FR2372145A1 - - Google Patents

Info

Publication number
FR2372145A1
FR2372145A1 FR7722352A FR7722352A FR2372145A1 FR 2372145 A1 FR2372145 A1 FR 2372145A1 FR 7722352 A FR7722352 A FR 7722352A FR 7722352 A FR7722352 A FR 7722352A FR 2372145 A1 FR2372145 A1 FR 2372145A1
Authority
FR
France
Prior art keywords
tetradecapeptides
phé
cys
thr
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7722352A
Other languages
English (en)
Other versions
FR2372145B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2372145A1 publication Critical patent/FR2372145A1/fr
Application granted granted Critical
Publication of FR2372145B1 publication Critical patent/FR2372145B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des tétradécapeptides de formule L -Ala - Gly - L - Cys - L - Lys L - Asn - L - Phé - L - Phé - L - Trp - L - Lys - L - Thr - Y - L - Thr - L - Sér. - L - Cys - OH où Y est L-Cha, L-Leu ou D-Phé, ainsi que leurs sels d'addition d'acide pharmaceutiquement acceptables et non toxiques, leurs préparations et les intermédiaires utilisables dans la synthèse de ces tétradécapeptides. Les tétradécapeptides obtenus ainsi que leurs sels daddition d'acide pharmaceutiquement acceptables inhibent la libération de l'hormone de croissance.
FR7722352A 1976-07-28 1977-07-21 Expired FR2372145B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/709,465 US4061607A (en) 1976-07-28 1976-07-28 Somatostatin analogs and intermediates thereto

Publications (2)

Publication Number Publication Date
FR2372145A1 true FR2372145A1 (fr) 1978-06-23
FR2372145B1 FR2372145B1 (fr) 1980-02-29

Family

ID=24849967

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7722352A Expired FR2372145B1 (fr) 1976-07-28 1977-07-21

Country Status (11)

Country Link
US (1) US4061607A (fr)
JP (1) JPS5315393A (fr)
BE (1) BE857072A (fr)
CA (2) CA1091650A (fr)
CH (1) CH632486A5 (fr)
DE (1) DE2733550A1 (fr)
FR (1) FR2372145B1 (fr)
GB (1) GB1580714A (fr)
IE (1) IE45101B1 (fr)
IL (2) IL52367A (fr)
NL (1) NL7708302A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199500A (en) * 1978-11-20 1980-04-22 Eli Lilly And Company Peptides related to somatostatin
US4199501A (en) * 1978-11-20 1980-04-22 Eli Lilly And Company Peptides related to somatostatin
US4428942A (en) 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
JPS61271437A (ja) * 1985-05-28 1986-12-01 Sumitomo Metal Ind Ltd 搬送原料のサンプリング方法

Also Published As

Publication number Publication date
BE857072A (fr) 1978-01-23
US4061607A (en) 1977-12-06
IE45101L (en) 1978-01-28
IL59819A0 (en) 1980-06-30
GB1580714A (en) 1980-12-03
IE45101B1 (en) 1982-06-16
NL7708302A (nl) 1978-01-31
CA1091650A (fr) 1980-12-16
JPS5315393A (en) 1978-02-13
FR2372145B1 (fr) 1980-02-29
IL52367A0 (en) 1977-08-31
DE2733550A1 (de) 1978-02-02
CA1100485A (fr) 1981-05-05
CH632486A5 (de) 1982-10-15
IL52367A (en) 1981-03-31

Similar Documents

Publication Publication Date Title
FR2387941A1 (fr) Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament
FR2356424A1 (fr) Compositions pharmaceutiques a base d'acide phophono-formique utiles pour lutter contre les infections virales
TNSN87033A1 (fr) TOLUNITRILES SUBSTITUES PAR DESα - HETEROCYCLES
FR2359144A1 (fr) Sels de l'acide clavulanique utilisable comme medicaments
FR2438654A1 (fr) Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose
DE3474140D1 (en) Imidazole-ethanol esters
ES477784A1 (es) Procedimiento para la preparacion de nuevas 2-fenilimino-imidazolidinas sustituidas.
FR2450820A1 (fr) Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation
ES466852A1 (es) Procedimiento para la preparacion de 2-bromo-6-fluor-n-2-i- midazolidinilidenbenzamina.
FR2372145A1 (fr)
FR2355822A1 (fr) Derives d'esters de l'acide indolacetique. utiles comme anti-inflammatoires et analgesiques
FR2457867A1 (fr) Nouveaux derives d'hydroxyamino-eburnane : leur procede de preparation, intermediaires utilises et utilisation comme medicament et comme intermediaire
GB1496491A (en) Dihydroergopeptine derivatives
ES461785A1 (es) Un metodo para la preparacion de un ester de acido behenico.
FR2412309A1 (fr) Compositions a base de derives d'isothiouree et leurs applications
FR2363560A1 (fr) Nouveau compose a action analgesique et compositions therapeutiques en contenant
GB1238095A (fr)
ES8504704A1 (es) Un compuesto de pirrol-2-acetilaminoacido
FR2450260A1 (fr) Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques
ES8300747A1 (es) Procedimiento para la preparacion de derivados de acido in- dolacetico
FR2359836A1 (fr) Ethers de zearaline utiles comme agents promoteurs de la croissance
GB1279380A (en) Improvements in or relating to hydantoins and compositions thereof
ES8602789A1 (es) Procedimiento para preparar derivados de 14-hidroxiimino- eburnano racemicos y opticamente activos
FR2355832A1 (fr) Sels de sulfonium d'esters d'acide acetique substitue et leur application a des compositions biocides
GB1492236A (en) Di-hydroethanoanthracene derivatives

Legal Events

Date Code Title Description
ST Notification of lapse