontinuation
- 1988-09-16 DK DK517588A patent/DK517588A/da not_active Application Discontinuation
- 1988-09-16 PT PT88526A patent/PT88526B/pt not_active IP Right Cessation
- 1988-09-16 DE DE8888115183T patent/DE3867403D1/de not_active Expired - Fee Related
- 1988-09-16 AU AU22340/88A patent/AU2234088A/en not_active Abandoned
- 1988-09-17 CN CN88107165A patent/CN1032785A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0541626B2 (pt) | 1993-06-24 |
| AU2234088A (en) | 1989-03-23 |
| CA1316180C (en) | 1993-04-13 |
| JPH02138A (ja) | 1990-01-05 |
| KR890005031A (ko) | 1989-05-11 |
| DE3867403D1 (de) | 1992-02-13 |
| ATE71083T1 (de) | 1992-01-15 |
| PT88526B (pt) | 1992-11-30 |
| DK517588D0 (da) | 1988-09-16 |
| DK517588A (da) | 1989-03-19 |
| EP0309827B1 (en) | 1992-01-02 |
| IL87765A0 (en) | 1989-02-28 |
| CN1032785A (zh) | 1989-05-10 |
| US4966915A (en) | 1990-10-30 |
| EP0309827A1 (en) | 1989-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19920505 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19931130 |