FR2453867A1 - Derives peptidiques d'acides phosphoniques - Google Patents

Derives peptidiques d'acides phosphoniques

Info

Publication number
FR2453867A1
FR2453867A1 FR7916925A FR7916925A FR2453867A1 FR 2453867 A1 FR2453867 A1 FR 2453867A1 FR 7916925 A FR7916925 A FR 7916925A FR 7916925 A FR7916925 A FR 7916925A FR 2453867 A1 FR2453867 A1 FR 2453867A1
Authority
FR
France
Prior art keywords
group
hydroxy
proteins
characterizing
alcoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7916925A
Other languages
English (en)
Inventor
Frank Ratcliffe Atherton
Michael John Hall
Cedric Herbert Hassall
Robert Wilson Lambert
Peter Stuart Ringrose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2453867A1 publication Critical patent/FR2453867A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES CHIMIQUES NOUVEAUX. CES COMPOSES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) OU L VAUT 2 OU 3, R ET R REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU UN GROUPE PROTECTEUR ALCOYLE INFERIEUR; R REPRESENTE UN ATOME D'HYDROGENE, LE GROUPE METHYLE OU HYDROXY-METHYLE OU UN GROUPE MONO-, DI- OU TRI-HALOMETHYLE, OU REPRESENTE UN GROUPE HYDROXY-METHYLE PROTEGE; ET R REPRESENTE LE GROUPE CARACTERISANT D'UN ACIDE A-AMINE DU TYPE NORMALEMENT RENCONTRE DANS LES PROTEINES OU UN GROUPE ALCOYLE INFERIEUR OU HYDROXYALCOYLE INFERIEUR AUTRE QUE LE GROUPE CARACTERISANT D'UN ACIDE A-AMINE DU TYPE NORMALEMENT RENCONTRE DANS LES PROTEINES, SAUF QUE TOUT GROUPE AMINO EVENTUELLEMENT PRESENT PEUT ETRE SOUS FORME PROTEGEE ET AVEC LA PRECISION QU'AU MOINS UN GROUPE R REPRESENTE UN GROUPE ALCOYLE INFERIEUR OU HYDROXY(ALCOYLE INFERIEUR) AUTRE QUE LE GROUPE CARACTERISANT D'UN ACIDE AMINE DU TYPE NORMALEMENT RENCONTRE DANS LES PROTEINES OU UN GROUPE HYDROXY-(ALCOYLE INFERIEUR) DONT LA FRACTION HYDROXY EST PROTEGEE; ET OU LA CONFIGURATION A L'ATOME DE CARBONE DESIGNE PAR A EST R LORSQUE R REPRESENTE AUTRE CHOSE QU'UN ATOME D'HYDROGENE ET LA CONFIGURATION A L'ATOME DE CARBONE DESIGNE PAR B EST L LORSQUE R REPRESENTE AUTRE CHOSE QU'UN ATOME D'HYDROGENE. CES COMPOSES SONT UTILES COMME INTERMEDIAIRES ET COMME PRODUITS PHARMACEUTIQUEMENT ACTIFS.
FR7916925A 1977-12-23 1979-06-29 Derives peptidiques d'acides phosphoniques Withdrawn FR2453867A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5366877 1977-12-23
GB7845272 1978-11-20

Publications (1)

Publication Number Publication Date
FR2453867A1 true FR2453867A1 (fr) 1980-11-07

Family

ID=26267312

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7835650A Withdrawn FR2453866A1 (fr) 1977-12-23 1978-12-19 Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques
FR7916925A Withdrawn FR2453867A1 (fr) 1977-12-23 1979-06-29 Derives peptidiques d'acides phosphoniques
FR7916924A Withdrawn FR2446838A1 (fr) 1977-12-23 1979-06-29 Derives peptidiques d'acides phosphoniques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7835650A Withdrawn FR2453866A1 (fr) 1977-12-23 1978-12-19 Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7916924A Withdrawn FR2446838A1 (fr) 1977-12-23 1979-06-29 Derives peptidiques d'acides phosphoniques

Country Status (24)

Country Link
US (1) US4250085A (fr)
EP (1) EP0002822B1 (fr)
JP (1) JPS5492922A (fr)
AR (1) AR222479A1 (fr)
AT (1) AT365166B (fr)
AU (1) AU4258178A (fr)
BR (1) BR7808474A (fr)
CA (1) CA1108125A (fr)
CS (1) CS210680B2 (fr)
DE (2) DE2855786A1 (fr)
DK (1) DK581178A (fr)
ES (2) ES476264A1 (fr)
FI (1) FI783959A (fr)
FR (3) FR2453866A1 (fr)
GR (1) GR72974B (fr)
IL (1) IL56241A0 (fr)
IT (1) IT1102755B (fr)
LU (1) LU80715A1 (fr)
MC (1) MC1243A1 (fr)
NL (1) NL7812314A (fr)
NO (1) NO784354L (fr)
NZ (1) NZ189205A (fr)
PT (1) PT68978A (fr)
SE (1) SE7813274L (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026867A1 (fr) * 1979-09-28 1981-04-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Acides peptidylphosphoniques, leur préparation et leur utilisation et préparations pharmaceutiques les contenant
EP0061172B1 (fr) * 1981-03-20 1985-06-19 Kyowa Hakko Kogyo Co., Ltd. Oligopeptides phosphorés, leurs procédés de préparation et compositions pharmaceutiques qui les contiennent
JPS57156498A (en) * 1981-03-20 1982-09-27 Kyowa Hakko Kogyo Co Ltd Novel physiologically active substance k-26
JPS5831992A (ja) * 1981-08-19 1983-02-24 Kyowa Hakko Kogyo Co Ltd 新規生理活性物質ｋ−４およびその製造法
JPS5885897A (ja) * 1981-11-17 1983-05-23 Kyowa Hakko Kogyo Co Ltd 光学活性な１−アミノ−２−（４−ヒドロキシフエニル）エチルホスホン酸およびその誘導体
EP0103867B1 (fr) * 1982-09-17 1986-12-17 Kyowa Hakko Kogyo Co., Ltd. Dérivé de peptide contenant du phosphore
PT77368A (en) * 1982-09-27 1983-10-01 Lilly Co Eli Improved process for preparing immunomodulating agents or rela-ting there to
US4482488A (en) * 1982-09-27 1984-11-13 Eli Lilly And Company Antibiotic A53868 and process for production thereof
FR2584077B1 (fr) * 1985-06-28 1988-07-08 Irceba L-di ou tripeptides possedant une activite biologique utilisable en medecine humaine et veterinaire, procede pour leur obtention et medicament en contenant
JPH02503440A (ja) * 1988-03-03 1990-10-18 イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド １，２‐ヒドロキシホスホネートおよびその誘導体
HUT58764A (en) * 1988-07-08 1992-03-30 Smithkline Beckman Corp Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates
US5468732A (en) * 1989-02-16 1995-11-21 Pfizer Inc. Phosphorus containing renin inhibitors
WO1990009172A1 (fr) * 1989-02-16 1990-08-23 Pfizer Inc. Inhibiteurs de renine contenant du phosphore
DE4417478A1 (de) 1994-05-19 1995-11-23 Basf Ag Verfahren zur Herstellung N-Z-geschützter N-methylierter Aminosäuren
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48835A (en) * 1975-01-27 1979-05-31 Sparamedica Ag Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem
CA1057082A (fr) * 1976-05-13 1979-06-26 Dale K. Bell Blocage de differentiel par piston mu par l'air
JPS6037745Y2 (ja) * 1976-05-18 1985-11-11 富士写真フイルム株式会社 磁気テ−プカセツト
IT1081511B (it) * 1976-07-13 1985-05-21 Hoffmann La Roche Derivati di peptidi e loro preparazione

Also Published As

Publication number Publication date
AT365166B (de) 1981-12-28
LU80715A1 (de) 1980-07-21
FI783959A (fi) 1979-06-24
BR7808474A (pt) 1979-08-21
IL56241A0 (en) 1979-03-12
NZ189205A (en) 1982-03-23
GR72974B (fr) 1984-01-20
DK581178A (da) 1979-06-24
CA1108125A (fr) 1981-09-01
JPS5492922A (en) 1979-07-23
ES482504A1 (es) 1980-04-01
DE2855786A1 (de) 1979-07-05
SE7813274L (sv) 1979-08-08
NO784354L (no) 1979-06-26
CS210680B2 (en) 1982-01-29
NL7812314A (nl) 1979-06-26
ES476264A1 (es) 1980-05-16
US4250085A (en) 1981-02-10
EP0002822B1 (fr) 1982-07-28
IT7831276A0 (it) 1978-12-22
FR2446838A1 (fr) 1980-08-14
AR222479A1 (es) 1981-05-29
IT1102755B (it) 1985-10-07
EP0002822A1 (fr) 1979-07-11
MC1243A1 (fr) 1979-10-26
DE2861980D1 (en) 1982-09-16
FR2453866A1 (fr) 1980-11-07
ATA918478A (de) 1981-05-15
AU4258178A (en) 1979-06-28
PT68978A (en) 1979-01-01

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Legal Events

Date Code Title Description
ST Notification of lapse