ES476264A1 - Un procedimiento para la preparacion de derivados peptidicos - Google Patents

Un procedimiento para la preparacion de derivados peptidicos

Info

Publication number
ES476264A1
ES476264A1 ES476264A ES476264A ES476264A1 ES 476264 A1 ES476264 A1 ES 476264A1 ES 476264 A ES476264 A ES 476264A ES 476264 A ES476264 A ES 476264A ES 476264 A1 ES476264 A1 ES 476264A1
Authority
ES
Spain
Prior art keywords
group
production
lower alkyl
hydrogen atom
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476264A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES476264A1 publication Critical patent/ES476264A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un procedimiento para la preparación de derivados peptídicos de la fórmula general **fórmula** en donde R1 representa un átomo de hidrógeno o el grupo metílico o hidroximetílico o un grupo monodi o trihalometílico R2 represesnta el grupo caracterizante de un alfa aminoácido del tipo que se encuentra normalmente en las proteínas o un grupo de alquilo inferior o hidroxi (alquilo inferior ) distinto del grupo caracterizante de un alfa aminoácido del tipo que se encuentra normalmente en las proteína o un grupo de alquilo inferior o hidroxi (alquilo inferior ) distinto del grupo caracterizante de un alfa aminoácido del tipo que se encuentra normalmente en las proteínas R3 representa un grupo de alquilo inferior , cicloalquilo inferior, alquenilo inferior, arilo o aril (alquilo inferior) R4 representa un átomo de hidrógeno o un grupo de alquilo inferior.
ES476264A 1977-12-23 1978-12-22 Un procedimiento para la preparacion de derivados peptidicos Expired ES476264A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5366877 1977-12-23
GB7845272 1978-11-20

Publications (1)

Publication Number Publication Date
ES476264A1 true ES476264A1 (es) 1980-05-16

Family

ID=26267312

Family Applications (2)

Application Number Title Priority Date Filing Date
ES476264A Expired ES476264A1 (es) 1977-12-23 1978-12-22 Un procedimiento para la preparacion de derivados peptidicos
ES482504A Expired ES482504A1 (es) 1977-12-23 1979-07-16 Un procedimiento para la preparacion de derivados peptidicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES482504A Expired ES482504A1 (es) 1977-12-23 1979-07-16 Un procedimiento para la preparacion de derivados peptidicos

Country Status (24)

Country Link
US (1) US4250085A (es)
EP (1) EP0002822B1 (es)
JP (1) JPS5492922A (es)
AR (1) AR222479A1 (es)
AT (1) AT365166B (es)
AU (1) AU4258178A (es)
BR (1) BR7808474A (es)
CA (1) CA1108125A (es)
CS (1) CS210680B2 (es)
DE (2) DE2855786A1 (es)
DK (1) DK581178A (es)
ES (2) ES476264A1 (es)
FI (1) FI783959A (es)
FR (3) FR2453866A1 (es)
GR (1) GR72974B (es)
IL (1) IL56241A0 (es)
IT (1) IT1102755B (es)
LU (1) LU80715A1 (es)
MC (1) MC1243A1 (es)
NL (1) NL7812314A (es)
NO (1) NO784354L (es)
NZ (1) NZ189205A (es)
PT (1) PT68978A (es)
SE (1) SE7813274L (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026867A1 (de) * 1979-09-28 1981-04-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Peptidylphosphonsäuren, deren Herstellung und Verwendung und sie enthaltende pharmazeutische Präparate
JPS5885897A (ja) * 1981-11-17 1983-05-23 Kyowa Hakko Kogyo Co Ltd 光学活性な１−アミノ−２−（４−ヒドロキシフエニル）エチルホスホン酸およびその誘導体
JPS57156498A (en) * 1981-03-20 1982-09-27 Kyowa Hakko Kogyo Co Ltd Novel physiologically active substance k-26
JPS5831992A (ja) * 1981-08-19 1983-02-24 Kyowa Hakko Kogyo Co Ltd 新規生理活性物質ｋ−４およびその製造法
EP0061172B1 (en) * 1981-03-20 1985-06-19 Kyowa Hakko Kogyo Co., Ltd. Phosphorus-containing oligopeptides, processes for preparation thereof and a pharmaceutical composition containing the same
EP0103867B1 (en) * 1982-09-17 1986-12-17 Kyowa Hakko Kogyo Co., Ltd. Phosphorus-containing peptide derivative
US4482488A (en) * 1982-09-27 1984-11-13 Eli Lilly And Company Antibiotic A53868 and process for production thereof
PT77368A (en) * 1982-09-27 1983-10-01 Lilly Co Eli Improved process for preparing immunomodulating agents or rela-ting there to
FR2584077B1 (fr) * 1985-06-28 1988-07-08 Irceba L-di ou tripeptides possedant une activite biologique utilisable en medecine humaine et veterinaire, procede pour leur obtention et medicament en contenant
HUT52785A (en) * 1988-03-03 1990-08-28 Squibb & Sons Inc Process for producing 1,2-hydroxy-phosphonates and derivatives
JPH03505875A (ja) * 1988-07-08 1991-12-19 スミスクライン・ベックマン・コーポレイション レトロウイルス・プロテアーゼ結合ペプチド
WO1990009172A1 (en) * 1989-02-16 1990-08-23 Pfizer Inc. Phosphorus containing renin inhibitors
US5468732A (en) * 1989-02-16 1995-11-21 Pfizer Inc. Phosphorus containing renin inhibitors
DE4417478A1 (de) 1994-05-19 1995-11-23 Basf Ag Verfahren zur Herstellung N-Z-geschützter N-methylierter Aminosäuren
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48835A (en) * 1975-01-27 1979-05-31 Sparamedica Ag Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem
CA1057082A (en) * 1976-05-13 1979-06-26 Dale K. Bell Air piston differential lockout
JPS6037745Y2 (ja) * 1976-05-18 1985-11-11 富士写真フイルム株式会社 磁気テ−プカセツト
IT1081511B (it) * 1976-07-13 1985-05-21 Hoffmann La Roche Derivati di peptidi e loro preparazione

Also Published As

Publication number Publication date
CS210680B2 (en) 1982-01-29
ATA918478A (de) 1981-05-15
ES482504A1 (es) 1980-04-01
FI783959A (fi) 1979-06-24
NL7812314A (nl) 1979-06-26
IT7831276A0 (it) 1978-12-22
AT365166B (de) 1981-12-28
AU4258178A (en) 1979-06-28
DE2855786A1 (de) 1979-07-05
JPS5492922A (en) 1979-07-23
EP0002822B1 (de) 1982-07-28
LU80715A1 (de) 1980-07-21
DE2861980D1 (en) 1982-09-16
CA1108125A (en) 1981-09-01
NZ189205A (en) 1982-03-23
NO784354L (no) 1979-06-26
GR72974B (es) 1984-01-20
SE7813274L (sv) 1979-08-08
MC1243A1 (fr) 1979-10-26
AR222479A1 (es) 1981-05-29
DK581178A (da) 1979-06-24
IT1102755B (it) 1985-10-07
BR7808474A (pt) 1979-08-21
FR2453866A1 (fr) 1980-11-07
IL56241A0 (en) 1979-03-12
PT68978A (en) 1979-01-01
FR2453867A1 (fr) 1980-11-07
EP0002822A1 (de) 1979-07-11
FR2446838A1 (fr) 1980-08-14
US4250085A (en) 1981-02-10

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