ES8304125A1 - "un procedimiento para la preparacion de nuevos derivados de oxodiazolopirimidina". - Google Patents

"un procedimiento para la preparacion de nuevos derivados de oxodiazolopirimidina".

Info

Publication number
ES8304125A1
ES8304125A1 ES508152A ES508152A ES8304125A1 ES 8304125 A1 ES8304125 A1 ES 8304125A1 ES 508152 A ES508152 A ES 508152A ES 508152 A ES508152 A ES 508152A ES 8304125 A1 ES8304125 A1 ES 8304125A1
Authority
ES
Spain
Prior art keywords
oxadiazolopyrimidine
intermediates
derivative
production
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508152A
Other languages
English (en)
Other versions
ES508152A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8304125A1 publication Critical patent/ES8304125A1/es
Publication of ES508152A0 publication Critical patent/ES508152A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE OXODIAZOLOPIRIMIDINA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R ES ALQUILO, ALQUENILO, ALQUINILO O ALCOXIALQUILO. CONSISTE EN LA REACCION DE 5-AMINO-7- 3,6-DIHIDRO-1(2H)-PIRIDIL -2H 1,2,4 OXADIAZOLO 2,3-C PIRIMIDIN-2-ONA CON UN DERIVADO DE AZOL DE FORMULA (II), EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y A PUEDE SER UNO DE VARIOS RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE -25 C Y LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE HIPERTENSIONES DE ORIGEN VASCULAR Y COMO VASODILATADORES.
ES508152A 1980-12-19 1981-12-18 "un procedimiento para la preparacion de nuevos derivados de oxodiazolopirimidina". Granted ES508152A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH941080 1980-12-19
CH635081 1981-10-02

Publications (2)

Publication Number Publication Date
ES8304125A1 true ES8304125A1 (es) 1983-02-16
ES508152A0 ES508152A0 (es) 1983-02-16

Family

ID=25699419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508152A Granted ES508152A0 (es) 1980-12-19 1981-12-18 "un procedimiento para la preparacion de nuevos derivados de oxodiazolopirimidina".

Country Status (23)

Country Link
US (2) US4410698A (es)
EP (1) EP0054866B1 (es)
KR (1) KR880001636B1 (es)
AR (1) AR229169A1 (es)
AT (1) ATE14734T1 (es)
AU (1) AU545324B2 (es)
BR (1) BR8108269A (es)
CA (1) CA1162538A (es)
CS (1) CS226738B2 (es)
DE (1) DE3171744D1 (es)
DK (1) DK148826C (es)
ES (1) ES508152A0 (es)
FI (1) FI71153C (es)
GR (1) GR76969B (es)
HU (1) HU183744B (es)
IE (1) IE51800B1 (es)
IL (1) IL64524A (es)
MC (1) MC1438A1 (es)
NO (1) NO158422C (es)
NZ (1) NZ199250A (es)
PH (1) PH17300A (es)
PT (1) PT74153B (es)
ZW (1) ZW28581A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148826C (da) * 1980-12-19 1986-03-24 Hoffmann La Roche Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade
CH649291A5 (de) * 1982-03-16 1985-05-15 Hoffmann La Roche Dicarbamate.
WO1986000616A1 (en) * 1984-07-13 1986-01-30 Gail Sansone Bazzano Substituted pyrimidine oxides useful for hair growth promotion
LU86959A1 (fr) * 1987-07-31 1989-03-08 Oreal Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
DE69715869T2 (de) * 1996-07-26 2003-05-28 Vantico Ag Auf epoxyharzen basierende imidazole enthaltende härtbare mischungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH638215A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-derivate.
CH638216A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-deriate.
CA1103245A (en) * 1978-07-21 1981-06-16 Jean-Claude Muller Process for the manufacture of novel oxadiazolopyrimidine derivatives
NZ190915A (en) * 1978-07-31 1984-07-31 Hoffmann La Roche Oxadiazolotriazine derivatives and pharmaceutical compositions
DK148826C (da) * 1980-12-19 1986-03-24 Hoffmann La Roche Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade

Also Published As

Publication number Publication date
EP0054866A2 (de) 1982-06-30
FI71153C (fi) 1986-11-24
CS226738B2 (en) 1984-04-16
US4360521A (en) 1982-11-23
FI814048L (fi) 1982-06-20
FI71153B (fi) 1986-08-14
AU7846481A (en) 1982-06-24
NZ199250A (en) 1984-04-27
CA1162538A (en) 1984-02-21
ATE14734T1 (de) 1985-08-15
IE812990L (en) 1982-06-19
IL64524A0 (en) 1982-03-31
ZW28581A1 (en) 1982-08-11
HU183744B (en) 1984-05-28
AR229169A1 (es) 1983-06-30
EP0054866B1 (de) 1985-08-07
IE51800B1 (en) 1987-04-01
BR8108269A (pt) 1982-10-05
AU545324B2 (en) 1985-07-11
NO158422C (no) 1988-09-07
PH17300A (en) 1984-07-18
DE3171744D1 (en) 1985-09-12
US4410698A (en) 1983-10-18
GR76969B (es) 1984-09-04
KR880001636B1 (ko) 1988-09-03
DK148826B (da) 1985-10-14
PT74153B (en) 1984-01-05
NO814359L (no) 1982-06-21
ES508152A0 (es) 1983-02-16
NO158422B (no) 1988-05-30
EP0054866A3 (en) 1982-09-01
MC1438A1 (fr) 1982-12-06
PT74153A (en) 1982-01-01
IL64524A (en) 1985-05-31
DK504881A (da) 1982-06-20
DK148826C (da) 1986-03-24

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