FR2450260A1 - Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques - Google Patents

Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques

Info

Publication number
FR2450260A1
FR2450260A1 FR7835551A FR7835551A FR2450260A1 FR 2450260 A1 FR2450260 A1 FR 2450260A1 FR 7835551 A FR7835551 A FR 7835551A FR 7835551 A FR7835551 A FR 7835551A FR 2450260 A1 FR2450260 A1 FR 2450260A1
Authority
FR
France
Prior art keywords
group
hydrogen atom
alcoyl
preparation
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7835551A
Other languages
English (en)
Inventor
Frank Ratcliffe Atherton
Michael John Hall
Cedric Herbert Hassall
Robert Wilson Lambert
Peter Stuart Ringrose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2450260A1 publication Critical patent/FR2450260A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES DERIVES PEPTIDIQUES. IL S'AGIT DE COMPOSES DE FORMULE GENERALE : (CF DESSIN DANS BOPI) OU R REPRESENTE UN ATOME D'HYDROGENE, UN GROUPE METHYLE OU HYDROXYMETHYLE OU UN GROUPE MONO-, DI- OU TRIHALOMETHYLE, R REPRESENTE UN ALCOYLE INFERIEUR, UN GROUPE HYDROXY-(ALCOYLE INFERIEUR) OU GUANIDINO-(ALCOYLE INFERIEUR) AUTRE QUE LE GROUPE CARACTERISANT D'UN ACIDE ALPHA-AMINE DU TYPE NORMALEMENT RENCONTRE DANS LES PROTEINES; LA CONFIGURATION A L'ATOME DE CARBONE DESIGNE COMME A EST R LORSQUE R REPRESENTE AUTRE CHOSE QU'UN ATOME D'HYDROGENE ET LA CONFIGURATION A L'ATOME DE CARBONE DESIGNE COMME B EST L, ET LEURS SELS UTILISABLES EN PHARMACIE. CES COMPOSES SONT UTILES NOTAMMENT EN PHARMACIE POUR RENFORCER L'ACTIVITE DES ANTIBIOTIQUES.
FR7835551A 1977-12-20 1978-12-18 Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques Withdrawn FR2450260A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5293877 1977-12-20
GB7842727 1978-11-01

Publications (1)

Publication Number Publication Date
FR2450260A1 true FR2450260A1 (fr) 1980-09-26

Family

ID=26267167

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7835551A Withdrawn FR2450260A1 (fr) 1977-12-20 1978-12-18 Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques

Country Status (23)

Country Link
EP (1) EP0002534B1 (fr)
JP (1) JPS5492921A (fr)
AT (1) AT366057B (fr)
AU (1) AU4248378A (fr)
BR (1) BR7808342A (fr)
CS (1) CS211394B2 (fr)
CU (1) CU35001A (fr)
DE (2) DE2854292A1 (fr)
DK (1) DK536578A (fr)
ES (1) ES476124A1 (fr)
FI (1) FI783886A (fr)
FR (1) FR2450260A1 (fr)
GR (1) GR73085B (fr)
IL (1) IL56208A0 (fr)
IT (1) IT1102401B (fr)
LU (1) LU80671A1 (fr)
MC (1) MC1242A1 (fr)
NL (1) NL7812311A (fr)
NO (1) NO784285L (fr)
NZ (1) NZ189151A (fr)
PT (1) PT68938A (fr)
SE (1) SE7813069L (fr)
ZA (1) ZA786976B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1307787C (fr) * 1986-06-11 1992-09-22 Melanie J. Loots Inhibiteurs de l'enzyme de conversion de l'angiotensine, a base d'aminoalcanoylamino-alkylphosphonate a substitution
CN110156640A (zh) * 2019-06-14 2019-08-23 南京博源医药科技有限公司 一种n-苄氧羰基-氨基酸的制备工艺
CN110143896A (zh) * 2019-06-14 2019-08-20 南京博源医药科技有限公司 一种n-苄氧羰基-l-己氨酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1081511B (it) * 1976-07-13 1985-05-21 Hoffmann La Roche Derivati di peptidi e loro preparazione
DE2632188A1 (de) * 1976-07-16 1978-01-26 Hoffmann La Roche Wirkstoffkombinationen
GB1585275A (en) * 1976-07-21 1981-02-25 Roche Products Ltd Peptide derivatives of phosphonic and phosphinic acids

Also Published As

Publication number Publication date
IT1102401B (it) 1985-10-07
GR73085B (fr) 1984-01-31
NL7812311A (nl) 1979-06-22
CU35001A (en) 1981-12-04
DE2861537D1 (en) 1982-02-25
AU4248378A (en) 1979-06-28
NZ189151A (en) 1981-05-15
MC1242A1 (fr) 1979-10-26
ES476124A1 (es) 1980-07-16
AT366057B (de) 1982-03-10
ATA904178A (de) 1981-07-15
EP0002534A1 (fr) 1979-06-27
NO784285L (no) 1979-06-21
DE2854292A1 (de) 1979-07-05
DK536578A (da) 1979-06-21
LU80671A1 (de) 1980-01-22
IT7831023A0 (it) 1978-12-19
CS211394B2 (en) 1982-02-26
EP0002534B1 (fr) 1982-01-13
IL56208A0 (en) 1979-03-12
PT68938A (en) 1979-01-01
ZA786976B (en) 1980-07-30
BR7808342A (pt) 1979-08-07
JPS5492921A (en) 1979-07-23
FI783886A (fi) 1979-06-21
SE7813069L (sv) 1979-06-21

Similar Documents

Publication Publication Date Title
FR2439187A1 (fr) Derives de 1-piperazine-carboxamides et -carbothioamides substitues, procede de preparation et compositions pharmaceutiques les contenant
FR2453866A1 (fr) Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques
FR2384743A1 (fr) Complexes optiquement actifs amino-acide-acide mandelique, et procedes pour leur preparation et la separation de leurs composants
FR2413389A1 (fr) Composes a tete de pont azotee ayant une action anti-allergique et procede pour leur preparation
FR2387235A1 (fr) Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
FR2450820A1 (fr) Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation
FR2394546A1 (fr) Nouveaux derives de 1,2,3,4,6,7-hexahydro-11bah-benzo(a)-quinolizine, leur preparation et leur application en tant que medicaments
EP1069125A3 (fr) Dérivés carbamates de 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones et d'analogues de l'acide 1-amino-1-cyclopropane carboxylique, procédé pour leur préparation et leur application comme médicaments
FR2506772A1 (fr) Glycosides d'anthracycline, procede pour les preparer et leur usage comme medicament
FR2407928A1 (fr) Derives de quinazoline utiles comme medicaments antihypertenseurs et procede de leur preparation
FR2457294A1 (fr) Derives de l'acide penicillanique utiles comme medicaments, compositions therapeutiques les contenant et procedes de leur preparation
FR2418797A1 (fr) Nouveaux derives heterocycliques d'acide acetique, leur procede de preparation et leur application en therapeutique
IE820539L (en) Substituted biphenyl compounds
FR2444029A1 (fr) Nouveaux derives d'acide phenylcyclopropane-carboxylique, leur procede de preparation et leur application comme insecticides et acaricides
FR2450260A1 (fr) Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques
BE904656A (fr) Ethers cyclopentyliques, leur preparation et formulations pharmaceutiques les contenant.
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
FR2457867A1 (fr) Nouveaux derives d'hydroxyamino-eburnane : leur procede de preparation, intermediaires utilises et utilisation comme medicament et comme intermediaire
FR2438649A1 (fr) Derives de 1-phenyl-1-propanol, leur preparation et leurs utilisations therapeutiques notamment comme antihypertenseurs, vasodilatateurs peripheriques et antithrombiques
BE906056A (fr) Derives de gonadoliberine contenant un acide aminocarboxylique aromatique en position 6, compositions pharmaceutiques et veterinaires les contenant et procede pour les preparer.
FR2446831A1 (fr) Derive oxyimino-e-homo-eburnane, procede pour le preparer et son utilisation dans une composition pharmaceutique pour la preparation de derives ester de l'acide apovincaminique
FR2411173A1 (fr) Anthranilates de n-hydroxyalkyl-carboxamides et leur application comme reticulants
FR2616325B1 (fr) Composition contenant de l'hydroquinone et de l'acide kojique et composition pharmaceutique, notamment dermatologique, a activite depigmentante ou anti-inflammatoire, ou cosmetique comprenant de l'acide kojique et de l'hydroquinone
FR2416013A1 (fr) Derives d'acide (-)-(cis)-1,2-epoxypropylphosphonique, leur preparation et compositions pharmaceutiques les contenant
FR2455596A1 (fr) Nouveaux antibiotiques presentant une activite antibacterienne, leur procede de production, leur souche servant a leur obtention et les compositions pharmaceutiques les contenant

Legal Events

Date Code Title Description
ST Notification of lapse